dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0050872
Uniprot Accession E9Q4S1; PDE8B_MOUSE;
Genbank Protein ID
Genbank Nucleotide ID
Protein Name High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B
Protein Synonyms/Alias
Gene Name Pde8b
Gene Synonyms/Alias
Organism Mus musculus(Mouse)
NCBI Taxa ID 10090
Functional Description
(View all)		 Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in specific signaling in the thyroid gland (By similarity).
Phosphorylation Sites
 dbPAF PTMs: 8
PositionPeptidesSourceReferences ( PMIDs )
331VYYARRKSGDSIQQHcurated25338131
377IHRIHRDSGDNSQTEPhosphoSitePlus;curated22135298; 25338131
426PSMARIHSMTIEAPIcurated25338131
469LRTTELYSPQLGTKDPhosphoSitePlus22135298
497TDGLRRLSGNEYVFTPHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;UniProt;curated21081558; 19060867; 22135298; 21183079; 25338131
731NKPLAAESEGSDCECPhosphoPep 2.0;PhosphoSitePlus;UniProt;curated19060867; 22135298; 21183079
734LAAESEGSDCECNPTPHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;UniProt;curated21081558; 19060867; 22135298; 21183079; 22807455
863CKTLRLPSDS-----curated25338131
Sequence
(Fasta)		MGCAPSIHVS QSGVIYCRDS DESNSPRQTS SVSQGPTAPL HGLFVQTDAA DAMPPSRAAG 60
PPGAVRVRRS RAELGSGSST GSSGPATTTC RGRRRHCCSS AEAETQTSYT SVKVLLIFAK 120
EDSQSDGFWW ACDRAGYRCN IARTPESALE CFLDKHHEII VIDHRQSRNF DAEAVCRSIR 180
ATNPSEHTVI LAVVSQASDD HEEASVLPLL HAGFNRRFME NSSIIACYNE LIQIEHGEVR 240
SQFKLRACNS VFTALDHCHE AIEITSDDHV IQYVNPAFER MMGYHKGELL GKELADLPKS 300
DKNRADLLDT INTCIKKGKE WQGVYYARRK SGDSIQQHVK ITPVIGQGGK IRHFVSLKKL 360
CCTTDSNKQI HRIHRDSGDN SQTEPHSFRH KSRRKESIDV KSISSRGSDA PSLQNRRYPS 420
MARIHSMTIE APITKVINII NAAQENSPVT VAEALDRVLE ILRTTELYSP QLGTKDEDPH 480
TSDLVGGLMT DGLRRLSGNE YVFTKNVHHS HSHLSMPITI NDVPPSIAQL LDNEESWDFN 540
IFELEAVTHK RPLVYLGLKV FSRFGVCEFL NCTETTLRAW LQVIEANYHS SNAYHNSTHA 600
ADVLHATAFF LGKERVKGSL DQLDEVAALI AATVHDVDHP GRTNSFLCNA GSELAVLYND 660
TAVLESHHTA LAFQLTVKDT KCNIFKNIDR NHYRTLRQAI IDMVLATEMT KHFEHVNKFV 720
NSINKPLAAE SEGSDCECNP TGKNFPENQI LIKRMMIKCA DVANPCRPLD LCIEWAGRIS 780
EEYFAQTDEE KRQGLPVVMP VFDRNTCSIP KSQISFIDYF ITDMFDAWDA FAHLPALMQH 840
LADNYKHWKT LDDLKCKTLR LPSDS 866
Keyword

KW-0114--cAMP
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
Interpro

IPR003607--HD/PDEase_dom
IPR000014--PAS
IPR023088--PDEase
IPR002073--PDEase_catalytic_dom
IPR023174--PDEase_CS
IPR013938--PDEase_PDE8
PROSITE

PS50112--PAS
PS00126--PDEASE_I
Pfam

PF13426--PAS_9
PF08629--PDE8
PF00233--PDEase_I
Gene Ontology

GO:0004115--F:3',5'-cyclic-AMP phosphodiesterase activity
GO:0046872--F:metal ion binding
GO:0001662--P:behavioral fear response
GO:0006198--P:cAMP catabolic process
GO:0090032--P:negative regulation of steroid hormone biosynthetic process
GO:0050885--P:neuromuscular process controlling balance
GO:0035106--P:operant conditioning
GO:0007165--P:signal transduction
GO:0008542--P:visual learning