dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0051768
Uniprot Accession F6SEU4; SYGP1_MOUSE;
Genbank Protein ID NP_001268420.1;
Genbank Nucleotide ID NM_001281491.1;
Protein Name Ras/Rap GTPase-activating protein SynGAP
Protein Synonyms/Alias Neuronal RasGAP;Synaptic Ras GTPase-activating protein 1;Synaptic Ras-GAP 1;
Gene Name Syngap1
Gene Synonyms/Alias
Organism Mus musculus(Mouse)
NCBI Taxa ID 10090
Functional Description
(View all)		 Major constituent of the PSD essential for postsynaptic signaling. Inhibitory regulator of the Ras-cAMP pathway. Member of the NMDAR signaling complex in excitatory synapses, it may play a role in NMDAR-dependent control of AMPAR potentiation, AMPAR membrane trafficking and synaptic plasticity. Regulates AMPAR-mediated miniature excitatory postsynaptic currents. Exhibits dual GTPase-activating specificity for Ras and Rap. May be involved in certain forms of brain injury, leading to long-term learning and memory deficits (By similarity).
Phosphorylation Sites
 dbPAF PTMs: 80 (View all)
PositionPeptidesSourceReferences ( PMIDs )
12RASIHRGSIPAMSYAPhosphoPep 2.0;PhosphoSitePlus19060867; 22135298
18GSIPAMSYAPFRDVRPhosphoSitePlus22135298
34PPMHRTQYVHSPYDRPhosphoSitePlus;UniProt22135298; 18034455
37HRTQYVHSPYDRPGWPhosphoSitePlus22135298
39TQYVHSPYDRPGWNPPhosphoSitePlus;UniProt22135298; 18034455
85RNKLLRRTVSVPVEGPhosphoSitePlus22135298
87KLLRRTVSVPVEGRPPHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;curated21081558; 19060867; 22135298; 18034455; 19366988; 21183079
100RPHGEHEYHLGRSRRPhosphoSitePlus;SysPTM 2.022135298; 18034455; 19366988
105HEYHLGRSRRKSVPGPhosphoSitePlus22135298
109LGRSRRKSVPGGKQYPHOSIDA;PhosphoSitePlus21081558; 22135298
116SVPGGKQYSMEAAPAPHOSIDA;PhosphoPep 2.021081558; 19060867
117VPGGKQYSMEAAPAAPHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;curated21081558; 19060867; 22135298; 21183079
153SQPKLDRTSSFRQILPhosphoSitePlus22135298
155PKLDRTSSFRQILPRPhosphoSitePlus22135298
176DRARLMQSFKESHSHPhosphoSitePlus;curated22135298; 21183079
302TSKPRSASGDTVFWGPhosphoPep 2.0;PhosphoSitePlus;curated19060867; 22135298; 21183079
342RKKDKAGYVGLVTVPPHOSIDA;PhosphoSitePlus21081558; 22135298
369WYPVTLPTGSGGSGGPHOSIDA21081558
371PVTLPTGSGGSGGMGPHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;UniProt;curated21081558; 19060867; 22135298; 21183079; 20047950
374LPTGSGGSGGMGSGGPHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;curated21081558; 19060867; 22135298; 21183079
Sequence
(Fasta)		MSRSRASIHR GSIPAMSYAP FRDVRGPPMH RTQYVHSPYD RPGWNPRFCI ISGNQLLMLD 60
EDEIHPLLIR DRRSESSRNK LLRRTVSVPV EGRPHGEHEY HLGRSRRKSV PGGKQYSMEA 120
APAAPFRPSQ GFLSRRLKSS IKRTKSQPKL DRTSSFRQIL PRFRSADHDR ARLMQSFKES 180
HSHESLLSPS SAAEALELNL DEDSIIKPVH SSILGQEFCF EVTTSSGTKC FACRSAAERD 240
KWIENLQRAV KPNKDNSRRV DNVLKLWIIE ARELPPKKRY YCELCLDDML YARTTSKPRS 300
ASGDTVFWGE HFEFNNLPAV RALRLHLYRD SDKKRKKDKA GYVGLVTVPV ATLAGRHFTE 360
QWYPVTLPTG SGGSGGMGSG GGGGSGGGSG GKGKGGCPAV RLKARYQTMS ILPMELYKEF 420
AEYVTNHYRM LCAVLEPALN VKGKEEVASA LVHILQSTGK AKDFLSDMAM SEVDRFMERE 480
HLIFRENTLA TKAIEEYMRL IGQKYLKDAI GEFIRALYES EENCEVDPIK CTASSLAEHQ 540
ANLRMCCELA LCKVVNSHCV FPRELKEVFA SWRLRCAERG REDIADRLIS ASLFLRFLCP 600
AIMSPSLFGL MQEYPDEQTS RTLTLIAKVI QNLANFSKFT SKEDFLGFMN EFLELEWGSM 660
QQFLYEISNL DTLTNSSSFE GYIDLGRELS TLHALLWEVL PQLSKEALLK LGPLPRLLND 720
ISTALRNPNI QRQPSRQSER TRSQPMVLRG PSAEMQGYMM RDLNSSIDLQ SFMARGLNSS 780
MDMARLPSPT KEKPPPPPPG GGKDLFYVSR PPLARSSPAY CTSSSDITEP EQKMLSVNKS 840
VSMLDLQGDG PGGRLNSSSV SNLAAVGDLL HSSQASLTAA LGLRPAPAGR LSQGSGSSIT 900
AAGMRLSQMG VTTDGVPAQQ LRIPLSFQNP LFHMAADGPG PPAGHGGSSG HGPPSSHHHH 960
HHHHHHRGGE PPGDTFAPFH GYSKSEDLSS GVPKPPAASI LHSHSYSDEF GPSGTDFTRR 1020
QLSLQDSLQH MLSPPQITIG PQRPAPSGPG GGSGGGSGGG QPPPLQRGKS QQLTVSAAQK 1080
PRPSSGNLLQ SPEPSYGPAR PRQQSLSKEG SIGGSGGSGG GGGGGLKPSI TKQHSQTPST 1140
LNPTMPASER TVAWVSNMPH LSADIESAHI EREEYKLKEY SKSMDESRLD RVKEYEEEIH 1200
SLKERLHMSN RKLEEYERRL LSQEEQTSKI LMQYQARLEQ SEKRLRQQQV EKDSQIKSII 1260
GRLMLVEEEL RRDHPAMAEP LPEPKKRLLD AQERQLPPLG PTNPRVTLAP PWNGLAPPAP 1320
PPPPRLQITE NGEFRNTADH 1341
Keyword

KW-0965--Cell junction
KW-0181--Complete proteome
KW-0343--GTPase activation
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0729--SH3-binding
KW-0770--Synapse
Interpro

IPR000008--C2_dom
IPR021887--DUF3498
IPR011993--PH/PTB_dom
IPR001849--PH_domain
IPR023152--RasGAP_CS
IPR001936--RasGAP_dom
IPR008936--Rho_GTPase_activation_prot
IPR023315--SynGAP_C2_N
PROSITE

PS50003--PH_DOMAIN
PS00509--RAS_GTPASE_ACTIV_1
PS50018--RAS_GTPASE_ACTIV_2
Pfam

PF00168--C2
PF12004--DUF3498
PF00616--RasGAP
Gene Ontology

GO:0030054--C:cell junction
GO:0005737--C:cytoplasm
GO:0043198--C:dendritic shaft
GO:0031235--C:intrinsic component of the cytoplasmic side of the plasma membrane
GO:0016020--C:membrane
GO:0097481--C:neuronal postsynaptic density
GO:0005096--F:GTPase activator activity
GO:0016358--P:dendrite development
GO:0050771--P:negative regulation of axonogenesis
GO:0043524--P:negative regulation of neuron apoptotic process
GO:0046580--P:negative regulation of Ras protein signal transduction
GO:0007389--P:pattern specification process
GO:0043547--P:positive regulation of GTPase activity
GO:0007265--P:Ras protein signal transduction
GO:0043113--P:receptor clustering
GO:0048169--P:regulation of long-term neuronal synaptic plasticity
GO:0043408--P:regulation of MAPK cascade
GO:0050803--P:regulation of synapse structure or activity
GO:0048167--P:regulation of synaptic plasticity
GO:0008542--P:visual learning