dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0050850
Uniprot Accession E9Q401; RYR2_MOUSE; O70181; Q62174; Q62197; Q9ERN6;
Genbank Protein ID NP_076357.2;
Genbank Nucleotide ID NM_023868.2;
Protein Name Ryanodine receptor 2
Protein Synonyms/Alias
Gene Name Ryr2
Gene Synonyms/Alias
Organism Mus musculus(Mouse)
NCBI Taxa ID 10090
Functional Description
(View all)		 Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca(2+) levels due to activation of the L-type calcium channel CACNA1C. The calcium channel activity is modulated by formation of heterotetramers with RYR3. Required for cellular calcium ion homeostasis. Required for embryonic heart development.
Phosphorylation Sites
 dbPAF PTMs: 35 (View all)
PositionPeptidesSourceReferences ( PMIDs )
706STEGYSPYPGGGEEWPhosphoSitePlus22135298
819KFLPPPGYAACYEAVPhosphoSitePlus22135298
823PPGYAACYEAVLPKEPhosphoSitePlus22135298
1223NFGKDVSTLKYFTICdbPTM 3.0;PhosphoSitePlus21659604; 16381945; 23193290; 22135298
1317CAEVFSKSVAGGLPGdbPTM 3.0;PhosphoSitePlus;curated21183079; 16381945; 23193290; 22135298
1341LEDFDVDSDFEVLMKPhosphoPep 2.0;PhosphoSitePlus;UniProt;curated19060867; 22135298; 21183079
1402PDYSTGHSARLTEDVPhosphoSitePlus22135298
1495VCAGESMSPGQGRNNdbPTM 3.0;PHOSIDA;PhosphoSitePlus20415495; 16381945; 23193290; 21081558; 22135298
1864VPEEEGGTPEKEISIdbPTM 3.0;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;curated20415495; 21183079; 16381945; 23193290; 21081558; 19060867;
1870GTPEKEISIEDAKLEPHOSIDA;PhosphoSitePlus21081558; 22135298
2030TIRGRLLSLVEKVTYdbPTM 3.0;Phospho.ELM 9.0;PhosphoSitePlus;curated15790957; 16483256; 17693412; 21183079; 16381945; 23193290;
2362DPSRDGPSPTSGSSKdbPTM 3.0;PHOSIDA;PhosphoSitePlus;curated20415495; 16381945; 23193290; 21081558; 22135298; 20047950
2367GPSPTSGSSKTLDIEdbPTM 3.0;PhosphoPep 2.0;PhosphoSitePlus;curated21183079; 16381945; 23193290; 19060867; 22135298
2368PSPTSGSSKTLDIEEdbPTM 3.0;PhosphoSitePlus;UniProt;curated21183079; 16381945; 23193290; 22135298; 20047950
2692VSMMEKQSSMDSEGNPhosphoPep 2.0;curated19060867; 21183079; 25521595
2693SMMEKQSSMDSEGNFPhosphoPep 2.0;curated19060867; 25521595; 23882026
2696EKQSSMDSEGNFNPQPhosphoSitePlus;curated22135298; 25521595
2796ERTREGDSMALYNRTdbPTM 3.0;PhosphoPep 2.0;PhosphoSitePlus;UniProt;curated21183079; 16381945; 23193290; 19060867; 22135298
2807YNRTRRISQTSQVSIdbPTM 3.0;Phospho.ELM 9.0;PhosphoPep 2.0;PhosphoSitePlus;curated20431056; 21098440; 16381945; 23193290; 15790957; 16407108;
2809RTRRISQTSQVSIDAdbPTM 3.0;PhosphoPep 2.0;PhosphoSitePlus;curated21183079; 16381945; 23193290; 19060867; 22135298; 23882026
Sequence
(Fasta)		MADAGEGEDE IQFLRTDDEV VLQCTATIHK EQQKLCLAAE GFGNRLCFLE STSNSKNVPP 60
DLSICTFVLE QSLSVRALQE MLANTVEKSE GQVDVEKWKF MMKTAQGGGH RTLLYGHAIL 120
LRHSYSGMYL CCLSTSRSST DKLAFDVGLQ EDTTGEACWW TIHPASKQRS EGEKVRVGDD 180
LILVSVSSER YLHLSYGNSS WHVDAAFQQT LWSVAPISSG SEAAQGYLIG GDVLRLLHGH 240
MDECLTVPSG EHGEEQRRTV HYEGGAVSVH ARSLWRLETL RVAWSGSHIR WGQPFRLRHV 300
TTGKYLSLME DKNLLLMDKE KADVKSTAFA FRSSKEKLDV GVRKEVDGMG TSEIKYGDSI 360
CYIQHVDTGL WLTYQAVDVK SARMGSIQRK AIMHHEGHMD DGLNLSRSQH EESRTARVIR 420
STVFLFNRFI RGLDALSKKV KLPTIDLPIE SVSLSLQDLI GYFHPPDEHL EHEDKQNRLR 480
ALKNRQNLFQ EEGMINLVLE CIDRLHVYSS AAHFADVAGR EAGESWKSIL NSLYELLAAL 540
IRGNRKNCAQ FSGSLDWLIS RLERLEASSG ILEVLHCVLV ESPEALNIIK EGHIKSIISL 600
LDKHGRNHKV LDVLCSLCVC HGVAVRSNQH LICDNLLPGR DLLLQTRLVN HVSSMRPNIF 660
LGVSEGSAQY KKWYYELMVD HTEPFVTAEA THLRVGWAST EGYSPYPGGG EEWGGNGVGD 720
DLFSYGFDGL HLWSGCIART VSSPNQHLLR TDDVISCCLD LSAPSISFRI NGQPVQGMFE 780
NFNIDGLFFP VVSFSAGIKV RFLLGGRHGE FKFLPPPGYA ACYEAVLPKE KLKVEHSREY 840
KQERTYTRDL LGPTVSLTQA AFTPVPVDTS QIVLPPHLER IRERLAENIH ELWVMNKIEL 900
GWQYGPVRDD NKRQHPCLVE FCKLPEQERN YNLQMSLETL KTLLALGCHV GIADEHAEEK 960
VKKMKLPKNY QLTSGYKPAP MDLSFIKLTP SQEAMVDKLA ENAHNVWARD RIRQGWTYGI 1020
QQDVKNRRNP RLVPYTLLDD RTKKSNKDSL REAVRTLLGY GYHLEAPDQD HASRAEVCSG 1080
TGERFRIFRA EKTYAVKAGR WYFEFEAVTA GDMRVGWSRP GCQPDLELGS DDRAFAFDGF 1140
KAQRWHQGNE HYGRSWQAGD VVGCMVDMNE HTMMFTLNGE ILLDDSGSEL AFKDFDVGDG 1200
FIPVCSLGVA QVGRMNFGKD VSTLKYFTIC GLQEGYEPFA VNTNRDITMW LSKRLPQFLQ 1260
VPSNHEHIEV TRIDGTIDSS PCLKVTQKSF GSQNNNTDIM FYRLSMPIEC AEVFSKSVAG 1320
GLPGAGFYGP KNDLEDFDVD SDFEVLMKTA HGHLVPDRID KDKETPKPEF NNHKDYAQEK 1380
PSRLKQRFLL RRTKPDYSTG HSARLTEDVL ADDRDDYEYL MQTSTYYYSV RIFPGQEPAN 1440
VWVGWITSDF HQYDTGFDLD RVRTVTVTLG DEKGKVHESI KRSNCYMVCA GESMSPGQGR 1500
NNSNGLEIGC VVDAASGLLT FIANGKELST YYQVEPSTKL FPAVFAQATS PNVFQFELGR 1560
IKNVMPLSAG LFKSEHKNPV PQCPPRLHVQ FLSHVLWSRM PNQFLKVDVS RISERQGWLV 1620
QCLDPLQFMS LHIPEENRSV DILELTEQEE LLQFHYHTLR LYSAVCALGN HRVAHALCSH 1680
VDEPQLLYAI ENKYMPGLLR AGYYDLLIDI HLSSYATARL MMNNEFIVPM TEETKSITLF 1740
PDENKKHGLP GIGLSTSLRP RMRFSSPSFV SISNDCYQYS PEFPLDILKA KTIQMLTEAV 1800
KEGSLHARDP VGGTTEFLFV PLIKLFYTLL IMGIFHNEDL KHILQLIEPS VFKEAAVPEE 1860
EGGTPEKEIS IEDAKLEGEE EAKGGKRPKE GLLQMKLPEP VKLQMCLLLQ YLCDCQVRHR 1920
IEAIVAFSDD FVAKLQDNQR FRYNEVMQAL NMSAALTARK TREFRSPPQE QINMLLNFKD 1980
DKSECPCPEE IRDQLLDFHE DLMTHCGIEL DEDGSLDGSN DLTIRGRLLS LVEKVTYLKK 2040
KQAEKPVASD SRKCSSLQQL ISETMVRWAQ ESVIEDPELV RAMFVLLHRQ YDGIGGLVRA 2100
LPKTYTINGV SVEDTINLLA SLGQIRSLLS VRMGKEEEKL MIRGLGDIMN NKVFYQHPNL 2160
MRALGMHETV MEVMVNVLGG GESKEITFPK MVANCCRFLC YFCRISRQNQ KAMFDHLSYL 2220
LENSSVGLAS PAMRGSTPLD VAAASVMDNN ELALALREPD LEKVVRYLAG CGLQSCQMLV 2280
SKGYPDIGWN PVEGERYLDF LRFAVFCNGE SVEENANVVV RLLIRRPECF GPALRGEGGN 2340
GLLAAMEEAI KIAEDPSRDG PSPTSGSSKT LDIEEEEDDT IHMGNAIMTF YAALIDLLGR 2400
CAPEMHLIHA GKGEAIRIRS ILRSLIPLGD LVGVISIAFQ MPTIAKDGKV VEPDMSAGFC 2460
PDHKAAMVLF LDRVYGIEVQ DFLLHLLEVG FLPDLRAAAS LDTAALSATD MALALNRYLC 2520
TAVLPLLTRC APLFAGTEHH ASLIDSLLHT VYRLSKGCSL TKAQRDSIEV CLLSICGQLR 2580
PSMMQHLLRR LVFDVPLLNE HAKMPLKLLT NHYERCWKYY CLPGGWGNFG AASEEELHLS 2640
RKLFWGIFDA LSQKKYEQEL FKLALPCLSA VAGALPPDYM ESNYVSMMEK QSSMDSEGNF 2700
NPQPVDTSNI TIPEKLEYFI NKYAEHSHDK WSMDKLANGW IYGEIYSDSS KIQPLMKPYK 2760
LLSEKEKEIY RWPIKESLKT MLAWGWRIER TREGDSMALY NRTRRISQTS QVSIDAAHGY 2820
SPRAIDMSNV TLSRDLHAMA EMMAENYHNI WAKKKKLELE SKGGGNHPLL VPYDTLTAKE 2880
KAKDREKAQD IFKFLQISGY VVSRGFKDLD LDTPSIEKRF AYSFLQQLIR YVDEAHQYIL 2940
EFDGGSRSKG EHFPYEQEIK FFAKVVLPLI DQYFKNHRLY FLSAASRPLC TGGHASNKEK 3000
EMVTSLFCKL GVLVRHRISL FGNDATSIVN CLHILGQTLD ARTVMKTGLD SVKSALRAFL 3060
DNAAEDLEKT MENLKQGQFT HTRSQPKGVT QIINYTTVAL LPMLSSLFEH IGQHQFGEDL 3120
ILEDVQVSCY RILTSLYALG TSKSIYVERQ RSALGECLAA FAGAFPIAFL ETHLDKHNVY 3180
SIYNTRSSRE RAALSLPANV EDVCPNIPSL EKLMTEIIEL AESGIRYTQM PYMMEVVLPM 3240
LCSYMSRWWE HGPENHPERA EMCCTALNSE HMNTLLGNIL KIIYNNLGID EGAWMKRLAV 3300
FSQPIINKVK PQLLKTHFLP LMEKLKKKAA MVVSEEDHLK AEARGDMSEA ELLILDEFTT 3360
LARDLYAFYP LLIRFVDYNR AKWLKEPNPE AEELFRMVAE VFIYWSKSHN FKREEQNFVV 3420
QNEINNMSFL ITDTKSKMSK AAISDQERKK MKRKGDRYSM QTSLIVAALK RLLPIGLNIC 3480
APGDQELIAL AKNRFSLKDT EEEVRDIIRS NIHLQGKLED PAIRWQMALY KDLPNRTEDP 3540
SDPERTVERV LGIANVLFHL EQKSKYTGRG YFSLVEHPQR SKKAVWHKLL SKQRKRAVVA 3600
CFRMAPLYNL PRHRAVNLFL QGYEKSWIET EEHYFEDKLI EDLAKPGAEL PEEDEAMKRV 3660
DPLHQLILLF SRTALTEKCK LEEDFLYMAY ADIMAKSCHD EEDDDGEEEV KSFEEKEMEK 3720
QKLLYQQARL HDRGAAEMVL QTISASKGET GPMVAATLKL GIAILNGGNS TVQQKMLDYL 3780
KEKKDVGFFQ SLAGLMQSCS VLDLNAFERQ NKAEGLGMVT EEGSGEKVLQ DDEFTCDLFR 3840
FLQLLCEGHN SDFQNYLRTQ TGNNTTVNII ISTVDYLLRV QESISDFYWY YSGKDIIDEQ 3900
GQRNFSKAIQ VAKQVFNTLT EYIQGPCTGN QQSLAHSRLW DAVVGFLHVF AHMQMKLSQD 3960
SSQIELLKEL MDLQKDMVVM LLSMLEGNVV NGTIGKQMVD MLVESSNNVE MILKFFDMFL 4020
KLKDLTSSDT FKEYDPDGKG VISKRDFHKA MESHKHYTQS ETEFLLSCAE TDENETLDYE 4080
EFVKRFHEPA KDIGFNVAVL LTNLSEHMPN DTRLQTFLEL AESVLNYFQP FLGRIEIMGS 4140
AKRIERVYFE ISESSRTQWE KPQVKESKRQ FIFDVVNEGG EKEKMELFVN FCEDTIFEMQ 4200
LAAQISESDL NERLANKEES EKERPEEQAP RMGFFSLLTI QSALFALRYN VLTLVRMLSL 4260
KSLKKQMKRM KKMTVKDMVL AFFSSYWSVF VTLLHFVASV CRGFFRIVSS LLLGGSLVEG 4320
AKKIKVAELL ANMPDPTQDE VRGDEEEGER KPLESALPSE DLTDLKELTE ESDLLSDIFG 4380
LDLKREGGQY KLIPHNPNAG LSDLMTNPVP VPEVQEKFQE QKAKEEKEEK EETKSEPEKA 4440
EGEDGEKEEK AKDEKSKQKL RQLHTHRYGE PEVPESAFWK KIIAYQQKLL NYFARNFYNM 4500
RMLALFVAFA INFILLFYKV STSSVVEGKE LPTRTSSDTA KVTNSLDSSP HRIIAVHYVL 4560
EESSGYMEPT LRILAILHTI ISFFCIIGYY CLKVPLVIFK REKEVARKLE FDGLYITEQP 4620
SEDDIKGQWD RLVINTQSFP NNYWDKFVKR KVMDKYGEFY GRDRISELLG MDKAALDFSD 4680
AREKKKPKKD SSLSAVLNSI DVKYQMWKLG VVFTDNSFLY LAWYMTMSVL GHYNNFFFAA 4740
HLLDIAMGFK TLRTILSSVT HNGKQLVLTV GLLAVVVYLY TVVAFNFFRK FYNKSEDGDT 4800
PDMKCDDMLT CYMFHMYVGV RAGGGIGDEI EDPAGDEYEI YRIIFDITFF FFVIVILLAI 4860
IQGLIIDAFG ELRDQQEQVK EDMETKCFIC GIGNDYFDTV PHGFETHTLQ EHNLANYLFF 4920
LMYLINKDET EHTGQESYVW KMYQERCWEF FPAGDCFRKQ YEDQLN 4967
Keyword

KW-0002--3D-structure
KW-0106--Calcium
KW-0107--Calcium channel
KW-0109--Calcium transport
KW-0112--Calmodulin-binding
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0407--Ion channel
KW-0406--Ion transport
KW-1071--Ligand-gated ion channel
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0703--Sarcoplasmic reticulum
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0813--Transport
Interpro

IPR001870--B30
2/SPRY--
IPR013320--ConA-like_dom
IPR011992--EF-hand-dom_pair
IPR002048--EF_hand_dom
IPR014821--Ins145_P3_rcpt
IPR005821--Ion_trans_dom
IPR016093--MIR_motif
IPR013662--RIH_assoc-dom
IPR000699--RIH_dom
IPR013333--Ryan_recept
IPR003032--Ryanodine_rcpt
IPR015925--Ryanodine_recept-rel
IPR009460--Ryanrecept_TM4-6
IPR003877--SPRY_dom
PROSITE

PS50188--B302_SPRY
PS50919--MIR
Pfam

PF08709--Ins145_P3_rec
PF00520--Ion_trans
PF02815--MIR
PF08454--RIH_assoc
PF06459--RR_TM4-6
PF01365--RYDR_ITPR
PF02026--RyR
PF00622--SPRY
Gene Ontology

GO:0034704--C:calcium channel complex
GO:0070062--C:extracellular exosome
GO:0016021--C:integral component of membrane
GO:0016020--C:membrane
GO:0043234--C:protein complex
GO:0030017--C:sarcomere
GO:0016529--C:sarcoplasmic reticulum
GO:0033017--C:sarcoplasmic reticulum membrane
GO:0005790--C:smooth endoplasmic reticulum
GO:0030018--C:Z disc
GO:0005262--F:calcium channel activity
GO:0005509--F:calcium ion binding
GO:0048763--F:calcium-induced calcium release activity
GO:0015278--F:calcium-release channel activity
GO:0005516--F:calmodulin binding
GO:0019899--F:enzyme binding
GO:0042802--F:identical protein binding
GO:0005218--F:intracellular ligand-gated calcium channel activity
GO:0097159--F:organic cyclic compound binding
GO:0034236--F:protein kinase A catalytic subunit binding
GO:0034237--F:protein kinase A regulatory subunit binding
GO:0019901--F:protein kinase binding
GO:0043621--F:protein self-association
GO:0005219--F:ryanodine-sensitive calcium-release channel activity
GO:0043924--F:suramin binding
GO:0030509--P:BMP signaling pathway
GO:0070588--P:calcium ion transmembrane transport
GO:0006816--P:calcium ion transport
GO:0060402--P:calcium ion transport into cytosol
GO:0019722--P:calcium-mediated signaling
GO:0035584--P:calcium-mediated signaling using intracellular calcium source
GO:0060070--P:canonical Wnt signaling pathway
GO:0060048--P:cardiac muscle contraction
GO:0003300--P:cardiac muscle hypertrophy
GO:0006874--P:cellular calcium ion homeostasis
GO:0071313--P:cellular response to caffeine
GO:0071872--P:cellular response to epinephrine stimulus
GO:0060401--P:cytosolic calcium ion transport
GO:0005513--P:detection of calcium ion
GO:0003143--P:embryonic heart tube morphogenesis
GO:0072599--P:establishment of protein localization to endoplasmic reticulum
GO:0003220--P:left ventricular cardiac muscle tissue morphogenesis
GO:1901896--P:positive regulation of calcium-transporting ATPase activity
GO:0010460--P:positive regulation of heart rate
GO:0051284--P:positive regulation of sequestering of calcium ion
GO:0098735--P:positive regulation of the force of heart contraction
GO:0086029--P:Purkinje myocyte to ventricular cardiac muscle cell signaling
GO:0098910--P:regulation of atrial cardiac muscle cell action potential
GO:0098904--P:regulation of AV node cell action potential
GO:0055117--P:regulation of cardiac muscle contraction
GO:0010882--P:regulation of cardiac muscle contraction by calcium ion signaling
GO:0010881--P:regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
GO:0002027--P:regulation of heart rate
GO:0098907--P:regulation of SA node cell action potential
GO:0098911--P:regulation of ventricular cardiac muscle cell action potential
GO:0051209--P:release of sequestered calcium ion into cytosol
GO:0014808--P:release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:0031000--P:response to caffeine
GO:0001666--P:response to hypoxia
GO:0014850--P:response to muscle activity
GO:0035994--P:response to muscle stretch
GO:0051775--P:response to redox state
GO:0097050--P:type B pancreatic cell apoptotic process
GO:0086005--P:ventricular cardiac muscle cell action potential