dbPAF - database of Phospho-sites in Animals and Fungi

Protein
Gene
PTMs
Sequence
Keyword
GO
TOP

dbPAF Protein Information

Tag

Content

dbPAF ID

dbPAF-0050840

Uniprot Accession

E9Q3L2; E9Q3L2_MOUSE;

Genbank Protein ID

NP_001001983.2;

Genbank Nucleotide ID

NM_001001983.2;

Protein Name

Protein Pi4ka

Protein Synonyms/Alias

Gene Name

Pi4ka

Gene Synonyms/Alias

Organism

Mus musculus(Mouse)

NCBI Taxa ID

10090

Functional Description
(View all)

Phosphorylation Sites

dbPAF PTMs: 22 (View all)

Position	Peptides	Source	References ( PMIDs )
172	LEGVRRRSFNDFRSI	PHOSIDA;PhosphoSitePlus;curated	21081558; 22135298; 23684622; 22817900; 21183079; 22807455;
192	LTVCQEGTLKRKTSS	PhosphoSitePlus;curated	22135298; 22817900; 21183079
197	EGTLKRKTSSVSSIS	PHOSIDA;PhosphoSitePlus;curated	21081558; 22135298; 23684622; 23567750
198	GTLKRKTSSVSSISQ	PHOSIDA;PhosphoSitePlus;SysPTM 2.0;curated	21081558; 22135298; 17242355; 19366988; 23684622; 22817900;
199	TLKRKTSSVSSISQV	PHOSIDA;PhosphoSitePlus;SysPTM 2.0;curated	21081558; 22135298; 17242355; 19366988; 23684622; 22817900;
201	KRKTSSVSSISQVSP	PhosphoSitePlus;SysPTM 2.0;curated	22135298; 17242355; 19366988; 23684622; 22817900; 21183079;
202	RKTSSVSSISQVSPE	PHOSIDA;PhosphoSitePlus;SysPTM 2.0;curated	21081558; 22135298; 17242355; 19366988; 23684622; 22817900;
204	TSSVSSISQVSPERG	PHOSIDA;PhosphoSitePlus;curated	21081558; 22135298; 23684622; 25338131
207	VSSISQVSPERGIPP	PHOSIDA;PhosphoSitePlus;SysPTM 2.0;curated	21081558; 22135298; 18056256; 19366988; 22817900; 21183079;
476	QYHTVAGSDIKISVT	PhosphoSitePlus;curated	22135298; 23684622; 25338131
487	ISVTNEHSESTLNVL	curated	25338131
849	EYMRVLRSTDPDRFQ	PhosphoSitePlus	22135298
850	YMRVLRSTDPDRFQV	PhosphoSitePlus	22135298
872	KAIQKDKSGMMQCVI	PHOSIDA	21081558
973	DIHKDQPYYDIPDAP	PhosphoSitePlus	22135298
988	YRITVPDTYEARESI	PhosphoSitePlus	22135298
1311	ADVVPNATIRNVLRE	PhosphoSitePlus	22135298
1364	FSDKKYLTASQLVPP	PHOSIDA;curated	21081558; 25521595
1366	DKKYLTASQLVPPDN	PHOSIDA;PhosphoSitePlus;SysPTM 2.0;curated	21081558; 22135298; 18056256; 19366988; 25521595; 25338131
1378	PDNQDTRSNLDITVG	PHOSIDA;PhosphoSitePlus;SysPTM 2.0;curated	21081558; 22135298; 17242355; 19366988; 21743459; 22817900;

Sequence
(Fasta)

MCPVDFHGIF QLDERRRDAV IALGIFLIES DLQHKDCVVP YLLRLLRGLP KVYWVEESTA 60
RKGRGNLPVA ESFSFCLVTL LSDVACRDPS LRDEILEAIL QVLHVLLGMC QALEIQEKEY 120
LCKYAIPCLI GISRSFGRYS NSEESLLSKL FPKVSPHSLR IPEELEGVRR RSFNDFRSIL 180
PSNLLTVCQE GTLKRKTSSV SSISQVSPER GIPPPSSPGG SAFHYFEASC LPDGTALEPE 240
YYFSTISSSF SISPLFNGIT YKEFCIPLEM LRELLNLVKK IVEEPVLKSL DAIVAGVMEA 300
NPSADLYYTT FSDPLYLTMF KMLRDTLYYM KDLPTSFVKE IHDFVLEQFN MSQGELQKIL 360
HDADRIHSEM SPLKLRCQAN AACVDLMVWA VKDEQGAENL CIKLSEKLQS KTSSKVIIAH 420
LPLLICCLQG LGRLCERFPV VVHSVTPSLR DFLVIPSPVL VKLYKYHSQY HTVAGSDIKI 480
SVTNEHSEST LNVLPGKKNQ PSMYEQLRDI AIDNICRCLK AGLTVDPVIV EAFLASLSNR 540
LYISQESDKD AHLIPDHTIR ALGHIAVALR DTPKVMEPIL QILQQKFCQP PSPLDVLIID 600
QLGCLVITGN QYIYQEVWNL FQQISVKASS VVYSATKDYK DHGYRHCSLA VINALANIAA 660
NIQEEHLVDE LLMNLLELFV QLGLEGKRAS ERASEKGPAL KASSSAGNLG VLIPVIAVLT 720
RRLPPIKEAK PRLQKLFRDF WLYSVLMGFA VEGSGLWPEE WYEGVCEIAT KSPLLTFPSK 780
EPLRSVLQYN SAMKNDTVTP AELSELRSTI INLLDPPPEV SALINKLDFA MSTYLLSVYR 840
LEYMRVLRST DPDRFQVMFC YFEDKAIQKD KSGMMQCVIA VADKVFDAFL NMMAEKAKTK 900
ENEEELERHA QFLLVNFNHI HKRIRRVADK YLSGLVDKFP HLLWSGTVLK TMLDILQTLS 960
LSLSADIHKD QPYYDIPDAP YRITVPDTYE ARESIVKDFA ARCGMILQEA MKWAPTVTKS 1020
HLQEYLNKHQ NWVSGLSQHT GLAMATESIL HFAGYNKQNT TLGATQLTER PACVKKDYSN 1080
FMASLNLRNR YAGEVHGMIR FSGATGQMSD LNKMMVQDLI TALDHSHPQH YTQAMFKLTA 1140
MLISSKDCDP QLLHHLCWGP LRMFNEHGME TALACWEWLL AGKNGVEVPF MREMAGAWHM 1200
TVEQKFGLFS VETKEADPLA ASEASQPRPC PPEVTPHYIW IDFLVQRFEI AKYCSSDQVE 1260
IFSSLLQRSM SLNIGGARGS MNRHVAAIGP RFKLLTLGLS LLHADVVPNA TIRNVLREKI 1320
YSTAFDYFSC PPKFPTQGEK RLREDISIMI KFWTAMFSDK KYLTASQLVP PDNQDTRSNL 1380
DITVGSRQQA TQGWINTYPL SSGMSTISKK SGMSKKTNRG SQLHKYYMKR RTLLLSLLAT 1440
EIERLITWYN PLSAPELELD QAGENSVANW RSKYISLSEK QWKDNVNLAW SISPYLAVQL 1500
PARFKNTEAI GNEVTRLVRL DPGAVSDVPE AIKFLVTWHT IDADAPELSH VLCWAPTDPP 1560
TGLSYFSSMY PPHPLTAQYG VKVLRSFPPD AILFYIPQIV QALRYDKMGY VREYILWAAA 1620
KSQLLAHQFI WNMKTNIYLD EEGHQKDPDI GDLLEQLVEE ITGSLSGPAK DFYQREFDFF 1680
NKITNVSAII KPYPKGDERK KACLSALSEV KVQPGCYLPS NPEAIVLDID YKSGTPMQSA 1740
AKAPYLAKFK VKRCGVSELE KEGLQCRSDA EDECFSQEAD GKKICWQAAI FKVGDDCRQD 1800
MLALQIIDLF KNIFQLVGLD LFVFPYRVVA TAPGCGVIEC IPDCTSRDQL GRQTDFGMYD 1860
YFTRQYGDES TLAFQQARYN FIRSMAAYSL LLFLLQIKDR HNGNIMLDKK GHIIHIDFGF 1920
MFESSPGGNL GWEPDIKLTD EMVMIMGGKM EATPFKWFME MCVRGYLAVR PYMDAVVSLV 1980
TLMLDTGLPC FRGQTIKLLK HRFSPNMTER EAANFIMKVI QNCFLSNRSR TYDMIQYYQN 2040
DIPY 2045

Fasta Sequence

>E9Q3L2|Pi4ka|Mus musculus(Mouse)
MCPVDFHGIFQLDERRRDAVIALGIFLIESDLQHKDCVVPYLLRLLRGLPKVYWVEESTARKGRGNLPVAESFSFCLVTLLSDVACRDPSLRDEILEAILQVLHVLLGMCQALEIQEKEYLCKYAIPCLIGISRSFGRYSNSEESLLSKLFPKVSPHSLRIPEELEGVRRRSFNDFRSILPSNLLTVCQEGTLKRKTSSVSSISQVSPERGIPPPSSPGGSAFHYFEASCLPDGTALEPEYYFSTISSSFSISPLFNGITYKEFCIPLEMLRELLNLVKKIVEEPVLKSLDAIVAGVMEANPSADLYYTTFSDPLYLTMFKMLRDTLYYMKDLPTSFVKEIHDFVLEQFNMSQGELQKILHDADRIHSEMSPLKLRCQANAACVDLMVWAVKDEQGAENLCIKLSEKLQSKTSSKVIIAHLPLLICCLQGLGRLCERFPVVVHSVTPSLRDFLVIPSPVLVKLYKYHSQYHTVAGSDIKISVTNEHSESTLNVLPGKKNQPSMYEQLRDIAIDNICRCLKAGLTVDPVIVEAFLASLSNRLYISQESDKDAHLIPDHTIRALGHIAVALRDTPKVMEPILQILQQKFCQPPSPLDVLIIDQLGCLVITGNQYIYQEVWNLFQQISVKASSVVYSATKDYKDHGYRHCSLAVINALANIAANIQEEHLVDELLMNLLELFVQLGLEGKRASERASEKGPALKASSSAGNLGVLIPVIAVLTRRLPPIKEAKPRLQKLFRDFWLYSVLMGFAVEGSGLWPEEWYEGVCEIATKSPLLTFPSKEPLRSVLQYNSAMKNDTVTPAELSELRSTIINLLDPPPEVSALINKLDFAMSTYLLSVYRLEYMRVLRSTDPDRFQVMFCYFEDKAIQKDKSGMMQCVIAVADKVFDAFLNMMAEKAKTKENEEELERHAQFLLVNFNHIHKRIRRVADKYLSGLVDKFPHLLWSGTVLKTMLDILQTLSLSLSADIHKDQPYYDIPDAPYRITVPDTYEARESIVKDFAARCGMILQEAMKWAPTVTKSHLQEYLNKHQNWVSGLSQHTGLAMATESILHFAGYNKQNTTLGATQLTERPACVKKDYSNFMASLNLRNRYAGEVHGMIRFSGATGQMSDLNKMMVQDLITALDHSHPQHYTQAMFKLTAMLISSKDCDPQLLHHLCWGPLRMFNEHGMETALACWEWLLAGKNGVEVPFMREMAGAWHMTVEQKFGLFSVETKEADPLAASEASQPRPCPPEVTPHYIWIDFLVQRFEIAKYCSSDQVEIFSSLLQRSMSLNIGGARGSMNRHVAAIGPRFKLLTLGLSLLHADVVPNATIRNVLREKIYSTAFDYFSCPPKFPTQGEKRLREDISIMIKFWTAMFSDKKYLTASQLVPPDNQDTRSNLDITVGSRQQATQGWINTYPLSSGMSTISKKSGMSKKTNRGSQLHKYYMKRRTLLLSLLATEIERLITWYNPLSAPELELDQAGENSVANWRSKYISLSEKQWKDNVNLAWSISPYLAVQLPARFKNTEAIGNEVTRLVRLDPGAVSDVPEAIKFLVTWHTIDADAPELSHVLCWAPTDPPTGLSYFSSMYPPHPLTAQYGVKVLRSFPPDAILFYIPQIVQALRYDKMGYVREYILWAAAKSQLLAHQFIWNMKTNIYLDEEGHQKDPDIGDLLEQLVEEITGSLSGPAKDFYQREFDFFNKITNVSAIIKPYPKGDERKKACLSALSEVKVQPGCYLPSNPEAIVLDIDYKSGTPMQSAAKAPYLAKFKVKRCGVSELEKEGLQCRSDAEDECFSQEADGKKICWQAAIFKVGDDCRQDMLALQIIDLFKNIFQLVGLDLFVFPYRVVATAPGCGVIECIPDCTSRDQLGRQTDFGMYDYFTRQYGDESTLAFQQARYNFIRSMAAYSLLLFLLQIKDRHNGNIMLDKKGHIIHIDFGFMFESSPGGNLGWEPDIKLTDEMVMIMGGKMEATPFKWFMEMCVRGYLAVRPYMDAVVSLVTLMLDTGLPCFRGQTIKLLKHRFSPNMTEREAANFIMKVIQNCFLSNRSRTYDMIQYYQNDIPY

Keyword

KW-0181--Complete proteome
KW-0418--Kinase
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0808--Transferase

Interpro

IPR016024--ARM-type_fold
IPR011009--Kinase-like_dom
IPR000403--PI3/4_kinase_cat_dom
IPR018936--PI3/4_kinase_CS
IPR015433--PI_Kinase
IPR001263--PInositide-3_kin_accessory_dom

PROSITE

PS00915--PI3_4_KINASE_1
PS00916--PI3_4_KINASE_2
PS50290--PI3_4_KINASE_3
PS51545--PIK_HELICAL

Pfam

PF00454--PI3_PI4_kinase
PF00613--PI3Ka

Gene Ontology

GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0005925--C:focal adhesion
GO:0016020--C:membrane
GO:0005886--C:plasma membrane
GO:0004430--F:1-phosphatidylinositol 4-kinase activity
GO:0046854--P:phosphatidylinositol phosphorylation
GO:0048015--P:phosphatidylinositol-mediated signaling