dbPAF Protein Information
| Tag | Content | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| dbPAF ID | dbPAF-0051011 | ||||||||||||
| Uniprot Accession | E9Q9K5; TRDN_MOUSE; Q8VIN7; Q8VIN8; Q8VIN9; Q9CV36; | ||||||||||||
| Genbank Protein ID | NP_084002.2; | ||||||||||||
| Genbank Nucleotide ID | NM_029726.2; | ||||||||||||
| Protein Name | Triadin | ||||||||||||
| Protein Synonyms/Alias | |||||||||||||
| Gene Name | Trdn | ||||||||||||
| Gene Synonyms/Alias | |||||||||||||
| Organism | Mus musculus(Mouse) | ||||||||||||
| NCBI Taxa ID | 10090 | ||||||||||||
| Functional Description (View all) |
Contributes to the regulation of lumenal Ca2+ release via the sarcoplasmic reticulum calcium release channels RYR1 and RYR2, a key step in triggering skeletal and heart muscle contraction. Required for normal organization of the triad junction, where T-tubules and the sarcoplasmic reticulum terminal cisternae are in close contact. Required for normal skeletal muscle strength (PubMed:19843516). Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats. | ||||||||||||
| Phosphorylation Sites |
dbPAF PTMs: 2
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| Sequence (Fasta) | MTEITAEGNA STTTTVIDNK NGCIPKSPGK VLKRSVTEDI VTTFSSPAAW LLVIALIITW 60 SAVAIVMFDL VDYKNFSASS IAKIGSDPLK LVNDAVEETT DWIYGFFSLL SDIISSEGDE 120 DDEDADEDID KGEIEEPPLK RKEIHQEKAE KEEKPEKKIQ TKASHREREK GKEKLKGEKP 180 EKTATHKEKL EKKERPETKM MAKEDKKIKT KEKTEEKAKK EMKVGKQEKV KPTAAKAKET 240 PKTPPKARKK DDKEMPAVHE QKDQYAFCRY MIDMFVHGDL KPGQSPVMPP PSLTPSKPAL 300 STTALEEKEK EEKKKMEKKD TSDTKKKEKE VKKKSEETTI DGKGKEPGKP PETKQMTAKL 360 TTQAAARKDE KKEESKKMRK PTEEQPKGKK QEKKEKHIEP AKTPKKEHPG PSEKLKKAKA 420 EQAKEEIAAA STKKALHGKK EEKAKTVEQE VKKEKSGKSS SDLKDKEVKK EKSGKSSSDL 480 KDKEPQLKNE EKSKPQVKKE AKLASSDKGQ TRKQNITRPE QVIPHVKPEK AEHQEKGHPS 540 IKKDKPKPSS KGAPEVPDSG KKKIEKSEKE SKVPTREENL QVYNVTKAEK PGKIPKDSKE 600 APASKKDKED SKEAPTSKKD KEDSKDVPHS KKDKEVTDDV SSPKKQTRPI SFFQCVYLNG 660 YNGYGFQFPV TPVQQPGENP GKTNSPGQKQ QEQ 694 |
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| Keyword | KW-0025--Alternative splicing |
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| Interpro | IPR010798--Triadin |
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| PROSITE | |||||||||||||
| Pfam | |||||||||||||
| Gene Ontology | GO:0005737--C:cytoplasm |