dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0050809
Uniprot Accession E9Q286; ICE1_MOUSE; Q6ZQ20;
Genbank Protein ID NP_659086.2;
Genbank Nucleotide ID NM_144837.3;
Protein Name Little elongation complex subunit 1
Protein Synonyms/Alias Interactor of little elongator complex ELL subunit 1;
Gene Name Ice1
Gene Synonyms/Alias Kiaa0947;
Organism Mus musculus(Mouse)
NCBI Taxa ID 10090
Functional Description
(View all)		 Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III. Specifically acts as a scaffold protein that promotes the LEC complex formation and recruitment and RNA polymerase II occupancy at snRNA genes in subnuclear bodies (By similarity).
Phosphorylation Sites
 dbPAF PTMs: 17
PositionPeptidesSourceReferences ( PMIDs )
303AFCEERHSEVSGQRPPhosphoSitePlus22135298
399YTAESRAYFDLLEKIPhosphoSitePlus22135298
676ENSLSTLSPKSKLGTPhosphoSitePlus;UniProt;curated22135298; 21183079; 21743459; 25338131
754AGFTRRSSGSADSTScurated25338131
761SGSADSTSWHRSDVLPhosphoSitePlus22135298
914ICDSPSDSLLAENFSPhosphoSitePlus;curated22135298; 21183079
1577MAGTDRSTPTNCSPDPhosphoSitePlus;curated22135298; 21183079
1582RSTPTNCSPDTLSKIPhosphoSitePlus;UniProt;curated22135298; 21183079
1607LLPPLIATPPRSSQTPhosphoSitePlus;UniProt;curated22135298; 21183079
1616PRSSQTLSPLVPNSGcurated25338131
1629SGPSSRSSPAGHVSPcurated21183079
1676AASGRIVSSPLQFCAPhosphoSitePlus22135298
1677ASGRIVSSPLQFCAAPhosphoSitePlus;curated22135298; 25338131
1820RLRLDNKSPEPDTREPHOSIDA;PhosphoSitePlus;curated21081558; 22135298; 21183079; 25338131
2205KILEAWRTQTSNAIPPhosphoSitePlus22135298
2207LEAWRTQTSNAIPSAPhosphoSitePlus22135298
2208EAWRTQTSNAIPSAIPhosphoSitePlus22135298
Sequence
(Fasta)		MMPGETHPAA PGPADLARCQ GCASLQQNLN EYVEALIALK QKIINTDNLL TEYQKKCDEL 60
QFARRENSTL HHQVEQMLQK ISPLQKCQEE LGSLKAELEE KKSSLKLYQD THQEYARVKE 120
ECLRTDAQKK KLEAKVKKLE EAAVKQTQDF KQLRNEKKIL EKEFKKTQER LDEFSKQKNE 180
KELRHIGTQI SSDSHGSIDK RKVKVLLKEL WLCVNTAHRL SGEGGRRIPE KPAKGSSAAR 240
ASEQDELLPV QGGPARAADM RSFFSKLSME MEGDFSSSES AEEELPSGAS PSTEHAFCEE 300
RHSEVSGQRP DDGNRTNVYD HEHFFDDDLQ AAIDFFKLPP PLLSPVPSPP PMASGSLPSS 360
LAPESFFGEF TDSSDSDSVP PRDSMESALE DYTAESRAYF DLLEKIKRSD QYVKKPGSLE 420
ATQAVNSLTP LGFVTGRTAL GEPSAAASLA QGRHWTESSE FVRDRGDSVE EAERMVEARE 480
VDKSVQVGKG LLKHNRKLWL EMASRGPARK KEAGAGESEI CFSSLGKRTF SELIESEGKT 540
LSSKALCPSQ SEFSKRTLTD GSASKSPCVT GSGRFQRRER DVRESTPQSG ICAAAAGRGH 600
SARLPSSSSA TSVPVSVCSN HQTPWPGCVS VGTPAEGTCT EQKSPTRTLN TFLLRSEPTA 660
CFPKENDPEN SLSTLSPKSK LGTSTFSDWK SRGLESFSTL KSTAKGHSLP QSVFPKPTGG 720
GQCKGRGPGA TLILPKSDWT SLARSQAGFT RRSSGSADST SWHRSDVLRR GSGGSPRASS 780
EYQQRTRLQL EKATPASQNS SLTAMHGPSG ESTIPPESNA AAALLPNQVS VITKQARPRR 840
VLGSSLEPWQ PHGNTLSPAV NGGKETGLMP SVSACVGDGD PIAQVPEQIA DKETPSPEVS 900
VSWRNPICDS PSDSLLAENF SCSTDRKLPF SSEDNIFQCA MNEHLQQKPT KSPQTTQSGA 960
SRLEAGELLP SGVTSGVFPA EQVPHGPHHQ ADTEAPVVAR ESHSAPQNAS APPVVPSRGP 1020
LRARVPTVPV CPSSLSRAEE ETQGTSQSSL PGASYCYTGI RERGEEDTEV EDEAVSCSEG 1080
EHEAEAVMGR RQQEQAEDSH RPLGDPEAGV GEAGHPSDVG DLTSALEECN LSTLLYIDKL 1140
STSEVVMVLE SCQLGDYSSR VSASECASKG SLSEEMNTEL RQSEISRKKC GKRLWEEKLL 1200
RASEEWAESE GDDSCGRTSC QHAQCPLEVP SDVLTKTGEE LDTNPVDCGG TDTEHALLES 1260
THHSQAAEDL TEDALPEETS SPMPHTAELP DPSAVDGGGS SPLSSRSDPE HIQSSYEDEP 1320
NSGECLSIGE EGLAEPGELL TLSSDSSTPP RLEQSSDCVA ETAFRYQISA VTSEVISVLI 1380
NKDQDLVIEK GDNWTIISGV AISPGMEQVV LCDTLGDAAS SQDQGGLDDG SMEKSPEASP 1440
SGPLPQEPPC GGDLSGAQED ISSNGQSANF DKSRLRNRPV KPSIWIRSQI YDQTLETEKV 1500
ASDHTYYNWK LEPLGKNKPR SKISNKDQAS KLAKTLVLNR GEVHLNEVPQ PASGEGTNIK 1560
LPRSQAQPIM AGTDRSTPTN CSPDTLSKIR QEVGPPLPPL LPPLIATPPR SSQTLSPLVP 1620
NSGPSSRSSP AGHVSPLCEV PGPPVLSPWP EELQQASPLD PSPSPSTAAA SGRIVSSPLQ 1680
FCAATPKHAL PVPGRLPSCA PGHAAVSGPQ QENSVKILDT MYPELSARAR TLSLLKGNMQ 1740
LSRGSTVDGK VLPGRVSALL GLKAITSTST AFVLTGGSSG ADGSQGKSQD SGVQQDAGGK 1800
RTLAVSMLRS AKRLRLDNKS PEPDTREVTG EGVPEDPQGG SPLAEVVPAE EEQADVPVCS 1860
AASLLRVNPR EMAESYNIAI TRALRKIAES SFDLLPVIRS HVYVGNISKK PVMRDQEKEV 1920
VYEFSTTNKH LGEYLLRSIL SELKIQKTSL DHSYIHALCR VYVGICRQLG DLERARLFCY 1980
SLLKEDFPES EKLTLFIANM WREVFLSQSA ISEAMQLVAR QRARGEVLNC LRAFLSWEKN 2040
APIDVGIVVS KLLLTIQLCP KTEFQSSEEF GEDLSANIWE YIFAIDLLCC HQRWIWTHDN 2100
IISKELWPVM DKWIKYRKGH SNIAYTPDVI VASVLRLIGR LGQLGLKEGF PTAVKNISSV 2160
IGMFIQHAQD EDIPWGVQLA AVYALCDLSP SNPAEISKIL EAWRTQTSNA IPSAIVHCLE 2220
EVGSLSADGS AGCTSKGDSA P 2242
Keyword

KW-0007--Acetylation
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
Interpro
PROSITE
Pfam
Gene Ontology

GO:0015030--C:Cajal body
GO:0035363--C:histone locus body
GO:0008023--C:transcription elongation factor complex
GO:0035327--C:transcriptionally active chromatin
GO:0090316--P:positive regulation of intracellular protein transport
GO:0031334--P:positive regulation of protein complex assembly
GO:0045945--P:positive regulation of transcription from RNA polymerase III promoter
GO:0042795--P:snRNA transcription from RNA polymerase II promoter
GO:0042796--P:snRNA transcription from RNA polymerase III promoter