dbPAF Protein Information
| Tag | Content | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| dbPAF ID | dbPAF-0050869 | ||||||||
| Uniprot Accession | E9Q4P1; WDFY1_MOUSE; Q5DTX9; | ||||||||
| Genbank Protein ID | NP_001104749.1; XP_011237011.1; | ||||||||
| Genbank Nucleotide ID | NM_001111279.1; XM_011238709.1; | ||||||||
| Protein Name | WD repeat and FYVE domain-containing protein 1 | ||||||||
| Protein Synonyms/Alias | WD40- and FYVE domain-containing protein 1; | ||||||||
| Gene Name | Wdfy1 | ||||||||
| Gene Synonyms/Alias | Kiaa1435; | ||||||||
| Organism | Mus musculus(Mouse) | ||||||||
| NCBI Taxa ID | 10090 | ||||||||
| Functional Description (View all) |
Positively regulates TLR3- and TLR4-mediated signaling pathways by bridging the interaction between TLR3 or TLR4 and TICAM1. Promotes TLR3/4 ligand-induced activation of transcription factors IRF3 and NF-kappa-B, as well as the production of IFN-beta and inflammatory cytokines (PubMed:25736436). | ||||||||
| Phosphorylation Sites |
dbPAF PTMs: 1
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| Sequence (Fasta) | MAAEIHSRPQ SSRPVLLSKI EGHQDAVTAA LLIPKEDGVI TASEDRTIRV WLKRDSGQYW 60 PSIYHTMASP CSAMAYHHDS RRIFVGQDNG AVMEFHVSED FNKMNFIKTY PAHQNRVSAI 120 IFSLAAEWVI STGHDKCVSW MCTRSGNMLG RHFFSSWASC LQYDLDTQHA FVGDYSGQIT 180 LLKLEQNTCS VITTLKGHEG SIACLWWDPI QRLLFSGASD NSVIMWDIGG RKGRTLLLQG 240 HHDRVQSLCY LQLTRQLVSC SADGGIAVWN MDVSREEAPQ WLESDSCQKC EQPFFWNIKQ 300 MWDTKTLGLR QHHCRKCGQA VCGKCSSKRS SYPVMGFEFQ VRVCDSCYDS IKDEDRTSLA 360 TFHEGKHNIS HMSMDIARGL MVTCGTDRVV KIWDMTPVVG CSLATGFSPH 411 |
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| Keyword | KW-0181--Complete proteome |
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| Interpro | IPR020472--G-protein_beta_WD-40_rep |
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| PROSITE | PS00678--WD_REPEATS_1 |
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| Pfam | |||||||||
| Gene Ontology | GO:0005829--C:cytosol |