dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0051796
Uniprot Accession F6VFS9; F6VFS9_MOUSE;
Genbank Protein ID
Genbank Nucleotide ID
Protein Name Guanylate cyclase
Protein Synonyms/Alias
Gene Name Gucy2d
Gene Synonyms/Alias
Organism Mus musculus(Mouse)
NCBI Taxa ID 10090
Functional Description
(View all)
Phosphorylation Sites
 dbPAF PTMs: 2
PositionPeptidesSourceReferences ( PMIDs )
924LFDAVLDSHDVYKVEPhosphoSitePlus22135298
1049KIDVRGQTELKGKGLcurated20469934
Sequence
(Fasta)		SGLQQGCHFE GQNWTAPHWK TCLPCQGPWR LTVSHLKTVS SISVLSVVFW SVLLWADSLS 60
LLAWARETFT LGVLGPWDCD PIFAQALPSI ATQLAVDQVN QDASLLPGSQ LDFKVLPTGC 120
DTPHALATFV AHKNIVAAFV GPVNPGFCSA AALLAQGWGK SLFSWACEAP EGGGDLVPTL 180
PSAADVLLSV MRHFGWARWA IVSSHQDIWV TTAQQLATAF RTHGLPIGLV TSLGPGEKGA 240
TEVCKQLHSV HGLKIVVLCM HSALLGGLEQ TTLLHCAWEE GLTDGRLVFL PYDTLLFALP 300
YGNRSYLVLD DHGPLQEAYD AVLTVSLESS PESHAFTATE MSGGATANLE PEQVSPLFGT 360
IYDAVILLAH ALNRSETHGA GLSGAHLGDH VRALDVAGFS QRIRTDGKGR RLAQYVILDT 420
DGEGSQLVPT HILDTSTWQV QPLGKPIHFP GGSPPAHDAS CWFDPNTLCI RGVQPLGSLL 480
TLTIACVLAL VGGFLAYFIR LGLQQLRLLR GPHRILLTSQ ELTFLQRTPS RRRPHVDSGS 540
ESRSVVDGGS PRSVTQGSAR SLPAFLEHTN VALYQGEWVW LKKFEAGVAP DLRPSSLSFL 600
RKLREMRHEN VTAFLGLFVG PGVSAMVLEH CARGSLEDLL QNENLRLDWT FKASLLLDLI 660
RGLRYLHHRR FPHGRLKSRN CVVDTRFVLK ITDHGYAEFL ESHCSSRPQP APEELLWTAP 720
ELLRGPGKAT FKGDVFSLAI ILQEVLTRDP PYCSWGLSAE EIIRKVASPP PLCRPLVSPD 780
QGPLECIQLM QLCWEEAPDD RPSLDQIYTQ FKSINQGKKT SVVDSMLRML EKYSESLEDL 840
VQERTEELEL ERRKTERLLS QMLPPSVAHA LKMGTTVEPE YFDQVTIYFS DIVGFTTISA 900
LSEPIEVVGF LNDLYTLFDA VLDSHDVYKV ETIGDAYMVA SGLPRRNGNR HAAEIANLAL 960
DILSYAGNFR MRHAPDVPIR VRAGLHSGPC VAGVVGLTMP RYCLFGDTVN TASRMESTGL 1020
PYRIHVSQST VQALLSLDEG YKIDVRGQTE LKGKGLEETY WLTGKVGFCR PLPTPLSIKP 1080
GDPWQDRINQ EIRTGFAKAR QGLAEPRKSG EAGPGP 1117
Keyword

KW-0141--cGMP biosynthesis
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0456--Lyase
KW-0472--Membrane
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix
Interpro

IPR001054--A/G_cyclase
IPR018297--A/G_cyclase_CS
IPR001828--ANF_lig-bd_rcpt
IPR011009--Kinase-like_dom
IPR029787--Nucleotide_cyclase
IPR028082--Peripla_BP_I
IPR000719--Prot_kinase_dom
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
PROSITE

PS00452--GUANYLATE_CYCLASE_1
PS50125--GUANYLATE_CYCLASE_2
PS50011--PROTEIN_KINASE_DOM
Pfam

PF01094--ANF_receptor
PF00211--Guanylate_cyc
PF07714--Pkinase_Tyr
Gene Ontology

GO:0008074--C:guanylate cyclase complex, soluble
GO:0016021--C:integral component of membrane
GO:0005886--C:plasma membrane
GO:0005524--F:ATP binding
GO:0004383--F:guanylate cyclase activity
GO:0004672--F:protein kinase activity
GO:0006182--P:cGMP biosynthetic process
GO:0035556--P:intracellular signal transduction
GO:0007165--P:signal transduction