dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0050885
Uniprot Accession E9Q555; RN213_MOUSE; Q8BVK6;
Genbank Protein ID
Genbank Nucleotide ID
Protein Name E3 ubiquitin-protein ligase RNF213
Protein Synonyms/Alias
Gene Name Rnf213
Gene Synonyms/Alias
Organism Mus musculus(Mouse)
NCBI Taxa ID 10090
Functional Description
(View all)
Probable E3 ubiquitin-protein ligase that may play a role in angiogenesis. May also have an ATPase activity (By similarity).
Phosphorylation Sites
dbPAF PTMs: 21 (View all)
PositionPeptidesSourceReferences ( PMIDs )
45DNTLVVSSTPEGKTEcurated25338131
65REEEVLLSSTDPGKEcurated25338131
79ELEKPEESDSNASWTcurated25338131
81EKPEESDSNASWTTQcurated25338131
84EESDSNASWTTQMSKcurated25338131
252PPIDAAASPVKTAGKPhosphoSitePlus;curated22135298; 25266776; 25338131
256AAASPVKTAGKETGEPhosphoSitePlus22135298
271DVRKPKPSPVSPVASPhosphoSitePlus;curated22135298; 25266776; 23684622; 25338131
274KPKPSPVSPVASKHGPHOSIDA;PhosphoSitePlus;curated21081558; 22135298; 25266776; 23684622; 25338131
278SPVSPVASKHGDQEAPhosphoSitePlus;curated22135298; 25266776
298LATPVRKSNEGGNTQPhosphoSitePlus;curated22135298; 25266776; 23684622; 25338131
581LEGKSGESLPADCPVPhosphoSitePlus22135298
1178VIKLPNSSSYKRETHcurated25338131
2230ATPTLHTSDQSPGRQcurated25338131
2233TLHTSDQSPGRQSVTPhosphoSitePlus;curated22135298; 25338131
2518ETADRLGSIPLRQLVPhosphoSitePlus22135298
2864GIFVSRGSPNEKELIcurated25338131
4359IKESKILSDPNIRCFPhosphoSitePlus22135298
4503NNEDRTQTGHVLGSPPhosphoSitePlus22135298
4509QTGHVLGSPQSSGVAPhosphoSitePlus22135298
Sequence
(Fasta)
MECPQCGHVS SEKAPKFCSE CGQKLPSAAT VQGDLKNDNT LVVSSTPEGK TEQGAVLREE 60
EVLLSSTDPG KELEKPEESD SNASWTTQMS KKEKRRRKRQ GTISSSEAPS SGLWSLDMPP 120
SPGSHNSALP QNQAQQGGAA SQPGHPLDTE NMPMEDGFVH TEGSGSPLQG QAAERTDAQS 180
NLAPSDLAEV KDLNTSKPSV DKGLPLDGGP ALSAFKGHPK MTDASQKAPL PESKGETSGQ 240
EKKVPPIDAA ASPVKTAGKE TGEDVRKPKP SPVSPVASKH GDQEAELKGK LATPVRKSNE 300
GGNTQPEDQR KPGEGRNFAA AVKTQQAAAP QQAAAPEPTS AFNPRDTVTV YFHAIVSRHF 360
GFNPEEHKVY VRGGEGLGQK GWTDACEMYC TQDLHDLGSL VEGKMDIPRQ SLDKPIPYKY 420
VIHRGGSSKD TVEYEFIYEQ AQKKGEHVNR CLRVVSTSLG NGDWHQYDDI ICMRSTGFFQ 480
QAKNRILDST RKELLKGKKQ AAVVMLDRIF SVLQPWSDIN LQSFMTQFLQ FYSVVREPMI 540
HDGRARKWTS LQYEEKEVWT NLWEHVKKQM APFLEGKSGE SLPADCPVRS KLTLGLSILF 600
MVEAAEFTVP KKDLDSLCYL LIPSAGSPEA LHSDLSPVLR IRQRWRIYLT NLCLRCIDER 660
CDRWLGILPL LHTCMQKSPP KKNSKSQPED TWAGLEGISF SEFRDKAPTS QPLQFMQSKM 720
ALLRVDEYLF RSWLSVVPLE SLSSYLENSI DYLSDVPVRV LDCLQGISYR LPGLRKISNQ 780
NMKKDVENVF KMLMHLVDIY QHRIFGENLL QIYLTECLTL HETVCNITAN HQFFEIPALS 840
AELICKLLEL SPPGHTDEGL PEKSYEDLVT STLQEALATT RNWLRSLFKS RMLSISSAYV 900
RLTYSEEMAV WRRLVEIGFP EKHGWKGSLL GDMEGRLKQE PPRLQISFFC SSQCRDGGLH 960
DSVSRSFEKC VIEAVSSACQ SQTSVLEGLS CQDLQKFGTL LSAVITKSWP VHNGEPVFDV 1020
DEIFKYLLKW PDVRQLFELC GTNEKIIDNI TEEGRQLMAT AESVFQKVAG ELENGTIVVG 1080
QLELILEHQS QFLDIWNLNR RRLPSQEKAC DVRSLLKRRR DDLLFLKQEK RYVESLLRQL 1140
GRVKHLVQVD FGNIEIIHSQ DLSNKKLNEA VIKLPNSSSY KRETHYCLSP DIREMASKLD 1200
SLKDSHIFQD FWQETAESLN TLDKDPRELK VSLPEVLEYL YNPCYDNFYT LYENLKSGKI 1260
TFAEVDAIFK DFVDKYDELK NDLKFMCTMN PQDQKGWISE RVGQIKEYHT LHQAVSSAKV 1320
ILQVRRALGV TGDFSVLNPL LNFADSFEDF GNEKLDQISP QFIKAKQLLQ DISEPRQRCL 1380
EELARQTELV AWLHKALEDI NELKVFVDLA SISAGENDID VDRVACFHDA VQGYASLLYK 1440
MDERTNFSDF MNHLQELWRA LDNDQHLPDK LKDSARNLEW LKTVKESHGS VELSSLSLAT 1500
AINSRGVYVI EAPKDGQKIS PDTVLRLLLP DGHGYPEALR TYSTEELKEL LNKLMLMSGK 1560
KDHNSNTEVE KFSEVFSNMQ RLVHVFIKLH CAGNMLFRTW TAKVYCCPDG GIFMNFGLEL 1620
LSQLTEKGDV IQLLGALCRQ MEDFLDNWKT VVAQKRAEHF YLNFYTAEQL VYLSSELRKP 1680
RPSEAALMML SFIKGKCTVQ DLVQATSACE SKADRYCLRE VMKKLPQQLL SEPSLMGKLQ 1740
VIMMQSLVYM SAFLPHCLDL DALGRCLAHL ATMGGTPVER PLPKGLQAGQ PNLILCGHSE 1800
VLPAALAIYM QAPRQPLPTF DEVLLCTPAT TIEEVELLLR RCLTSGSQGH KVYSLLFADQ 1860
LSYEVGCQAE EFFQSLCTRA HREDYQLVIL CDAAREHCYI PSTFSQYKVP LVPQAPLPNI 1920
QAYLQSHYQV PKRLLSAATV FRDGLCVGIV TSERAGVGKS LYVNTLHTKL KAKLRDETVP 1980
LKIIRLTEPH LDENQVLSAL LPFLKEKYQK MPVIFHIDIS TSVQTGIPIF LFKLLILQYL 2040
MDINGKIWRR SPGHLYLVEI PQGLSVQPKR SSKLNARAPL FKFLDLFPKV TCRPPKEVID 2100
MELTPERSHT DPAMDPVEFC SEAFQRPYQY LKRFHQQQNL DTFQYEKGSV EGSPEECLQH 2160
FLIYCGLINP SWSELRNFAW FLNCQLKDCE ASIFCKSAFT GDTLRGFKNF VVTFMILMAR 2220
DFATPTLHTS DQSPGRQSVT IGEVVEEDLA PFSLRKRWES EPHPYVFFNG DHMTMTFIGF 2280
HLETNNNGYV DAINPSNGKV IKKDVMTKEL FDGLRLQRVP FNIDFDNLPR YEKLERLCLA 2340
LGIEWPIDPD ETYELTTDNM LKILAIEMRF RCGIPVIIMG ETGCGKTRLI KFLSDLKRGS 2400
VEAETMKLVK VHGGTTPSMI YSKVKEAERT AFSNKAQHKL DTILFFDEAN TTEAVSCIKE 2460
ILCDRTVDGE HLHEDSGLHI IAACNPYRKH SQEMILRLES AGLGYRVSAE ETADRLGSIP 2520
LRQLVYRVHA LPPSLIPLVW DFGQLNDSAE KLYIQQIVQR LVDSVSVNPS ETCVIADVLS 2580
ASQMFMRKRE NECGFVSLRD VERCVKVFRW FHDHSDMLLK ELDKFLHESS DSTHTFERDP 2640
VLWSLVMAIG VCYHASLEEK ASYRTAIARC FPKPYNSSRA ILDEVTHVQD LFLRGAPIRT 2700
NIARNLALKE NVFMMVICIE LKIPLFLVGK PGSSKSLAKI IVADAMQGQA AFSELFRCLK 2760
QVHLVSFQCS PHSTPQGIIS TFKQCARFQQ GKDLGQYVSV VVLDEVGLAE DSPKMPLKTL 2820
HPLLEDGCIE DDPAPYKKVG FVGISNWALD PAKMNRGIFV SRGSPNEKEL IESAEGICSS 2880
DRLVQDKIRG YFAPFAKAYE TVCQKQDKEF FGLRDYYSLI KMVFAKAKAS KRGLSPQDIT 2940
HAVLRNFSGK DNIQALSIFT ASLPEARYKE EVSTVELIKQ NIYPGPQASS RGLDGAESRY 3000
LLVLTRNYVA LQILQQTFFE GQQPEIIFGS SFPQDQEYTQ ICRNINRVKI CMETGKMVVL 3060
LNLQNLYESL YDALNQYYVY LGGQKYVDLG LGTHRVKCRV HTAFRLIVIE EKDVVYKQFP 3120
VPLINRLEKH YLDMNTVLQP WQKSIVQELQ QWAHEFADVK ADQFIARHKY SPADVFIGYH 3180
SDACASVVLQ AVERQGCRDL TEELYRKVSE EARSILLDCA TPDAVVRLSG SSLGSFTAKQ 3240
LSQEYYYAQQ HNSFVDFLQA HLRMTHHECR AVFTEITTFS RLLTGNDCDV LASELRGLAS 3300
KPVVLSLQQY DTEYSFLKDV RSWLTNPGKR KVLVIQADFD DGTRSAQLVA SAKYTAINEI 3360
NKTQGTKDFV FVYFVTKLSR MGSGTSYVGF HGGLWRSVHI DDLRRSTIMA SDVTKLQNVT 3420
ISQLFKPEDK PEQEEMEIET SQSKELAEEQ MEVEDSEEMK KASDPRSCDC SQFLDTTRLV 3480
QSCVQGAVGM LRDQNESCAR NMRRVTILLD LLNEDNTRNA SFLRESKMRL HVLLNKQEEN 3540
QVRSLKEWVT REAANQDALQ EAGTFRHTLW KRVQDVVTPI LASMIAHIDR DGNLELLAQP 3600
DSPAWVQDLW MFIYSDIKFL NISLVLNNTR SNSEMSFILV QSHMNLLKDA YNAVPFSWRI 3660
RDYLEELWVQ AQYITDTEGL SKKFVEIFQK TPLGVFLAQF PVAQQQKLLQ SYLKDFLLLT 3720
MKVSSREELM FLQMALWSCL RELQEASGTP DETYKFPLSL PWVHLAFQHF RTRLQNFSRI 3780
LTIHPQVLSS LSQAAEKHSL AGCEMTLDAF AAMACAEMLK GDLLKPSPKA WLQLVKNLST 3840
PLELVCSEGY LCDSGSMTRS VIQEVRALWN RIFSIALFVE HVLLGTESHI PELSPLVTTY 3900
VSLLDKCLEE DSNLKTCRPF VAVMTTLCDC KDKASKKFSR FGIQPCFICH GDAQDPVCLP 3960
CDHVYCLRCI QTWLIPGQMM CPYCLTDLPD KFSPTVSQDH RKAIEKHAQF RHMCNSFFVD 4020
LVSTMCFKDN TPPEKSVIDT LLSLLFVQKE LLRDASQKHR EHTKSLSPFD DVVDQTPVIR 4080
SVLLKLLLKY SFHEVKDYIQ NYLTQLEKKA FLTEDKTELY LLFISCLEDS VHQKTSAGCR 4140
NLEQVLREEG HFLRTYSPGL QGQEPVRIAS VEYLQEVARV RLCLDLAADF LSELQEGSEL 4200
AEDKRRFLKH VEEFCTRVNN DWHRVYLVRK LSSQRGMEFV QSFSKQGHPC QWVFPRKVIA 4260
QQVRNRDHVS LMDRYLVHGN EYKAVRDATA KAVLECKTLD IGNALMACRS PKPQQTAYLL 4320
LALYTEVAAL YRSPNGSLHP EAKQLEAVNK FIKESKILSD PNIRCFARSL VDNTLPLLKI 4380
RSANSILKGT VTEMAVHVAT ILLCGHNQIL KPLRNLAFYP VNMANAFLPT MPEDLLVHAR 4440
TWRGLENVTW YTCPRGHPCS VGECGRPMQE STCLDCGLPV GGLNHTPHEG FSAIRNNEDR 4500
TQTGHVLGSP QSSGVAEVSD RGQSPVVFIL TRLLTHLAML VGATHNPQAL TVIIKPWVQD 4560
PQGFLQQHIQ RDLEQLTKML GRSADETIHV VHLILSSLLR VQSHGVLNFN AELSTKGCRN 4620
NWEKHFETLL LRELKHLDKN LPAINALISQ DERISSNPVT KIIYGDPATF LPHLPQKSII 4680
HCSKIWSCRR KITVEYLQHI VEQKNGKETV PVLWHFLQKE AELRLVKFLP EILALQRDLV 4740
KQFQNVSRVE YSSIRGFIHS HSSDGLRKLL HDRITIFLST WNALRRSLET NGEIKLPKDY 4800
CCSDLDLDAE FEVILPRRQG LGLCGTALVS YLISLHNNMV YTVQKFSNED NSYSVDISEV 4860
ADLHVISYEV ERDLNPLILS NCQYQVQQGG ETSQEFDLEK IQRQISSRFL QGKPRLTLKG 4920
IPTLVYRRDW NYEHLFMDIK NKMAQSSLPN LAISTISGQL QSYSDACEAL SIIEITLGFL 4980
STAGGDPGMD LNVYIEEVLR MCDQTAQVLK AFSRCQLRHI IALWQFLSAH KSEQRLRLNK 5040
ELFREIDVQY KEELSTQHQR LLGTFLNEAG LDAFLLELHE MIVLKLKGPR AANSFNPNWS 5100
LKDTLVSYME TKDSDILSEV ESQFPEEILM SSCISVWKIA ATRKWDRQSR 5151
Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1017--Isopeptide bond
KW-0436--Ligase
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR003593--AAA+_ATPase
IPR027417--P-loop_NTPase
IPR031248--RNF213
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam
Gene Ontology

GO:0005737--C:cytoplasm
GO:0016020--C:membrane
GO:0005730--C:nucleolus
GO:0016887--F:ATPase activity
GO:0016874--F:ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0051865--P:protein autoubiquitination
GO:0016567--P:protein ubiquitination