| Tag |
Content |
| dbPAF ID |
dbPAF-0050901 |
| Uniprot Accession |
E9Q5R7; NAL12_MOUSE; Q3UEM3;
|
| Genbank Protein ID |
NP_001028603.1;
|
| Genbank Nucleotide ID |
NM_001033431.1;
|
| Protein Name |
NACHT, LRR and PYD domains-containing protein 12 |
| Protein Synonyms/Alias |
Monarch-1;PYRIN-containing APAF1-like protein 7;PYPAF7; |
| Gene Name |
Nlrp12 |
| Gene Synonyms/Alias |
NALP12; |
| Organism |
Mus musculus(Mouse) |
| NCBI Taxa ID |
10090 |
Functional Description
(View all) |
May mediate activation of CASP1 via ASC and promote activation of NF-kappa-B via IKK.Functional Description
May mediate activation of CASP1 via ASC and promote activation of NF-kappa-B via IKK. |
Phosphorylation Sites
|
dbPAF PTMs: 1 | Position | Peptides | Source | References ( PMIDs ) |
|---|
| 577 | RNLGWSISPQVKEEV | curated | 25338131 |
|
Sequence
(Fasta) | MLPSTARDGL YRLSTYLEEL EAGELKKFKL FLGIAEDLSQ DKIPWGRMEK AGPLEMAQLM 60
VAHMGTREAW LLALSTFQRI HRKDLWERGQ GEDLVRVTPN NGLCLFESQS ACPLDVSPNA 120
PRKDLQTTYK DYVRRKFQLM EDRNARLGEC VNLSNRYTRL LLVKEHSNPI WTQQKFVDVE 180
WERSRTRRHQ TSPIQMETLF EPDEERPEPP HTVVLQGAAG MGKSMLAHKV MLDWADGRLF 240
QGRFDYVFYI SCRELNRSHT QCSVQDLISS CWPERGISLE DLMQAPDRLL FIIDGFDKLH 300
PSFHDAQGPW CLCWEEKQPT EVLLGSLIRR LLLPQVSLLI TTRPCALEKL HGLLEHPRHV 360
EILGFSEEAR KEYFYRYFHN TGQASRVLSF LMDYEPLFTM CFVPMVSWVV CTCLKQQLES 420
GELLRQTPRT TTAVYMFYLL SLMQPKPGTP TFKVPANQRG LVSLAAEGLW NQKILFDEQD 480
LGKHGLDGAD VSTFLNVNIF QKGIKCEKFY SFIHLSFQEF FAAMYCALNG REAVRRALAE 540
YGFSERNFLA LTVHFLFGLL NEEMRCYLER NLGWSISPQV KEEVLAWIQN KAGSEGSTLQ 600
HGSLELLSCL YEVQEEDFIQ QALSHFQVVV VRSISTKMEH MVCSFCARYC RSTEVLHLHG 660
SAYSTGMEDD PPEPSGVQTQ STYLQERNML PDVYSAYLSA AVCTNSNLIE LALYRNALGS 720
QGVRLLCQGL RHASCKLQNL RLKRCQISGS ACQDLAAAVI ANRNLIRLDL SDNSIGVPGL 780
ELLCEGLQHP RCRLQMIQLR KCLLEAAAGR SLASVLSNNS YLVELDLTGN PLEDSGLKLL 840
CQGLRHPVCR LRTLWLKICH LGQASCEDLA STLKMNQSLL ELDLGLNDLG DSGVLLLCEG 900
LSHPDCKLQT LRLGICRLGS VACVGIASVL QVNTCLQELD LSFNDLGDRG LQLLGEGLRH 960
QTCRLQKLWL DNCGLTSKAC EDLSSILGIS QTLHELYLTN NALGDTGVCL LCKRLRHPGC 1020
KLRVLWLFGM DLNKKTHRRM AALRVTKPYL DIGC
1055Fasta Sequence
>E9Q5R7|Nlrp12|Mus musculus(Mouse)
MLPSTARDGLYRLSTYLEELEAGELKKFKLFLGIAEDLSQDKIPWGRMEKAGPLEMAQLMVAHMGTREAWLLALSTFQRIHRKDLWERGQGEDLVRVTPNNGLCLFESQSACPLDVSPNAPRKDLQTTYKDYVRRKFQLMEDRNARLGECVNLSNRYTRLLLVKEHSNPIWTQQKFVDVEWERSRTRRHQTSPIQMETLFEPDEERPEPPHTVVLQGAAGMGKSMLAHKVMLDWADGRLFQGRFDYVFYISCRELNRSHTQCSVQDLISSCWPERGISLEDLMQAPDRLLFIIDGFDKLHPSFHDAQGPWCLCWEEKQPTEVLLGSLIRRLLLPQVSLLITTRPCALEKLHGLLEHPRHVEILGFSEEARKEYFYRYFHNTGQASRVLSFLMDYEPLFTMCFVPMVSWVVCTCLKQQLESGELLRQTPRTTTAVYMFYLLSLMQPKPGTPTFKVPANQRGLVSLAAEGLWNQKILFDEQDLGKHGLDGADVSTFLNVNIFQKGIKCEKFYSFIHLSFQEFFAAMYCALNGREAVRRALAEYGFSERNFLALTVHFLFGLLNEEMRCYLERNLGWSISPQVKEEVLAWIQNKAGSEGSTLQHGSLELLSCLYEVQEEDFIQQALSHFQVVVVRSISTKMEHMVCSFCARYCRSTEVLHLHGSAYSTGMEDDPPEPSGVQTQSTYLQERNMLPDVYSAYLSAAVCTNSNLIELALYRNALGSQGVRLLCQGLRHASCKLQNLRLKRCQISGSACQDLAAAVIANRNLIRLDLSDNSIGVPGLELLCEGLQHPRCRLQMIQLRKCLLEAAAGRSLASVLSNNSYLVELDLTGNPLEDSGLKLLCQGLRHPVCRLRTLWLKICHLGQASCEDLASTLKMNQSLLELDLGLNDLGDSGVLLLCEGLSHPDCKLQTLRLGICRLGSVACVGIASVLQVNTCLQELDLSFNDLGDRGLQLLGEGLRHQTCRLQKLWLDNCGLTSKACEDLSSILGISQTLHELYLTNNALGDTGVCLLCKRLRHPGCKLRVLWLFGMDLNKKTHRRMAALRVTKPYLDIGC
|
| Keyword |
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0433--Leucine-rich repeat
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0677--Repeat
|
| Interpro |
IPR004020--DAPIN
IPR011029--DEATH-like_dom
IPR001611--Leu-rich_rpt
IPR007111--NACHT_NTPase
IPR029495--NATCH-assoc
IPR027417--P-loop_NTPase
|
| PROSITE |
PS50824--DAPIN
PS51450--LRR
PS50837--NACHT
|
| Pfam |
PF14484--FISNA
PF02758--PYRIN
|
| Gene Ontology |
GO:0005737--C:cytoplasm
GO:0005524--F:ATP binding
GO:0071345--P:cellular response to cytokine stimulus
GO:0036336--P:dendritic cell migration
GO:0050710--P:negative regulation of cytokine secretion
GO:0070373--P:negative regulation of ERK1 and ERK2 cascade
GO:0043124--P:negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0050728--P:negative regulation of inflammatory response
GO:0050711--P:negative regulation of interleukin-1 secretion
GO:0045409--P:negative regulation of interleukin-6 biosynthetic process
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:1901223--P:negative regulation of NIK/NF-kappaB signaling
GO:0031953--P:negative regulation of protein autophosphorylation
GO:0009968--P:negative regulation of signal transduction
GO:0045751--P:negative regulation of Toll signaling pathway
GO:0045345--P:positive regulation of MHC class I biosynthetic process
GO:0043281--P:regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043122--P:regulation of I-kappaB kinase/NF-kappaB signaling
GO:0008588--P:release of cytoplasmic sequestered NF-kappaB
|
