dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0051084
Uniprot Accession E9QNP1; E9QNP1_MOUSE;
Genbank Protein ID
Genbank Nucleotide ID
Protein Name Microtubule-actin cross-linking factor 1
Protein Synonyms/Alias
Gene Name Macf1
Gene Synonyms/Alias
Organism Mus musculus(Mouse)
NCBI Taxa ID 10090
Functional Description
(View all)
Phosphorylation Sites
 dbPAF PTMs: 2
PositionPeptidesSourceReferences ( PMIDs )
24VPEKAPISPKKRVRFPhosphoSitePlus;curated22135298; 21183079
42WRGKKILTPEASHREPhosphoSitePlus;curated22135298; 21183079
Sequence
(Fasta)		MGNSLGCVKE PKESIAVPEK APISPKKRVR FKRKWRGKKI LTPEASHREE ALEGTGVIEE 60
TETLTKLTAR LPKEPGVGGA EHPPSDIFLP GDSAPNSGVG DQGMIVQVKE SFQAEIQTAH 120
LLLENESSVV GGAWDSLEEG MTVIAHLLDN PAERNCEKSV SQLVEFPRTA SCSSRAVLLP 180
LQGETAVEQG GTLLRHRHRS STLPRTDYPS ETVDQDQPSE GWSVGGRTKS VPSAPPTGSW 240
IAKCSVASSI PKQSGDPIHT EPTHVGLVSC KGPIMPASQS DLSVSGITVS ILPSSSGYGS 300
DGLRLHGIRP EDTEPEKTST PFSEEDGTLS LEISDIYISG ESGDMSAKEK LLLWTQKVTA 360
GYTGVKCTNF SSCWSDGKMF NALIHRYRPD LVDMERVQVQ SNRENLEQAF EVAERLGVTR 420
LLDAEDVDVP SPDEKSVITY VSSIYDAFPK VPEGGEGISA TEVDSRWQEY QSRVDSLIPW 480
IRQHTILMSD KSFPQNPVEL KALYNQYIHF KETEILAKER EKGRIKELYK LLEVWIEFGR 540
IKLPQGYHPN HVEEEWGKLI VEMLEREKSL RPAVERLELL LQIANKIQNG ALNCEEKLTL 600
AKNTLQADAA HLESGQPVQC ESDVIMYIQE CEGLIRQLQV DLQILRDEKY YQLEELAFRV 660
MRLQDELVTL RLECTNLYRK GHFSSLELVP PSTLTTTHLK AEPLNKTTHS SSTSWFRKPM 720
TRTELVSISS SEDEGNLRFV YELLSWVEEM QMKLERAEWG NDLPSVELQL ETQQHIHTSV 780
EELGSSVKEA RLYEGKMSQN FHTSYVETLG KLETQYCKLK ETSSFRMRHL QSLHKFVSRA 840
TAELIWLNGK EEEELACDWS DSNPNISAKK TYFSELTMEL EGKQDVFRSL QDTAEVLSLE 900
NHPAKQTVEA YSAAVQSQLQ WMKQLCLCVE QHVKENAAYF QFFSDARDLE SFLRNLQDSI 960
KRKYTCDRST SLSRLEDLLQ DSMDEKEQLI QSKSSVASLV GRSKTIVQLK PRNPDHVLKS 1020
TLSVKAICDY RQIEITICKN DECVLEDNSQ RTKWKVISPT GNEAMVPSVC FLIPPPNKEA 1080
IEMASRVEQS YQKVMALWHQ LHINTKSLIS WNYLRKDLDT VQTWSLEKLR SLAPGECHQV 1140
MKNLQAHYED FLQDSHDSAL FSVADRLRIE EEVEACKAHF QHLMKSLENE DKEETLAKVY 1200
ISELKNIRLL LEECEQRLLK QIQSPASSKT DRDARQDITL RIAEQEHTQE DLQHLRSDLD 1260
AISMKCNVFL QQSPSGSSAT TLRSELNLMV EKMDHVYGLS TVYLNKLKTI DVIVRSMQDA 1320
ELLVKGYEIK LSQEEAVPAD LSALESHRTT LQHWLSDVKD KNSVFSVLDE EITKAKKVAE 1380
QLRHPASEPN LDLERYQEKG SQLQERWHRV IAQLETRQSE VESIQEVLRD YRACHGTLIK 1440
WIEETTAQQE MMKPGQAEDS RVLSEQLSQQ TELFAEIERN QTKLDQCQKF SQQYSTIVKD 1500
YELQLMTYKA FVESQQKSPG KRRRMISSSD AITQEFMDLR TRYTALVTLT TQHVKYISDA 1560
LRRLEEEEKV VEEEKQEHVE KVKDLLGWVS TLARNTQGTT TSSHTSASAD IEKAILEQQV 1620
LAEELTTKKE QVSEAIKTSQ IFLAKHGHKL SEGEKEQISE QLRVLNKTYH DLCDGSANQL 1680
QQLQSELAQQ TEQKTLQKQQ DTCHKKLEDL CNWVGQAERA LERHQGGASG KSSLLCSRTK 1740
VTFKDLQGDI QSHSTSFATA VKDIEGFLEE NQTKLSPQEL TALREKLHQA KEQYEVLQER 1800
TRVAQKELEE AVTSALQQET EKSKAATELA ENKRKIDALL DWVLLWGHLR ESHRLAFQEW 1860
SSSLELAEKQ TLAATDGHVD VNQVPETLDR QYELMKARHQ ELLSQQQNFI VATQSVQSFL 1920
DQHSHNLTPE ERQKLQEKLG ELKEQYAASL ARSEAELKQT QALRDELQKF LQDHKEFENW 1980
LQQSENELDS MHKGGSSPEA LNSLLKRQGS FSEDVISHKG DLRFVTISGQ KVLETENNFE 2040
EGQEPSATRN LVNEKLKDAT ERYTTLHSKC IRLGSHLSML LGQYQQFQSS ADSLQAWVLT 2100
CEASVGKLLS DTVASDPGVL QQQLATTKQL QEELAEHQVP VEKLQKAAHD LLDIEGEPAL 2160
DCRPIQETTD SISSRFQNLS CSLDERSALL QKAIAQSQSV QESMESLLQS IREVEQNLER 2220
DQVASLSSGV IQEALANNMK LKQDIARQKS SLEATHDMVT RFMETADSNS ASVLQGKLAE 2280
LSQRFQQLQL QQQEKESNLK KLLPQAEMFE QLSNKLQQFM ENKSRLLASG NQPDQDIAHF 2340
SQQIQELTLA MEDQKENLDT LEHLVTTLGS CGFALDLSQH QDKIQNLKKD FTELQKTVQE 2400
REKDASTCQE QLDEFRKLIR TFQKWLKETE GNVPPAKTFV SAKELEKQIE HLKDLISDWE 2460
SKGALLGEIN AKGTALESLI MDITAPDSQA KTGSILPPVG SSVGSVNGYH TCKDLTEIQC 2520
DMFDVNSKYE KLWEVLRERQ ESLQTVFSRM EEVQKEASSV LQWLESKEEV LKAMDATLSP 2580
TKTETVKAQA ESNKAFLAEL EQNSPKIQKV KEALAGLLKT YPNSQEAENW KKMQEDLNSR 2640
WEKATEVTVA RQKQLEESAS HLACFQAAES QLRPWLMEKE LMMGVLGPLS IDPNMLNAQK 2700
QQVQFMLKEF EARRQQHEQL NEAAQGILTG PGDMSPSASQ VHKDLQSISQ KWVELTDKLN 2760
SRSSQIDQAI VKSTQYQDLL QDLSEKVKAI GQRLSGQSAI STQPEAVKQQ LEETSEIRSD 2820
LGQLDNEIKE AQTLCQELSL LIGEQYLKDE LKKRLETVAL PLQGLEDLAA DRMNRLQAAL 2880
ASTQQFQQMF DELRTWLDEK QSQQAKNCPI SAKLERLQCQ LQENEEFQKN LNQHSGSYEV 2940
IVAEGEALLL SVPPGEEKKT LQNQLVELRS HWEDLSKKTA NRQSRLKDCM QKAQKYQGHV 3000
EDLVPWIDEC KSKMSELQVT LDPVQLESSL LRSKAMLNEA EKRRSLLEIL NSAADILINS 3060
SEIDEDEIRD EKAGLNQNMD AITEELQAKT SSLEEMTQRL KEFQESFKNI EKKVEGAKHQ 3120
LEIFDALGSQ ACSNKNLEKL KAQQEVLQAL EPQVDYLRNF TQGLVEDAPD GSDASPLVHQ 3180
AEVAQQEFLE VKQRVSSSCL TMENKLEGIG QFHCRVREMF SQLADLDDEL DGMGAIGRDT 3240
DSLQSQIEDV RLFLNKIQAL RFDIEDSEAE CRKMLEEEGT LDLLGLKREL EALNKQCGKL 3300
TERGKVRQEQ LELTLGRVED FYRKLKALND AATAAEEGEA LQWIVGTEVD VINQQLADFK 3360
LFQKDQVDPL QVKLQQVNGL GQGLIQSAGK NCDVQGLEHD MDEINTRWNT LNKKVAQRIA 3420
QLQEALLHCG KFQDALEPLL SWLTDTEELI ANQKPPSAEY KVVKAQIQEQ KLLQRLLDDR 3480
KATVDMLQAE GGRIAQSAEL ADREKITGQL ESLERRWTDL LSKAAARQKQ LEDILVLAKQ 3540
FHETAEPISD FLSVTEKKLA NSEPVGTQTA KIHQQIIRHK ALNEEIINRK KNVDQAIKNG 3600
QALLKQTTGE EVLLIQEKLD GIKTRYADIT LTSSKALRTL EQARQLATKF HSTYEELTGW 3660
LREAEEELAA SGGQSPTGEQ IPQFQQRQKE LKKEVMEHRL VLDTVNEVSH ALLELVPWRA 3720
REGLDKLVSD ANEQYKLISD TVGQRVDEID AAIQRSQQYE QAADAELAWV AETKRKLMAL 3780
GPIRLEQDQT TAQLQVQKAF SIDIIRHKDS MDELFSHRGE IFSTCGEEQK AVLQEKTECL 3840
IQQYEAVSLL NSERYARLER AQVLVNQFWE TYEELSPWAE ETLALIAQLP PPAVDHEQLR 3900
QQQEEMRQLR ESIAEHKPHI DKILKIGPQL KELNPEEGKM VEEKYQKAEN MYAQIKDEVR 3960
QRALALDEAV SQSAQFHDKI EPMLETLENL SSRLRMPPLI PAEVDKIREC ISDNKSATVE 4020
LEKLQPSFEA LKRRGEELIG RSQGADKDLA AKEIQDKLDQ MVFFWEDIKA RSEEREIKFL 4080
DVLELAEKFW YDMAALLTTI KDTQDIVHDL ESPGIDPSII KQQVEAAETI KEETDGLHEE 4140
LEFIRILGAD LIFACGETEK PEVKKSIDEM NNAWENLNKT WKERLEKLED AMQAAVQYQD 4200
TLQAMFDWLD NTVIKLCTMP PVGTDLNTVK DQLNEMKEFK VEVYQQQIEM EKLNHQGELM 4260
LKKATDETDR DIIREPLTEL KHLWENLGEK IAHRQHKLEG ALLALGQFQH ALEELMSWLT 4320
HTEELLDAQR PISGDPKVIE VELAKHHVLK NDVLAHQATV ATVNKAGSEL LESSAGDDAS 4380
SLRSRLETMN QCWESVLQKT EEREQQLQST LQQAQGFHSE IEDFLLELNR MENQLSASKP 4440
TGGLPETARE QLDTHMELHS QLRAKEEIYN QLLDKGRLML LSRGDSGSGS KTEQSVALLE 4500
QKWHAVSSKV EERKSKLEEA LSLATEFQNS LQEFINWLTL AEQSLNIASP PSLILNTVLS 4560
QIEEHKVFAN EVNDHRDQII ELDQTGNQLK FLSQKQDVVL IKNLLVSVQS RWEKVVQRSI 4620
ERGRSLDDAR KRAKQFHEAW KKLIDWLEDA ESHLDSELEI SNDPDKIKLQ LSKHKEFQKT 4680
LGGKQPVYDT TIRTGRALKE KTLLAGDTQK LDNLLGEVRD KWDTVCGKSV ERQHKLEEAL 4740
LFSGQFMDAL QALVDWLYKV EPQLAEDQPV HGDLDLVMNL MDAHKVFQKE LGKRTGTVQV 4800
LKRSGRELIE GSRDDTTWVK GQLQELSTRW DTVCKLSVSK QSRLEQALKQ AEEFRDTVHM 4860
LLEWLSEAEQ TLRFRGALPD DTEALQSLID THKEFMKKVE EKRVDVNTAV AMGEAILAVC 4920
HPDCITTIKH WITIIRARFE EVLTWAKQHQ QRLETALSEL VANAELLEEL LAWIQWAETT 4980
LIQRDQEPIP QNIDRVKALI TEHQSFMEEM TRKQPDVDRV TKTYKRKSVE PTHAPFMEKS 5040
RSGSRKSLNQ PTPPPMPILS QSEAKNPRIN QLSARWQQVW LLALERQRKL NDALDRLEEL 5100
CPELKEFANF DFDVWRKKYM RWMNHKKSRV MDFFRRIDKD QDGKITRQEF IDGILASKFP 5160
TTKLEMTAVA DIFDRDGDGY IDYYEFVAAL HPNKDAYRPT TDADKIEDEV TRQVAQCKCA 5220
KRFQVEQIGE NKYRVTLGRQ FGDSQQLRLV RILRSTVMVR VGGGWMALDE FLVKNDPCRA 5280
RGRTNIELRE KFILPEGASQ GMTPFRSRGR RSKPSSRAAS PTRSSSSASQ SNHSCTSMPS 5340
SPATPASGTK VISSSGSKLK RPTPAFHSSR TSLAGDTSNS SSPASTGAKA NRADPKKSAS 5400
RPGSRAGSRA GSRASSRRGS DASDFDLLET QSACSDTSES SAAGGQGSSR RGLTKPSKIP 5460
TMSKKTTTAS PRTPGPKR 5479
Keyword

KW-0106--Calcium
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0677--Repeat
Interpro

IPR001715--CH-domain
IPR011992--EF-hand-dom_pair
IPR018247--EF_Hand_1_Ca_BS
IPR002048--EF_hand_dom
IPR003108--GAS2_dom
IPR028408--Macf1
IPR018159--Spectrin/alpha-actinin
IPR002017--Spectrin_repeat
PROSITE

PS50021--CH
PS00018--EF_HAND_1
PS50222--EF_HAND_2
PS51460--GAR
Pfam

PF00307--CH
PF13499--EF-hand_7
PF02187--GAS2
PF00435--Spectrin
Gene Ontology

GO:0015629--C:actin cytoskeleton
GO:0005938--C:cell cortex
GO:0015630--C:microtubule cytoskeleton
GO:0097481--C:neuronal postsynaptic density
GO:0003779--F:actin binding
GO:0016887--F:ATPase activity
GO:0005509--F:calcium ion binding
GO:0008017--F:microtubule binding
GO:0007050--P:cell cycle arrest
GO:0007163--P:establishment or maintenance of cell polarity
GO:0001707--P:mesoderm formation
GO:0006620--P:posttranslational protein targeting to membrane
GO:0008104--P:protein localization
GO:0016055--P:Wnt signaling pathway