dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0051685
Uniprot Accession F2Z4A3; F2Z4A3_MOUSE;
Genbank Protein ID NP_001074755.2; XP_006509337.1;
Genbank Nucleotide ID NM_001081286.2; XM_006509274.2;
Protein Name Protein Fat1
Protein Synonyms/Alias
Gene Name Fat1
Gene Synonyms/Alias
Organism Mus musculus(Mouse)
NCBI Taxa ID 10090
Functional Description
(View all)
Phosphorylation Sites
dbPAF PTMs: 16
PositionPeptidesSourceReferences ( PMIDs )
151NDLRPLFSPTSYSVSPHOSIDA21081558
153LRPLFSPTSYSVSLPPhosphoSitePlus22135298
158SPTSYSVSLPENTAIPhosphoSitePlus22135298
1666VTVADNASPKFTSKEPhosphoSitePlus22135298
1692GSFVGMVSAHSQSSVPhosphoSitePlus22135298
1695VGMVSAHSQSSVMYEPhosphoSitePlus22135298
3755KFCDEKVSVDENVMScurated22135298
3924SLEVEGNYAKLVLDEPhosphoSitePlus22135298
4244SKLNKNIYSDIPPQVPhosphoSitePlus;SysPTM 2.022135298; 18563927; 19366988
4274RNNLDRNSFEGSAIPPhosphoSitePlus;curated22135298; 22817900; 21183079; 25338131
4355KPLEEKPSQPYSAREPHOSIDA;PhosphoSitePlus;curated21081558; 22135298; 25338131
4359EKPSQPYSARESLSEPhosphoSitePlus;curated22135298; 25338131
4375QSLSSFQSESCDDNGPhosphoSitePlus22135298
4475RDMPAAGSLGSSSRSPHOSIDA;PhosphoSitePlus;SysPTM 2.0;curated21081558; 22135298; 18846507; 19366988; 21743459; 22817900;
4478PAAGSLGSSSRSRQRPHOSIDA;PhosphoSitePlus;SysPTM 2.0;curated21081558; 22135298; 18846507; 19366988; 22817900; 21183079;
4479AAGSLGSSSRSRQRFcurated25338131
Sequence
(Fasta)
MGRHLTLLLL LLLFLQQFGD SDGSQRLEPT PPIQFTHFQY NVTVHENSAA KTYVGHPRKM 60
GIYILDPSWE IRYKIVSGDS ENLFKAEEYV LGDFCFLRIR TKGGNTAILN REVRDHYTLI 120
VKAVEKATDA EARAKVRVQV LDTNDLRPLF SPTSYSVSLP ENTAIRTSIA RVSATDADIG 180
TNGEFYYSFK DRTDVFAIHP TSGVVVLTGR LDFLETQLYE LEILAADRGM KLYGSSGVSS 240
LAKLTVHVEQ ANECAPIITA VTLSPSELDK DPTYAIITVE DCDQGANGEI ASLSIVAGDL 300
LQQFKTVRSF PGSKAFKVKA VGAVDWDSHP YGYNLTLQAK DKGTPPQFSP VKVVHIISPQ 360
FRAGPVKFEM DVYRAEISEF APPHTPVVLV KAIPSYSHLR YVFKSAPGKP KFGLNHNTGL 420
ISILEPIRRQ HTSHFELEVT TSDKRASARV VVKVLGTNSN PPEFTQTSYK ASIDENAPIG 480
AAVTRVSAMD PDEGENGYVT YSIANLNHVP FVIDHFTGTV STSENLDYEL MPRVYTLRIR 540
ASDWGLPYRR EVEVLATITL NNLNDNTPLF ERINCEGTIP RDLGVGEQIT TVSAIDADEL 600
QLVRYQIEAG NELDLFGLNP SSGVLSLKHS LTDGLGAKVS FHSLRITATD GENFATPLYI 660
NLTVAASRKP VNLQCEETGV AKMLAEKLLQ ANKLHSQGDV EDIFFDSYSV NTHTPQFGVT 720
LPTGIEVKEN LPVGANILFM NATDLDSGFN GKLVYAISGG NDDSCFTIDM ETGVLKVLSP 780
LDREVMDKYT LNITVYDLGI PQRAAWRLLD VTVLDANDNA PEFLQESYFV EVSEDKEVNS 840
EIIQVEATDK DLGPSGHVTY AILTDTEKFS IDSMTGVVKI IQPLDREVQP VHYLKIEARD 900
QATEEPRLFS TVLLKVSLDD VNDNPPRFIP PNYSVKVRED LPEGTIIMWL EAYDPDVGQS 960
SQVRYSLLDH GEGHFDVDKL SGAVRIVQQL DFEKKQLYNL TVRAKDKGKP VSLSSTCYVE 1020
VEVVDVNENL HTPVFSSFVE KGVVKEDVPT GSSVMTVSAH DEDTGRDGEI RYSIRDGSGI 1080
GVFRIDEETG VIETSDRLDR ESTSHYWLTV YATDQGVVPL SSFIEVYIEV EDVNDNAPQT 1140
SEPVYYPEIM ENSPKDVSVV QIEAFDPDSS SNDKLTYRIT SGNPQGFFSI HPKTGLITTT 1200
SRKLDREQQD EHILEVTVTD NGVPPRSTIA RVIVKILDEN DNRPQFLQKF YKIRLPEREK 1260
ADGDRSASKR EPLYRVIAAD KDEGPNAELS YSIEEGNEHG RFSIEPKTGV VSSKKFSAAG 1320
EYDILSIKAV DNGRPQKSST TRLHIEWISK PKPSSEPISF EESVFSFTVM ESDPVAHMIG 1380
VISVEPPGMP LWFDIIGGNY DSHFDVDKGT GTIIVAKPLD AEQKSSYNLT VEATDGTTTI 1440
LTQVLIKVID TNDHRPQFST SKYEVAVPED TEPEVEILQI SAVDRDEKNK LIYTLQSSID 1500
PASLKKFRLD PATGALYTAE KLDHEAIHQH VLTVMVRDQD VPVKRNFARI VVNVSDKNDH 1560
APWFTSPSYD GRVYESAAVG SVVLQVTALD KDKGRNAEVL YSIESGNIGN SFTIDPILGS 1620
IKTARELDRS HQVDYDLMVK ATDKGDPPMS EMTSVRIAVT VADNASPKFT SKEYSAEISE 1680
AIRIGSFVGM VSAHSQSSVM YEIRDGNMGD AFNINPHSGS IITQRALDFE TLPMYSLTVQ 1740
GTNMAGLSTN TTVVVHVRDE NDNPPVFTQA EYSGFISESA SVNSVVLTDR NVPLVIRATD 1800
ADRESNALLV YQIVEPSVHN YFAIDPTTGA IRTVLSLDYE ETHAFHFTVQ VHDMGTPRLF 1860
AEYAANVTVH VIDINDCPPV FSKSLYEVSL LLPTYRGVNV ITVNATDADS KAFSQVMYSI 1920
TEGNIGEKFS MDHKTGTIAI QNTTQLRSRY ELTVRASDGR FTSMASVKIN VKESRESPLK 1980
FTQDAYSAVV KENSTEARTL AVITAIGNPL NEPLFYRILN PDRRFKISHT SGVLSTTGIP 2040
FDREQQETFD VVVEVTKEHE PSAVAHVVVK VTVEDQNDNA PVFVNLPYYA VVKVDAEVGH 2100
VIRYVTAIDR DSGRNGDIHY YLKEHHDHFQ IGPSGDISLK KQFEHDTLNK EYLVTVVAKD 2160
GGSPAFSAEV LVPITVMNKA MPVFEKAFYS AEIPENIQMH SPVVHIQANS PEGLKVFYSI 2220
TDGDPFSQFT INFNTGVVNV IAPLDFESHP AYKLSVRATD SLTGAHAEVF VDIIVEDIND 2280
NPPVFVQPSY STTLSEASVI GTPVLQVRAT DSDSEPNRGI SYQLIGNHSK SHDHFHIDSN 2340
TGLISLVRAL DYEQSQQHRI FVRAVDGGMP ALSSDVVVTV AVTDLNDNPP LFEQQVYEAR 2400
ISEHAAHGHF VMCVRACDAD SSDLDKLEYS ILSGNDHKSF IIDRETGIIT LSNLRRHTLK 2460
PFYSLNVSVS DGVFRSSARV NVTVMGGNLH SPVFHQNEYE VELAENAPLH TLVVQVKASD 2520
RDSGIYSHVT YHIVNDFAKD RFYVNDRGQI FTLEKLDRET PAEKVISIRL MAKDAGGKVA 2580
FCTVNVILTD DNDNAPQFRS TKYEVNIGSS AAKGTSVVKV FASDADEGSN ADVTYAIEAD 2640
SESVKENLEI NKLTGLITTK ESLIGLENEF FTFFVRAVDS GSPPRESVVP VYIKILPPEV 2700
QLPRFSEPFY TYTISEDTPI GTEIDLIRVE HGGAVLYILV KGNTPESNRD EFFVIDRQNG 2760
RLKLEKSLDH ETTKWYQFSI LARCTLDDYE VVASIDVSIQ VKDANDNSPV LESSPYEAFI 2820
VENLPGGSRV IQIRASDLDS GANGQVMYSL DQSQDADIIE SFAINMETGW ITTLKELDHE 2880
ERASYQIKVV ASDHGEKVQL SSTAIVGVTV TDVNDSPPRF TAEIYKGTVS EDDPPGGVIA 2940
ILSTTDADTE EINRQVSYFI TGGDALGQFA VENVQSDWRV YVKKPLDREQ KDSYLLTVTA 3000
TDGTFSSKAR VEVKVLDAND NSPVCEKTSY SDTIPEDALP GKLVMQVSAT DADIRSNAEI 3060
TYTLFGSGAE KFKLNPDTGE LRTLALLDRE EQAVYNLLVK ATDGGGRSCQ AAIVLTLEDV 3120
NDNAPEFTAE PYTITVFENT EPGTPLTRVQ ATDADTGLNR KISYSLVESA DGQFSINERS 3180
GIIQLEKHLD RELQAVYTLT LKAVDQGLPR RLTATGTVVV SVLDINDNPP VFEYREYGAS 3240
VSEDIVIGTE VLQVYAASRD IEANAEITYA IISGNEHGKF SIDSKTGAIF IIESLDYESS 3300
HEYYLTVEAT DGGTPSLSDV ATVNINVTDI NDNSPVFSQD TYTTVVSEDA ALEQPVITIM 3360
ADDADGPSNS HIHYSIIEGN QGSPFTIDPV RGEVKVTKPL DRETISGYTL TVQAADNGNP 3420
PRVNTTTVNI DVSDVNDNAP LFSRDNYSVI IQENKPVGFS VLKLVVTDKD SSHNGPPFFF 3480
TIVSGNDENA FEVNQHGVLL TAATIKRKVK DHYLLHVKVA DSGKPQLSSM THIDIRVIEE 3540
SIHPPAILPL EIFITAFGEE YSGGVIGKIH ATDQDVYDTL MYSLDPHMDG LFSVSSTGGK 3600
LIAHRKLDIG QYLLNVSVTD GKFTTVADIT VHIQQVTQEM LNHTVAIRFA NLTPEEFVGD 3660
YWRNFQRALR NILGVRKNDI QIVSLQPSEP HSHLDVLLFV ERSGGTHVST KQLLHKINSS 3720
VTDVEEIIGV RILEVFQKLC AGLDCPWKFC DEKVSVDENV MSTHSTARLS FVTPRHHRTA 3780
VCLCKDGTCP PVHHGCEDNP CPAGSECVAD PREEKYSCVC PGGGFGKCPG SSSITFTGNS 3840
FVKYRLLENE NRLEMKLSMR LRTYSSHAVV MYARGTDYSI LEIHTGRLQY KFDCGSGPGI 3900
VSVQSIQVND GQWHAVSLEV EGNYAKLVLD EVHTASGTAP GALKTLNLDN YVFFGGHLRQ 3960
QGTKHGRGAQ VASGFRGCMD SIYLNGQELP LNNKPRAYAH IEEWVDLSHG CLLTATEDCS 4020
SSPCQNGGVC NPSPTGGYYC KCSALYVGTF CEVSVNPCSS NPCLYGGTCM VDNGGFVCQC 4080
RGLYTGQRCQ LSPYCKDDPC KNGGTCFDSL DGAVCQCDSG FRGERCQSDI DECAGNPCRN 4140
GALCENTHGS YHCNCSQEYR GKHCEDASPN HYVSTPWNIG LAEGIGIIVF IAGIVLLVMV 4200
FVLCRKMISR KKKRQAEPED KRLGPTTAFL QRPYFDSKLN KNIYSDIPPQ VPVRPISYTP 4260
SIPSDSRNNL DRNSFEGSAI PEHPEFSTFN PESMHGHRKA VAVCSVAPNL PPPPPSNSPS 4320
DSDSIQKPSW DFDYDAKVVD LDPCLSKKPL EEKPSQPYSA RESLSEVQSL SSFQSESCDD 4380
NGYHWDTSDW MPSVPLPDIQ EFPNYEAIDE HTPLYSADPN AIDTDYYPGG YDIESDFPPP 4440
PEDFPAPDEL PPLPPEFSDQ FESIHPPRDM PAAGSLGSSS RSRQRFNLNQ YLPNFYPADM 4500
SEPQKQGAGE NSPCREPYTP YPPGYQRNFE APTIENMPMS VYASTASCSD VSACCEVESE 4560
VMMSDYESGD DGHFEEVTIP PLDSQQHTEV 4591
Keyword

KW-0106--Calcium
KW-0130--Cell adhesion
KW-0181--Complete proteome
KW-1015--Disulfide bond
KW-0245--EGF-like domain
KW-0472--Membrane
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0677--Repeat
KW-0732--Signal
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR002126--Cadherin
IPR015919--Cadherin-like
IPR020894--Cadherin_CS
IPR013320--ConA-like_dom
IPR001881--EGF-like_Ca-bd_dom
IPR013032--EGF-like_CS
IPR000742--EGF-like_dom
IPR000152--EGF-type_Asp/Asn_hydroxyl_site
IPR018097--EGF_Ca-bd_CS
IPR009030--Growth_fac_rcpt_N_dom
IPR001791--Laminin_G

PROSITE

PS00010--ASX_HYDROXYL
PS00232--CADHERIN_1
PS50268--CADHERIN_2
PS00022--EGF_1
PS01186--EGF_2
PS50026--EGF_3
PS01187--EGF_CA
PS50025--LAM_G_DOMAIN

Pfam

PF00028--Cadherin
PF00008--EGF
PF07645--EGF_CA
PF02210--Laminin_G_2

Gene Ontology

GO:0030054--C:cell junction
GO:0005911--C:cell-cell junction
GO:0070062--C:extracellular exosome
GO:0030175--C:filopodium
GO:0005925--C:focal adhesion
GO:0016021--C:integral component of membrane
GO:0030027--C:lamellipodium
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0005886--C:plasma membrane
GO:0005509--F:calcium ion binding
GO:0007015--P:actin filament organization
GO:0007163--P:establishment or maintenance of cell polarity
GO:0007156--P:homophilic cell adhesion via plasma membrane adhesion molecules
GO:0016337--P:single organismal cell-cell adhesion