dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0050853
Uniprot Accession E9Q414; APOB_MOUSE; Q3UH74; Q497D8; Q61314; Q61318; Q8CGG8;
Genbank Protein ID NP_033823.2;
Genbank Nucleotide ID NM_009693.2;
Protein Name Apolipoprotein B-100
Protein Synonyms/Alias
Gene Name Apob
Gene Synonyms/Alias
Organism Mus musculus(Mouse)
NCBI Taxa ID 10090
Functional Description
(View all)		 Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B-100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor.
Phosphorylation Sites
 dbPAF PTMs: 12
PositionPeptidesSourceReferences ( PMIDs )
458SYFDVDHSRSPVLQDPhosphoSitePlus22135298
460FDVDHSRSPVLQDIAPhosphoSitePlus22135298
498VIGNMGRTMEQVMPAPhosphoSitePlus22135298
607ILNSEELYVQDLKVLPhosphoSitePlus22135298
622IKNALENSQFPTIMDPhosphoSitePlus22135298
626LENSQFPTIMDFRKFPhosphoSitePlus22135298
731GRVPDGVSKVLVDHFPhosphoSitePlus22135298
947NTLHLVSTTKTEVIPPhosphoSitePlus22135298
2608LQEGNFQTPVFIVPLPhosphoSitePlus22135298
4013TEWRYKESDGERYIKPhosphoSitePlus22135298
4018KESDGERYIKINWEEPhosphoSitePlus22135298
4057ANKYHLEYVSSELRKPhosphoSitePlus22135298
Sequence
(Fasta)		MGPRKPALRT PLLLLFLLLF LDTSVWAQDE VLENLSFSCP KDATRFKHLR KYVYNYEAES 60
SSGVQGTADS RSATKINCKV ELEVPQICGF IMRTNQCTLK EVYGFNPEGK ALMKKTKNSE 120
EFAAAMSRYE LKLAIPEGKQ IVLYPDKDEP KYILNIKRGI ISALLVPPET EEDQQELFLD 180
TVYGNCSTQV TVNSRKGTVP TEMSTERNLQ QCDGFQPIST SVSPLALIKG LVHPLSTLIS 240
SSQTCQYTLD PKRKHVSEAV CDEQHLFLPF SYKNKYGIMT RVTQKLSLED TPKINSRFFS 300
EGTNRMGLAF ESTKSTSSPK QADAVLKTLQ ELKKLSISEQ NAQRANLFNK LVTELRGLTG 360
EAITSLLPQL IEVSSPITLQ ALVQCGQPQC YTHILQWLKT EKAHPLLVDI VTYLMALIPN 420
PSTQRLQEIF NTAKEQQSRA TLYALSHAVN SYFDVDHSRS PVLQDIAGYL LKQIDNECTG 480
NEDHTFLILR VIGNMGRTME QVMPALKSSV LSCVRSTKPS LLIQKAALQA LRKMELEDEV 540
RTILFDTFVN GVAPVEKRLA AYLLLMKNPS SSDINKIAQL LQWEQSEQVK NFVASHIANI 600
LNSEELYVQD LKVLIKNALE NSQFPTIMDF RKFSRNYQIS KSASLPMFDP VSVKIEGNLI 660
FDPSSYLPRE SLLKTTLTVF GLASLDLFEI GLEGKGFEPT LEALFGKQGF FPDSVNKALY 720
WVNGRVPDGV SKVLVDHFGY TTDGKHEQDM VNGIMPIVDK LIKDLKSKEI PEARAYLRIL 780
GKELSFVRLQ DLQVLGKLLL SGAQTLQGIP QMVVQAIREG SKNDLFLHYI FMDNAFELPT 840
GAGLQLQVSS SGVFTPGIKA GVRLELANIQ AELVAKPSVS LEFVTNMGII IPDFAKSSVQ 900
MNTNFFHESG LEARVALKAG QLKVIIPSPK RPVKLFSGSN TLHLVSTTKT EVIPPLVENR 960
QSWSTCKPLF TGMNYCTTGA YSNASSTESA SYYPLTGDTR YELELRPTGE VEQYSATATY 1020
ELLKEDKSLV DTLKFLVQAE GVQQSEATVL FKYNRRSRTL SSEVLIPGFD VNFGTILRVN 1080
DESAKDKNTY KLILDIQNKK ITEVSLVGHL SYDKKGDGKI KGVVSIPRLQ AEARSEVHTH 1140
WSSTKLLFQM DSSATAYGST ISKRVTWRYD NEIIEFDWNT GTNVDTKKVA SNFPVDLSHY 1200
PRMLHEYANG LLDHRVPQTD VTFRDMGSKL IVATNTWLQM ATRGLPYPQT LQDHLNSLSE 1260
LNLLKMGLSD FHIPDNLFLK TDGRVKYTMN RNKINIDIPL PLGGKSSKDL KMPESVRTPA 1320
LNFKSVGFHL PSREVQVPTF TIPKTHQLQV PLLGVLDLST NVYSNLYNWS ASYTGGNTSR 1380
DHFSLQAQYR MKTDSVVDLF SYSVQGSGET TYDSKNTFTL SCDGSLHHKF LDSKFKVSHV 1440
EKFGNSPVSK GLLTFETSSA LGPQMSATVH LDSKKKQHLY VKDIKVDGQF RASSFYAQGK 1500
YGLSCERDVT TGQLSGESNM RFNSTYFQGT NQIVGMYQDG ALSITSTSDL QDGIFKNTAS 1560
LKYENYELTL KSDSSGQYEN FAASNKLDVT FSTQSALLRS EHQANYKSLR LVTLLSGSLT 1620
SQGVELNADI LGTDKINTGA HKATLKIARD GLSTSATTNL KYSPLLLENE LNAELGLSGA 1680
SMKLSTNGRF KEHHAKFSLD GRAALTEVSL GSIYQAMILG ADSKNIFNFK LSREGLRLSN 1740
DLMGSYAEMK LDHTHSLNIA GLSLDFFSKM DNIYSGDKFY KQNFNLQLQP YSFITTLSND 1800
LRYGALDLTN NGRFRLEPLK LNVGGNFKGT YQNNELKHIY TISYTDLVVA SYRADTVAKV 1860
QGVEFSHRLN ADIEGLTSSV DVTTSYNSDP LHFNNVFHFS LAPFTLGIDT HTSGDGKLSF 1920
WGEHTGQLYS KFLLKAEPLA LIVSHDYKGS TSHSLPYESS ISTALEHTVS ALLTPAEQTS 1980
TWKFKTKLND KVYSQDFEAY NTKDKIGVEL SGRADLSGLY SPIKLPFFYS EPVNVLNGLE 2040
VNDAVDKPQE FTIIAVVKYD KNQDVHTINL PFFKSLPDYL ERNRRGMISL LEAMRGELQR 2100
LSVDQFVRKY RAALSRLPQQ IHHYLNASDW ERQVAGAKEK ITSFMENYRI TDNDVLIAID 2160
SAKINFNEKL SQLETYAIQF DQYIKDNYDP HDLKRTIAEI IDRIIEKLKI LDEQYHIRVN 2220
LAKSIHNLYL FVENVDLNQV SSSNTSWIQN VDSNYQVRIQ IQEKLQQLRT QIQNIDIQQL 2280
AAEVKRQMDA IDVTMHLDQL RTAILFQRIS DIIDRVKYFV MNLIEDFKVT EKINTFRVIV 2340
RELIEKYEVD QHIQVLMDKS VELAHRYSLS EPLQKLSNVL QRIEIKDYYE KLVGFIDDTV 2400
EWLKALSFKN TIEELNRLTD MLVKKLKAFD YHQFVDKTNS KIREMTQRIN AEIQALKLPQ 2460
KMEALKLLVE DFKTTVSNSL ERLKDTKVTV VIDWLQDILT QMKDHFQDTL EDVRDRIYQM 2520
DIQRELEHFL SLVNQVYSTL VTYMSDWWTL TAKNITDFAE QYSIQNWAES IKVLVEQGFI 2580
VPEMQTFLWT MPAFEVSLRA LQEGNFQTPV FIVPLTDLRI PSIRINFKML KNIKIPLRFS 2640
TPEFTLLNTF HVHSFTIDLL EIKAKIIRTI DQILSSELQW PLPEMYLRDL DVVNIPLARL 2700
TLPDFHVPEI TIPEFTIPNV NLKDLHVPDL HIPEFQLPHL SHTIEIPAFG KLHSILKIQS 2760
PLFILDANAN IQNVTTSGNK AEIVASVTAK GESQFEALNF DFQAQAQFLE LNPHPPVLKE 2820
SMNFSSKHVR MEHEGEIVFD GKAIEGKSDT VASLHTEKNE VEFNNGMTVK VNNQLTLDSH 2880
TKYFHKLSVP RLDFSSKASL NNEIKTLLEA GHVALTSSGT GSWNWACPNF SDEGIHSSQI 2940
SFTVDGPIAF VGLSNNINGK HLRVIQKLTY ESGFLNYSKF EVESKVESQH VGSSILTANG 3000
RALLKDAKAE MTGEHNANLN GKVIGTLKNS LFFSAQPFEI TASTNNEGNL KVGFPLKLTG 3060
KIDFLNNYAL FLSPRAQQAS WQASTRFNQY KYNQNFSAIN NEHNIEASIG MNGDANLDFL 3120
NIPLTIPEIN LPYTEFKTPL LKDFSIWEET GLKEFLKTTK QSFDLSVKAQ YKKNSDKHSI 3180
VVPLGMFYEF ILNNVNSWDR KFEKVRNNAL HFLTTSYNEA KIKVDKYKTE NSLNQPSGTF 3240
QNHGYTIPVV NIEVSPFAVE TLASSHVIPT AISTPSVTIP GPNIMVPSYK LVLPPLELPV 3300
FHGPGNLFKF FLPDFKGFNT IDNIYIPAMG NFTYDFSFKS SVITLNTNAG LYNQSDIVAH 3360
FLSSSSFVTD ALQYKLEGTS RLMRKRGLKL ATAVSLTNKF VKGSHDSTIS LTKKNMEASV 3420
RTTANLHAPI FSMNFKQELN GNTKSKPTVS SSIELNYDFN SSKLHSTATG GIDHKFSLES 3480
LTSYFSIESF TKGNIKSSFL SQEYSGSVAN EANVYLNSKG TRSSVRLQGA SKVDGIWNVE 3540
VGENFAGEAT LQRIYTTWEH NMKNHLQVYS YFFTKGKQTC RATLELSPWT MSTLLQVHVS 3600
QLSSLLDLHH FDQEVILKAN TKNQKISWKG GVQVESRVLQ HNAQFSNDQE EIRLDLAGSL 3660
DGQLWDLEAI FLPVYGKSLQ ELLQMDGKRQ YLQASTSLLY TKNPNGYLLS LPVQELADRF 3720
IIPGIKLNDF SGVKIYKKLS TSPFALNLTM LPKVKFPGID LLTQYSTPEG SSVPIFEATI 3780
PEIHLTVSQF TLPKSLPVGN TVFDLNKLAN MIADVDLPSV TLPEQTIVIP PLEFSVPAGI 3840
FIPFFGELTA RAGMASPLYN VTWSAGWKTK ADHVETFLDS MCTSTLQFLE YALKVVETHK 3900
IEEDLLTYNI KGTLQHCDFN VEYNEDGLFK GLWDWQGEAH LDITSPALTD FHLYYKEDKT 3960
SLSASAASST IGTVGLDSST DDQSVELNVY FHPQSPPEKK LSIFKTEWRY KESDGERYIK 4020
INWEEEAASR LLGSLKSNVP KASKAIYDYA NKYHLEYVSS ELRKSLQVNA EHARRMVDEM 4080
NMSFQRVARD TYQNLYEEML AQKSLSIPEN LKKRVLDSIV HVTQKYHMAV MWLMDSFIHF 4140
LKFNRVQFPG YAGTYTVDEL YTIVMKETKK SLSQLFNGLG NLLSYVQNQV EKSRLINDIT 4200
FKCPFFSKPC KLKDLILIFR EELNILSNIG QQDIKFTTIL SSLQGFLERV LDIIEEQIKC 4260
LKDNESTCVA DHINMVFKIQ VPYAFKSLRE DIYFVLGEFN DFLQSILQEG SYKLQQVHQY 4320
MKALREEYFD PSMVGWTVKY YEIEENMVEL IKTLLVSFRD VYSEYSVTAA DFASKMSTQV 4380
EQFVSRDIRE YLSMLTDING KWMEKIAELS IVAKETMKSW VTAVAKIMSD YPQQFHSNLQ 4440
DFSDQLSSYY EKFVGESTRL IDLSIQNYHV FLRYITELLR KLQVATANNV SPYIKLAQGE 4500
LMITF 4506
Keyword

KW-0007--Acetylation
KW-0153--Cholesterol metabolism
KW-0162--Chylomicron
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1015--Disulfide bond
KW-0325--Glycoprotein
KW-0358--Heparin-binding
KW-0427--LDL
KW-0443--Lipid metabolism
KW-0445--Lipid transport
KW-0449--Lipoprotein
KW-0564--Palmitate
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0691--RNA editing
KW-0964--Secreted
KW-0732--Signal
KW-0753--Steroid metabolism
KW-1207--Sterol metabolism
KW-0813--Transport
KW-0850--VLDL
Interpro

IPR022176--ApoB100_C
IPR015819--Lipid_transp_b-sht_shell
IPR001747--Lipid_transpt_N
IPR009454--Lipid_transpt_open_b-sht
IPR015816--Vitellinogen_b-sht_N
IPR015255--Vitellinogen_open_b-sht
IPR015817--Vitellinogen_open_b-sht_sub1
IPR015818--Vitellinogen_open_b-sht_sub2
IPR011030--Vitellinogen_superhlx
PROSITE

PS51211--VITELLOGENIN
Pfam

PF12491--ApoB100_C
PF06448--DUF1081
PF09172--DUF1943
PF01347--Vitellogenin_N
Gene Ontology

GO:0015629--C:actin cytoskeleton
GO:0042627--C:chylomicron
GO:0005737--C:cytoplasm
GO:0005783--C:endoplasmic reticulum
GO:0070062--C:extracellular exosome
GO:0005576--C:extracellular region
GO:0005794--C:Golgi apparatus
GO:0034363--C:intermediate-density lipoprotein particle
GO:0034362--C:low-density lipoprotein particle
GO:0034359--C:mature chylomicron
GO:0043025--C:neuronal cell body
GO:0005886--C:plasma membrane
GO:0034361--C:very-low-density lipoprotein particle
GO:0031983--C:vesicle lumen
GO:0012506--C:vesicle membrane
GO:0017127--F:cholesterol transporter activity
GO:0008201--F:heparin binding
GO:0035473--F:lipase binding
GO:0050750--F:low-density lipoprotein particle receptor binding
GO:0005543--F:phospholipid binding
GO:0048844--P:artery morphogenesis
GO:0071379--P:cellular response to prostaglandin stimulus
GO:0071356--P:cellular response to tumor necrosis factor
GO:0033344--P:cholesterol efflux
GO:0042632--P:cholesterol homeostasis
GO:0008203--P:cholesterol metabolic process
GO:0030301--P:cholesterol transport
GO:0009566--P:fertilization
GO:0001701--P:in utero embryonic development
GO:0016042--P:lipid catabolic process
GO:0006629--P:lipid metabolic process
GO:0042158--P:lipoprotein biosynthetic process
GO:0042159--P:lipoprotein catabolic process
GO:0042157--P:lipoprotein metabolic process
GO:0042953--P:lipoprotein transport
GO:0034383--P:low-density lipoprotein particle clearance
GO:0034374--P:low-density lipoprotein particle remodeling
GO:0007399--P:nervous system development
GO:0010886--P:positive regulation of cholesterol storage
GO:0010628--P:positive regulation of gene expression
GO:0010884--P:positive regulation of lipid storage
GO:0010744--P:positive regulation of macrophage derived foam cell differentiation
GO:0009791--P:post-embryonic development
GO:0045540--P:regulation of cholesterol biosynthetic process
GO:0009743--P:response to carbohydrate
GO:0032496--P:response to lipopolysaccharide
GO:0010269--P:response to selenium ion
GO:0009615--P:response to virus
GO:0030317--P:sperm motility
GO:0007283--P:spermatogenesis
GO:0019433--P:triglyceride catabolic process
GO:0006642--P:triglyceride mobilization