dbPAF Protein Information
| Tag | Content |
|---|---|
| dbPAF ID | dbPAF-0051041 |
| Uniprot Accession | E9QAM5; HELZ2_MOUSE; B9A0U1; |
| Genbank Protein ID | NP_898985.2; XP_006500662.1; |
| Genbank Nucleotide ID | NM_183162.2; XM_006500599.2; |
| Protein Name | Helicase with zinc finger domain 2 |
| Protein Synonyms/Alias | PPAR-gamma DNA-binding domain-interacting protein 1;PDIP1;PPAR-gamma DBD-interacting protein 1; |
| Gene Name | Helz2 |
| Gene Synonyms/Alias | |
| Organism | Mus musculus(Mouse) |
| NCBI Taxa ID | 10090 |
| Functional Description (View all) |
Helicase that acts as a transcriptional coactivator for a number of nuclear receptors including PPARA, PPARG, THRA, THRB and RXRA. |
| Phosphorylation Sites |
dbPAF PTMs: 5 |
| Sequence (Fasta) | MASVGCSLRS ASTSATNGPS LAGLCAKVDL YLGCSRCTQC LNESTYILRE VEHTCPREIL 60 LARFKQAAES KIWRKVGRRP SFPTPMRYQV CHYYRPGLGC RRHWNRCTFA RSPEEALVWT 120 FELKNNLPRL KLKEAVQGTR APDRLQTPAD TIRAEFGGHF QLLCAICFTC CPPCLCPVDP 180 RGHCPKHQIC PTLLIHVIVE GLKRQFVEVR PLPQRRHPLN YCMYVGRGVP CRHGASRCEY 240 AHSAVEMAVW KAEQLDGLQR GDLLTYPLFG ENKWKASPNP NPPVTKLYCH ACLVTCNSQE 300 AFENHCSSLE HAQMVAFDQA VPWKHRAPPM GLSKFDLCPR PDLCEHGEVC IKAHSKQELQ 360 EWVQRAQDME LREQAAWQDG LVPYQARLLA EYQRSSKEVS VMAETIRGVS VTCHPPPVHQ 420 AQEKIQHQWV FTIHSEDPLL HVALLNQEPG AAFSLVAPSL PPHQLYAQGK HFCVQSSPAQ 480 YKVGVLVQAV AFGSFEQWVV FDFGRRPVLL QKLKLQLGQT HSQGLNGKPA PSHPQELECW 540 HTGNRHVVLE VDWTPEQEAL MAKYKLPSLA LEFNQIVPDW GPISRSNYRQ RMHKFLYEEE 600 AAQQQLVAKL AMKGQVSLKT ALETPALGML FAPPGALYAK VPFHSSLLPD TDQGFLLSRA 660 VSTALVAPVP APNSTVYQVR LEARASSDHA LWLLLPARCC MALGLQAQDS PILEVQFQID 720 PMTFRFWHQA VDALLEEHLV VPDLPACTLP HPWPTPPSFR GNHKQKLAVG LIAGRRPEGT 780 KHIPPLLIYG PFGTGKTYTL AMAALEVVQQ PHTKVLICTH TNSAADIYIR EYFHDYVSSG 840 HPEATPLRVM YADRPPRQTD PTTLQYCCLT EDRQAFRPPT GPELVHHRLV VTTTSQAREL 900 QVPAGFFSHI FIDEAAQMLE CEALIPLSYA LSLTRVVLAG DHMQVTPRLF SVPRDKSARH 960 TLLHRLFLYY QQEAHKIAQQ SRIIFHENYR STAAIINFVS HHFYLAKGNP IQASGKVPRH 1020 PQHYPLMFCH VAGSPEQDMS MTSWLNSAEV TQVVEKVREI YNTWPHCWGP REQRHICAVS 1080 HGAQVSALRQ ELRRRNLGEV SVGSFEILPG REFRVVVLSS VHNRNSLLSP GAPTSEFFTE 1140 PRVLNTVMTR AQSQLVAVGD AVALCSSGAC RNLWRSFIRE CIEHHSAFPE ELSLEQIEQG 1200 VAQRQNWASL TLKARGPETE QKSMAQGPQR LIAEGTMVTV KAETRAEAAA KAQTAAVAAE 1260 DTASGNSASR DAAAEVSTLE GGMSEEDSES DFWPSDWELN ADDAILKELL DESQQVTVTV 1320 REDGLLDTVV CSAPQKAREY TNLPSSVLWK FLRSNSKQFR RCSFLQETFE RALATPLDDM 1380 ASSPIQVRGR LNCGMAFTGD EVLVQILGPA GDDRCVPGSL QGRVMGVLKR RRHELAFVCR 1440 MDEWDPRIMI PINGSVTKIF VAEMKDPQQV PIHRLIQGQV QRVRHETLKP EDRSTRLFWV 1500 RIVLWRERFY YPLGIVLEVL PKAITWEQGL YILDLEHGLK AHTPDPASVS KALQRYRSEL 1560 NTAAGHREDY RHFLTFTVDP QGACNLDDAL SVRDLGPVYE VAVHIADVAS LVPKDGALDV 1620 EARQQGTVFY APNREPVLML PASLCQDALS LLPGQDRLAI SLFLTMEKGG GQIKSLRFAP 1680 SIIRSDRQLS YEEAEELIKR HPGAGLELPA HLDSVEACVV AACYFSWMLR RQRLSAACYY 1740 EPPDEDSVLG FRTAHIMVQE YMIQFNSHVA EFLVSNKHTQ TLTPLRWQPT PSRQQLDSVF 1800 KKYRGLVPLS LHLCHHSNTD YTPNKQLHLL TSLWKQVQLA AGTQDYSQMV DLIAADDMHP 1860 SLAPACLDLR RALGRSVFGR SSQGKQQPAV HHSLQVDWYT WATSPIRRYL DVVLQRLILL 1920 ALGHRGSTYS NRDIDGLCLD FSRQYASAQS YQRRAYSLHL AIQLKSQPQN KLGFVVDVEM 1980 GARCFKVLFP INRETLPDPC PIHYHSLQLA EHPQELVSQT GVRLVWRRRM YSVQASKLPL 2040 PLLGTSLDPH TQTVDAALWM KLLMLLKEQR WPEIAALIQE QDKRFHPREK VKIHQSRCGH 2100 FVEVVYELGS GDTLQVQLGS SLQRGFLAPT LKLWTVVPGF SLCLEHMERP GDCFSSHVHQ 2160 ALQDQYLQVG EYSGAWGPRC ALESLTNAVT ENDSIVLHDV HISWDTSQGQ LQGTFQLEAA 2220 FLQEKCINIH FGCCYLCIRL EGLPLPLDSS LPGPSGLGPF LNIDPNTYTW VAHGLSGDWD 2280 HELAGGDWDQ ENVDDRQEAP KQVYFLIHHM TMEKVPEEVL RPSARFTVEV LSKQLPDLRK 2340 EEAVRQLKTA SPLVISIALG LPIPEIRWPI SGPRRLVSEL RWPIPGPRRP VSEPHRPMSG 2400 PCGPISEPCR SIPEPCRGNW PRQHSFHKAS TSRFLERQNY NIPAGHHKLN QSQDRAVRSA 2460 LQKQFTVIQG PPGTGKTVVG FHIVYWFHRS NQEQMPTDSS PSGEEQLGGP CVLYCGPSNK 2520 SVDVLGGLLL RRKTEMKPLR VYGEQAEATE FPLPGVSNRS LFGKTSQEGR PNQSLRSITL 2580 HHRIRQAPNP YAAEIRKFDA QLREGKIFSK EDLRVYRRVL GKARKHELER HSVILCTCSC 2640 AASKSLKILN VRQILIDEAG MATEPETLIP LVCFSKTVEK VVLLGDHKQL RPVVKSEQLQ 2700 SLGMDRSLFE RYHRDAIMLD TQYRMHKDIC SFPSVEFYGG KLKTWSDLRR LPSILGHTGK 2760 PSCSVIFGSV QGHEQKLLVS TEDGNENSRA NPEEVTQVVR IIKQLTLDRT VDPKDIAVLT 2820 PYNAQAAAIS RGLMQRGVTG VTVTSITKSQ GSEWRYVIVS TVRTCPRSDV DQRPTKSWLK 2880 KFLGFVVDPH QVNVAITRAQ EALCIIGDHL LLRCCPLWHR LLDFCEAQHS LVSAEKVRVQ 2940 RKSALSS 2948 |
| Keyword | KW-0010--Activator |
| Interpro | IPR003593--AAA+_ATPase |
| PROSITE | PS00028--ZINC_FINGER_C2H2_1 |
| Pfam | |
| Gene Ontology | GO:0016020--C:membrane |