dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0051079
Uniprot Accession E9QN47; E9QN47_MOUSE; E9QKN1;
Genbank Protein ID NP_001171191.1;
Genbank Nucleotide ID NM_001177720.1;
Protein Name MAP kinase-activating death domain protein
Protein Synonyms/Alias
Gene Name Madd
Gene Synonyms/Alias
Organism Mus musculus(Mouse)
NCBI Taxa ID 10090
Functional Description
(View all)
Phosphorylation Sites
 dbPAF PTMs: 3
PositionPeptidesSourceReferences ( PMIDs )
155STPDVNQSPRGKRRAPHOSIDA21081558
1620SSEEDLRTPPRPVSSPhosphoSitePlus22135298
1627TPPRPVSS-------PhosphoSitePlus22135298
Sequence
(Fasta)		MVQKKFCPRL LDYLVIVGAR HPSSDSVAQT PELLRRYPLE DHPEFPLPPD VVFFCQPEGC 60
LSVRQRRMSL RDDTSFVFTL TDKDTGVTRY GICVNFYRSF QKRMPKEKVE GGAGPRGKEG 120
AHTSGASEEA AAGSSESGST LQPPSADSTP DVNQSPRGKR RAKAGSRSRN STLTSLCVLS 180
HYPFFSTFRE CLYTLKRLVD CCSERLLGKK LGIPRGVQRD TMWRIFTGSL LVEEKSSALL 240
QDLREIEAWI YRLLRSPVPV SGQKRVDIEV LPQELQQALT FALPDPSRFT LVDFPLHLPL 300
ELLGVDACLQ VLTCILLEHK VVLQSRDYNA LSMSVMAFVA MIYPLEYMFP VIPLLPTCMA 360
SAEQLLLAPT PYIIGVPASF FLYKLDFKMP DDVWLVDLDS NRVIAPTNAE VLPILPEPES 420
LELKKHLKQA LASMSLNTQP ILNLEKFHEG QEIPLLLGRP SNDLQSTPST EFNPLIYGND 480
VDSVDVATRV AMVRFFNSAN VLQGFQMHTR TLRLFPRPVV AFQAGSFLAS RPRQTPFAEK 540
LARTQAVEYF GEWILNPSNY AFQRIHNNTF DPALIGDKPK WYAHQLQPIH YRVYDGNSQL 600
AEALSVPPER DSDSDPTEDS GSDSQDYDDS SSSYSSLGDF VSEMMKCDIN GDTPNVDPLT 660
HAALGDASEV EIDELQPQKE GEEPGPDSEN SQENPPLRSS SSTTASSSPS TVVHSAHSEA 720
ADSTEMGDKA TAGISKPLPP VPPSICKSTV DRRQTETGEG SVCQRTYDNP YFEPQYGFPP 780
EEDEEEQGES YTPRFSQHVS GSRAQKLLRP NSLKLASDSD AESDSRASSP NSTVSNNSTE 840
GFGGIMSFAS SLYRNHSTSF SLSNLTLPTK GAREKTTPFP SLKGNRRALV DQKSSVIKHS 900
PTVKREPSSP QGRSSNSSEN QQFLKEVVHS VLDGQGVGWL NMKKVRRLLE SEQLRVFVLS 960
KLNRAVQSED DARQDVIQDV EISRKVYKGM LDLLKCTVLS LEQSYAHAGL GGMASIFGLL 1020
EIAQTHYYSK EPDKRKRSPT ENVNTPVGKD PGLAGRGDPK AMAQLRVPQL GPRAPSATGK 1080
GPKELDTRSL KEENFVASVE LWNKHQEVKK QKALEKQRPE GIKPVFDLGE TEEKKSQMSA 1140
DSGVSLTSAS QRTDQDSVIG VSPAVMIRSS SQDSEVSTVV SNSSGETLGA DSDLSSNAGD 1200
GPGGEGSAHL ASSRATLSDS EIETNSATSA IFGKAHSLKP KEKPAGSPIR SSEDVSQRVY 1260
LYEGLLGRDK GSMWDQLEDA AMETFSLSKE RSTLWDQMQF WEDAFLDAVM LEREGMGMDQ 1320
GPQEMIDRYL SLGEHDRKRL EDDEDRLLAT LLHNLISYML LMKVNKNDIR KKVRRLMGKS 1380
HIGLVYSQQV NEVLDQLNSL NGRDLSIRSS GSRHMKKQTF VVHAGTDTNG DIFFMEVCDD 1440
CVVLRSNIGT VYERWWYEKL INMTYCPKTK VLCLWRRNGS ETQLNKFYTK KCRELYYCVK 1500
DSMERAAARQ QSIKPGPELG GEFPVQDMKT GEGGLLQVTL EGINLKFMHN QERKVFIELN 1560
HIKKCNTVRG VFVLEEFVPE IKEVVSHKYK TPMAHEICYS VLCLFSYVAA VRSSEEDLRT 1620
PPRPVSS 1628
Keyword

KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome
Interpro

IPR005112--dDENN_dom
IPR001194--DENN_dom
IPR005113--uDENN_dom
PROSITE

PS50947--DDENN
PS50211--DENN
PS50946--UDENN
Pfam

PF02141--DENN
PF03456--uDENN
Gene Ontology

GO:0005737--C:cytoplasm
GO:0016021--C:integral component of membrane
GO:0005886--C:plasma membrane
GO:0017112--F:Rab guanyl-nucleotide exchange factor activity
GO:0000187--P:activation of MAPK activity
GO:0097194--P:execution phase of apoptosis
GO:2001234--P:negative regulation of apoptotic signaling pathway
GO:0043547--P:positive regulation of GTPase activity
GO:0042981--P:regulation of apoptotic process
GO:0051726--P:regulation of cell cycle
GO:2001236--P:regulation of extrinsic apoptotic signaling pathway
GO:1902041--P:regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:0032483--P:regulation of Rab protein signal transduction