dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0051956
Uniprot Accession F8VQC1; F8VQC1_MOUSE;
Genbank Protein ID NP_079967.1;
Genbank Nucleotide ID NM_025691.1;
Protein Name Signal recognition particle subunit SRP72
Protein Synonyms/Alias
Gene Name Srp72
Gene Synonyms/Alias
Organism Mus musculus(Mouse)
NCBI Taxa ID 10090
Functional Description
(View all)		 Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane.
Phosphorylation Sites
 dbPAF PTMs: 18
PositionPeptidesSourceReferences ( PMIDs )
79TKVLANNSLSFEKAYcurated25338131
139YRDLVRNSQDDYDEEPhosphoSitePlus22135298
282KDQNVFDSKKKVKLTPhosphoSitePlus22135298
443YQSHQPKSPAHLSLIPhosphoSitePlus22135298
524DVEALENSPGATYIRPhosphoSitePlus;curated22135298; 20469934; 23567750; 25338131
571KNYDPKVTPDPERWLPhosphoSitePlus;curated22135298; 23684622
610QGATAGASSELDASKPhosphoSitePlus;curated22135298; 25338131
611GATAGASSELDASKAPhosphoSitePlus;curated22135298; 25338131
620LDASKAVSSPPTSPRPHOSIDA;PhosphoSitePlus;curated21081558; 22135298; 23684622; 22817900; 21183079; 25338131
621DASKAVSSPPTSPRPPHOSIDA;PhosphoSitePlus;SysPTM 2.0;curated21081558; 22135298; 17242355; 19366988; 23684622; 21743459;
624KAVSSPPTSPRPGSAPHOSIDA;PhosphoSitePlus;SysPTM 2.0;curated21081558; 22135298; 17242355; 19366988; 23684622; 22817900;
625AVSSPPTSPRPGSAAPHOSIDA;PhosphoSitePlus;SysPTM 2.0;curated21081558; 22135298; 17242355; 19366988; 23684622; 21743459;
630PTSPRPGSAATISSSPHOSIDA;PhosphoSitePlus;SysPTM 2.0;curated21081558; 22135298; 17242355; 19366988; 23684622; 22817900;
633PRPGSAATISSSASNPhosphoSitePlus;curated22135298; 23684622; 23567750
635PGSAATISSSASNIVPhosphoSitePlus;curated22135298; 23684622
636GSAATISSSASNIVPPhosphoSitePlus;SysPTM 2.0;curated22135298; 17242355; 19366988; 22817900; 21183079
637SAATISSSASNIVPPPhosphoSitePlus22135298
639ATISSSASNIVPPRHPhosphoSitePlus22135298
Sequence
(Fasta)		MASGGSGGVS VPALWSEVNR YGQNSDFTRA LKTVNKILQI NKDDVTALHC KVVCLIQNGS 60
FKEALNVINT HTKVLANNSL SFEKAYCEYR LNRIENALKT IESATQQTDK LKELYGQVLY 120
RLERYDECLA VYRDLVRNSQ DDYDEERKTN LSAVVAAQSN WEKVVPENLG LQEGTHELCY 180
NAACALIGQG QLTQAMKILQ KAEDLCRRSF SEDSDGAEED PQAELAIIHG QMAYIMQLQG 240
RTEEALQLYN QIIKLKPTDV ALLAVIANNI ITINKDQNVF DSKKKVKLTN AEGVEFKLSK 300
RQLQAIEFNK ALLAMYTNQA EQCRKIAASL QSQSPEYLLP VLIQAAQLCR EKQHTKAIEL 360
LQEFSDQHPE NAAEIKLTMA QLKISQGNIS KACLILRSIE ELRHKPGMVS ALVTMYSHEE 420
DIDSAIEVFT QAIQWYQSHQ PKSPAHLSLI REAANFKLKY GRKKEAVSDL EQLWKQNSKD 480
IHTLAQLISA YSLVDPEKAK ALSKHLPSSD SMSLKVDVEA LENSPGATYI RKKGGKVTGD 540
NQPKEQGQGD LKKKKKKKKG KLPKNYDPKV TPDPERWLPM RERSYYRGRK KGKKKDQIGK 600
GTQGATAGAS SELDASKAVS SPPTSPRPGS AATISSSASN IVPPRHQKPA GAPATKKKQQ 660
QKKKKGGKSG W 672
Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0687--Ribonucleoprotein
KW-0733--Signal recognition particle
Interpro

IPR013699--Signal_recog_part_SRP72_RNA-bd
IPR026270--SRP72
IPR031545--SRP_TPR_like
IPR013026--TPR-contain_dom
IPR011990--TPR-like_helical_dom
IPR013105--TPR_2
IPR019734--TPR_repeat
PROSITE

PS50005--TPR
PS50293--TPR_REGION
Pfam

PF08492--SRP72
PF17004--SRP_TPR_like
PF07719--TPR_2
PF13181--TPR_8
PF13371--TPR_9
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005783--C:endoplasmic reticulum
GO:0005730--C:nucleolus
GO:0005886--C:plasma membrane
GO:0005786--C:signal recognition particle, endoplasmic reticulum targeting
GO:0008312--F:7S RNA binding
GO:0044822--F:poly(A) RNA binding
GO:0005047--F:signal recognition particle binding
GO:0042493--P:response to drug
GO:0006614--P:SRP-dependent cotranslational protein targeting to membrane