dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0050946
Uniprot Accession E9Q7D5; E9Q7D5_MOUSE;
Genbank Protein ID NP_598435.1; XP_006506450.1;
Genbank Nucleotide ID NM_133674.1; XM_006506387.2;
Protein Name Protein Arhgef5
Protein Synonyms/Alias
Gene Name Arhgef5
Gene Synonyms/Alias
Organism Mus musculus(Mouse)
NCBI Taxa ID 10090
Functional Description
(View all)
Phosphorylation Sites
 dbPAF PTMs: 22 (View all)
PositionPeptidesSourceReferences ( PMIDs )
319RVWVLRDSEEEGQDQcurated25338131
593TQHLRSNSFPGSHRTPhosphoSitePlus;curated22135298; 23684622; 21183079; 25338131
646SRDGIVFSDSSTALFcurated21183079
720IPPEKRHSYSHIVERPhosphoSitePlus;curated22135298; 23684622; 21743459; 21183079; 25338131
742ASTLKRHSHPPPLTLPhosphoSitePlus22135298
760LHRSSKGSFSLVPDScurated21183079
779QHRPLPSTPESPNHTPhosphoSitePlus22135298
782PLPSTPESPNHTQTSPhosphoSitePlus;curated22135298; 18846507; 25338131
851KSRGRSKSIQGGVIHPhosphoSitePlus;curated22135298; 23684622; 25338131
883TLSVGRTSWPPATGRcurated21183079
891WPPATGRSTESLPLTcurated25338131
953SEPPVRGSFRRSAPQcurated21183079; 25338131
957VRGSFRRSAPQEEFNcurated21743459; 25338131
1001RRDPARTSESSSEQVcurated21183079
1029RQGLRRPSILPESSSPhosphoSitePlus;curated22135298; 18846507
1049AAGRLPGSSDSVVFRcurated25338131
1101QSQQRLDSLAEPHGLPhosphoSitePlus;curated22135298; 18846507
1109LAEPHGLSSPRHRRKPhosphoSitePlus;curated22135298; 21743459; 25338131
1110AEPHGLSSPRHRRKAPhosphoSitePlus;curated22135298; 21183079; 18846507; 25338131
1120HRRKALVSSDSYLQRPhosphoSitePlus;curated22135298; 18846507; 25338131
Sequence
(Fasta)		MEAEEPEYGV STEVPDIEEL KTIPEGIMRS SQIPALDPEA QEDRDPSYKW TDGHRPVMNQ 60
SKVLRDMGDH TPNSMAIFFK KESSDMETSQ EILLAEACNT PDQQEAVIQS LKDRLSRTIA 120
APELLACAVQ EEWLDIPSKL DNRVGAELQS ELMSLTLAVS KEKEEEETSP DTSIPRGSWP 180
PCKTHPGETE QTQGSGSELL RQGKQLQLEA TQENQGQEGF LQSQEAQGLE EQEGQEVEIQ 240
EEGTLNEGIC FGGLLGEQEE VEEGFNGNEE EQKQGQIQSY MLLGGQWENE GLSGELEGLN 300
YSERGQENRE RRVWVLRDSE EEGQDQESRE VEERRVATQY TENQRLVEKS EIVKRKQRDH 360
DQTGKVMPVR DQKEVVDSGD RVQGNGDSGG QTAVEGSRPG EDSKPSLPVA SVDPEVLSPG 420
TLFPGISSSV ADIPQIQKEP VCEELSPQAP ALEPTEWSHQ PISPPASFAP EESLDNRTHN 480
SQQEEFRLRK GIEVVSASTS VAPSGTRDSP PFSPPNVFSS TATLSPVSSS VILPEETPTA 540
SASADTPHHC GPCETPPLPA KSSRYPCATS DTANPHSPLS SYTGVTQHLR SNSFPGSHRT 600
EQTPDSLGMS LSFSHLELPQ RPPKPAIYGS LTPRRNRRSR DGIVFSDSST ALFALKQDSE 660
EFTSNPERPS SPHGSPTWGS PQNSAFAIGS PANVSSPPTV SMDMTIREAL LPIPPEKRHS 720
YSHIVERDGL LHEVASTLKR HSHPPPLTLS SGLHRSSKGS FSLVPDSTVA RQHRPLPSTP 780
ESPNHTQTSI PSRLRYNKPL PPTPDMPEFY HPSISSSYIS RMYRPLPPVP IIDPSSEPPP 840
LPPKSRGRSK SIQGGVIHSG GQAKPRPNNQ DWTASTLSVG RTSWPPATGR STESLPLTSR 900
CNNEVSPGLA FSNMTNLLSP SSPTTPWIPD LQRPTTKDES GLTEESEPPV RGSFRRSAPQ 960
EEFNNTRRSA LGSRKNSEKP LHHQLEKASS WPHRRDPART SESSSEQVVL GQVPNKQKGW 1020
NRQGLRRPSI LPESSSDLRN PAAGRLPGSS DSVVFREKKP KEGMGGFSRR CSKLISSQLL 1080
YQEYSDVVLN KEIQSQQRLD SLAEPHGLSS PRHRRKALVS SDSYLQRLSM ASSGSLWQEI 1140
PVVRNSTVLL SMTHEDQKLQ EAKFELIVSE ASYLRSLNIA VDHFQHSAQL RGTLSNQDHQ 1200
WLFSRLQDVR DVSTTFLSDL EENFENNIFS FQVCDVVLNH AADFHRVYLP YVTNQTYQER 1260
TFQSLMNSNS SFREVLEKLE SDPICQRLSL KSFLILPFQR ITRLKLLLQN ILKRTQPGSS 1320
EEAEATKAHH ALEKLIRDCN SNVQRMRRTE ELIYLSQKIE FECKIFPLIS QSRWLVKSGE 1380
LTALEFSVSP GLRRKLTTRP VHLHLFNDCL LLSRPREGSR FLVFDHAPFS SIRGEKCEMK 1440
LHGPHKNLFR LFLLHNAQGT QVEFLFRTET QSEKLRWISA LAMPREELDL LECYDSPQVQ 1500
CLRAYKPREN DELALEKADV VMVTQQSSDG WLEGVRLSDG EQGWFPVQQV EFISNPEVRA 1560
QNLKEAHRVK TAKLQLVEQQ V 1582
Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome
Interpro

IPR029212--ARHGEF5/35_N
IPR000219--DH-domain
IPR001331--GDS_CDC24_CS
IPR011993--PH/PTB_dom
IPR001849--PH_domain
IPR001452--SH3_domain
PROSITE

PS00741--DH_1
PS50010--DH_2
PS50002--SH3
Pfam

PF15441--ARHGEF5_35
PF00621--RhoGEF
PF14604--SH3_9
Gene Ontology

GO:0071944--C:cell periphery
GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0005085--F:guanyl-nucleotide exchange factor activity
GO:0005089--F:Rho guanyl-nucleotide exchange factor activity
GO:0030036--P:actin cytoskeleton organization
GO:0035556--P:intracellular signal transduction
GO:0002408--P:myeloid dendritic cell chemotaxis
GO:0043547--P:positive regulation of GTPase activity
GO:0043507--P:positive regulation of JUN kinase activity
GO:0071803--P:positive regulation of podosome assembly
GO:1904591--P:positive regulation of protein import
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051496--P:positive regulation of stress fiber assembly
GO:0032956--P:regulation of actin cytoskeleton organization
GO:0051493--P:regulation of cytoskeleton organization
GO:0043087--P:regulation of GTPase activity
GO:0035023--P:regulation of Rho protein signal transduction