dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0050935
Uniprot Accession E9Q700; E9Q700_MOUSE;
Genbank Protein ID
Genbank Nucleotide ID
Protein Name Fibroblast growth factor receptor 2
Protein Synonyms/Alias
Gene Name Fgfr2
Gene Synonyms/Alias
Organism Mus musculus(Mouse)
NCBI Taxa ID 10090
Functional Description
(View all)
Phosphorylation Sites
dbPAF PTMs: 1
PositionPeptidesSourceReferences ( PMIDs )
130GEYICKVSNYIGQANPhosphoSitePlus22135298
Sequence
(Fasta)
MVSWGRFICL VLVTMATLSL ARPSFSLVED TTLEPEERSP HRPILQAGLP ANASTVVGGD 60
VEFVCKVYSD AQPHIQWIKH VEKNGSKYGP DGLPYLKVLK HSGINSSNAE VLALFNVTEM 120
DAGEYICKVS NYIGQANQSA WLTVLPKQQA PVREKEITAS PDYLEIAIYC IGVFLIACMV 180
VTVIFCRMKT TTKKPDFSSQ PAVHKLTKRI PLRRQVTVSA ESSSSMNSNT PLVRITTRLS 240
STADTPMLAG VSEYELPEDP KWEFPRDKLT LGKPLGEGCF GQVVMAEAVG IDKDKPKEAV 300
TVAVKMLKDD ATEKDLSDLV SEMEMMKMIG KHKNIINLLG ACTQDGPLYV IVEYASKGNL 360
REYLRARRPP GMEYSYDINR VPEEQMTFKD LVSCTYQLAR GMEYLASQKC IHRDLAARNV 420
LVTENNVMKI ADFGLARDIN NIDYYKKTTN GRLPVKWMAP EALFDRVYTH QSDVWSFGVL 480
MWEIFTLGGS PYPGIPVEEL FKLLKEGHRM DKPTNCTNEL YMMMRDCWHA VPSQRPTFKQ 540
LVEDLDRILT LTTNEEYLDL TQPLEQYSPS YPDTRSSCSS GDDSVFSPDP MPYEPCLPQY 600
PHINGSVKT
Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0472--Membrane
KW-0547--Nucleotide-binding
KW-1267--Proteomics identification
KW-0675--Receptor
KW-1185--Reference proteome
KW-0732--Signal
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR007110--Ig-like_dom
IPR013783--Ig-like_fold
IPR013098--Ig_I-set
IPR003598--Ig_sub2
IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS50835--IG_LIKE
PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR

Pfam

PF07679--I-set
PF07714--Pkinase_Tyr

Gene Ontology

GO:0005938--C:cell cortex
GO:0009986--C:cell surface
GO:0005737--C:cytoplasm
GO:0005576--C:extracellular region
GO:0005887--C:integral component of plasma membrane
GO:0043231--C:intracellular membrane-bounded organelle
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0005524--F:ATP binding
GO:0017134--F:fibroblast growth factor binding
GO:0005007--F:fibroblast growth factor-activated receptor activity
GO:0042803--F:protein homodimerization activity
GO:0001525--P:angiogenesis
GO:0007409--P:axonogenesis
GO:0060348--P:bone development
GO:0030282--P:bone mineralization
GO:0060349--P:bone morphogenesis
GO:0060667--P:branch elongation involved in salivary gland morphogenesis
GO:0060670--P:branching involved in labyrinthine layer morphogenesis
GO:0060442--P:branching involved in prostate gland morphogenesis
GO:0060445--P:branching involved in salivary gland morphogenesis
GO:0048755--P:branching morphogenesis of a nerve
GO:0060449--P:bud elongation involved in lung branching
GO:0045165--P:cell fate commitment
GO:0007267--P:cell-cell signaling
GO:0060365--P:coronal suture morphogenesis
GO:0048565--P:digestive tract development
GO:0048701--P:embryonic cranial skeleton morphogenesis
GO:0048557--P:embryonic digestive tract morphogenesis
GO:0048568--P:embryonic organ development
GO:0048562--P:embryonic organ morphogenesis
GO:0009880--P:embryonic pattern specification
GO:0061031--P:endodermal digestive tract morphogenesis
GO:0048730--P:epidermis morphogenesis
GO:0030855--P:epithelial cell differentiation
GO:0050673--P:epithelial cell proliferation
GO:0060664--P:epithelial cell proliferation involved in salivary gland morphogenesis
GO:0060441--P:epithelial tube branching involved in lung morphogenesis
GO:0008543--P:fibroblast growth factor receptor signaling pathway
GO:0060595--P:fibroblast growth factor receptor signaling pathway involved in mammary gland specification
GO:0022612--P:gland morphogenesis
GO:0031069--P:hair follicle morphogenesis
GO:0001701--P:in utero embryonic development
GO:0042472--P:inner ear morphogenesis
GO:0032808--P:lacrimal gland development
GO:0060601--P:lateral sprouting from an epithelium
GO:0070307--P:lens fiber cell development
GO:0060174--P:limb bud formation
GO:0048286--P:lung alveolus development
GO:0030324--P:lung development
GO:0060463--P:lung lobe morphogenesis
GO:0060484--P:lung-associated mesenchyme development
GO:0060615--P:mammary gland bud formation
GO:0003149--P:membranous septum morphogenesis
GO:0048762--P:mesenchymal cell differentiation
GO:0060915--P:mesenchymal cell differentiation involved in lung development
GO:0060916--P:mesenchymal cell proliferation involved in lung development
GO:0030901--P:midbrain development
GO:0016331--P:morphogenesis of embryonic epithelium
GO:0035264--P:multicellular organism growth
GO:0008285--P:negative regulation of cell proliferation
GO:0045839--P:negative regulation of mitotic nuclear division
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0007528--P:neuromuscular junction development
GO:0042476--P:odontogenesis
GO:0035265--P:organ growth
GO:0009887--P:organ morphogenesis
GO:0030916--P:otic vesicle formation
GO:0003148--P:outflow tract septum morphogenesis
GO:0018108--P:peptidyl-tyrosine phosphorylation
GO:0090263--P:positive regulation of canonical Wnt signaling pathway
GO:0060045--P:positive regulation of cardiac muscle cell proliferation
GO:0051781--P:positive regulation of cell division
GO:0008284--P:positive regulation of cell proliferation
GO:0050679--P:positive regulation of epithelial cell proliferation
GO:0060501--P:positive regulation of epithelial cell proliferation involved in lung morphogenesis
GO:0070374--P:positive regulation of ERK1 and ERK2 cascade
GO:0043410--P:positive regulation of MAPK cascade
GO:0002053--P:positive regulation of mesenchymal cell proliferation
GO:0010518--P:positive regulation of phospholipase activity
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0030177--P:positive regulation of Wnt signaling pathway
GO:0009791--P:post-embryonic development
GO:0060527--P:prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
GO:0060523--P:prostate epithelial cord elongation
GO:0060512--P:prostate gland morphogenesis
GO:0046777--P:protein autophosphorylation
GO:0060687--P:regulation of branching involved in prostate gland morphogenesis
GO:0010453--P:regulation of cell fate commitment
GO:0042127--P:regulation of cell proliferation
GO:0050678--P:regulation of epithelial cell proliferation
GO:0070372--P:regulation of ERK1 and ERK2 cascade
GO:0040036--P:regulation of fibroblast growth factor receptor signaling pathway
GO:0060688--P:regulation of morphogenesis of a branching structure
GO:0040014--P:regulation of multicellular organism growth
GO:0051150--P:regulation of smooth muscle cell differentiation
GO:0008589--P:regulation of smoothened signaling pathway
GO:0048608--P:reproductive structure development
GO:0060529--P:squamous basal epithelial stem cell differentiation involved in prostate gland acinus development
GO:0048489--P:synaptic vesicle transport
GO:0001657--P:ureteric bud development
GO:0055010--P:ventricular cardiac muscle tissue morphogenesis