dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0050897
Uniprot Accession E9Q5K9; YTDC1_MOUSE; E9PW44; E9Q7Z8; Q69Z54; Q80V25; Q8R5E6;
Genbank Protein ID NP_808348.2;
Genbank Nucleotide ID NM_177680.3;
Protein Name YTH domain-containing protein 1
Protein Synonyms/Alias
Gene Name Ythdc1
Gene Synonyms/Alias Kiaa1966;
Organism Mus musculus(Mouse)
NCBI Taxa ID 10090
Functional Description
(View all)		 Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability. Regulates alternative splice site selection.
Phosphorylation Sites
 dbPAF PTMs: 21 (View all)
PositionPeptidesSourceReferences ( PMIDs )
54RKSERMESTDTKRQKPhosphoSitePlus22135298
118ADRKIRLSSSSSREPPhosphoSitePlus;curated22135298; 25338131
119DRKIRLSSSSSREPYPhosphoSitePlus;curated22135298; 25338131
120RKIRLSSSSSREPYKPhosphoSitePlus;curated22135298; 25338131
121KIRLSSSSSREPYKScurated25338131
122IRLSSSSSREPYKSQPhosphoSitePlus;curated22135298; 25338131
146DSERRAKSPTPDGSEPHOSIDA;PhosphoSitePlus;curated21081558; 22135298; 23684622; 21743459; 22817900; 21183079;
148ERRAKSPTPDGSERIPHOSIDA;PhosphoSitePlus;curated21081558; 22135298; 23684622; 22817900; 21183079; 25338131
152KSPTPDGSERIGLEVPHOSIDA;PhosphoSitePlus;curated21081558; 22135298; 23684622; 25338131
164LEVDRRASRSSQSSKcurated25338131
267EEGNDYDTRSEASDSPhosphoSitePlus;curated22135298; 23684622
309RKRARGISPIVFDRSPHOSIDA;PhosphoSitePlus;SysPTM 2.0;UniProt;curated21081558; 22135298; 18388127; 19366988; 21183079; 23684622;
316SPIVFDRSGSSASESPHOSIDA;PhosphoSitePlus;curated21081558; 22135298; 23684622; 25338131
318IVFDRSGSSASESYAPHOSIDA;PhosphoSitePlus;curated21081558; 22135298; 23684622; 25338131
319VFDRSGSSASESYAGPHOSIDA;PhosphoSitePlus;curated21081558; 22135298; 23684622; 25338131
321DRSGSSASESYAGSEPHOSIDA;PhosphoSitePlus;curated21081558; 22135298; 23684622; 25338131
418QGFARLSSESHHGGSPhosphoSitePlus22135298
420FARLSSESHHGGSPIPhosphoSitePlus;curated22135298; 21743459
425SESHHGGSPIHWVLPPHOSIDA;PhosphoSitePlus;UniProt;curated21081558; 22135298; 21183079; 21743459; 22817900; 25338131
516RHKRRMHSQPRSRGRPHOSIDA;PhosphoSitePlus21081558; 22135298
Sequence
(Fasta)		MAADSREEKD GELNVLDDIL TEVPEQDDEL YNPESEQDKN EKKGSKRKSE RMESTDTKRQ 60
KPSIHSRQLI SKPLSSSVSN NKRIVSTKGK SVTEYKNEEY QRSERNKRLD ADRKIRLSSS 120
SSREPYKSQP EKTCLRKRDS ERRAKSPTPD GSERIGLEVD RRASRSSQSS KEEVNSEDYG 180
SDHETGSSGS SEQGNNTENE EEGGEEDVEE DEEVDEDAED DEEVDEDAEE EEEEDEEEEE 240
DEDEDEEEEE YEQDERDQKE EGNDYDTRSE ASDSGSESVS FTDGSVRSGS GTDGSDEKKK 300
ERKRARGISP IVFDRSGSSA SESYAGSEKK HEKLSSSVRA VRKDQTSKLK YVLQDARFFL 360
IKSNNHENVS LAKAKGVWST LPVNEKKLNL AFRSARSVIL IFSVRESGKF QGFARLSSES 420
HHGGSPIHWV LPAGMSAKML GGVFKIDWIC RRELPFTKSA HLTNPWNEHK PVKIGRDGQE 480
IELECGTQLC LLFPPDESID LYQLIHKMRH KRRMHSQPRS RGRPSRREPV RDVGRRRPED 540
YDIHNSRKKP RIDYPPEFHQ RPGYVKDPRY QEVDSFTNLI PNRRFSGVRR DVFLNGSYND 600
YVREFHNMGP PPPWQGMPPY PGIEQPPHHP YYQHHAPPPQ AHPPYSGHHP VPHEARYRDK 660
RVHDYDMRVD DFLRRTQAVV SGRRSRPRER DRERERDRPR DNRRDRERDR GRDRERERER 720
ICDRDRDRGE RGRYRR 737
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-1017--Isopeptide bond
KW-0507--mRNA processing
KW-0508--mRNA splicing
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0694--RNA-binding
KW-0832--Ubl conjugation
Interpro

IPR007275--YTH_domain
PROSITE

PS50882--YTH
Pfam

PF04146--YTH
Gene Ontology

GO:0016604--C:nuclear body
GO:0005634--C:nucleus
GO:1990247--F:N6-methyladenosine-containing RNA binding
GO:0044822--F:poly(A) RNA binding
GO:0003723--F:RNA binding
GO:0006376--P:mRNA splice site selection