dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0050981
Uniprot Accession E9Q8I9; FRY_MOUSE; Q4VA57; Q5DTL4; Q8BIW6; Q8BUA0; Q8CG91;
Genbank Protein ID NP_766475.2; XP_006504993.1;
Genbank Nucleotide ID NM_172887.2; XM_006504930.2;
Protein Name Protein furry homolog
Protein Synonyms/Alias
Gene Name Fry
Gene Synonyms/Alias Kiaa4143;
Organism Mus musculus(Mouse)
NCBI Taxa ID 10090
Functional Description
(View all)		 Plays a crucial role in the structural integrity of mitotic centrosomes and in the maintenance of spindle bipolarity by promoting PLK1 activity at the spindle poles in early mitosis. May function as a scaffold promoting the interaction between AURKA and PLK1, thereby enhancing AURKA-mediated PLK1 phosphorylation.
Phosphorylation Sites
 dbPAF PTMs: 33 (View all)
PositionPeptidesSourceReferences ( PMIDs )
489GKPAKAFSLNPERMNPhosphoSitePlus22135298
895MPLVDPNSPVNAKKTPHOSIDA;PhosphoSitePlus21081558; 22135298
932VAKPSIMSPGHLRASPhosphoSitePlus22135298
940PGHLRASTPEIMATTcurated21183079
947TPEIMATTPDGTVSYPhosphoSitePlus22135298
951MATTPDGTVSYDNKAPhosphoSitePlus22135298
1379SRLLLPGSSPSSPEDPHOSIDA;PhosphoSitePlus;curated21081558; 22135298; 21183079
1380RLLLPGSSPSSPEDEPhosphoSitePlus;curated22135298; 21183079
1382LLPGSSPSSPEDEVKPHOSIDA;PhosphoSitePlus;UniProt;curated21081558; 22135298; 21183079
1383LPGSSPSSPEDEVKDPHOSIDA;PhosphoSitePlus;UniProt;curated21081558; 22135298; 21183079
1593EDKNDPISPYTGWLLPhosphoSitePlus22135298
1728TLTMQPAYQPEYLYTPhosphoSitePlus22135298
1936SDLFTVLSRSSSPDLPHOSIDA;PhosphoSitePlus;UniProt;curated21081558; 22135298; 21183079
1939FTVLSRSSSPDLSSSPhosphoSitePlus;curated22135298; 21183079; 25521595
1940TVLSRSSSPDLSSSSPhosphoSitePlus;UniProt;curated22135298; 21183079; 25521595
1945SSSPDLSSSSKLTASSysPTM 2.017203969; 19366988
1946SSPDLSSSSKLTASRSysPTM 2.017203969; 19366988
1955KLTASRKSTGQLNVNPHOSIDA;curated21081558; 21183079
1968VNPGTPGSGGGGGGSPhosphoSitePlus22135298
1991SRHQRSFSVPKKFGVPhosphoSitePlus22135298
Sequence
(Fasta)		MASQQDSGFF EISIKYLLKS WSNASPVGNG YIKPPVPPAS GTHREKGPPA MLPINVDPDS 60
KPGEYVLKSL FVNFTTQAER KIRIIMAEPL EKPLTKSLQR GEDPQFDQVI SSMSSLSEYC 120
LPSILRTLFD WYKRQNGIED ESHEYRPRTS NKSKSDEQQR DYLMERRDLA IDFIFSLVLI 180
EVLKQIPLHP VIDSLIHDII NLAFKHFKYK EGYLGPNTGN MHIVADLYAE VIGVLAQAKF 240
PAVKKKFMAE LKELRHKEQS PYVVQSIISL IMGMKFFRIK MYPVEDFEAS LQFMQECAHY 300
FLEVKDKDIK HALAGLFVEI LVPVAAAVKN EVNVPCLRNF VESLYDTTLE LSSRKKHSLA 360
LYPLVTCLLC VSQKQLFLNR WHVFLNNCLS NLKNKDPKMA RVALESLYRL LWVYMIRIKC 420
ESNTATQSRL ITITTTLFPK GSRGVVPRDM PLNIFVKIIQ FIAQERLDFA MKEIIFDFLC 480
VGKPAKAFSL NPERMNIGLR AFLVIADSLQ QKDGEPPMPV TGAVLPSGNT LRVKKTYLSK 540
TLTEEEAKMI GMSLYYSQVR KAVGNILRHL DKEVGRCMML TNVQMLNKEP EDMITGERKP 600
KIDLFRTCVA AIPRLLPDGM SKLELIDLLA RLSIHMDDEL RHIAQNSLQG LLVDFSDWRE 660
DVLFGFTNFL LREVNDMHHT LLDSSLKLLL QLLTQWKLVI QTQGRAYEQA NKIRNSELIP 720
NGSSHRMQSE RGPHCSVLHA VEGFALVLLC SFQVATRKLS VLILKEIRAL FLALGQPEDD 780
DRPMIDVMDQ LSSSILESFI HVAVSDSATL PPTHNVDLQW LVEWNAVLVN SHYDVKSPSH 840
VWIFAQSVKD PWVLCLFSFL RQENLPKHCP TALSYAWPYA FTRLQSVMPL VDPNSPVNAK 900
KTSTASSGDN YVTLWRNYLI LCFGVAKPSI MSPGHLRAST PEIMATTPDG TVSYDNKAIG 960
TPSVGVLLKQ LVPLMRLESI EITESLVLGF GRTNSLVFRE LVEELHPLMK EALERRPENK 1020
KRRERRDLLR LQLLRIFELL ADAGVISDST NGALERDTLA LGALFLEYVD LTRMLLEAEN 1080
DKEVEILKDI RAHFSAMVAN LIQCVPVHHR RFLFPQQSLR HHLFILFSQW AGPFSIMFTP 1140
LDRYSDRNHQ ITRYQYCALK AMSAVLCCGP VFDNVGLSPD GYLYKWLDNI LACQDLRVHQ 1200
LGCEVVMLLL ELNPDQINLF NWAIDRCYTG SYQLASGCFK AIATVCGNRN YPFDIVTLLN 1260
LVLFKASDTN REIYEVSMQL MQILEAKLFV HSKKVAEQRP GSILYGTHGP LPPLYSVSLA 1320
LLSCELARMY PELTLPLFSE VSQRFPTTHP NGRQIMLTYL LPWLHNIELV DSRLLLPGSS 1380
PSSPEDEVKD REGEVTASHG LKGNGWGSPE ATSLVLNNLM YMTAKYGDEV PGAEMENAWN 1440
ALANNEKWSN NLRVTLQFLI SLCGVSSDTI LLPYIKKVAT YLCRNNTIQT MEELLFELQQ 1500
TEPVNPIVQH CDNPPFYRFT ASSKASAAAS GTTSSSNTVV AGQDSFPDPE ESKILKESDD 1560
RFSNVIRAHT RLESRYSNSS GGSYDEDKND PISPYTGWLL SITEAKQPQP LPMPCSGGCW 1620
APLVDYLPET ITPRGPLHRC NIAVIFMTEM VVDHSVREDW ALHLPLLLHA VFLGLDHYRP 1680
EVFEHSKKLL LHLLIALSCN SNFHAIASVL LQTREMGEAK TLTMQPAYQP EYLYTGGFDF 1740
LREDQSSPVP DSGLNSSSTS SSISLGGSSG NLPQMTQEVE DVEAATETDE KASKLIEFLT 1800
TRAFGPLWCH EDITPKNQNS KSAEQLSNFL RHVVSVFKDS RSGFHLEQHL SEVALQTALA 1860
SSSRHYAGRS FQIFRALKQP LSAHALSDLL SRLVEVIGEH GDEIQGYVME ALLTLEAAVD 1920
NLSDCLKNSD LFTVLSRSSS PDLSSSSKLT ASRKSTGQLN VNPGTPGSGG GGGGSGNTTT 1980
AERSRHQRSF SVPKKFGVVD RSSDPPRSAT LDRIQACTQQ GLSSKTRSNS SLKESLTDPS 2040
HVSHPTNLLA TIFWVTVALM ESDFEFEYLM ALRLLNRLLA HMPLEKAENR EKLEKLQAQL 2100
KWADFPGLQQ LLLKGFTSLT TTDLTLQLFS LLTSVSKVPM VDSSQAIGFP LNVLCLLPQL 2160
IQHFENPNQF CKDIAERIAQ VCLEEKNPKL SNLAHVMTLY KTHSYTRDCA TWVNVVCRYL 2220
HEAYADITLN MVTYLAELLE KGLPSMQQPL LQVIYSLLSY MDLSVVPVKQ FNMEVLKTIE 2280
KYVQSIHWRE ALNILKLVVS RSASLVLPSY QHSDLSKIEL HRVWTSASKE LPGKTLDFHF 2340
DISETPIIGR RYDELQNSSG RDGKPRAMAV TRSASSTSSG SNSNVLVPVS WKRPQYSQKR 2400
TKEKLVHVLS LCGQEVGLSK NPSVIFSSCG DLDLPEHQTS LVSSEDGPRE QENMDDTNSE 2460
QQFRVFRDFD FLDVELEDGE GESMDNFNWG VRRRSLDSLD KCDMQILEER QLSRSTPSLN 2520
KMSHEDSDES SEEDLTASQI LEHSDLIMNL SPSEEANPME LLTSACDSAP ADPHSFNTRM 2580
ANFEASLPDI NNLQISEGSK AEAVPEEEDT TVHEDDLSSS INELPAAFEC SDSFSLDMTE 2640
AEEKGNRGLD QYTLASFGEG DRGVSPPPSP FFSAILAAFQ PAACDDAEEA WRSHINQLMC 2700
DSDGSCAVYT FHVFSSLFKN IQKRFCFLTC DAASYLGDNL RGIGSKFVSS SQMLTSCSEC 2760
PTLFVDAETL LSCGLLDKLK FSVLELQEYL DTYNNRKEAT LSWLANCKAT FAGGSRDGVI 2820
TCQPGDSEEK QLELCQRLYK LHFQLLLLYQ SYCKLIGQVH EVSSVPELLN MSRELSDLKR 2880
NLKEATAAIA TDPLYIEGAW SEPTFTSTEA AIQSMLECLK NNELGKALRQ IKECRSLWPN 2940
DIFGSSSDDE VQTLLNIYFR HQTLGQTGTY ALVGSNHSLT EICTKLMELN MEIRDMIRRA 3000
QNYRVLTAFL PDSSVSGTSL 3021
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0597--Phosphoprotein
KW-1185--Reference proteome
Interpro

IPR025614--Cell_morpho_N
IPR025481--Cell_Morphogen_C
IPR029473--MOR2-PAG1_mid
PROSITE
Pfam

PF14225--MOR2-PAG1_C
PF14228--MOR2-PAG1_mid
PF14222--MOR2-PAG1_N
Gene Ontology

GO:0005938--C:cell cortex
GO:0005815--C:microtubule organizing center
GO:0030427--C:site of polarized growth
GO:0000922--C:spindle pole
GO:0004857--F:enzyme inhibitor activity
GO:0090527--P:actin filament reorganization
GO:0000902--P:cell morphogenesis
GO:0043086--P:negative regulation of catalytic activity
GO:1904428--P:negative regulation of tubulin deacetylation
GO:0031175--P:neuron projection development