dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0051032
Uniprot Accession E9QA63; E9QA63_MOUSE;
Genbank Protein ID
Genbank Nucleotide ID
Protein Name Microtubule-actin cross-linking factor 1
Protein Synonyms/Alias
Gene Name Macf1
Gene Synonyms/Alias
Organism Mus musculus(Mouse)
NCBI Taxa ID 10090
Functional Description
(View all)
Phosphorylation Sites
dbPAF PTMs: 1
PositionPeptidesSourceReferences ( PMIDs )
2968SREAAVLSEEELDQEPHOSIDA;curated21081558; 21183079
Sequence
(Fasta)
MSSSDEETLS ERSCRSERSC RSERSYRSER SGSLSPCPPG DTLPWNLPLH EQKKRKSQDS 60
VLDPAERAVV RVADERDRVQ KKTFTKWVNK HLMKVRKHIN DLYEDLRDGH NLISLLEVLS 120
GIKLPREKGR MRFHRLQNVQ IALDFLKQRQ VKLVNIRNDD ITDGNPKLTL GLIWTIILHF 180
QISDIYISGE SGDMSAKEKL LLWTQKVTAG YTGVKCTNFS SCWSDGKMFN ALIHRYRPDL 240
VDMERVQVQS NRENLEQAFE VAERLGVTRL LDAEDVDVPS PDEKSVITYV SSIYDAFPKV 300
PEGGEGISAT EVDSRWQEYQ SRVDSLIPWI RQHTILMSDK SFPQNPVELK ALYNQYIHFK 360
ETEILAKERE KGRIKELYKL LEVWIEFGRI KLPQGYHPNH VEEEWGKLIV EMLEREKSLR 420
PAVERLELLL QIANKIQNGA LNCEEKLTLA KNTLQADAAH LESGQPVQCE SDVIMYIQEC 480
EGLIRQLQVD LQILRDEKYY QLEELAFRVM RLQDELVTLR LECTNLYRKG HFSSLELVPP 540
STLTTTHLKA EPLNKTTHSS STSWFRKPMT RTELVSISSS EDEGNLRFVY ELLSWVEEMQ 600
MKLERAEWGN DLPSVELQLE TQQHIHTSVE ELGSSVKEAR LYEGKMSQNF HTSYVETLGK 660
LETQYCKLKE TSSFRMRHLQ SLHKFVSRAT AELIWLNGKE EEELACDWSD SNPNISAKKT 720
YFSELTMELE GKQDVFRSLQ DTAEVLSLEN HPAKQTVEAY SAAVQSQLQW MKQLCLCVEQ 780
HVKENAAYFQ FFSDARDLES FLRNLQDSIK RKYTCDRSTS LSRLEDLLQD SMDEKEQLIQ 840
SKSSVASLVG RSKTIVQLKP RNPDHVLKST LSVKAICDYR QIEITICKND ECVLEDNSQR 900
TKWKVISPTG NEAMVPSVCF LIPPPNKEAI EMASRVEQSY QKVMALWHQL HINTKSLISW 960
NYLRKDLDTV QTWSLEKLRS LAPGECHQVM KNLQAHYEDF LQDSHDSALF SVADRLRIEE 1020
EVEACKAHFQ HLMKSLENED KEETLAKVYI SELKNIRLLL EECEQRLLKQ IQSPASSKTD 1080
RDARQDITLR IAEQEHTQED LQHLRSDLDA ISMKCNVFLQ QSPSGSSATT LRSELNLMVE 1140
KMDHVYGLST VYLNKLKTID VIVRSMQDAE LLVKGYEIKL SQEEAVPADL SALESHRTTL 1200
QHWLSDVKDK NSVFSVLDEE ITKAKKVAEQ LRHPASEPNL DLERYQEKGS QLQERWHRVI 1260
AQLETRQSEV ESIQEVLRDY RACHGTLIKW IEETTAQQEM MKPGQAEDSR VLSEQLSQQT 1320
ELFAEIERNQ TKLDQCQKFS QQYSTIVKDY ELQLMTYKAF VESQQKSPGK RRRMISSSDA 1380
ITQEFMDLRT RYTALVTLTT QHVKYISDAL RRLEEEEKVV EEEKQEHVEK VKDLLGWVST 1440
LARNTQGTTT SSHTSASADI EKAILEQQVL AEELTTKKEQ VSEAIKTSQI FLAKHGHKLS 1500
EGEKEQISEQ LRVLNKTYHD LCDGSANQLQ QLQSELAQQT EQKGCRAVAG VIDLGTVEIF 1560
PIFRAMQKGL IDQDTGLVLL ESQIIMSGLI DPENSEKLSL EEGLTRNFIN LPIYQQLLGL 1620
RDSLSLVSRL TGTLGSLSVV EAIEKKIISE RLGLKVLEVH LATGGFSLPP SENCINLEEA 1680
FHQGFIASSL HSELQSHLRS SKNLIDPNTA EKVGLLDLMQ RCIIHQESGL KLLPVKQLAG 1740
GMVSLKSGRK VSIFRAVQEG LIDRQVTVRL LEAQLFAGGI VDPRTGHRLT VEEAVRHNLI 1800
DQDMACAILI RQLQTGGIID TVTGDRMTID EAVTNNLVAA KIALVILESL WSFMGLLLPE 1860
SGEILPITDA LEQGIVSTEL AHKILHNRQQ IEALFLPTLT EIWSWEKATE SGILDKDLVN 1920
NLRSVCIPDM MPHIQLADSA EQSKVGFAAG KPPVSGPREE GSSHGEKLLF QLMTHSYIHA 1980
HTGQRLLLLD QELVEMLTSR DDCQVILPEV FEIQHQRLNT SEALQELYTG TISQISSAKH 2040
PRKPCESQFL SQNKDYPSQE NCTEAKGERS VVGIECSPAE SPERELFLKE QEAIIENVGS 2100
LKVINKVKLK LQRPLLGSRK EEQAETLREE NISGDPLLVE CPEESEGKDL STEKSKCQTP 2160
TKCSFTCHKE QVKTIKDIPS ETGTSLIKSQ NQMSQFQVDT SVGLRSEFKS EHDMNVNSLE 2220
KELKEELLVK DGHKQSQEGQ SVADGQTVAL EKTDTEDNAD EPALLHSSPF EDATLSTLSA 2280
QLQDGGIFNE ETGQKLLLNE AIAQGLVSSH TAVKLMGKLN MFRGFFDSQT CESLTTEEVI 2340
DEGLMDEKLL YNVLMSDKAI SGILDPRTHS LCSVKEAVAA GLLDKETATR ILEGQVITGG 2400
IVDLKRGKKL SVTLASNLGL VDTADQTELI NLEKATKGRG AEKAVKERLI ELQMETAGLM 2460
DPESKAPLTV LQSIDRGILE REAAVYLLTK QVLDGGIIHH ISGLRLSVDN AFKHGLIGED 2520
MARQLRKVEN FIHYQFFHPQ TKEALSFSEA IKLDLVSPDL KREIQEIQDF SGNLGDFIYG 2580
QKLTLAKTNK EESLANKTEL PSGVMHGVID PENCTIIPYS ELVKKCRIDT ESGWRYLEVI 2640
PFSDIKDEAG NNVLTPPEAI QLGKVDFASA LKVLEAQANT GGIIDMATGK RVTLASALEK 2700
KLLDENMARI IASHQMLSGG IIDIYSDQRV TLNDAVEKRL ISPELAAMIQ VDPLAEQGGT 2760
GVCELKGDFL RKELLSESSK TPRESYSKEK HEAVLQAGSL CAPEKAGIRG SNGEKAEKGR 2820
KISVEMEGQR QDEKASSDNK VSASILSPFG FEGESSYQVS VTHPCSESCD LKPREETRSC 2880
MKKCAVVERD KVVTQIKMVS HVKQSTSGLD AEEARERQGR MVSKEQGSHY ETAGNLLSER 2940
SVRVDRRVRR EMGGEQSVQM SREAAVLSEE ELDQEVTIGD EPDSFVKSQS MKMIGNDKGK 3000
EAGIEKDISV VCKIEGFPSQ MTSKDASLTN QDALPFYTEG ETKTVNLCSI LKPGEKLSQE 3060
TASTVQKEPL SSEIPRPERL NSQESDEEPQ ISDVPHISKG DMAAQITTRQ ETTDVQDLYI 3120
TSKSSETKDK IFPSKNYIEK LHQEIPMDPT RSHKLKEATI STLETEGISY LDSSDIKSLC 3180
EDSKADHKSC GHQKSKVTTT QAKKSLEVVD LLVRDTEEGS SEDRVGQRGP RVLASLLPEK 3240
LPTRTVQSEN IRQHDAVIPA ISEIREEMAL SLPCSVVKVD GKIPKEKHKE ILGDEQGPFM 3300
AIPSGKGIEG VNPEPCRATQ NVFTRRLCLE HDEKLVSYLS LLRDIEMRTK QIQPLELNVA 3360
ELQDLLGQAK ELDRELKDLS TVVSQELECV DRIVISQPQE VPAQLLKALE KDAKNLQKSL 3420
DSVSDSWSSR FLHLQSAVEV KKATVLNRHK ELQGKLQDLR AWVGRASLTL NSKGCDTETD 3480
ADSLSHTLQP YKDMKQSMAE RKSQLDALAL DIQLFISEHP QDLSLQQNQE MLQFLSELQR 3540
SFQGLVEHTA AQKDVVQGHL QQVQQEVQVK TLQKQQDTCH KKLEDLCNWV GQAERHWRGT 3600
RAEPLGKSSL LCAEPNVKDL QGDIQSHSTS FATAVKDIEG FLEENQTKLS PQELTALREK 3660
LHQAKEQYEV LQERTRVAQK ELEEAVTSAL QQETEKSKAA TELAENKRKI DALLDWLLWG 3720
HLRESHRLAF QEWSSSLELA WKQTLAATDG HVDVNQVPET LDRQYELMKA RHQELLSQQQ 3780
NFIVATQSVQ SFLDQHSHNL TPEERQKLQE KLGELKEQYA ASLARSEAEL KQTQALRDEL 3840
QKFLQDHKEF ENWLQQSENE LDSMHKGGSS PEALNSLLKR QGSFSEDVIS HKGDLRFVTI 3900
SGQKVLETEN NFEEGQEPSA TRNLVNEKLK DATERYTTLH SKCIRLGSHL SMLLGQYQQF 3960
QSSADSLQAW VLTCEASVGK LLSDTVASDP GVLQQQLATT KQLQEELAEH QVPVEKLQKA 4020
AHDLLDIEGE PALDCRPIQE TTDSISSRFQ NLSCSLDERS ALLQKAIAQS QSVQESMESL 4080
LQSIREVEQN LERDQVASLS SGVIQEALAN NMKLKQDIAR QKSSLEATHD MVTRFMETAD 4140
SNSASVLQGK LAELSQRFQQ LQLQQQEKES NLKKLLPQAE MFEQLSNKLQ QFMENKSRLL 4200
ASGNQPDQDI AHFSQQIQEL TLAMEDQKEN LDTLEHLVTT LGSCGFALDL SQHQDKIQNL 4260
KKDFTELQKT VQEREKDAST CQEQLDEFRK LIRTFQKWLK ETEGNVPPAK TFVSAKELEK 4320
QIEHLKDLIS DWESKGALLG EINAKGTALE SLIMDITAPD SQAKTGSILP PVGSSVGSVN 4380
GYHTCKDLTE IQCDMFDVNS KYEKLWEVLR ERQESLQTVF SRMEEVQKEA SSVLQWLESK 4440
EEVLKAMDAT LSPTKTETVK AQAESNKAFL AELEQNSPKI QKVKEALAGL LKTYPNSQEA 4500
ENWKKMQEDL NSRWEKATEV TVARQKQLEE SASHLACFQA AESQLRPWLM EKELMMGVLG 4560
PLSIDPNMLN AQKQQVQFML KEFEARRQQH EQLNEAAQGI LTGPGDMSPS ASQVHKDLQS 4620
ISQKWVELTD KLNSRSSQID QAIVKSTQYQ DLLQDLSEKV KAIGQRLSGQ SAISTQPEAV 4680
KQQLEETSEI RSDLGQLDNE IKEAQTLCQE LSLLIGEQYL KDELKKRLET VALPLQGLED 4740
LAADRMNRLQ AALASTQQFQ QMFDELRTWL DEKQSQQAKN CPISAKLERL QCQLQENEEF 4800
QKNLNQHSGS YEVIVAEGEA LLLSVPPGEE KKTLQNQLVE LRSHWEDLSK KTANRQSRLK 4860
DCMQKAQKYQ GHVEDLVPWI DECKSKMSEL QVTLDPVQLE SSLLRSKAML NEAEKRRSLL 4920
EILNSAADIL INSSEIDEDE IRDEKAGLNQ NMDAITEELQ AKTSSLEEMT QRLKEFQESF 4980
KNIEKKVEGA KHQLEIFDAL GSQACSNKNL EKLKAQQEVL QALEPQVDYL RNFTQGLVED 5040
APDGSDASPL VHQAEVAQQE FLEVKQRVSS SCLTMENKLE GIGQFHCRVR EMFSQLADLD 5100
DELDGMGAIG RDTDSLQSQI EDVRLFLNKI QALRFDIEDS EAECRKMLEE EGTLDLLGLK 5160
RELEALNKQC GKLTERGKVR QEQLELTLGR VEDFYRKLKA LNDAATAAEE GEALQWIVGT 5220
EVDVINQQLA DFKLFQKDQV DPLQVKLQQV NGLGQGLIQS AGKNCDVQGL EHDMDEINTR 5280
WNTLNKKVAQ RIAQLQEALL HCGKFQDALE PLLSWLTDTE ELIANQKPPS AEYKVVKAQI 5340
QEQKLLQRLL DDRKATVDML QAEGGRIAQS AELADREKIT GQLESLERRW TDLLSKAAAR 5400
QKQLEDILVL AKQFHETAEP ISDFLSVTEK KLANSEPVGT QTAKIHQQII RHKALNEEII 5460
NRKKNVDQAI KNGQALLKQT TGEEVLLIQE KLDGIKTRYA DITLTSSKAL RTLEQARQLA 5520
TKFHSTYEEL TGWLREAEEE LAASGGQSPT GEQIPQFQQR QKELKKEVME HRLVLDTVNE 5580
VSHALLELVP WRAREGLDKL VSDANEQYKL ISDTVGQRVD EIDAAIQRSQ QYEQAADAEL 5640
AWVAETKRKL MALGPIRLEQ DQTTAQLQVQ KAFSIDIIRH KDSMDELFSH RGEIFSTCGE 5700
EQKAVLQEKT ECLIQQYEAV SLLNSERYAR LERAQVLVNQ FWETYEELSP WAEETLALIA 5760
QLPPPAVDHE QLRQQQEEMR QLRESIAEHK PHIDKILKIG PQLKELNPEE GKMVEEKYQK 5820
AENMYAQIKD EVRQRALALD EAVSQSAQFH DKIEPMLETL ENLSSRLRMP PLIPAEVDKI 5880
RECISDNKSA TVELEKLQPS FEALKRRGEE LIGRSQGADK DLAAKEIQDK LDQMVFFWED 5940
IKARSEEREI KFLDVLELAE KFWYDMAALL TTIKDTQDIV HDLESPGIDP SIIKQQVEAA 6000
ETIKEETDGL HEELEFIRIL GADLIFACGE TEKPEVKKSI DEMNNAWENL NKTWKERLEK 6060
LEDAMQAAVQ YQDTLQAMFD WLDNTVIKLC TMPPVGTDLN TVKDQLNEMK EFKVEVYQQQ 6120
IEMEKLNHQG ELMLKKATDE TDRDIIREPL TELKHLWENL GEKIAHRQHK LEGALLALGQ 6180
FQHALEELMS WLTHTEELLD AQRPISGDPK VIEVELAKHH VLKNDVLAHQ ATVATVNKAG 6240
SELLESSAGD DASSLRSRLE TMNQCWESVL QKTEEREQQL QSTLQQAQGF HSEIEDFLLE 6300
LNRMENQLSA SKPTGGLPET AREQLDTHME LHSQLRAKEE IYNQLLDKGR LMLLSRGDSG 6360
SGSKTEQSVA LLEQKWHAVS SKVEERKSKL EEALSLATEF QNSLQEFINW LTLAEQSLNI 6420
ASPPSLILNT VLSQIEEHKV FANEVNDHRD QIIELDQTGN QLKFLSQKQD VVLIKNLLVS 6480
VQSRWEKVVQ RSIERGRSLD DARKRAKQFH EAWKKLIDWL EDAESHLDSE LEISNDPDKI 6540
KLQLSKHKEF QKTLGGKQPV YDTTIRTGRA LKEKTLLAGD TQKLDNLLGE VRDKWDTVCG 6600
KSVERQHKLE EALLFSGQFM DALQALVDWL YKVEPQLAED QPVHGDLDLV MNLMDAHKVF 6660
QKELGKRTGT VQVLKRSGRE LIEGSRDDTT WVKGQLQELS TRWDTVCKLS VSKQSRLEQA 6720
LKQAEEFRDT VHMLLEWLSE AEQTLRFRGA LPDDTEALQS LIDTHKEFMK KVEEKRVDVN 6780
TAVAMGEAIL AVCHPDCITT IKHWITIIRA RFEEVLTWAK QHQQRLETAL SELVANAELL 6840
EELLAWIQWA ETTLIQRDQE PIPQNIDRVK ALITEHQSFM EEMTRKQPDV DRVTKTYKRK 6900
SVEPTHAPFM EKSRSGSRKS LNQPTPPPMP ILSQSEAKNP RINQLSARWQ QVWLLALERQ 6960
RKLNDALDRL EELCPELKEF ANFDFDVWRK KYMRWMNHKK SRVMDFFRRI DKDQDGKITR 7020
QEFIDGILAS KFPTTKLEMT AVADIFDRDG DGYIDYYEFV AALHPNKDAY RPTTDADKIE 7080
DEVTRQVAQC KCAKRFQVEQ IGENKYRFFL GNQFGDSQQL RLVRILRSTV MVRVGGGWMA 7140
LDEFLVKNDP CRARGRTNIE LREKFILPEG ASQGMTPFRS RGRRSKPSSR AASPTRSSSS 7200
ASQSNHSCTS MPSSPATPAS GTKVISSSGS KLKRPTPAFH SSRTSLAGDT SNSSSPASTG 7260
AKANRADPKK SASRPGSRAG SRAGSRASSR RGSDASDFDL LETQSACSDT SESSAAGGQG 7320
SSRRGLTKPS KIPTMSKKTT TASPRTPGPK R 7352
Keyword

KW-0009--Actin-binding
KW-0106--Calcium
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0677--Repeat

Interpro

IPR001589--Actinin_actin-bd_CS
IPR001715--CH-domain
IPR011992--EF-hand-dom_pair
IPR018247--EF_Hand_1_Ca_BS
IPR002048--EF_hand_dom
IPR003108--GAS2_dom
IPR028408--Macf1
IPR001101--Plectin_repeat
IPR018159--Spectrin/alpha-actinin
IPR002017--Spectrin_repeat

PROSITE

PS00019--ACTININ_1
PS00020--ACTININ_2
PS50021--CH
PS00018--EF_HAND_1
PS50222--EF_HAND_2
PS51460--GAR

Pfam

PF00307--CH
PF13499--EF-hand_7
PF02187--GAS2
PF00681--Plectin
PF00435--Spectrin

Gene Ontology

GO:0015629--C:actin cytoskeleton
GO:0005938--C:cell cortex
GO:0015630--C:microtubule cytoskeleton
GO:0097481--C:neuronal postsynaptic density
GO:0003779--F:actin binding
GO:0016887--F:ATPase activity
GO:0005509--F:calcium ion binding
GO:0008017--F:microtubule binding
GO:0007050--P:cell cycle arrest
GO:0007163--P:establishment or maintenance of cell polarity
GO:0001707--P:mesoderm formation
GO:0006620--P:posttranslational protein targeting to membrane
GO:0008104--P:protein localization
GO:0016055--P:Wnt signaling pathway