| Tag |
Content |
| dbPAF ID |
dbPAF-0050970 |
| Uniprot Accession |
E9Q828; E9Q828_MOUSE;
|
| Genbank Protein ID |
XP_006529790.1;
|
| Genbank Nucleotide ID |
XM_006529727.2;
|
| Protein Name |
Calcium-transporting ATPase |
| Protein Synonyms/Alias |
|
| Gene Name |
Atp2b4 |
| Gene Synonyms/Alias |
|
| Organism |
Mus musculus(Mouse) |
| NCBI Taxa ID |
10090 |
Functional Description
(View all) |
This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.Functional Description
This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. |
Phosphorylation Sites
|
dbPAF PTMs: 2 |
Sequence
(Fasta) | MTNPPGQSVS ANTVAESHEG EFGCTLMDLR KLMELRGADA VAQISAHYGG VQEICTRLKT 60
SPIEGLSGNP ADLEKRRLVF GKNVIPPKRP KTFLELVWEA LQDVTLIILE IAAIISLVLS 120
FYRPPGGDNE ICGHIASSPE EEEEGETGWI EGAAILASVI IVVLVTAFND WSKEKQFRGL 180
QSRIELEQKF SIIRNGQLIQ LPVAEIVVGD IAQIKYGDLL PADGILIQGN DLKIDESSLT 240
GESDHVKKTL DKDPMLLSGT HVMEGSGRMV VTAVGVNSQT GIIFTLLGAS EEEDDDDKKK 300
KGKKQGAPEN RNKAKTQDGV ALEIQPLNSQ EGLDSEDKEK KIARIPKKEK SVLQGKLTRL 360
AVQIGKAGLI MSVLTVVILI LYFVVDNFVI QRREWLPECT PVYIQYFVKF FIIGVTVLVV 420
AVPEGLPLAV TISLAYSVKK MMKDNNLVRH LDACETMGNA TAICSDKTGT LTMNRMTVVQ 480
AYIGGTHYRQ IPQPDVFPPK VLELIVNGIS INCAYTSKIQ PPEKEGGLPR QVGNKTECGL 540
LGFVTDLKQD YQAVRNEVPE EKLFKVYTFN SVRKSMSTVI RKPEGGFRMF SKGASEIMLR 600
RCDRILNKEG EIKSFRSKDR DNMVRNVIEP MASEGLRTIC LAYRDFDGTE PSWDIEGEIL 660
TSLICIAVVG IEDPVRPEVP DAIAKCKRAG ITVRMVTGDN VNTARAIATK CGILTPKDDF 720
LCLEGKEFNS LIRNEKGEVE QEKLDKIWPK LRVLARSSPT DKHTLVKGII DSTAGEQRQV 780
VAVTGDGTND GPALKKADVG FAMGIAGTDV AKEASDIILT DDNFTSIVKA VMWGRNVYDS 840
ISKFLQFQLT VNVVAVIVAF TGACITQDSP LKAVQMLWVN LIMDTFASLA LATEPPTESL 900
LRRRPYGRNK PLISRTMMKN ILGHAVYQLL IVFLLVFAGD TLFDIDSGRK APLNSPPSQH 960
YTIVFNTFVL MQLFNEINAR KIHGEKNVFA GVYRNIIFCT VVLGTFFCQI MIVELGGKPF 1020
SCTSLTMEQW MWCLFIGIGE LLWGQVISAI PTKSLKFLKE AGHGSDKEDI SRDTEGMDEI 1080
DLAEMELRRG QILWVRGLNR IQTQIDVINK FQTEAPLKRV RENMTQHLDV KLVPSSYSAA 1140
VASLRTCPSI SSAISSAVTS PPVGNQSRQT VP
1173Fasta Sequence
>E9Q828|Atp2b4|Mus musculus(Mouse)
MTNPPGQSVSANTVAESHEGEFGCTLMDLRKLMELRGADAVAQISAHYGGVQEICTRLKTSPIEGLSGNPADLEKRRLVFGKNVIPPKRPKTFLELVWEALQDVTLIILEIAAIISLVLSFYRPPGGDNEICGHIASSPEEEEEGETGWIEGAAILASVIIVVLVTAFNDWSKEKQFRGLQSRIELEQKFSIIRNGQLIQLPVAEIVVGDIAQIKYGDLLPADGILIQGNDLKIDESSLTGESDHVKKTLDKDPMLLSGTHVMEGSGRMVVTAVGVNSQTGIIFTLLGASEEEDDDDKKKKGKKQGAPENRNKAKTQDGVALEIQPLNSQEGLDSEDKEKKIARIPKKEKSVLQGKLTRLAVQIGKAGLIMSVLTVVILILYFVVDNFVIQRREWLPECTPVYIQYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTMNRMTVVQAYIGGTHYRQIPQPDVFPPKVLELIVNGISINCAYTSKIQPPEKEGGLPRQVGNKTECGLLGFVTDLKQDYQAVRNEVPEEKLFKVYTFNSVRKSMSTVIRKPEGGFRMFSKGASEIMLRRCDRILNKEGEIKSFRSKDRDNMVRNVIEPMASEGLRTICLAYRDFDGTEPSWDIEGEILTSLICIAVVGIEDPVRPEVPDAIAKCKRAGITVRMVTGDNVNTARAIATKCGILTPKDDFLCLEGKEFNSLIRNEKGEVEQEKLDKIWPKLRVLARSSPTDKHTLVKGIIDSTAGEQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTFASLALATEPPTESLLRRRPYGRNKPLISRTMMKNILGHAVYQLLIVFLLVFAGDTLFDIDSGRKAPLNSPPSQHYTIVFNTFVLMQLFNEINARKIHGEKNVFAGVYRNIIFCTVVLGTFFCQIMIVELGGKPFSCTSLTMEQWMWCLFIGIGELLWGQVISAIPTKSLKFLKEAGHGSDKEDISRDTEGMDEIDLAEMELRRGQILWVRGLNRIQTQIDVINKFQTEAPLKRVRENMTQHLDVKLVPSSYSAAVASLRTCPSISSAISSAVTSPPVGNQSRQTVP
|
| Keyword |
KW-0067--ATP-binding
KW-0106--Calcium
KW-0109--Calcium transport
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0406--Ion transport
KW-0472--Membrane
KW-0547--Nucleotide-binding
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0813--Transport
|
| Interpro |
IPR030319--ATP2B1/4
IPR022141--ATP_Ca_trans_C
IPR006068--ATPase_P-typ_cation-transptr_C
IPR004014--ATPase_P-typ_cation-transptr_N
IPR023299--ATPase_P-typ_cyto_domN
IPR018303--ATPase_P-typ_P_site
IPR023298--ATPase_P-typ_TM_dom
IPR008250--ATPase_P-typ_transduc_dom_A
IPR023214--HAD-like_dom
IPR006408--P-type_ATPase_IIB
IPR001757--P_typ_ATPase
|
| PROSITE |
PS00154--ATPASE_E1_E2
|
| Pfam |
PF12424--ATP_Ca_trans_C
PF00689--Cation_ATPase_C
PF00690--Cation_ATPase_N
PF00122--E1-E2_ATPase
|
| Gene Ontology |
GO:0005887--C:integral component of plasma membrane
GO:0043231--C:intracellular membrane-bounded organelle
GO:0016020--C:membrane
GO:0005886--C:plasma membrane
GO:0030315--C:T-tubule
GO:0030018--C:Z disc
GO:0005524--F:ATP binding
GO:0005388--F:calcium-transporting ATPase activity
GO:0005516--F:calmodulin binding
GO:0046872--F:metal ion binding
GO:0050998--F:nitric-oxide synthase binding
GO:0036487--F:nitric-oxide synthase inhibitor activity
GO:0030165--F:PDZ domain binding
GO:0030346--F:protein phosphatase 2B binding
GO:0070588--P:calcium ion transmembrane transport
GO:0006816--P:calcium ion transport
GO:0098655--P:cation transmembrane transport
GO:0006874--P:cellular calcium ion homeostasis
GO:0071872--P:cellular response to epinephrine stimulus
GO:1901205--P:negative regulation of adrenergic receptor signaling pathway involved in heart process
GO:1900082--P:negative regulation of arginine catabolic process
GO:0070885--P:negative regulation of calcineurin-NFAT signaling cascade
GO:1903243--P:negative regulation of cardiac muscle hypertrophy in response to stress
GO:1903249--P:negative regulation of citrulline biosynthetic process
GO:0045019--P:negative regulation of nitric oxide biosynthetic process
GO:0010751--P:negative regulation of nitric oxide mediated signal transduction
GO:0051001--P:negative regulation of nitric-oxide synthase activity
GO:0098736--P:negative regulation of the force of heart contraction
GO:2000481--P:positive regulation of cAMP-dependent protein kinase activity
GO:0033138--P:positive regulation of peptidyl-serine phosphorylation
GO:1902806--P:regulation of cell cycle G1/S phase transition
GO:0006357--P:regulation of transcription from RNA polymerase II promoter
GO:0051599--P:response to hydrostatic pressure
|
