| Tag |
Content |
| dbPAF ID |
dbPAF-0050905 |
| Uniprot Accession |
E9Q612; PTPRO_MOUSE; Q7TSY7;
|
| Genbank Protein ID |
NP_035346.3;
|
| Genbank Nucleotide ID |
NM_011216.3;
|
| Protein Name |
Receptor-type tyrosine-protein phosphatase O |
| Protein Synonyms/Alias |
|
| Gene Name |
Ptpro |
| Gene Synonyms/Alias |
GLEPP1;Ptpn15;PTPU2; |
| Organism |
Mus musculus(Mouse) |
| NCBI Taxa ID |
10090 |
Functional Description
(View all) |
Possesses tyrosine phosphatase activity. Plays a role in regulating the glomerular pressure/filtration rate relationship through an effect on podocyte structure and function.Functional Description
Possesses tyrosine phosphatase activity. Plays a role in regulating the glomerular pressure/filtration rate relationship through an effect on podocyte structure and function. |
Phosphorylation Sites
|
dbPAF PTMs: 8 |
Sequence
(Fasta) | MGHLPRGTLG GRRLLPLLGL FVLLKIVTTF HVAVQDDNNI VVSLEASDIV SPASVYVVRV 60
AGESKNYFFE FEEFNSTLPP PVVFKATYHG LYYIITLVVV NGNVVTKPSR SITVLTKPLP 120
VTSVSIYDYK PSPETGVLFE IHYPEKYNVF SRVNISYWEG RDFRTMLYKD FFKGKTVFNH 180
WLPGLCYSNI TFQLVSEATF NKSTLVEYSG VSHEPKQHRT APYPPRNISV RFVNLNKNNW 240
EEPSGSFPED SFIKPPQDSI GRDRRFHFPE ETPETPPSNV SSGSPPSNVS SAWPDPNSTD 300
YESTSQPFWW DSASAAPENE EDFVSALPAD YDTETTLDRT EKPTADPFSA FPVQMTLSWL 360
PPKPPTAFDG FNILIEREEN FTDYLTVDEE AHEFVAELKE PGKYKLSVTT FSSSGACETR 420
KSQSAKSLSF YISPTGEWIE ELTEKPQHVS VHVLSSTTAL MSWTSSQENY NSTIVSVVSL 480
TCQKQKESQR LEKQYCTQVN SSKPVIENLV PGAQYQVVMY LRKGPLIGPP SDPVTFAIVP 540
TGIKDLMLYP LGPTAVVLSW TRPILGVFRK YVVEMFYFNP TTMTSEWTTY YEIAATVSLT 600
ASVRIASLLP AWYYNFRVTM VTWGDPELSC CDSSTISFIT APVAPEITSV EYFNSLLYIS 660
WTYGDATTDL SHSRMLHWMV VAEGRKKIKK SVTRNVMTAI LSLPPGDIYN LSVTACTERG 720
SNTSLPRLVK LEPAPPKSLF AVNKTQTSVT LLWVEEGVAD FFEVFCQQLG SGHNGKLQEP 780
VAVSSHVVTI SSLLPATAYN CSVTSFSHDT PSVPTFIAVS TMVTEVNPNV VVISVLAILS 840
TLLIGLLLVT LVILRKKHLQ MARECGAGTF VNFASLEREG KLPYSWRRSV FALLTLLPSC 900
LWTDYLLAFY INPWSKNGLK KRKLTNPVQL DDFDSYIKDM AKDSDYKFSL QFEELKLIGL 960
DIPHFAADLP LNRCKNRYTN ILPYDFSRVR LVSMNEEEGA DYINANYIPG YNSPQEYIAT 1020
QGPLPETRND FWKMVLQQKS HIIVMLTQCN EKRRVKCDHY WPFTEEPIAY GDITVEMVSE 1080
EEEEDWASRH FRINYADEAQ DVMHFNYTAW PDHGVPPANA AESILQFVFT VRQQAAKSKG 1140
PMIIHCSAGV GRTGTFIALD RLLQHIRDHE FVDILGLVSE MRSYRMSMVQ TEEQYIFIHQ 1200
CVQLMWLRKK QQFCISDVIY ENVSKS
1227Fasta Sequence
>E9Q612|Ptpro|Mus musculus(Mouse)
MGHLPRGTLGGRRLLPLLGLFVLLKIVTTFHVAVQDDNNIVVSLEASDIVSPASVYVVRVAGESKNYFFEFEEFNSTLPPPVVFKATYHGLYYIITLVVVNGNVVTKPSRSITVLTKPLPVTSVSIYDYKPSPETGVLFEIHYPEKYNVFSRVNISYWEGRDFRTMLYKDFFKGKTVFNHWLPGLCYSNITFQLVSEATFNKSTLVEYSGVSHEPKQHRTAPYPPRNISVRFVNLNKNNWEEPSGSFPEDSFIKPPQDSIGRDRRFHFPEETPETPPSNVSSGSPPSNVSSAWPDPNSTDYESTSQPFWWDSASAAPENEEDFVSALPADYDTETTLDRTEKPTADPFSAFPVQMTLSWLPPKPPTAFDGFNILIEREENFTDYLTVDEEAHEFVAELKEPGKYKLSVTTFSSSGACETRKSQSAKSLSFYISPTGEWIEELTEKPQHVSVHVLSSTTALMSWTSSQENYNSTIVSVVSLTCQKQKESQRLEKQYCTQVNSSKPVIENLVPGAQYQVVMYLRKGPLIGPPSDPVTFAIVPTGIKDLMLYPLGPTAVVLSWTRPILGVFRKYVVEMFYFNPTTMTSEWTTYYEIAATVSLTASVRIASLLPAWYYNFRVTMVTWGDPELSCCDSSTISFITAPVAPEITSVEYFNSLLYISWTYGDATTDLSHSRMLHWMVVAEGRKKIKKSVTRNVMTAILSLPPGDIYNLSVTACTERGSNTSLPRLVKLEPAPPKSLFAVNKTQTSVTLLWVEEGVADFFEVFCQQLGSGHNGKLQEPVAVSSHVVTISSLLPATAYNCSVTSFSHDTPSVPTFIAVSTMVTEVNPNVVVISVLAILSTLLIGLLLVTLVILRKKHLQMARECGAGTFVNFASLEREGKLPYSWRRSVFALLTLLPSCLWTDYLLAFYINPWSKNGLKKRKLTNPVQLDDFDSYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSHIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMVSEEEEEDWASRHFRINYADEAQDVMHFNYTAWPDHGVPPANAAESILQFVFTVRQQAAKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWLRKKQQFCISDVIYENVSKS
|
| Keyword |
KW-0181--Complete proteome
KW-0325--Glycoprotein
KW-0378--Hydrolase
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0904--Protein phosphatase
KW-0675--Receptor
KW-1185--Reference proteome
KW-0677--Repeat
KW-0732--Signal
KW-0812--Transmembrane
KW-1133--Transmembrane helix
|
| Interpro |
IPR003961--FN3_dom
IPR013783--Ig-like_fold
IPR029021--Prot-tyrosine_phosphatase-like
IPR000242--PTPase_domain
IPR016130--Tyr_Pase_AS
IPR000387--TYR_PHOSPHATASE_dom
|
| PROSITE |
PS50853--FN3
PS00383--TYR_PHOSPHATASE_1
PS50056--TYR_PHOSPHATASE_2
PS50055--TYR_PHOSPHATASE_PTP
|
| Pfam |
PF00041--fn3
PF00102--Y_phosphatase
|
| Gene Ontology |
GO:0016324--C:apical plasma membrane
GO:0043197--C:dendritic spine
GO:0070062--C:extracellular exosome
GO:0016021--C:integral component of membrane
GO:0016328--C:lateral plasma membrane
GO:0005886--C:plasma membrane
GO:0042803--F:protein homodimerization activity
GO:0004725--F:protein tyrosine phosphatase activity
GO:0017147--F:Wnt-protein binding
GO:0007411--P:axon guidance
GO:0000902--P:cell morphogenesis
GO:0072112--P:glomerular visceral epithelial cell differentiation
GO:0032835--P:glomerulus development
GO:0030032--P:lamellipodium assembly
GO:0002548--P:monocyte chemotaxis
GO:0090090--P:negative regulation of canonical Wnt signaling pathway
GO:0003105--P:negative regulation of glomerular filtration
GO:0035335--P:peptidyl-tyrosine dephosphorylation
GO:0003093--P:regulation of glomerular filtration
GO:0036060--P:slit diaphragm assembly
|
