dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0050966
Uniprot Accession E9Q7X6; HEG1_MOUSE; Q3TR26; Q6GQS6; Q8CED0;
Genbank Protein ID
Genbank Nucleotide ID
Protein Name Protein HEG homolog 1
Protein Synonyms/Alias
Gene Name Heg1
Gene Synonyms/Alias
Organism Mus musculus(Mouse)
NCBI Taxa ID 10090
Functional Description
(View all)		 Receptor component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May be acting by stabilizing endothelial cell junctions.
Phosphorylation Sites
 dbPAF PTMs: 11
PositionPeptidesSourceReferences ( PMIDs )
401GGRQLASSSEAGDGRcurated25338131
487GRSYAESSSSSSSTScurated25338131
488RSYAESSSSSSSTSScurated25338131
536SDHTDHGYVPSTFTKPhosphoSitePlus22135298
650PSQPQPFSSALPSTRPhosphoSitePlus22135298
668STSETTTSSPSPSPIPhosphoSitePlus22135298
673TTSSPSPSPISLLVSPhosphoSitePlus22135298
1260DVPKNPRSQEWGREAPhosphoSitePlus;curated22135298; 21183079
1275IEMHENGSTKNLLQMPhosphoPep 2.0;PhosphoSitePlus;curated19060867; 22135298; 23684622; 21183079; 25338131
1276EMHENGSTKNLLQMTPhosphoPep 2.0;curated19060867; 23684622
1315GLPGSRHSCIFPGQYPhosphoPep 2.0;PhosphoSitePlus;UniProt;curated19060867; 22135298; 21183079; 23684622
Sequence
(Fasta)		MATPRAPRWP PPSLLLLLLL PLLLLPPAAP GARGSLPSPA HRTLLPVAGP LSPPGAGHTA 60
PGPGVATRRG RSGRVPRGVS AAAARNRWLE SNNPEPHIGC SPSYQSQEDH SGSRKGVTAQ 120
NARMSHSSSE GPENPPLLPE TSAEWSNMAS SHRADIAGLR RGPSPEITTA PTAHSSLLSL 180
ESLPESPSSS RSQRRITPSQ TESGTSLGFL ERTRELPEEG TVHTQVAGTW VSRQASHPAL 240
EPGEPTVLSQ KRNSSGQEHS GPPFSWSQSH PPPSDHPSSS GSIKNGNNFT ALQNPSVTQT 300
KSMLITDTYT NGVPRTLRSL PVGVDPADET EGFPEHSRLG ITSMSVRSSP SVKDSRTNSG 360
LTEHLGDGEG TELSTENGYG LPSIHWQSDA PSFGGRQLAS SSEAGDGRAM PLTEAVFRSD 420
PSIGGGESTG RWILTKKKTS TDAAESSALH PEAGGAGGLT QSSHAAQQPR GGGEDSGMGG 480
RSYAESSSSS SSTSSSESLD SSAPLREHSL TGLSYTREHG SDAGQRTSSD HTDHGYVPST 540
FTKGERTLLS ITDNTSYSEA SESSTSSVKI SDSPSQAQPK QSSMSSDDDE PAQSSTESPV 600
LHTSNLPTYT STVNMPNTLV LDTGTKPVED PSDSRVPSTQ PSPSQPQPFS SALPSTRSPG 660
STSETTTSSP SPSPISLLVS TLAPYSVSQT TFPHPSSTLV PHRPREPRVT SVQMSTAISA 720
IALIPSNQTA NPKNQSTPQQ EKPITEAKSP SLVSPPTDST KAVTVSLPPG APWSPALTGF 780
STGPALPATS TSLAQMSPAL TSAMPQTTHS PVTSPSTLSH VEALTSGAVV VHTTPKKPHL 840
PTNPEILVPH ISTEGAITTE GNREHTDPTT QPIPLTTSTT SAGERTTELG RAEESSPSHF 900
LTPSSPQTTD VSTAEMLTSR YITFAAQSTS QSPTALPPLT PVNSCTVNPC LHDGKCIVDL 960
TGRGYRCVCP PAWQGENCSV DVNECLSSPC PPLATCNNTQ GSFTCRCPVG YQLEKGICNL 1020
VRTFVTEFKL KKTFLNTTAE NHSNTQELEN EIAQTLNVCF STLPGYIRTT AHVSREPSTV 1080
FISLKTTFAL ASNVTLFDLA DRIQKYVNSC RSSAEVCQLL GSQRRVFRAG SLCKRKSPEC 1140
DKETSICTDL DGVALCQCKS GYFQFNKMDH SCRACEDGYR LENETCMSCP FGLGGLNCGN 1200
PYQLITVVIA AAGGGLLLIL GVALIVTCCR KSKNDISKLI FKSGDFQMSP YTDVPKNPRS 1260
QEWGREAIEM HENGSTKNLL QMTDVYYSPT NVRNPELERN GLYPAYTGLP GSRHSCIFPG 1320
QYNPSFISDE SRRRDYF 1338
Keyword

KW-0025--Alternative splicing
KW-0106--Calcium
KW-0965--Cell junction
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-1015--Disulfide bond
KW-0245--EGF-like domain
KW-0325--Glycoprotein
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0732--Signal
KW-0812--Transmembrane
KW-1133--Transmembrane helix
Interpro

IPR001881--EGF-like_Ca-bd_dom
IPR013032--EGF-like_CS
IPR000742--EGF-like_dom
IPR000152--EGF-type_Asp/Asn_hydroxyl_site
IPR018097--EGF_Ca-bd_CS
PROSITE

PS00010--ASX_HYDROXYL
PS00022--EGF_1
PS01186--EGF_2
PS50026--EGF_3
PS01187--EGF_CA
Pfam

PF00008--EGF
PF07645--EGF_CA
Gene Ontology

GO:0009986--C:cell surface
GO:0005911--C:cell-cell junction
GO:0009897--C:external side of plasma membrane
GO:0016021--C:integral component of membrane
GO:0005509--F:calcium ion binding
GO:0003209--P:cardiac atrium morphogenesis
GO:0055017--P:cardiac muscle tissue growth
GO:0045216--P:cell-cell junction organization
GO:0001885--P:endothelial cell development
GO:0001886--P:endothelial cell morphogenesis
GO:0007507--P:heart development
GO:0001701--P:in utero embryonic development
GO:0030324--P:lung development
GO:0003017--P:lymph circulation
GO:0001945--P:lymph vessel development
GO:0035264--P:multicellular organism growth
GO:0060039--P:pericardium development
GO:0090271--P:positive regulation of fibroblast growth factor production
GO:0009791--P:post-embryonic development
GO:0050878--P:regulation of body fluid levels
GO:0001944--P:vasculature development
GO:0001570--P:vasculogenesis
GO:0048845--P:venous blood vessel morphogenesis
GO:0003281--P:ventricular septum development
GO:0003222--P:ventricular trabecula myocardium morphogenesis