dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0050880
Uniprot Accession E9Q4Z2; ACACB_MOUSE; Q6JIZ0;
Genbank Protein ID NP_598665.2; XP_006530176.1;
Genbank Nucleotide ID NM_133904.2; XM_006530113.2;
Protein Name Acetyl-CoA carboxylase 2
Protein Synonyms/Alias ACC-beta;
Gene Name Acacb
Gene Synonyms/Alias Acc2;Accb;
Organism Mus musculus(Mouse)
NCBI Taxa ID 10090
Functional Description
(View all)		 Catalyzes the ATP-dependent carboxylation of acetyl-CoA to malonyl-CoA (By similarity). Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase (By similarity). Involved in inhibition of fatty acid and glucose oxidation and enhancement of fat storage (PubMed:11283375, PubMed:12920182, PubMed:15677334, PubMed:18487439, PubMed:22362781). May play a role in regulation of mitochondrial fatty acid oxidation through malonyl-CoA-dependent inhibition of carnitine palmitoyltransferase 1 (PubMed:10677481).
Phosphorylation Sites
 dbPAF PTMs: 38 (View all)
PositionPeptidesSourceReferences ( PMIDs )
44VEANLLSSEESLSASPhosphoSitePlus;curated22135298; 21183079
47NLLSSEESLSASELSPhosphoSitePlus;UniProt;curated22135298; 21183079; 22817900
49LSSEESLSASELSGEcurated21183079
81DASQQRNSLPSSCQRPhosphoSitePlus22135298
136PPSQRTVSPSREDRKPhosphoSitePlus;curated22135298; 23684622; 22817900; 21183079
138SQRTVSPSREDRKQAPhosphoSitePlus;curated22135298; 22817900; 21183079
164LGSLDDNSSDEDPSAcurated21183079
181FQNSSRKSSRASLGTPhosphoSitePlus;curated22135298; 21183079
185SRKSSRASLGTLSQEPhosphoSitePlus;SysPTM 2.0;curated22135298; 17242355; 19366988; 21743459; 22817900; 21183079
188SSRASLGTLSQEAALSysPTM 2.017242355; 19366988
190RASLGTLSQEAALNTPhosphoSitePlus;curated22135298; 23567750
197SQEAALNTSDPESHAPhosphoSitePlus;UniProt;curated22135298; 21183079; 22817900
198QEAALNTSDPESHAPPhosphoSitePlus;curated22135298; 22817900; 21183079
202LNTSDPESHAPTMRPPhosphoSitePlus;curated22135298; 22817900; 21183079
206DPESHAPTMRPSMSGSysPTM 2.017242355; 19366988
210HAPTMRPSMSGLHLVPhosphoSitePlus22135298
212PTMRPSMSGLHLVKRPHOSIDA;PhosphoSitePlus;SysPTM 2.0;curated21081558; 22135298; 17242355; 19366988; 21743459; 21183079
236HRDFTVASPAEFVTRPhosphoPep 2.0;PhosphoSitePlus;curated19060867; 22135298; 23684622
290IRFVVMVTPEDLKANPhosphoSitePlus;SysPTM 2.0;curated22135298; 18779572; 19366988; 22817900
446FPLMIKASEGGGGKGPhosphoSitePlus22135298
Sequence
(Fasta)		MVLLLFLTCL VFSCLTFSWL KIWGKMTDSK PLTNSKVEAN LLSSEESLSA SELSGEQLQE 60
HGDHSCLSYR GPRDASQQRN SLPSSCQRPP RNPLSSNDTW PSPELQTNWT AAPGPEVPDA 120
NGLSFPARPP SQRTVSPSRE DRKQAHIKRQ LMTSFILGSL DDNSSDEDPS AGSFQNSSRK 180
SSRASLGTLS QEAALNTSDP ESHAPTMRPS MSGLHLVKRG REHKKLDLHR DFTVASPAEF 240
VTRFGGNRVI EKVLIANNGI AAVKCMRSIR RWAYEMFRNE RAIRFVVMVT PEDLKANAEY 300
IKMADQYVPV PGGPNNNNYA NVELIIDIAK RIPVQAVWAG WGHASENPKL PELLCKHEIA 360
FLGPPSEAMW ALGDKIASTI VAQTLQIPTL PWSGSGLTVE WTEDSRHQGK CISVPEDVYE 420
QGCVKDVDEG LQAAEKIGFP LMIKASEGGG GKGIRKAESA EDFPMLFRQV QSEIPGSPIF 480
LMKLAQNARH LEVQVLADQY GNAVSLFGRD CSIQRRHQKI IEEAPATIAA PAVFEFMEQC 540
AVLLAKMVGY VSAGTVEYLY SQDGSFHFLE LNPRLQVEHP CTEMIADVNL PAAQLQIAMG 600
VPLHRLKDIR LLYGESPWGV TPIPFETPLS PPIARGHVIA ARITSENPDE GFKPSSGTVQ 660
ELNFRSNKNV WGYFSVAAAG GLHEFADSQF GHCFSWGENR EEAISNMVVA LKELSIRGDF 720
RTTVEYLVNL LETESFQNND IDTGWLDHLI AQRVQAEKPD IMLGVVCGAL NVADAMFRTC 780
MTEFLHSLER GQVLPADSLL NIVDVELIYG GIKYALKVAR QSLTMFVLIM NGCHIEIDAH 840
RLNDGGLLLS YNGSSYTTYM KEEVDSYRIT IGNKTCVFEK ENDPTVLRSP SAGKLMQYTV 900
EDGDHVEAGS SYAEMEVMKM IMTLNVQESG RVKYIKRPGV ILEAGCVVAR LELDDPSKVH 960
AAQPFTGELP AQQTLPILGE KLHQVFHGVL ENLTNVMSGY CLPEPFFSMK LKDWVQKLMM 1020
TLRHPSLPLL ELQEIMTSVA GRIPAPVEKA VRRVMAQYAS NITSVLCQFP SQQIATILDC 1080
HAATLQRKAD REVFFMNTQS IVQLVQRYRS GTRGYMKAVV LDLLRKYLNV EHHFQQAHYD 1140
KCVINLREQF KPDMTQVLDC IFSHSQVAKK NQLVTMLIDE LCGPDPTLSD ELTSILCELT 1200
QLSRSEHCKV ALRARQVLIA SHLPSYELRH NQVESIFLSA IDMYGHQFCP ENLKKLILSE 1260
TTIFDVLPTF FYHENKVVCM ASLEVYVRRG YIAYELNSLQ HRELPDGTCV VEFQFMLPSS 1320
HPNRMAVPIS VSNPDLLRHS TELFMDSGFS PLCQRMGAMV AFRRFEEFTR NFDEVISCFA 1380
NVQTDTLLFS KACTSLYSEE DSKSLREEPI HILNVAIQCA DHMEDEALVP VFRAFVQSKK 1440
HILVDYGLRR ITFLVAQERE FPKFFTFRAR DEFAEDRIYR HLEPALAFQL ELSRMRNFDL 1500
TAVPCANHKM HLYLGAAKVK EGLEVTDHRF FIRAIIRHSD LITKEASFEY LQNEGERLLL 1560
EAMDELEVAF NNTSVRTDCN HIFLNFVPTV IMDPLKIEES VRDMVMRYGS RLWKLRVLQA 1620
EVKINIRQTT SDSAIPIRLF ITNESGYYLD ISLYREVTDS RSGNIMFHSF GNKQGSLHGM 1680
LINTPYVTKD LLQAKRFQAQ SLGTTYVYDF PEMFRQALFK LWGSPEKYPK DILTYTELVL 1740
DSQGQLVEMN RLPGCNEVGM VAFKMRFKTP EYPEGRDAVV IGNDITFQIG SFGIGEDFLY 1800
LRASEMARTE GIPQIYLAAN SGARMGLAEE IKQIFQVAWV DPEDPHKGFR YLYLTPQDYT 1860
QISSQNSVHC KHIEDEGESR YVIVDVIGKD ANLGVENLRG SGMIAGEASL AYEKTVTISM 1920
VTCRALGIGA YLVRLGQRVI QVENSHIILT GAGALNKVLG REVYTSNNQL GGVQIMHTNG 1980
VSHVTVPDDF EGVCTILEWL SFIPKDNRSP VPITTPSDPI DREIEFTPTK APYDPRWMLA 2040
GRPHPTLKGT WQSGFFDHGS FKEIMAPWAQ TVVTGRARLG GIPVGVIAVE TRTVEVAVPA 2100
DPANLDSEAK IIQQAGQVWF PDSAYKTAQV IRDFNKERLP LMIFANWRGF SGGMKDMYEQ 2160
MLKFGAYIVD GLRLYEQPIL IYIPPCAELR GGSWVVLDST INPLCIEMYA DKESRGGVLE 2220
PEGTVEIKFR KKDLVKTIRR IDPVCKKLVG QLGKAQLPDK DRKELEGQLK AREELLLPIY 2280
HQVAVQFADL HDTPGHMLEK GIISDVLEWK TARTFFYWRL RRLLLEAQVK QEILRASPEL 2340
NHEHTQSMLR RWFVETEGAV KAYLWDSNQV VVQWLEQHWS AKDGLRSTIR ENINYLKRDS 2400
VLKTIQSLVQ EHPEVIMDCV AYLSQHLTPA ERIQVAQLLS TTESPASS 2449
Keyword

KW-0021--Allosteric enzyme
KW-0067--ATP-binding
KW-0092--Biotin
KW-0181--Complete proteome
KW-0275--Fatty acid biosynthesis
KW-0276--Fatty acid metabolism
KW-0436--Ligase
KW-0444--Lipid biosynthesis
KW-0443--Lipid metabolism
KW-0464--Manganese
KW-0472--Membrane
KW-0479--Metal-binding
KW-0496--Mitochondrion
KW-0511--Multifunctional enzyme
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0809--Transit peptide
Interpro

IPR013537--AcCoA_COase_cen
IPR011761--ATP-grasp
IPR013815--ATP_grasp_subdomain_1
IPR013816--ATP_grasp_subdomain_2
IPR005481--BC-like_N
IPR011764--Biotin_carboxylation_dom
IPR005482--Biotin_COase_C
IPR000089--Biotin_lipoyl
IPR000022--Carboxyl_trans
IPR005479--CbamoylP_synth_lsu-like_ATP-bd
IPR029045--ClpP/crotonase-like_dom
IPR011763--COA_CT_C
IPR011762--COA_CT_N
IPR016185--PreATP-grasp_dom
IPR011054--Rudment_hybrid_motif
IPR011053--Single_hybrid_motif
PROSITE

PS50975--ATP_GRASP
PS50979--BC
PS50968--BIOTINYL_LIPOYL
PS50989--COA_CT_CTER
PS50980--COA_CT_NTER
PS00866--CPSASE_1
PS00867--CPSASE_2
Pfam

PF08326--ACC_central
PF02785--Biotin_carb_C
PF00364--Biotin_lipoyl
PF01039--Carboxyl_trans
PF00289--CPSase_L_chain
PF02786--CPSase_L_D2
Gene Ontology

GO:0012505--C:endomembrane system
GO:0016020--C:membrane
GO:0005739--C:mitochondrion
GO:0005634--C:nucleus
GO:0003989--F:acetyl-CoA carboxylase activity
GO:0005524--F:ATP binding
GO:0004075--F:biotin carboxylase activity
GO:0046872--F:metal ion binding
GO:0006084--P:acetyl-CoA metabolic process
GO:0097009--P:energy homeostasis
GO:0006633--P:fatty acid biosynthetic process
GO:2001295--P:malonyl-CoA biosynthetic process
GO:0043086--P:negative regulation of catalytic activity
GO:0031999--P:negative regulation of fatty acid beta-oxidation
GO:0046322--P:negative regulation of fatty acid oxidation
GO:0010629--P:negative regulation of gene expression
GO:0050995--P:negative regulation of lipid catabolic process
GO:0060421--P:positive regulation of heart growth
GO:0010884--P:positive regulation of lipid storage
GO:0051289--P:protein homotetramerization
GO:0010906--P:regulation of glucose metabolic process
GO:0031667--P:response to nutrient levels