| Tag |
Content |
| dbPAF ID |
dbPAF-0050974 |
| Uniprot Accession |
E9Q876; E9Q876_MOUSE;
|
| Genbank Protein ID |
NP_780419.2;
|
| Genbank Nucleotide ID |
NM_175210.3;
|
| Protein Name |
Protein Abca12 |
| Protein Synonyms/Alias |
|
| Gene Name |
Abca12 |
| Gene Synonyms/Alias |
|
| Organism |
Mus musculus(Mouse) |
| NCBI Taxa ID |
10090 |
Functional Description
(View all) |
|
Phosphorylation Sites
|
dbPAF PTMs: 2 |
Sequence
(Fasta) | MASQFHQLRI LVWKNWLGVK RQPLWTLVLI LWPVIIFIIL AITRTKFPPT AKPTCYLAPR 60
NLPSAGFFPF LQTLLCDTDS KCKDTPYGPR DLLRRKGIDG PLFKESEILK KPSNPKRDSN 120
LSLRSTQVPE RSHTSLATVP PRPSYDLEGT GTENFNGSQL LTRILGLEKL LKQNSTPEDI 180
RRELCESYPG YTADYAFSWV TLGKNVFNKF CLSNMTLLES SLQELKYQVS QMSSDPDNQK 240
RVFRGLVQVL SFFSQVQQQR EVWQLLSSLP DVFQNGTSLS SLFGVLQKAN RVLLVVQKVY 300
PRVQTDEGFS TLQKSVKHLL NTLDSPMQGD NSTHAWSDDD EQTLSPSSLA AQLLILENFE 360
DAILNISSNS PYSPYLACVR NMTDNLAKGS PDNLKLLQST IHFRKSFLQN GSSEDSFPPF 420
LEILKSKLSQ LRNLTELLCE SETFSSIKKS CQFSNMSFER LCEDHAFHVQ LIEAAELGTD 480
LTTGLLYHDN IISAKLRGLL TGDPSKINLN VDWLLEQALQ MNYLENITRL IPTVEAMLHV 540
NTSADASEKP GQLREMFKNI DLLKEDLRAI GMSNTSIDKL LAIPIPDNRA EIISRVFWLH 600
SCDTNVTNPK LEDAMKEFCK LPLPERSHQS YLIGLTLLHY LDIYNFTYKV FFPRKDQKPM 660
ERMMELFIKL REILNQLASG THPLLDKMRS LRQMHLPRSV PLTQAMYRNT RMNSPAGSFS 720
TISQALCSQG ITTEYLTAML PSSQKPKGNH TKDFLTYKLT KEEIASKYGI PLNATPFCFS 780
LYKDIINMPA GPVIWAFLKP MLLGKILYSP YNPTTKAIME KSNVTLRQLA ELREKSQEWM 840
DKSPIFMNSF HLLNQTIPML QNTLRNPFVQ VFVKFSVGLD AVELLKQIDD LDVLRLKLVN 900
NIDIIDQLNT LSSLTVNISS CVLYDRIQAS DTVEEMETVA EQLYKSNELF GSVIFKLPSN 960
GSLHRGFDPE KVSLPPIVRY TIRMSLKTAQ TTRSIRTKIW APGPHNSPSH NQIYGRAFIY 1020
LQDSIERAII ELQTGRNSQE VAVQVQAVPY PCFMKDNFLT SVSYSLPIVL MVAWVVFIAA 1080
FVKKLVYEKD LRLHEYMKMM GVNSCSHFFA WLIESIGFLL VTIAILIVIL KFGNILPKTN 1140
GFILFLYFSD YSFSVIAMSY LISVFFNNTN IAALIGSLIY VIAFFPFIVL VTVEDELSYV 1200
IKVFMSLLSP TAFSYASQYI ARYEEQGVGL QWENMYKSPV QDDTTSFGWL CCLILADSFI 1260
YFFIAWYVRN VFPGTYGMAA PWYFPILPSY WKERFGCAEV KHEKSNGLMF TNIMMQNTNP 1320
SASKTSPDCA FPSNIEPEPK DLQVGVALHG VTKIYGSKTA VENLNLNFYE GHITSLLGPN 1380
GAGKTTTISM LTGLFGATAG TIFVYGKDIK TDLNTVRKNM GVCMQHDVLF SYLTTKEHLL 1440
LYGSIKVPHW TKTQLHEEVK RTLKDTGLYS HRHKRVGTLS GGMKRKLSIS IALIGGSRVV 1500
ILDEPSTGVD PCSRRSIWDV ISKNKTARTI ILSTHHLDEA EVLSDRIAFL EQGGLRCCGS 1560
PFYLKEAFGD GYHLTLTKKK SPNLDTNAIC DTVAVTAMIQ SHLPEAYLKE DIGGELVYVL 1620
PPFSTKVSGA YLSLLRALDK GMGKLNIGCY GISDTTVEEV FLNLTKDSQK SSNMSLEHLT 1680
QRKVGNPSAN GTSTPDDLSV SSSNFTDRDD KVLTRSEKLE GFGLLLKKIM AILIKRFHHT 1740
RRNWKGLIAQ VILPIVFVAT AMGLGTLRDS SNSYPEIMIS PSIYGTSEQT AFYANFDPST 1800
SGLVSALWNF PGIDNVCLNT SDLQCLKKDD LGKWNTSGEA IDNFGVCSCS DNVQECPKFN 1860
YHPPHRRTYS SQVIYNLTGK HMENYLITTA NHFVQKRYGG WSFGMKLTND LRFDVTAVPD 1920
NRTLAKVWYD PEGYHSLPAY LNSLNNFLLR VNMSEYDAAR HGIIMYSHPY PGVQDQEQAT 1980
ISSLIDILVA LSILMGYSVT TASFVTYIVR EHQTKAKQLQ HISGIGVTCY WVTNFIYDMV 2040
FYLVPVAFSI GVIAIFKLPA FYSGNNLGAV SLLLLLFGYA TFSWMYLLAG LFHETGMAFI 2100
TYVCVNLFFG INSIVSLSVV YFLSKEKPND PTLELISETL KRIFLIFPQF CFGYGLIELS 2160
QQQAVLDFLK AYGVEYPSET FEMDKLGAMF VALVSQGTMF FLLRLLINEW LIKKLRLFFR 2220
KFTSSPIMET VDEDEDVRAE RFRVESGAAE FDLVQLHRLT KTYQLIHKKI IAVNNISLGI 2280
PAGECFGLLG VNGAGKTTIF KMLTGDIIPS SGNILIRNKS GSLGHVDSHS SLVGYCPQED 2340
ALDDLVTVEE HLYFYARVHG IPEKDIKDTV HKLLRRLHLM AYKDRSTSMC SYGTKRKLST 2400
ALALIGKPSI LLLDEPSSGM DPKSKRHLWR IISEEVQNKC SVILTSHSME ECEALCTRLA 2460
IMVNGRFQCI GSLQHIKSRF GRGFTVKVHL KNNKVSMETL TKFMQLHFPK TYLKDQHLSM 2520
LEYHVPVTAG GVANIFDLLE TNKTALNITN FLVSQTTLEE VFINFAKDQK SYENVDTSSQ 2580
GSTISVDSQE DQLDS
2596Fasta Sequence
>E9Q876|Abca12|Mus musculus(Mouse)
MASQFHQLRILVWKNWLGVKRQPLWTLVLILWPVIIFIILAITRTKFPPTAKPTCYLAPRNLPSAGFFPFLQTLLCDTDSKCKDTPYGPRDLLRRKGIDGPLFKESEILKKPSNPKRDSNLSLRSTQVPERSHTSLATVPPRPSYDLEGTGTENFNGSQLLTRILGLEKLLKQNSTPEDIRRELCESYPGYTADYAFSWVTLGKNVFNKFCLSNMTLLESSLQELKYQVSQMSSDPDNQKRVFRGLVQVLSFFSQVQQQREVWQLLSSLPDVFQNGTSLSSLFGVLQKANRVLLVVQKVYPRVQTDEGFSTLQKSVKHLLNTLDSPMQGDNSTHAWSDDDEQTLSPSSLAAQLLILENFEDAILNISSNSPYSPYLACVRNMTDNLAKGSPDNLKLLQSTIHFRKSFLQNGSSEDSFPPFLEILKSKLSQLRNLTELLCESETFSSIKKSCQFSNMSFERLCEDHAFHVQLIEAAELGTDLTTGLLYHDNIISAKLRGLLTGDPSKINLNVDWLLEQALQMNYLENITRLIPTVEAMLHVNTSADASEKPGQLREMFKNIDLLKEDLRAIGMSNTSIDKLLAIPIPDNRAEIISRVFWLHSCDTNVTNPKLEDAMKEFCKLPLPERSHQSYLIGLTLLHYLDIYNFTYKVFFPRKDQKPMERMMELFIKLREILNQLASGTHPLLDKMRSLRQMHLPRSVPLTQAMYRNTRMNSPAGSFSTISQALCSQGITTEYLTAMLPSSQKPKGNHTKDFLTYKLTKEEIASKYGIPLNATPFCFSLYKDIINMPAGPVIWAFLKPMLLGKILYSPYNPTTKAIMEKSNVTLRQLAELREKSQEWMDKSPIFMNSFHLLNQTIPMLQNTLRNPFVQVFVKFSVGLDAVELLKQIDDLDVLRLKLVNNIDIIDQLNTLSSLTVNISSCVLYDRIQASDTVEEMETVAEQLYKSNELFGSVIFKLPSNGSLHRGFDPEKVSLPPIVRYTIRMSLKTAQTTRSIRTKIWAPGPHNSPSHNQIYGRAFIYLQDSIERAIIELQTGRNSQEVAVQVQAVPYPCFMKDNFLTSVSYSLPIVLMVAWVVFIAAFVKKLVYEKDLRLHEYMKMMGVNSCSHFFAWLIESIGFLLVTIAILIVILKFGNILPKTNGFILFLYFSDYSFSVIAMSYLISVFFNNTNIAALIGSLIYVIAFFPFIVLVTVEDELSYVIKVFMSLLSPTAFSYASQYIARYEEQGVGLQWENMYKSPVQDDTTSFGWLCCLILADSFIYFFIAWYVRNVFPGTYGMAAPWYFPILPSYWKERFGCAEVKHEKSNGLMFTNIMMQNTNPSASKTSPDCAFPSNIEPEPKDLQVGVALHGVTKIYGSKTAVENLNLNFYEGHITSLLGPNGAGKTTTISMLTGLFGATAGTIFVYGKDIKTDLNTVRKNMGVCMQHDVLFSYLTTKEHLLLYGSIKVPHWTKTQLHEEVKRTLKDTGLYSHRHKRVGTLSGGMKRKLSISIALIGGSRVVILDEPSTGVDPCSRRSIWDVISKNKTARTIILSTHHLDEAEVLSDRIAFLEQGGLRCCGSPFYLKEAFGDGYHLTLTKKKSPNLDTNAICDTVAVTAMIQSHLPEAYLKEDIGGELVYVLPPFSTKVSGAYLSLLRALDKGMGKLNIGCYGISDTTVEEVFLNLTKDSQKSSNMSLEHLTQRKVGNPSANGTSTPDDLSVSSSNFTDRDDKVLTRSEKLEGFGLLLKKIMAILIKRFHHTRRNWKGLIAQVILPIVFVATAMGLGTLRDSSNSYPEIMISPSIYGTSEQTAFYANFDPSTSGLVSALWNFPGIDNVCLNTSDLQCLKKDDLGKWNTSGEAIDNFGVCSCSDNVQECPKFNYHPPHRRTYSSQVIYNLTGKHMENYLITTANHFVQKRYGGWSFGMKLTNDLRFDVTAVPDNRTLAKVWYDPEGYHSLPAYLNSLNNFLLRVNMSEYDAARHGIIMYSHPYPGVQDQEQATISSLIDILVALSILMGYSVTTASFVTYIVREHQTKAKQLQHISGIGVTCYWVTNFIYDMVFYLVPVAFSIGVIAIFKLPAFYSGNNLGAVSLLLLLFGYATFSWMYLLAGLFHETGMAFITYVCVNLFFGINSIVSLSVVYFLSKEKPNDPTLELISETLKRIFLIFPQFCFGYGLIELSQQQAVLDFLKAYGVEYPSETFEMDKLGAMFVALVSQGTMFFLLRLLINEWLIKKLRLFFRKFTSSPIMETVDEDEDVRAERFRVESGAAEFDLVQLHRLTKTYQLIHKKIIAVNNISLGIPAGECFGLLGVNGAGKTTIFKMLTGDIIPSSGNILIRNKSGSLGHVDSHSSLVGYCPQEDALDDLVTVEEHLYFYARVHGIPEKDIKDTVHKLLRRLHLMAYKDRSTSMCSYGTKRKLSTALALIGKPSILLLDEPSSGMDPKSKRHLWRIISEEVQNKCSVILTSHSMEECEALCTRLAIMVNGRFQCIGSLQHIKSRFGRGFTVKVHLKNNKVSMETLTKFMQLHFPKTYLKDQHLSMLEYHVPVTAGGVANIFDLLETNKTALNITNFLVSQTTLEEVFINFAKDQKSYENVDTSSQGSTISVDSQEDQLDS
|
| Keyword |
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0472--Membrane
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix
|
| Interpro |
IPR003593--AAA+_ATPase
IPR026082--ABC_A
IPR003439--ABC_transporter-like
IPR017871--ABC_transporter_CS
IPR030371--ABCA12
IPR027417--P-loop_NTPase
|
| PROSITE |
PS00211--ABC_TRANSPORTER_1
PS50893--ABC_TRANSPORTER_2
|
| Pfam |
PF00005--ABC_tran
|
| Gene Ontology |
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0097209--C:epidermal lamellar body
GO:0005887--C:integral component of plasma membrane
GO:0043231--C:intracellular membrane-bounded organelle
GO:0005743--C:mitochondrial inner membrane
GO:0005886--C:plasma membrane
GO:0034191--F:apolipoprotein A-I receptor binding
GO:0005524--F:ATP binding
GO:0042626--F:ATPase activity, coupled to transmembrane movement of substances
GO:0017127--F:cholesterol transporter activity
GO:0005319--F:lipid transporter activity
GO:0005548--F:phospholipid transporter activity
GO:0005102--F:receptor binding
GO:0035627--P:ceramide transport
GO:0033344--P:cholesterol efflux
GO:0061436--P:establishment of skin barrier
GO:0031424--P:keratinization
GO:0030216--P:keratinocyte differentiation
GO:0055088--P:lipid homeostasis
GO:0006869--P:lipid transport
GO:0048286--P:lung alveolus development
GO:0033700--P:phospholipid efflux
GO:0010875--P:positive regulation of cholesterol efflux
GO:2000010--P:positive regulation of protein localization to cell surface
GO:0072659--P:protein localization to plasma membrane
GO:0045055--P:regulated secretory pathway
GO:0032940--P:secretion by cell
GO:0043129--P:surfactant homeostasis
GO:0055085--P:transmembrane transport
|
