dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0051072
Uniprot Accession E9QMD3; E9QMD3_MOUSE;
Genbank Protein ID NP_031522.2; XP_006530648.1;
Genbank Nucleotide ID NM_007496.2; XM_006530585.2;
Protein Name Zinc finger homeobox protein 3
Protein Synonyms/Alias
Gene Name Zfhx3
Gene Synonyms/Alias
Organism Mus musculus(Mouse)
NCBI Taxa ID 10090
Functional Description
(View all)
Phosphorylation Sites
dbPAF PTMs: 2
PositionPeptidesSourceReferences ( PMIDs )
1909PEGAEGNTGPKESLPcurated20469934
3431PVPQGPASPDKDPAKPHOSIDA;curated21081558; 23684622
Sequence
(Fasta)
MEGCDSPVVS GKDNGCGIPQ HRQWTELNSA HLPDKPSSME QPTGESHGPL DSLRAPFNER 60
LADSSTSAGP PAEPASKEVS CNECSASFSS LQTYMEHHCP GTHPPPALRE ESASDTSEEG 120
EEESDVENLA GEIVYQPDGS AYIVESLSQL AQSGAACGSS SGSGAVPSLF LNSLPGVGGK 180
QGDPSCAAPV YPQIINTFHI ASSFGKWFEG SDPAFPNTSA LAGLSPVLHS FRVFDVRHKS 240
NKDYLNSDGS AKSSCVSKDV PNNVDLSKFD GFVLYGKRKP ILMCFLCKLS FGYVRSFVTH 300
AVHDHRMTLS EEERKLLSNK NISAIIQGIG KDKEPLVSFL EPKNKNFQHP LVSTANLIGP 360
GHSFYGKFSG IRMEGEEALP AVAAAGPEQP QAGLLTPSTL LNLGGLTSSV LKTPITSVPL 420
GPLASSPTKS SEGKDSGAAE GDKQESGGHQ DCFSEKVEPA EEEEAEEEEE EEEEAEEEEE 480
EEEEEEEEEE EGCKGLFPND LEEELEDRPS EESGAPAGGS SKKDLALSNQ SISNSPLMPN 540
VLQTLSRGPA STTSNSASNF VVFDGANRRS RLSFNSEGVR ANVAEGRRLD FADESANKDS 600
ATAPEPNEST EGDDGGFVPH HQHAGSLCEL GVGECPSGSG VECPKCDTVL GSSRSLGGHM 660
TMMHSRNSCK TLKCPKCNWH YKYQQTLEAH MKEKHPEPGG SCVYCKSGQP HPRLARGESY 720
TCGYKPFRCE VCNYSTTTKG NLSIHMQSDK HLNNMQNLQN GGGEQVFSHS AGAAAAAAAA 780
AAAAANIGSS CGAPSPTKPK TKPTWRCEVC DYETNVARNL RIHMTSEKHM HNMMLLQQNM 840
TQIQHNRHLG LGSLPSPAEA ELYQYYLAQN MNLPNLKMDS TASDAQFMMS GFQLDPTGPM 900
AAMTPALVGG EIPLDMRLGG GQLVSEELMN LGESFIQTND PSLKLFQCAV CNKFTTDNLD 960
MLGLHMNVER SLSEDEWKAV MGDSYQCKLC RYNTQLKANF QLHCKTDKHV QKYQLVAHIK 1020
EGGKANEWRL KCVAIGNPVH LKCNACDYYT NSLEKLRLHT VNSRHEASLK LYKHLQQHES 1080
GVEGESCYYH CVLCNYSTKA KLNLIQHVRS MKHQRSESLR KLQRLQKGLP EEDEDLGQIF 1140
TIRRCPSTDP EEAVEDAEGP SEASADPEEL AKDQGSGSEE GQSKRAASSS QAEKELTDSP 1200
ATTKRTSFPG SSETPLSSKR PKASEEIKPE QMYQCPYCKY SNADVNRLRV HAMTQHSVQP 1260
LLRCPLCQDM LNNKIHLQLH LTHLHSVAPD CVEKLIMTVT APEMVMPSSM FLPAAAADRD 1320
GNSTLEEAGK QPEASEDPGK NILPPASMEH GGDLKPTSAD PSCGREDSGF LCWKKGCNQV 1380
FKTSATLQTH FNEVHAKRPQ LPVSDRHVYK YRCNQCSLAF KTIEKLQLHS QYHVIRAATM 1440
CCLCQRSFRT FQALKKHLET SHLELSEADI QQLYGGLLAN GDLLAMGDPT LAEDHTIIVE 1500
EDKEEESDLE DKQSPTGSDS GSVQEDSGSE PKRALPFRKG PNFTMEKFLD PSRPYKCTVC 1560
KESFTQKNIL LVHYNSVSHL HKLKRALQES ATGQPEPTSS PDNKPFKCNT CNVAYSQSST 1620
LEIHMRSVLH QTKARAAKLE AASGNSNGTG NSGGVSLSSS TPSPVGSSGA NNTFTATNPS 1680
SAAMAPSVNA LSQVPPESVV MPPLGNPISA NIASPSEPKE ANRKKLADMI ASRQQQQQQQ 1740
QQQQQQAQTL AQAQAQVQAH LQQELQQQAA LIQSQLFNPT LLPHFPMTTE TLLQLQQQQH 1800
LLFPFYIPSA EFQLNPEVSL PVTSGALTLT GSGPGLLEDL KAQVQIPQQS HQQILQQQQQ 1860
QSQLSLSQSH SALLQPSQHP EKKNKVVIKE KDKESQRERE GPEGAEGNTG PKESLPDASK 1920
AKEKKDLAPG GGSEGTMLPP RIASDARGNA TKALLENFGF ELVIQYNENK QKAQKKNGKA 1980
EQGGESLEKL ECDSCGKLFS NILILKSHQE HVHQNYFPFK QLERFAKQYR EHYDKLYPLR 2040
PQTPEPPPPP PPPPPPPLPT APPQPASAPA IPASAPPITS PTIAPAQPSV PLTQLSMPME 2100
LPIFSPLMMQ TMPLQTLPAQ LPPQLGPVEP LPADLAQLYQ HQLNPTLLQQ QNKRPRTRIT 2160
DDQLRVLRQY FDINNSPSEE QIKEMADKSG LPQKVIKHWF RNTLFKERQR NKDSPYNFSN 2220
PPITSLEELK IDSRPPSPEP QKQEYWGSKR SSRTRFTDYQ LRVLQDFFDA NAYPKDDEFE 2280
QLSNLLNLPT RVIVVWFQNA RQKARKNYEN QGEGKDGERR ELTNDRYIRT SNLNYQCKKC 2340
SLVFQRIFDL IKHQKKLCYK DEDEEGQDDS QNEDSMDAME ILTPTSSSCS TPMPSQAYST 2400
PAPSAAAANT APSAFLQLTA ETDELATFNS KAEASDEKPK QADPPSAQPN QTQEKQGQPK 2460
PEMQQQLEQL EQKTNAPQPK LPQPAAPSLP QPPPQAPPPQ CPLPQSSPSP SQLSHLPLKP 2520
LHTSTPQQLA NLPPQLIPYQ CDQCKLAFPS FEHWQEHQQL HFLSAQNQFI HPQFLDRSLD 2580
MPFMLFDPSN PLLASQLLSG AIPQIPASSA TSPSTPTSTM NTLKRKLEEK ASASPGENDS 2640
GTGGEEPQRD KRLRTTITPE QLEILYQKYL LDSNPTRKML DHIAHEVGLK KRVVQVWFQN 2700
TRARERKGQF RAVGPAQAHR RCPFCRALFK AKTALEAHIR SRHWHEAKRA GYNLTLSAML 2760
LDCDGGLQMK GDIFDGTSFS HLPPSSSDGQ GVPLSPVSKT MELSPRTLLS PSSIKVEGIE 2820
DFESPSMSSV NLNFDQTKLD NDDCSSVNTA ITDTTTGDEG NADNDSATGI ATETKSSAPN 2880
EGLTKAAMMA MSEYEDRLSS GLVSPAPSFY SKEYDNEGTV DYSETSSLAD PCSPSPGASG 2940
SAGKSGDGGD RPGQKRFRTQ MTNLQLKVLK SCFNDYRTPT MLECEVLGND IGLPKRVVQV 3000
WFQNARAKEK KSKLSMAKHF GINQTSYEGP KTECTLCGIK YSARLSVRDH IFSQQHISKV 3060
KDTIGSQLDK EKEYFDPATV RQLMAQQELD RIKKANEVLG LAAQQQGMFD NAPLQALNLP 3120
TTYPALQGIP PVLLPGLNSP SLPGFTPANT ALTSPKPNLM GLPSTTVPSP GLPTSGLPNK 3180
PSSASLSSPT PAQATMAMAP QPPPQPQQPQ PPVQQPPPPP AAQQIPAPQL TPQQQRKDKD 3240
GEKGKEKEKA HKGKGEPLPV PKKEKGEAPP AATATISAPL PAMEYAVDPA QLQALQAALT 3300
SDPTALLTSQ FLPYFVPGFS PYYAPQIPGA LQSGYLQPMY GMEGLFPYSP ALSQALMGLS 3360
PGSLLQQYQQ YQQSLQEAIQ QQQQQQQQQQ QQQQRQLQQQ QQQQQQKVQQ QQQQQQQPKA 3420
SQTPVPQGPA SPDKDPAKES PKPEEQKNVP REVSPLLPKP PEEPEAESKS ASADSLCDPF 3480
IVPKVQYKLV CRKCQAGFGD EEAARSHLKS LCCFGQSVVN LQEMVLHVPT GSGGSGGGGG 3540
GSGGGGGSYH CLACESALCG EEALSQHLES ALHKHRTITR AARNAKEHPS LLPHSACFPD 3600
PSTASTSQSA AHSNDSPPPP SAAPSSSASP HASRKSWPPV GSRASAAKPP SFPPLSSSST 3660
VTSSSCSTSG VQPSMPTDDY SEESDTDLSQ KSDGPASPVE GPKDPSCPKD SGLTSVGTDT 3720
FRL 3724
Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0371--Homeobox
KW-0539--Nucleus
KW-1267--Proteomics identification
KW-1185--Reference proteome

Interpro

IPR017970--Homeobox_CS
IPR001356--Homeobox_dom
IPR009057--Homeodomain-like
IPR007087--Znf_C2H2
IPR015880--Znf_C2H2-like
IPR013087--Znf_C2H2/integrase_DNA-bd
IPR003604--Znf_U1

PROSITE

PS00027--HOMEOBOX_1
PS50071--HOMEOBOX_2
PS00028--ZINC_FINGER_C2H2_1
PS50157--ZINC_FINGER_C2H2_2

Pfam

PF00046--Homeobox

Gene Ontology

GO:0005737--C:cytoplasm
GO:0043231--C:intracellular membrane-bounded organelle
GO:0005739--C:mitochondrion
GO:0016604--C:nuclear body
GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0005667--C:transcription factor complex
GO:0019899--F:enzyme binding
GO:0043565--F:sequence-specific DNA binding
GO:0044212--F:transcription regulatory region DNA binding
GO:0008270--F:zinc ion binding
GO:0007420--P:brain development
GO:0007050--P:cell cycle arrest
GO:0045662--P:negative regulation of myoblast differentiation
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0045663--P:positive regulation of myoblast differentiation
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0045664--P:regulation of neuron differentiation
GO:0071559--P:response to transforming growth factor beta