dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0050894
Uniprot Accession E9Q5G3; KIF23_MOUSE; Q80V30; Q99PT8;
Genbank Protein ID NP_077207.3;
Genbank Nucleotide ID NM_024245.4;
Protein Name Kinesin-like protein KIF23
Protein Synonyms/Alias
Gene Name Kif23
Gene Synonyms/Alias
Organism Mus musculus(Mouse)
NCBI Taxa ID 10090
Functional Description
(View all)		 Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Essential for cytokinesis in Rho-mediated signaling. Required for the localization of ECT2 to the central spindle. Plus-end-directed motor enzyme that moves antiparallel microtubules in vitro (By similarity).
Phosphorylation Sites
 dbPAF PTMs: 32 (View all)
PositionPeptidesSourceReferences ( PMIDs )
18KPVIKKGSQTNLKDPPhosphoSitePlus22135298
20VIKKGSQTNLKDPVGPhosphoSitePlus22135298
125KTYTMTGSPGSGGLLPhospho.ELM 9.022067460
160FKSNDRNSMEIQCEVPhosphoSitePlus;UniProt;curated22135298; 21183079; 21743459
450DKVICGLTPGRRYRNPhospho.ELM 9.0;PhosphoSitePlus22067460; 22135298
501TLPKLADTLEKRHHLPhospho.ELM 9.0;PhosphoSitePlus22067460; 22135298
540SLSNKENYVQEKLNEPhosphoSitePlus22135298
583LEKTTTIYEEDKRNLPhosphoSitePlus22135298
606QKLQRQFSDKRRLEAPhosphoSitePlus22135298
671PEKPERPSRERDREKPhosphoSitePlus22135298
683REKIIPRSVSPSPLPPhosphoSitePlus;UniProt;curated22135298; 21183079; 22817900
685KIIPRSVSPSPLPLSPhosphoSitePlus;UniProt;curated22135298; 21183079; 22817900
687IPRSVSPSPLPLSSNPhosphoSitePlus22135298
692SPSPLPLSSNNIAQIPhosphoSitePlus;curated22135298; 22817900; 21183079
715QPQLHRRSNSCSSISPhosphoSitePlus22135298
717QLHRRSNSCSSISVAPhospho.ELM 9.0;PhosphoSitePlus;curated22067460; 22135298; 21183079
719HRRSNSCSSISVASCPhosphoSitePlus22135298
720RRSNSCSSISVASCIPhosphoSitePlus22135298
735SEWEQKLSPFSTPVNPhospho.ELM 9.0;PhosphoSitePlus22067460; 22135298
739QKLSPFSTPVNVTSLPhosphoSitePlus22135298
Sequence
(Fasta)		MKSAKAKTVR KPVIKKGSQT NLKDPVGVYC RVRPLSFPDQ ECCVEVINST TLQLHTPEGY 60
RLNRNGDYKE TQYSFKRVFG THTTQKELFD VVANPLVDDL IHGKNGLLFT YGVTGSGKTY 120
TMTGSPGSGG LLPRCLNMIF NSIGSFQAKR YVFKSNDRNS MEIQCEVDAL LERQKREALP 180
IPKTPSSKRQ ADPEFADMIN VQEFCKAEEV DEDSVYGVFV SYIEIYNNYI YDLLEEVQFD 240
PIKPKLPQSK TLREDKNHNM YVAGCTEVEV KSTEEAFEVF WRGQKKRRIA NTHLNRESSR 300
SHSVFSIKLV QAPLDADGDN VLQEKEQITI SQLSLVDLAG SERTNRTKAE GNRLREAGNI 360
NQSLMTLRTC MEVLRENQTY GTNKMVPYRD SKLTHLFKNY FDGEGKVRMI VCVNPKAEDY 420
EESLQVMRFA EVTQEVEVAR PVDKVICGLT PGRRYRNLPR GGPVGDEPLV PEVILQSFPP 480
LPPCKLLDIN DEETLPKLAD TLEKRHHLRQ LMTEDLNKKC LAFKALLKEF DNSLSNKENY 540
VQEKLNEREK VISGQKLEIE RLEKKNKTLE YKIEILEKTT TIYEEDKRNL QQELESQNQK 600
LQRQFSDKRR LEARLQGMVT ETSMKWQKEC ERRVAATQLE MQNKLWVKDE KLKQLKAIVT 660
EPKPEKPERP SRERDREKII PRSVSPSPLP LSSNNIAQIS NGQQLMSQPQ LHRRSNSCSS 720
ISVASCISEW EQKLSPFSTP VNVTSLARHR QQEPGQSKTC IVSDRRRGMC WTEGREMVPT 780
FSSEIGVEED HCRRNTPIPV RHRRSRSAGS RWVDHKPASN VQTETVMQPH VPHAITVSVA 840
NEKALAKCEK YMLTHQELAS DGEIQTKVIK GDVYKTRGGG QSVQFTDIET LKQELPTGSR 900
KRRSSTLAPA QPDGTESEWT DVETRCSVAV EMRAGSQLGP GYQHHAQPKR KKP 954
Keyword

KW-0067--ATP-binding
KW-0131--Cell cycle
KW-0132--Cell division
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0493--Microtubule
KW-0498--Mitosis
KW-0505--Motor protein
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0832--Ubl conjugation
Interpro

IPR032384--Kif23_Arf-bd
IPR027640--Kinesin-like_fam
IPR019821--Kinesin_motor_CS
IPR001752--Kinesin_motor_dom
IPR027417--P-loop_NTPase
PROSITE

PS00411--KINESIN_MOTOR_1
PS50067--KINESIN_MOTOR_2
Pfam

PF00225--Kinesin
PF16540--MKLP1_Arf_bdg
Gene Ontology

GO:0097149--C:centralspindlin complex
GO:0005813--C:centrosome
GO:0005737--C:cytoplasm
GO:0005925--C:focal adhesion
GO:0045171--C:intercellular bridge
GO:0005871--C:kinesin complex
GO:0005874--C:microtubule
GO:0030496--C:midbody
GO:0072686--C:mitotic spindle
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0005819--C:spindle
GO:0005524--F:ATP binding
GO:0016887--F:ATPase activity
GO:0008017--F:microtubule binding
GO:0003777--F:microtubule motor activity
GO:0007018--P:microtubule-based movement
GO:0000281--P:mitotic cytokinesis
GO:0051256--P:mitotic spindle midzone assembly
GO:0032467--P:positive regulation of cytokinesis