| Tag |
Content |
| dbPAF ID |
dbPAF-0051793 |
| Uniprot Accession |
F6VAN0; ATF6A_MOUSE; B2RU98; Q8BZ84;
|
| Genbank Protein ID |
NP_001074773.1;
|
| Genbank Nucleotide ID |
NM_001081304.1;
|
| Protein Name |
Cyclic AMP-dependent transcription factor ATF-6 alpha |
| Protein Synonyms/Alias |
|
| Gene Name |
Atf6 |
| Gene Synonyms/Alias |
|
| Organism |
Mus musculus(Mouse) |
| NCBI Taxa ID |
10090 |
Functional Description
(View all) |
Transcription factor that acts during endoplasmic reticulum stress by activating unfolded protein response target genes. Binds DNA on the 5'-CCAC[GA]-3'half of the ER stress response element (ERSE) (5'-CCAAT-N(9)-CCAC[GA]-3') and of ERSE II (5'-ATTGG-N-CCACG-3'). Binding to ERSE requires binding of NF-Y to ERSE. Could also be involved in activation of transcription by the serum response factor (By similarity).Functional Description
Transcription factor that acts during endoplasmic reticulum stress by activating unfolded protein response target genes. Binds DNA on the 5'-CCAC[GA]-3'half of the ER stress response element (ERSE) (5'-CCAAT-N(9)-CCAC[GA]-3') and of ERSE II (5'-ATTGG-N-CCACG-3'). Binding to ERSE requires binding of NF-Y to ERSE. Could also be involved in activation of transcription by the serum response factor (By similarity). |
Phosphorylation Sites
|
dbPAF PTMs: 5 |
Sequence
(Fasta) | MESPFSPVLP HGPDEDWEST LFAELGYFTD TDDVHFDAAH EAYENNFDHL NFDLDLMPWE 60
SDLWSPGSHF CSDMKAEPQP LSPASSSCSI SSPRSTDSCS STQHVPEELD LLSSSQSPLS 120
LYGDSCNSPS SVEPLKEEKP VTGPGNKTEH GLTPKKKIQM SSKPSVQPKP LLLPAAPKTQ 180
TNASVPAKAI IIQTLPALMP LAKQQSIISI QPAPTKGQTV LLSQPTVVQL QSPAVLSSAQ 240
PVLAVTGGAA QLPNHVVNVL PAPVVSSPVN GKLSVTKPVL QSATRSMGSD IAVLRRQQRM 300
IKNRESACQS RKKKKEYMLG LEARLKAALS ENEQLKKENG SLKRQLDEVV SENQRLKVPS 360
PKRRAVCVMI VLAFIMLNYG PMSMLEQESR RVKPSVSPAN QRRHLLEFSA KEVKDTSDGD 420
NQKDSYSYDH SVSNDKALMV LSEEPLLYMP PPPCQPLINT TESLRLNHEL RGWVHRHEVE 480
RTKSRRMTNS QQKARILQGA LEQGSNSQLM AVQYTETTSI SRNSGSELQV YYASPGSYQG 540
FFDAIRRRGD TFYVVSFRRD HLLLPATTHN KTTRPKMSIV LPAININDNV INGQDYEVMM 600
QIDCQVMDTR ILHIKSSSVP PYLRDHQRNQ TSTFFGSPPT TTETTHVVST IPESLQ
657Fasta Sequence
>F6VAN0|Atf6|Mus musculus(Mouse)
MESPFSPVLPHGPDEDWESTLFAELGYFTDTDDVHFDAAHEAYENNFDHLNFDLDLMPWESDLWSPGSHFCSDMKAEPQPLSPASSSCSISSPRSTDSCSSTQHVPEELDLLSSSQSPLSLYGDSCNSPSSVEPLKEEKPVTGPGNKTEHGLTPKKKIQMSSKPSVQPKPLLLPAAPKTQTNASVPAKAIIIQTLPALMPLAKQQSIISIQPAPTKGQTVLLSQPTVVQLQSPAVLSSAQPVLAVTGGAAQLPNHVVNVLPAPVVSSPVNGKLSVTKPVLQSATRSMGSDIAVLRRQQRMIKNRESACQSRKKKKEYMLGLEARLKAALSENEQLKKENGSLKRQLDEVVSENQRLKVPSPKRRAVCVMIVLAFIMLNYGPMSMLEQESRRVKPSVSPANQRRHLLEFSAKEVKDTSDGDNQKDSYSYDHSVSNDKALMVLSEEPLLYMPPPPCQPLINTTESLRLNHELRGWVHRHEVERTKSRRMTNSQQKARILQGALEQGSNSQLMAVQYTETTSISRNSGSELQVYYASPGSYQGFFDAIRRRGDTFYVVSFRRDHLLLPATTHNKTTRPKMSIVLPAININDNVINGQDYEVMMQIDCQVMDTRILHIKSSSVPPYLRDHQRNQTSTFFGSPPTTTETTHVVSTIPESLQ
|
| Keyword |
KW-0010--Activator
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0256--Endoplasmic reticulum
KW-0325--Glycoprotein
KW-0472--Membrane
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0735--Signal-anchor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0834--Unfolded protein response
|
| Interpro |
IPR029801--ATF6A
IPR004827--bZIP
|
| PROSITE |
PS50217--BZIP
PS00036--BZIP_BASIC
|
| Pfam |
PF00170--bZIP_1
|
| Gene Ontology |
GO:0005783--C:endoplasmic reticulum
GO:0005794--C:Golgi apparatus
GO:0030176--C:integral component of endoplasmic reticulum membrane
GO:0016020--C:membrane
GO:0005634--C:nucleus
GO:0046982--F:protein heterodimerization activity
GO:0000977--F:RNA polymerase II regulatory region sequence-specific DNA binding
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:1990440--P:positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
GO:0006986--P:response to unfolded protein
GO:0006351--P:transcription, DNA-templated
|
