dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0050886
Uniprot Accession E9Q557; DESP_MOUSE;
Genbank Protein ID NP_076331.2;
Genbank Nucleotide ID NM_023842.2;
Protein Name Desmoplakin
Protein Synonyms/Alias
Gene Name Dsp
Gene Synonyms/Alias
Organism Mus musculus(Mouse)
NCBI Taxa ID 10090
Functional Description
(View all)		 Major high molecular weight protein of desmosomes. Involved in the organization of the desmosomal cadherin-plakoglobin complexes into discrete plasma membrane domains and in the anchoring of intermediate filaments to the desmosomes.
Phosphorylation Sites
 dbPAF PTMs: 68 (View all)
PositionPeptidesSourceReferences ( PMIDs )
2------MSCNGGSHPdbPTM 3.0;PHOSIDA;PhosphoSitePlus;curated19367708; 16381945; 23193290; 21081558; 22135298; 23984901
7-MSCNGGSHPRINTLdbPTM 3.0;PHOSIDA;PhosphoSitePlus;curated19367708; 16381945; 23193290; 21081558; 22135298; 23984901
13GSHPRINTLGRMTRAdbPTM 3.0;PhosphoSitePlus;curated21183079; 16381945; 23193290; 22135298
18INTLGRMTRAESGPDdbPTM 3.0;PhosphoSitePlus;curated21183079; 16381945; 23193290; 22135298; 23984901
22GRMTRAESGPDLRYEdbPTM 3.0;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated19367708; 20139300; 21183079; 16381945; 23193290; 21081558;
28ESGPDLRYEMTYSGGPhosphoSitePlus22135298
32DLRYEMTYSGGGGGGPhosphoSitePlus22135298
33LRYEMTYSGGGGGGGPhosphoSitePlus22135298
47GGGGGGGTSRTFYSHPhosphoSitePlus22135298
48GGGGGGTSRTFYSHSPhosphoPep 2.0;PhosphoSitePlus19060867; 22135298
53GTSRTFYSHSRRCTVPhosphoSitePlus22135298
55SRTFYSHSRRCTVNDPhosphoSitePlus22135298
59YSHSRRCTVNDQNSDdbPTM 3.0;PhosphoPep 2.0;PhosphoSitePlus;UniProt;curated21183079; 16381945; 23193290; 19060867; 22135298
65CTVNDQNSDGYCQTGdbPTM 3.0;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;UniProt;curated19367708; 21183079; 16381945; 23193290; 21081558; 19060867;
68NDQNSDGYCQTGTMSdbPTM 3.0;PhosphoPep 2.0;PhosphoSitePlus;UniProt;curated21183079; 16381945; 23193290; 19060867; 22135298
71NSDGYCQTGTMSRHQPhosphoSitePlus22135298
73DGYCQTGTMSRHQNQdbPTM 3.0;PhosphoPep 2.0;PhosphoSitePlus;UniProt;curated21183079; 16381945; 23193290; 19060867; 22135298
177VPRVRRASSKGAGGYdbPTM 3.0;PhosphoPep 2.0;PhosphoSitePlus;curated21183079; 16381945; 23193290; 19060867; 22135298
178PRVRRASSKGAGGYTPhosphoPep 2.0;PhosphoSitePlus19060867; 22135298
184SSKGAGGYTCQSGSGdbPTM 3.0;PhosphoSitePlus;curated21183079; 16381945; 23193290; 22135298
Sequence
(Fasta)		MSCNGGSHPR INTLGRMTRA ESGPDLRYEM TYSGGGGGGG GGGGGGTSRT FYSHSRRCTV 60
NDQNSDGYCQ TGTMSRHQNQ NTIQEMLQNC SDCLMRAELI AQPELKFGEG MQLAWNRELD 120
EYFTQANDQM EIIDGLIREM RQMGQPCDAY QKRLLQLQEQ MRALYKAISV PRVRRASSKG 180
AGGYTCQSGS GWDEFTKRLT GECLGWMRQQ REEMDLMAWG VDAGSVEQHI NSHRSIHNTI 240
GDYRWQLDKI KADLREKSAI YQLEEEYENL LKASFERMDH LRQLQNIIQA TSREIMWIND 300
CEEEELLYDW SDKNTNIAQK QEAFSIRMSQ LEVKEKELNK LKQESDQLVL NQHPASDKIE 360
AYMDTLQTQW SWILQITKCI DVHLKENAAY FQFFEEAQST EAYLKGLQDS IRKKYPCDKN 420
MPLQHLLEQI KELEKEREKI IEYKRQVQNL VNKSKKIVQL KPRNPDYRSN KPIILRALCD 480
YKQDQKIVHK GDECILKDNN ERSKWYVTGP GGVDMLVPSV GLIIPPPNPL AVDLSCKIEQ 540
YYEAILALWN QLYINMKSLV SWHYCMIDIE KIRAMTIAKL KTMRQEDYMK TIEDLELHYQ 600
DFIKNSQGSE MFGDDDKRRM QSQFTDAQKH YQTLVIQLPG HPQHQTVTKT EITHLGTCQD 660
VNHNKVIETN RENDKQETWL LMELQKIRRQ MEHCEARMTL KNLLLAEQGS THHITVKINE 720
LKSVQNDSQA LAEVLNQLKD MLANFRGSEK YCYLQNEIFG LFQKLENING VSDGYLNSLC 780
SVRALLQAIL QTEDMLKVYE ARLTEEETVC LDLDKVEAYR CGLKKIKNDL NLKKSLLATM 840
KTELQKAQQI HSQSSQQYPL YDLDLGKFTE KVTQLTDRWQ KIDKQIDFRL WDLEKQIKQL 900
RNYRDNYQSF CKWLYDAKRR QDSLESMKFG DSNTVMRFLN EQKNLHSEIS GKRDKSEEVH 960
KIAELCANSI KDYELQLASY TSGLETLLNI PIKRTMVQSP SGVILQEAAD IHARYIELLT 1020
RSGDYYRFLS EMLKSLEDLK LKNTKIEVLE EELRLARDAN SENCNKNKFL DQNLQKYQAE 1080
CSQFKAKLVS LEELKRQAEL DGKSAKQNLD KCYGQIKELN EKITRLTYEI EDEKRRRKTV 1140
EDRFDQQKND YDQLQKARQC EKENLSWQKL ESEKAIKEKE YEIERLRVLL QEEGARKREY 1200
ENELAKVRNH YNEEMSNLRN KYETEINITK TTIKEISMQK EDDSKNLRNQ MDRLSRENRD 1260
LKDEIVRLND SILQATEQRR RAEENALQQK ACGSETMQKK QRLEIELKQV IQQRSEDNAR 1320
HKQSLEEAAK TIQDKNKEIE RLKAEYQEEA KRRWEYENEL SKVRNSYDEE IISLKNQFET 1380
EINITKTTIH QLTMQKEEDT SGYRAQIDNL TRENRSLCEE VKRLKNTLAQ TTENLRRVEE 1440
NAQQQKATGS EMSQRKQQLE IELRQVTQMR TEESMRYKQS LDDAAKTIQD KNKEIERLKQ 1500
LVDKETNERK CLEDENSKLQ RVQYDLQKAN NSATEAMSKL KVQEQELTRL RIDYERVSQE 1560
RTVKDQDITR IQSSLKDLQL QKQKAEEELS RLKRTASDES SKRKMLEEEL EAMRRSLKEQ 1620
AVKITNLTQQ LEQASIVKKR SEDDLRQQRD VLDGHVREKQ RTQEELRRLS LDVEALRRQL 1680
VQEQENVKQA HLRNEHFQKA IEDKSRSLNE SKIEIERLQS LTENLTKEHL MLEEELRNLR 1740
LEYDDLRRGR SEADSDKNST ISELRSQLQI SNNRTLELQG LINDLQRERE NLRQEIEKFQ 1800
KQALEASNRI QESKSQCTQV VQERESLLVK IKVLEQDKAR LQRLEDELNR AKATLEAESR 1860
VKQRLECEKQ QIQNDLNQWK TQYSRKEETI RKIESEREKS EREKNSLRSE IERLQAEIKR 1920
IEERCRRKLE DSSRETQSQL ESERCRLQKE IEKLRQRPYG SHRETQTEYE WTVDSSKLVF 1980
DGLRKKVTAM QLYECQLIDK TTLDKLLKGK KSVEEVASEI QPFLRGAGAI AGASASPKEK 2040
YSLVEAKRKK FITPESTVML LEAQAATGGI IDPHRNEKLT VDNAVARDLI DFDDRQQIYT 2100
AEKAITGFDD PFSGKTVSVS EAIKKNLIDR ETGMRLLEAQ LASGGVVDPV NSVFLPKDVA 2160
LARGLIDRDL YRSLNDPRDS QKNFVDPITK KKVSYMQLRE RCRIEPHTGL LLLSVQKRSM 2220
SFQGIRQPVT VTELVDSGIL RPSTVNELES GQISYDEVGE RIKDFLQGSS CIAGIYNETT 2280
KQKLGIYEAM KIGLVRPGTA LELLEAQAAT GFIVDPVSNL RLPVEEAYKR GLVGIEFKEK 2340
LLSAERAVTG YNDPETGNII SLFQAMNKEL IEKGHGIRLL EAQIATGGII DPKESHRLPV 2400
DMAYKRGYFN EELSEILSDP SDDTKGFFDP NTEENLTYLQ LKERCIKDEE TGLCLLPLKE 2460
KKKQVQTSQK NTLRKRRVVI VDPETNKEMS VQEAYKKGLI DYDTFKELCE QECEWEEITI 2520
TGSDGSTRVV LVDRKTGSQY DIQDAIDKGL VDRKFFDQYR SGSLSLTQFA DMISLKNGVG 2580
NSSGLGGSVN DDVFSSSRHD SVSKISTISS VRNLTIRSSS LSDPLEESSP IAAIFDTENL 2640
EKISIAEGIE RGIVDSITGQ RLLEAQACTG GIIHPTTGQK LSLQDAVNQG LIDQDMATRL 2700
KPAQKAFIGF EGVKGKKKMS AAEAVKEKWL PYEAGQRFLE FQFLTGGLVD PEVHGRISTE 2760
EAIRKGFIDG RAAQRLQDIS SYAKILTCPK TKLKISYKDA MNRSMVEDIT GLRLLEAASV 2820
SSKGLPSPYN MSAPGSRSGS RSGSRSGSRS GSRSGSRRGS FDATGNSSYS YSYSFSSSSI 2880
GGY 2884
Keyword

KW-0122--Cardiomyopathy
KW-0965--Cell junction
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0449--Lipoprotein
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
Interpro

IPR028462--Desmoplakin
IPR001101--Plectin_repeat
IPR018159--Spectrin/alpha-actinin
PROSITE
Pfam

PF00681--Plectin
Gene Ontology

GO:0016323--C:basolateral plasma membrane
GO:0005911--C:cell-cell junction
GO:0001533--C:cornified envelope
GO:0005737--C:cytoplasm
GO:0005856--C:cytoskeleton
GO:0030057--C:desmosome
GO:0070062--C:extracellular exosome
GO:0005916--C:fascia adherens
GO:0014704--C:intercalated disc
GO:0016020--C:membrane
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0044822--F:poly(A) RNA binding
GO:0030674--F:protein binding, bridging
GO:0005080--F:protein kinase C binding
GO:0097110--F:scaffold protein binding
GO:0005198--F:structural molecule activity
GO:0034332--P:adherens junction organization
GO:0086073--P:bundle of His cell-Purkinje myocyte adhesion involved in cell communication
GO:0002934--P:desmosome organization
GO:0045104--P:intermediate filament cytoskeleton organization
GO:0045109--P:intermediate filament organization
GO:0030216--P:keratinocyte differentiation
GO:0018149--P:peptide cross-linking
GO:0071896--P:protein localization to adherens junction
GO:0086091--P:regulation of heart rate by cardiac conduction
GO:0098911--P:regulation of ventricular cardiac muscle cell action potential
GO:0016337--P:single organismal cell-cell adhesion
GO:0043588--P:skin development
GO:0003223--P:ventricular compact myocardium morphogenesis
GO:0042060--P:wound healing