dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0050919
Uniprot Accession E9Q6J5; BD1L1_MOUSE; O35243; Q3TR39; Q3USW6; Q80TF0; Q8BHG7;
Genbank Protein ID NP_001074891.1;
Genbank Nucleotide ID NM_001081422.3;
Protein Name Biorientation of chromosomes in cell division protein 1-like 1
Protein Synonyms/Alias
Gene Name Bod1l
Gene Synonyms/Alias Kiaa1327;
Organism Mus musculus(Mouse)
NCBI Taxa ID 10090
Functional Description
(View all)
Component of the fork protection machinery required to protect stalled/damaged replication forks from uncontrolled DNA2-dependent resection. Acts by stabilizing RAD51 at stalled replication forks and protecting RAD51 nucleofilaments from the antirecombinogenic activities of FBXO18/FBH1 and BLM. Does not regulate spindle orientation.
Phosphorylation Sites
dbPAF PTMs: 91 (View all)
PositionPeptidesSourceReferences ( PMIDs )
236ERTSRKLSSQPSTDVPHOSIDA;PhosphoSitePlus;curated21081558; 22135298; 25338131
237RTSRKLSSQPSTDVSPhosphoSitePlus;curated22135298; 25338131
240RKLSSQPSTDVSTDKPHOSIDA;PhosphoSitePlus;curated21081558; 22135298; 25338131
241KLSSQPSTDVSTDKEPhosphoSitePlus22135298
262TEREKATSDSGGDGLPhosphoSitePlus;curated22135298; 25338131
264REKATSDSGGDGLEAcurated25338131
478KPYLYSKYYSDSDDEPHOSIDA;curated21081558; 21183079
480YLYSKYYSDSDDELTPHOSIDA;PhosphoSitePlus;SysPTM 2.0;UniProt;curated21081558; 22135298; 17242355; 19366988; 21183079; 21743459;
482YSKYYSDSDDELTVEPHOSIDA;PhosphoSitePlus;SysPTM 2.0;UniProt;curated21081558; 22135298; 17242355; 19366988; 21183079; 21743459;
578SKRRRKDSRNVDENSPhosphoSitePlus;curated22135298; 23684622
632SRPARRLSESLHSADPHOSIDA;PhosphoSitePlus;SysPTM 2.0;curated21081558; 22135298; 18846507; 19366988; 22817900; 21183079;
634PARRLSESLHSADENPHOSIDA;PhosphoSitePlus;SysPTM 2.0;curated21081558; 22135298; 18846507; 19366988; 22817900; 21183079;
637RLSESLHSADENKTEPhosphoSitePlus;curated22135298; 25338131
655EREYKRRTSTPVILEPhosphoSitePlus;curated22135298; 20469934
656REYKRRTSTPVILEGPhosphoSitePlus;UniProt;curated22135298; 21183079; 22817900; 25338131
657EYKRRTSTPVILEGAPhosphoSitePlus;UniProt;curated22135298; 21183079; 22817900; 25338131
750GDSVHKMSDETELHSPhosphoSitePlus;curated22135298; 22817900; 21183079
763HSSEKGETEESVRKQcurated21183079
766EKGETEESVRKQGQQPhosphoSitePlus22135298
795HKSERRLSVLGRDGKPHOSIDA;PhosphoSitePlus;curated21081558; 22135298; 22817900; 21183079
Sequence
(Fasta)
MATNPQPQPP PPAPPPPPPQ PQPPPPPPGP GAGPGASGPG SAGAGAGDPQ LVAMIVNHLK 60
SQGLFDQFRR DCLADVDTKP AYQNLRQRVD NFVANHLATH TWSPHLNKNQ LRNNIRQQVL 120
KSGMLESGID RIISQVVDPK INHTFRPQVE KAVHEFLATL NHKEEAAGST APDDEKPESS 180
VITQGAPAPG PSANVASDAM SILETITSLN QEANAARAST EMSNAKVSER TSRKLSSQPS 240
TDVSTDKERG SEDATEREKA TSDSGGDGLE AALKSEEPSD LPCPVEETKN HMKENNSLLL 300
LSKDAQQEST DPKIKSMDKG EKKPDGNEKG ERKKEKKEKT EKKIDHSKRN EDTQKVKDER 360
QAKDKEVEST KLPSEKSNSR ARAAEGTKED CSLLDSDVDG LTDITVSSVH TSDLSSFEED 420
TEEEVVVSES MEEGEITSED EEKNKQNKAK VQPGDSSDGK ARGVRHAYVH KPYLYSKYYS 480
DSDDELTVEQ RRQSIAKEKE ERLLRRRINR EKLEEKRKQK AEKTKSSKVK SQGKSTVDLE 540
DSSAKTLEPK APRIKEVLKE RKVLEKKVAL SKRRRKDSRN VDENSKKKPQ AEEESKEALK 600
TTEYCEKEKA SSKDLRHTHG KGEPSRPARR LSESLHSADE NKTESKVERE YKRRTSTPVI 660
LEGAQEETDT RDGKKQPERS ETNVEETQKQ KSTLKNEKYQ KKDDPETHGK GLPKKEAKSA 720
KERPEKEKAQ SEDKPSSKHK HKGDSVHKMS DETELHSSEK GETEESVRKQ GQQTKLSSDD 780
RTERKSKHKS ERRLSVLGRD GKPVSEYTIK TDEHARKDNK KEKHLSSEKS KAEHKSRRSS 840
DSKLQKDALS SKQHSVTSQK RSESCSEDKC ETDSTNADSS FKPEELPHKE RRRTKSLLED 900
KVVSKSKSKG QSKQTKAAET EAQEGVTRQV TTPKPDKEKN TEDNDTERQR KFKLEDRTSE 960
ETVTDPALEN TVSSAHSAQK DSGHRAKLAS IKEKHKTDKD STSSKLERKV SDGHRSRSLK 1020
HSNKDMKKKE ENKPDDKNGK EVDSSHEKGR GNGPVTEKKL SRRLCENRRG STSQEMAKED 1080
KLVANMSGTT SSSSLQRPKK STETTSIPEQ EPMEIDSEAA VENVSELSKT EDISSNSSQQ 1140
DTDFENVTKH KATAGVLKDE FRTSMVDSKP AAAVTCKSGR GLAVTSISER HADHKSTLTK 1200
KVHSQGNPSK AAPREREPIQ RGAQEVSVDS EVSRKALSRA PSENEKGQKN LKGMSKTTEE 1260
CGTHRNASLE YSTDSDLLSS SGSVTVVPQK ESHNSNTIPV IDREAISEGG RASTSLANHS 1320
DVPNQYSTVK KSEVHKTNGS KEGNDGFTVD MPTKANGGSK RHLSEDSQAT LLYSKESKIS 1380
IPLADKSMSV TGDNKNINKQ RSLMGTAKRE SDLKVNPDIK QDSAAGEHVV DLSTRKEAET 1440
VRRKHNKEIP TDVERKTENS EVDTSARRDS APVPQQRHGK MERGAAGSGR RDKAFIATST 1500
EGTDKGIMLN TVKTGDATTT SSEVGEKGTA LPCTSIEADE GFMMGACPKK HPLQVGAEAS 1560
ECTVFAAAEE GKGVVTEGFA ESEILLTSSK EGESGECAVA ESEDRVAGPL AAHTVQAEAN 1620
VNSITTEEKD DAVTSAGSEE KCGGSACTVE GTATFIGEVE SDGAVTSAGT EIRAGSLSSE 1680
DVDGSQENRI QVGPKKETEG TVTCTETKGR NDNFICLVTR VETQEQRVVT GADVVQVNAA 1740
KPQEANANQG DGSGTDGAEG ESAVTSTGIT EEDGEASANC TGSEDNREGC AISSETEESA 1800
ESAMDSTEAK DITNAPLVAA GPCDDEGIVT STGAKEEDDE DEGVVTSTGR GNEPGHASAC 1860
TGIEESEGMM VCESGEGGAQ IGPTIDHVNA EAGAATVNTN DSNVDSMSGA EKEIKDTNIC 1920
SSAKGIVESS VTSALAGNSD RPPVLCGSEG PMASASSHHS DSQLTRKETV EDTTISTGLV 1980
KGSDDVLVSG EVPECEVGHM SPRKNEECDG LMASTASCDV SNKDSLAGSK SQGNGLMIST 2040
STNACTPQIS AVIDVRGGHL STLSTEEIRD GVRVHREGFE APMPSAVSGE NSQLTASRSE 2100
EKDECAMIST SIGEEFELPI SSAVTVTCAE RQQPVAAVEE STTGPALVST EDFEVPMPSA 2160
PTEAESPLAS TSKEEKDECA LISTSIAEEC EASVFGVSRN APSVTDGNAV ISTSSVEDCE 2220
GSVSSAVPQE SVCPSVIPVE ETGDTAMIST STSEGREAVM VGTIPTDDDQ ATTVRGEDLS 2280
DAAIISTSTA ECVLTCTSLS RHEENQQATH NPEGNGGHLA TKQSKCELPM PSLVAERNCK 2340
CPGPFRMGKG VGPLMAVGTR GEHDRLPVCE PSVGQGQPGT ALCLGEEESH GMDCPGQDLN 2400
AKERNTLLSS VQRESKSAEA EAAGDSSTAR RTVRKDSERN ANSLSETNCL REPEQKPAED 2460
TSGSTHCLTA VNPGAEADGM LPITHAALEY PDHQEPESNL KTTTKCITGQ ESQMPSSHTG 2520
VLSAVCHVAP CASEQEGGLP TKSDHSGTWT SEGSPEKMGH VAGARQSFHR EGNLDVTLPP 2580
EDNGCGVGNE ESPPKGIGGL ELSTGLTTEI SVSSEEDTSH GVVAAPENPC VGRRRGAAEL 2640
QMEALLMRES LNVEKSESRI NEEIHFESQN KEEICCGRKG STEALSGCSV EADPEEVEEE 2700
EKQISQRNRK PDYSSSEEEL DDSPDVLDSR IETAQRQYSE TEPHDTKEEN SGDVEEFSSV 2760
TSKTNSSTGL EDRDEFSSSE GTGEKTEPNE DDGSIKSQED DHPIIIKRRR GRPRKYPAET 2820
AFKSKEDSKT ETDITTVEQS SPSGKLKVSQ ADESNKEIAN LEEKSTSNDD SEEKTASMRL 2880
RGRKPKRSLT SSDDAESSEP ERKRQKSVSE TSEDKKDEES DEEEEEEEEE EPLGATTRSA 2940
TRSEAQRKNH SKPSTRATSK LGIPETISPR NRQKLAKEKL STSEKVSKSP PLGRSKAQLS 3000
PSVKRKREVS PPGARTRGQQ KVDENPLKKA KR 3033
Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0238--DNA-binding
KW-1017--Isopeptide bond
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0832--Ubl conjugation

Interpro

IPR017956--AT_hook_DNA-bd_motif
IPR026955--Bod1-like

PROSITE
Pfam
Gene Ontology

GO:0005694--C:chromosome
GO:0005654--C:nucleoplasm
GO:0003677--F:DNA binding
GO:0006974--P:cellular response to DNA damage stimulus
GO:0006281--P:DNA repair
GO:0031297--P:replication fork processing