dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0051953
Uniprot Accession F8VQB6; MYO10_MOUSE; Q8R3S0; Q9JJY5;
Genbank Protein ID NP_062345.2; XP_006520088.1;
Genbank Nucleotide ID NM_019472.2; XM_006520025.2;
Protein Name Unconventional myosin-X
Protein Synonyms/Alias Unconventional myosin-10;
Gene Name Myo10
Gene Synonyms/Alias
Organism Mus musculus(Mouse)
NCBI Taxa ID 10090
Functional Description
(View all)		 Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. MYO10 binds to actin filaments and actin bundles and functions as plus end-directed motor. The tail domain binds to membranous compartments containing phosphatidylinositol 3,4,5-trisphosphate or integrins, and mediates cargo transport along actin filaments (By similarity). Regulates cell shape, cell spreading and cell adhesion. Stimulates the formation and elongation of filopodia. May play a role in neurite outgrowth and axon guidance. In hippocampal neurons it induces the formation of dendritic filopodia by trafficking the actin-remodeling protein VASP to the tips of filopodia, where it promotes actin elongation. Plays a role in formation of the podosome belt in osteoclasts.
Phosphorylation Sites
 dbPAF PTMs: 24 (View all)
PositionPeptidesSourceReferences ( PMIDs )
585ESRFDFIYDLFEHVSPhosphoSitePlus22135298
874SQREADLTRELEKQRcurated21183079
961RNIERSLSVGSEISGcurated21743459
964ERSLSVGSEISGEELdbPTM 3.0;PhosphoSitePlus;curated19367708; 16381945; 23193290; 22135298; 21743459
1024HGHSDQRTSGIRTSDcurated23684622; 25338131
1127QWSPDYRYSVGTYNSPhosphoSitePlus22135298
1128WSPDYRYSVGTYNSSPhosphoSitePlus22135298
1131DYRYSVGTYNSSGAYPhosphoSitePlus22135298
1132YRYSVGTYNSSGAYRPhosphoSitePlus22135298
1134YSVGTYNSSGAYRFSdbPTM 3.0;PhosphoSitePlus;curated21183079; 16381945; 23193290; 22135298; 21743459; 25338131
1135SVGTYNSSGAYRFSSdbPTM 3.0;PhosphoSitePlus;curated21183079; 16381945; 23193290; 22135298; 21743459
1138TYNSSGAYRFSSEGAPhosphoSitePlus22135298
1152AQSSFEDSEEDFDSRPHOSIDA21081558
1162DFDSRFDTDDELSYRcurated21743459
1277AKEIIDNTSKENGIDPhosphoSitePlus22135298
1278KEIIDNTSKENGIDIPhosphoSitePlus22135298
1715VYCHGGGSCKITINScurated25521595
1878STKTFTPYERLEKRRdbPTM 3.0;PhosphoSitePlus20116462; 16381945; 23193290; 22135298
1886ERLEKRRTSFLEGTLdbPTM 3.0;PhosphoSitePlus;curated21183079; 16381945; 23193290; 22135298; 21743459
1887RLEKRRTSFLEGTLRdbPTM 3.0;PHOSIDA;PhosphoSitePlus;curated19367708; 21183079; 21659604; 16381945; 23193290; 21081558;
Sequence
(Fasta)		MDSFFPEGAR VWLRENGQHF PSTVNSCAEG VVVFQTDYGQ VFTYKQSTIT NQKVTAMHPL 60
HEEGVDDMAS LAELHGGSIM YNLFQRYKRN QIYTYIGSII ASVNPYQPIA GLYERATMEE 120
YSRCHLGELP PHIFAIANEC YRCLWKRHDN QCVLISGESG AGKTESTKLI LKFLSVISQQ 180
TLDLGLQEKT SSVEQAILQS SPIMEAFGNA KTVYNNNSSR FGKFVQLNIC QQGNIQGGRI 240
VDYLLEKNRV VRQNPGERNY HIFYALLAGL DQGEREEFYL SLPENYHYLN QSGCTEDKTI 300
SDQESFRQVI TAMEVMQFSK EEVREVLRLL AGILHLGNIE FITAGGAQIP FKTALGRSAD 360
LLGLDPTQLT DALTQRSMIL RGEEILTPLS VQQAVDSRDS LAMALYARCF EWVIKKINSR 420
IKGKDDFKSI GILDIFGFEN FEVNHFEQFN INYANEKLQE YFNKHIFSLE QLEYSREGLV 480
WEDIDWIDNG ECLDLIEKKL GLLALINEES HFPQATDSTL LEKLHSQHAN NHFYVKPRVA 540
VNNFGVKHYA GEVQYDVRGI LEKNRDTFRD DLLNLLRESR FDFIYDLFEH VSSRNNQDTL 600
KCGSKHRRPT VSSQFKDSLH SLMATLSSSN PFFVRCIKPN TQKMPDQFDQ VVVLNQLRYS 660
GMLETVRIRK AGYAVRRPFQ DFYKRYKVLM RNLALPDDIR GKCTVLLQVY DASNSEWQLG 720
KTKVFLRESL EQKLEKRREE EIDRAAMVIR AHILGYLARK QYRKVLCGVV TIQKNYRAFL 780
ARKKFLHLKK AAIVFQKQLR GQLARRVYRQ LLAEKRELEE KKRREEEKKR EEEERERERA 840
QREADLLRAH QEAETRRQQE LEALQKSQRE ADLTRELEKQ RENKQVEEIL RLEKEIEDLQ 900
RMKERQELSL TEASLQKLQQ LRDEELRRLE DEACRAAQEF LESLNFDEID ECVRNIERSL 960
SVGSEISGEE LSELAESASG EKPNFNFSQP YPAEEEVDEG FEADDDAFKD SPNPSEHGHS 1020
DQRTSGIRTS DDSSEEDPYM NYTVVPTSPS ADSTVLLAAS MQDSASLHNS SSGESTYCMP 1080
QNNGDLPSPD GDYDYDQDDY EDGAITSGSS VTFSNSYGSQ WSPDYRYSVG TYNSSGAYRF 1140
SSEGAQSSFE DSEEDFDSRF DTDDELSYRR DSVYSCVTLP YFHSFLYMKG GLMNSWKRRW 1200
CVLKDETFLW FRSKQEALKQ GWLHKKGGGS STLSRRNWKK RWFVLRQSKL MYFENDSEEK 1260
LKGTVEVRTA KEIIDNTSKE NGIDIILADR TFHLIAESPE DASQWFSVLS QVHSSTDQEI 1320
REMHDEQANP QNAVGTLDVG LIDSVCASDS PDRPNSFVII TANRVLHCNA DTPEEMHHWI 1380
TLLQRSKGDT RVEGQEFIVR GWLHKEVKNS PKMSSLKLKK RWFVLTHNSL DYYKSSEKNA 1440
LKLGTLVLNS LCSVVPPDEK IFKETGYWNV TVYGRKHCYR LYTKLLNEAT RWSSAIQNVT 1500
DTKAPIDTPT QQLIQDIKEN CLNSDVVEQI YKRNPILRYT HHPLHSPLLP LPYGDINLNL 1560
LKDKGYTTLQ DEAIKIFNSL QQLESMSDPI PIIQGILQTG HDLRPLRDEL YCQLIKQTNK 1620
VPHPGSVGNL YSWQILTCLS CTFLPSRGIL KYLKFHLKRI REQFPGTEME KYALFIYESL 1680
KKTKCREFVP SRDEIEALIH RQEMTSTVYC HGGGSCKITI NSHTTAGEVV EKLIRGLAME 1740
DSRNMFALFE YNGQVDKAIE SRTIVADVLA KFEKLAATSE AGDAPWKFYF KLYCFLDTDS 1800
MPKDSVEFAF MFEQAHEAVI HGHHPAPEES LQVLAALRLQ YLQGDYTPHT SIPPLEEVYS 1860
VQRLRARISQ STKTFTPYER LEKRRTSFLE GTLRRSFRTG SVVRQKAEEE QMLDMWIKEE 1920
VCSARTSIID KWKKLQGMNQ EQAMAKYMAL IKEWPGYGST LFDVECKEGG FPQELWLGVS 1980
ADAVSVYKRG EGKPLEVFQY EHILSFGAPL ANTYKIVVDE RELLFETSEV VDVAKLMKAY 2040
ISMIVKKRYS TTRSVSSQGS SR 2063
Keyword

KW-0007--Acetylation
KW-0009--Actin-binding
KW-0877--Alternative promoter usage
KW-0067--ATP-binding
KW-0112--Calmodulin-binding
KW-1003--Cell membrane
KW-0966--Cell projection
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0903--Direct protein sequencing
KW-0472--Membrane
KW-0505--Motor protein
KW-0518--Myosin
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
Interpro

IPR019749--Band_41_domain
IPR014352--FERM/acyl-CoA-bd_prot_3-hlx
IPR019748--FERM_central
IPR000299--FERM_domain
IPR000048--IQ_motif_EF-hand-BS
IPR031971--MYO10_CC
IPR001609--Myosin_head_motor_dom
IPR000857--MyTH4_dom
IPR027417--P-loop_NTPase
IPR011993--PH/PTB_dom
IPR001849--PH_domain
PROSITE

PS50057--FERM_3
PS50096--IQ
PS51456--MYOSIN_MOTOR
PS51016--MYTH4
PS50003--PH_DOMAIN
Pfam

PF00373--FERM_M
PF00612--IQ
PF16735--MYO10_CC
PF00063--Myosin_head
PF00784--MyTH4
PF00169--PH
Gene Ontology

GO:0005938--C:cell cortex
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0030175--C:filopodium
GO:0031527--C:filopodium membrane
GO:0032433--C:filopodium tip
GO:0030027--C:lamellipodium
GO:0016459--C:myosin complex
GO:0043005--C:neuron projection
GO:0043025--C:neuronal cell body
GO:0005730--C:nucleolus
GO:0005886--C:plasma membrane
GO:0001726--C:ruffle
GO:0051015--F:actin filament binding
GO:0030898--F:actin-dependent ATPase activity
GO:0005524--F:ATP binding
GO:0005547--F:phosphatidylinositol-3,4,5-trisphosphate binding
GO:0060002--F:plus-end directed microfilament motor activity
GO:0030507--F:spectrin binding
GO:0048870--P:cell motility
GO:0030705--P:cytoskeleton-dependent intracellular transport
GO:0022409--P:positive regulation of cell-cell adhesion
GO:0008360--P:regulation of cell shape
GO:0051489--P:regulation of filopodium assembly