| Tag |
Content |
| dbPAF ID |
dbPAF-0050899 |
| Uniprot Accession |
E9Q5M7; E9Q5M7_MOUSE;
|
| Genbank Protein ID |
NP_001240801.1; XP_011239985.1;
|
| Genbank Nucleotide ID |
NM_001253872.1; XM_011241683.1;
|
| Protein Name |
Integrin alpha-L |
| Protein Synonyms/Alias |
|
| Gene Name |
Itgal |
| Gene Synonyms/Alias |
|
| Organism |
Mus musculus(Mouse) |
| NCBI Taxa ID |
10090 |
Functional Description
(View all) |
|
Phosphorylation Sites
|
dbPAF PTMs: 1 | Position | Peptides | Source | References ( PMIDs ) |
|---|
| 1159 | CLEPLRESDKD---- | PhosphoSitePlus;curated | 22135298; 21183079 |
|
Sequence
(Fasta) | MSFRIAGPRL LLLGLQLFAK AWSYNLDTRP TQSFLAQAGR HFGYQVLQIE DGVVVGAPGE 60
GDNTGGLYHC RTSSEFCQPV SLHGSNHTSK YLGMTLATDA AKGSLLACDP GLSRTCDQNT 120
YLSGLCYLFP QSLEGPMLQN RPAYQECMKG KVDLVFLFDG SQSLDRKDFE KILEFMKDVM 180
RKLSNTSYQF AAVQFSTDCR TEFTFLDYVK QNKNPDVLLG SVQPMFLLTN TFRAINYVVA 240
HVFKEESGAR PDATKVLVII TDGEASDKGN ISAAHDITRY IIGIGKHFVS VQKQKTLHIF 300
ASEPVEEFVK ILDTFEKLKD LFTDLQRRIY AIEGTNRQDL TSFNMELSSS GISADLSKGH 360
AVVGAVGAKD WAGGFLDLRE DLQGATFVGQ EPLTSDVRGG YLGYTVAWMT SRSSRPLLAA 420
GAPRYQHVGQ VLLFQAPEAG GRWNQTQKIE GTQIGSYFGG ELCSVDLDQD GEAELLLIGA 480
PLFFGEQRGG RVFTYQRRQS LFEMVSELQG DPGYPLGRFG AAITALTDIN GDRLTDVAVG 540
APLEEQGAVY IFNGKPGGLS PQPSQRIQGA QVFPGIRWFG RSIHGVKDLG GDRLADVVVG 600
AEGRVVVLSS RPVVDVVTEL SFSPEEIPVH EVECSYSARE EQKHGVKLKA CFRIKPLTPQ 660
FQGRLLANLS YTLQLDGHRM RSRGLFPDGS HELSGNTSIT PDKSCLDFHF HFPICIQDLI 720
SPINVSLNFS LLEEEGTPRD QKVGRAMQPI LRPSIHTVTK EIPFEKNCGE DKKCEANLTL 780
SSPARSGPLR LMSSASLAVE WTLSNSGEDA YWVRLDLDFP RGLSFRKVEM LQPHSRMPVS 840
CEELTEGSSL LTKTLKCNVS SPIFKAGQEV SLQVMFNTLL NSSWEDFVEL NGTVHCENEN 900
SSLQEDNSAA THIPVLYPVN ILTKEQENST LYISFTPKGP KTQQVQHVYQ VRIQPSAYDH 960
NMPTLEALVG VPWPHSEDPI TYTWSVQTDP LVTCHSEDLK RPSSEAEQPC LPGVQFRCPI 1020
VFRREILIQV TGTVELSKEI KASSTLSLCS SLSVSFNSSK HFHLYGSKAS EAQVLVKVDL 1080
IHEKEMLHVY VLSGIGGLVL LFLIFLALYK VGFFKRNLKE KMEADGGVPN GSPPEDTDPL 1140
AVPGEETKDM GCLEPLRESD KD
1163Fasta Sequence
>E9Q5M7|Itgal|Mus musculus(Mouse)
MSFRIAGPRLLLLGLQLFAKAWSYNLDTRPTQSFLAQAGRHFGYQVLQIEDGVVVGAPGEGDNTGGLYHCRTSSEFCQPVSLHGSNHTSKYLGMTLATDAAKGSLLACDPGLSRTCDQNTYLSGLCYLFPQSLEGPMLQNRPAYQECMKGKVDLVFLFDGSQSLDRKDFEKILEFMKDVMRKLSNTSYQFAAVQFSTDCRTEFTFLDYVKQNKNPDVLLGSVQPMFLLTNTFRAINYVVAHVFKEESGARPDATKVLVIITDGEASDKGNISAAHDITRYIIGIGKHFVSVQKQKTLHIFASEPVEEFVKILDTFEKLKDLFTDLQRRIYAIEGTNRQDLTSFNMELSSSGISADLSKGHAVVGAVGAKDWAGGFLDLREDLQGATFVGQEPLTSDVRGGYLGYTVAWMTSRSSRPLLAAGAPRYQHVGQVLLFQAPEAGGRWNQTQKIEGTQIGSYFGGELCSVDLDQDGEAELLLIGAPLFFGEQRGGRVFTYQRRQSLFEMVSELQGDPGYPLGRFGAAITALTDINGDRLTDVAVGAPLEEQGAVYIFNGKPGGLSPQPSQRIQGAQVFPGIRWFGRSIHGVKDLGGDRLADVVVGAEGRVVVLSSRPVVDVVTELSFSPEEIPVHEVECSYSAREEQKHGVKLKACFRIKPLTPQFQGRLLANLSYTLQLDGHRMRSRGLFPDGSHELSGNTSITPDKSCLDFHFHFPICIQDLISPINVSLNFSLLEEEGTPRDQKVGRAMQPILRPSIHTVTKEIPFEKNCGEDKKCEANLTLSSPARSGPLRLMSSASLAVEWTLSNSGEDAYWVRLDLDFPRGLSFRKVEMLQPHSRMPVSCEELTEGSSLLTKTLKCNVSSPIFKAGQEVSLQVMFNTLLNSSWEDFVELNGTVHCENENSSLQEDNSAATHIPVLYPVNILTKEQENSTLYISFTPKGPKTQQVQHVYQVRIQPSAYDHNMPTLEALVGVPWPHSEDPITYTWSVQTDPLVTCHSEDLKRPSSEAEQPCLPGVQFRCPIVFRREILIQVTGTVELSKEIKASSTLSLCSSLSVSFNSSKHFHLYGSKASEAQVLVKVDLIHEKEMLHVYVLSGIGGLVLLFLIFLALYKVGFFKRNLKEKMEADGGVPNGSPPEDTDPLAVPGEETKDMGCLEPLRESDKD
|
| Keyword |
KW-0130--Cell adhesion
KW-0181--Complete proteome
KW-0401--Integrin
KW-0472--Membrane
KW-1267--Proteomics identification
KW-0675--Receptor
KW-1185--Reference proteome
KW-0677--Repeat
KW-0732--Signal
KW-0812--Transmembrane
KW-1133--Transmembrane helix
|
| Interpro |
IPR013517--FG-GAP
IPR013519--Int_alpha_beta-p
IPR000413--Integrin_alpha
IPR013649--Integrin_alpha-2
IPR018184--Integrin_alpha_C_CS
IPR002035--VWF_A
|
| PROSITE |
PS51470--FG_GAP
PS00242--INTEGRIN_ALPHA
PS50234--VWFA
|
| Pfam |
PF01839--FG-GAP
PF00357--Integrin_alpha
PF08441--Integrin_alpha2
PF00092--VWA
|
| Gene Ontology |
GO:0009986--C:cell surface
GO:0005911--C:cell-cell junction
GO:0009897--C:external side of plasma membrane
GO:0070062--C:extracellular exosome
GO:0001772--C:immunological synapse
GO:0034687--C:integrin alphaL-beta2 complex
GO:0016020--C:membrane
GO:0050839--F:cell adhesion molecule binding
GO:0030369--F:ICAM-3 receptor activity
GO:0050798--P:activated T cell proliferation
GO:0007166--P:cell surface receptor signaling pathway
GO:0007160--P:cell-matrix adhesion
GO:0007157--P:heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
GO:0007229--P:integrin-mediated signaling pathway
GO:0007159--P:leukocyte cell-cell adhesion
GO:0050850--P:positive regulation of calcium-mediated signaling
GO:0022409--P:positive regulation of cell-cell adhesion
GO:0042102--P:positive regulation of T cell proliferation
GO:0043113--P:receptor clustering
GO:0022407--P:regulation of cell-cell adhesion
GO:0002291--P:T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
|
