Tag |
Content |
dbPAF ID |
dbPAF-0050935 |
Uniprot Accession |
E9Q700; E9Q700_MOUSE; |
Genbank Protein ID |
|
Genbank Nucleotide ID |
|
Protein Name |
Fibroblast growth factor receptor 2 |
Protein Synonyms/Alias |
|
Gene Name |
Fgfr2 |
Gene Synonyms/Alias |
|
Organism |
Mus musculus(Mouse) |
NCBI Taxa ID |
10090 |
Functional Description (View all) |
|
Phosphorylation Sites
|
dbPAF PTMs: 1 Position | Peptides | Source | References ( PMIDs ) |
---|
130 | GEYICKVSNYIGQAN | PhosphoSitePlus | 22135298 |
|
Sequence (Fasta) | MVSWGRFICL VLVTMATLSL ARPSFSLVED TTLEPEERSP HRPILQAGLP ANASTVVGGD 60 VEFVCKVYSD AQPHIQWIKH VEKNGSKYGP DGLPYLKVLK HSGINSSNAE VLALFNVTEM 120 DAGEYICKVS NYIGQANQSA WLTVLPKQQA PVREKEITAS PDYLEIAIYC IGVFLIACMV 180 VTVIFCRMKT TTKKPDFSSQ PAVHKLTKRI PLRRQVTVSA ESSSSMNSNT PLVRITTRLS 240 STADTPMLAG VSEYELPEDP KWEFPRDKLT LGKPLGEGCF GQVVMAEAVG IDKDKPKEAV 300 TVAVKMLKDD ATEKDLSDLV SEMEMMKMIG KHKNIINLLG ACTQDGPLYV IVEYASKGNL 360 REYLRARRPP GMEYSYDINR VPEEQMTFKD LVSCTYQLAR GMEYLASQKC IHRDLAARNV 420 LVTENNVMKI ADFGLARDIN NIDYYKKTTN GRLPVKWMAP EALFDRVYTH QSDVWSFGVL 480 MWEIFTLGGS PYPGIPVEEL FKLLKEGHRM DKPTNCTNEL YMMMRDCWHA VPSQRPTFKQ 540 LVEDLDRILT LTTNEEYLDL TQPLEQYSPS YPDTRSSCSS GDDSVFSPDP MPYEPCLPQY 600 PHINGSVKT
Fasta Sequence
>E9Q700|Fgfr2|Mus musculus(Mouse) MVSWGRFICLVLVTMATLSLARPSFSLVEDTTLEPEERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINSSNAEVLALFNVTEMDAGEYICKVSNYIGQANQSAWLTVLPKQQAPVREKEITASPDYLEIAIYCIGVFLIACMVVTVIFCRMKTTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPTNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLTQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEPCLPQYPHINGSVKT
|
Keyword |
KW-0067--ATP-binding KW-0181--Complete proteome KW-0418--Kinase KW-0472--Membrane KW-0547--Nucleotide-binding KW-1267--Proteomics identification KW-0675--Receptor KW-1185--Reference proteome KW-0732--Signal KW-0808--Transferase KW-0812--Transmembrane KW-1133--Transmembrane helix
|
Interpro |
IPR007110--Ig-like_dom IPR013783--Ig-like_fold IPR013098--Ig_I-set IPR003598--Ig_sub2 IPR011009--Kinase-like_dom IPR000719--Prot_kinase_dom IPR017441--Protein_kinase_ATP_BS IPR001245--Ser-Thr/Tyr_kinase_cat_dom IPR008266--Tyr_kinase_AS IPR020635--Tyr_kinase_cat_dom
|
PROSITE |
PS50835--IG_LIKE PS00107--PROTEIN_KINASE_ATP PS50011--PROTEIN_KINASE_DOM PS00109--PROTEIN_KINASE_TYR
|
Pfam |
PF07679--I-set PF07714--Pkinase_Tyr
|
Gene Ontology |
GO:0005938--C:cell cortex GO:0009986--C:cell surface GO:0005737--C:cytoplasm GO:0005576--C:extracellular region GO:0005887--C:integral component of plasma membrane GO:0043231--C:intracellular membrane-bounded organelle GO:0005654--C:nucleoplasm GO:0005634--C:nucleus GO:0005524--F:ATP binding GO:0017134--F:fibroblast growth factor binding GO:0005007--F:fibroblast growth factor-activated receptor activity GO:0042803--F:protein homodimerization activity GO:0001525--P:angiogenesis GO:0007409--P:axonogenesis GO:0060348--P:bone development GO:0030282--P:bone mineralization GO:0060349--P:bone morphogenesis GO:0060667--P:branch elongation involved in salivary gland morphogenesis GO:0060670--P:branching involved in labyrinthine layer morphogenesis GO:0060442--P:branching involved in prostate gland morphogenesis GO:0060445--P:branching involved in salivary gland morphogenesis GO:0048755--P:branching morphogenesis of a nerve GO:0060449--P:bud elongation involved in lung branching GO:0045165--P:cell fate commitment GO:0007267--P:cell-cell signaling GO:0060365--P:coronal suture morphogenesis GO:0048565--P:digestive tract development GO:0048701--P:embryonic cranial skeleton morphogenesis GO:0048557--P:embryonic digestive tract morphogenesis GO:0048568--P:embryonic organ development GO:0048562--P:embryonic organ morphogenesis GO:0009880--P:embryonic pattern specification GO:0061031--P:endodermal digestive tract morphogenesis GO:0048730--P:epidermis morphogenesis GO:0030855--P:epithelial cell differentiation GO:0050673--P:epithelial cell proliferation GO:0060664--P:epithelial cell proliferation involved in salivary gland morphogenesis GO:0060441--P:epithelial tube branching involved in lung morphogenesis GO:0008543--P:fibroblast growth factor receptor signaling pathway GO:0060595--P:fibroblast growth factor receptor signaling pathway involved in mammary gland specification GO:0022612--P:gland morphogenesis GO:0031069--P:hair follicle morphogenesis GO:0001701--P:in utero embryonic development GO:0042472--P:inner ear morphogenesis GO:0032808--P:lacrimal gland development GO:0060601--P:lateral sprouting from an epithelium GO:0070307--P:lens fiber cell development GO:0060174--P:limb bud formation GO:0048286--P:lung alveolus development GO:0030324--P:lung development GO:0060463--P:lung lobe morphogenesis GO:0060484--P:lung-associated mesenchyme development GO:0060615--P:mammary gland bud formation GO:0003149--P:membranous septum morphogenesis GO:0048762--P:mesenchymal cell differentiation GO:0060915--P:mesenchymal cell differentiation involved in lung development GO:0060916--P:mesenchymal cell proliferation involved in lung development GO:0030901--P:midbrain development GO:0016331--P:morphogenesis of embryonic epithelium GO:0035264--P:multicellular organism growth GO:0008285--P:negative regulation of cell proliferation GO:0045839--P:negative regulation of mitotic nuclear division GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter GO:0007528--P:neuromuscular junction development GO:0042476--P:odontogenesis GO:0035265--P:organ growth GO:0009887--P:organ morphogenesis GO:0030916--P:otic vesicle formation GO:0003148--P:outflow tract septum morphogenesis GO:0018108--P:peptidyl-tyrosine phosphorylation GO:0090263--P:positive regulation of canonical Wnt signaling pathway GO:0060045--P:positive regulation of cardiac muscle cell proliferation GO:0051781--P:positive regulation of cell division GO:0008284--P:positive regulation of cell proliferation GO:0050679--P:positive regulation of epithelial cell proliferation GO:0060501--P:positive regulation of epithelial cell proliferation involved in lung morphogenesis GO:0070374--P:positive regulation of ERK1 and ERK2 cascade GO:0043410--P:positive regulation of MAPK cascade GO:0002053--P:positive regulation of mesenchymal cell proliferation GO:0010518--P:positive regulation of phospholipase activity GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter GO:0030177--P:positive regulation of Wnt signaling pathway GO:0009791--P:post-embryonic development GO:0060527--P:prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis GO:0060523--P:prostate epithelial cord elongation GO:0060512--P:prostate gland morphogenesis GO:0046777--P:protein autophosphorylation GO:0060687--P:regulation of branching involved in prostate gland morphogenesis GO:0010453--P:regulation of cell fate commitment GO:0042127--P:regulation of cell proliferation GO:0050678--P:regulation of epithelial cell proliferation GO:0070372--P:regulation of ERK1 and ERK2 cascade GO:0040036--P:regulation of fibroblast growth factor receptor signaling pathway GO:0060688--P:regulation of morphogenesis of a branching structure GO:0040014--P:regulation of multicellular organism growth GO:0051150--P:regulation of smooth muscle cell differentiation GO:0008589--P:regulation of smoothened signaling pathway GO:0048608--P:reproductive structure development GO:0060529--P:squamous basal epithelial stem cell differentiation involved in prostate gland acinus development GO:0048489--P:synaptic vesicle transport GO:0001657--P:ureteric bud development GO:0055010--P:ventricular cardiac muscle tissue morphogenesis
|