dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0050793
Uniprot Accession E9Q1P8; I2BP2_MOUSE; Q8BJC6;
Genbank Protein ID NP_001158070.1;
Genbank Nucleotide ID NM_001164598.1;
Protein Name Interferon regulatory factor 2-binding protein 2
Protein Synonyms/Alias
Gene Name Irf2bp2
Gene Synonyms/Alias
Organism Mus musculus(Mouse)
NCBI Taxa ID 10090
Functional Description
(View all)		 Acts as a transcriptional corepressor in a IRF2-dependent manner, this repression is not mediated by histone deacetylase activities. Represses the NFAT1-dependent transactivation of NFAT-responsive promoters. Acts as a coactivator of VEGFA expression in cardiac and skeletal muscle (By similarity).
Phosphorylation Sites
 dbPAF PTMs: 37 (View all)
PositionPeptidesSourceReferences ( PMIDs )
15AAASRRQSCYLCDLPPhosphoSitePlus22135298
17ASRRQSCYLCDLPRMcurated21183079; 22807455
71GCFPEGRSPTGAQPAPHOSIDA;PhosphoSitePlus;SysPTM 2.0;curated21081558; 22135298; 17242355; 19366988; 25266776; 21743459;
73FPEGRSPTGAQPAAAPHOSIDA;PhosphoSitePlus;SysPTM 2.0;curated21081558; 22135298; 18846507; 19366988; 25266776
86AAKPPPLSAKDLLLQPHOSIDA;PhosphoSitePlus;curated21081558; 22135298; 25266776; 18846507; 25338131
157ILVPNGFSKLEEPPEPhosphoSitePlus;curated22135298; 22817900; 21183079; 25338131
169PPELNRQSPNPRRAHPhospho.ELM 9.0;PHOSIDA;PhosphoSitePlus;SysPTM 2.0;UniProt;curated19144319; 21081558; 22135298; 18846507; 19366988; 21183079;
208TLAAVSGTPGLGAQPPHOSIDA;PhosphoSitePlus;SysPTM 2.0;curated21081558; 22135298; 18846507; 19366988
226GTHKRPASVSSAAAEPhospho.ELM 9.0;PHOSIDA;PhosphoSitePlus;SysPTM 2.0;UniProt;curated19144319; 21081558; 22135298; 18846507; 19366988; 25266776;
228HKRPASVSSAAAEHEcurated25266776; 23684622; 25338131
229KRPASVSSAAAEHEAPhosphoSitePlus;curated22135298; 25266776; 23567750; 25338131
240EHEAREPSKEKAQPAPHOSIDA;curated21081558; 25266776
250KAQPAHRSPADSLSSPHOSIDA;PhosphoSitePlus;SysPTM 2.0;UniProt;curated21081558; 22135298; 17242355; 19366988; 18846507; 21183079;
254AHRSPADSLSSAAGAPhosphoSitePlus;curated22135298; 25266776; 23567750; 25338131
256RSPADSLSSAAGASEPhosphoSitePlus22135298
257SPADSLSSAAGASELPhosphoSitePlus22135298
262LSSAAGASELSAEGASysPTM 2.0;curated18846507; 19366988; 25266776
300ALHQHGHSGPFESKFcurated21743459
343TARKRKPSPEPEGEVPhospho.ELM 9.0;PHOSIDA;PhosphoSitePlus;SysPTM 2.0;UniProt;curated19144319; 21081558; 22135298; 18846507; 19366988; 21183079;
375EGLKIPITPTSSFVSPHOSIDA;PhosphoSitePlus;curated21081558; 22135298; 25266776; 23684622; 21183079
Sequence
(Fasta)		MAAAVAVAAA SRRQSCYLCD LPRMPWAMIW DFTEPVCRGC VNYEGADRVE FVIETARQLK 60
RAHGCFPEGR SPTGAQPAAA KPPPLSAKDL LLQPPPQLGH AGAEAARAQA MERYPLAPDR 120
APRLASDFST RAGAGLPQSA AQQSAPANGI LVPNGFSKLE EPPELNRQSP NPRRAHAVPP 180
TLVPLVNGSA ALGLSGRAAA TLAAVSGTPG LGAQPAELGT HKRPASVSSA AAEHEAREPS 240
KEKAQPAHRS PADSLSSAAG ASELSAEGAG KGRAPGEQDW ASRPKTVRDT LLALHQHGHS 300
GPFESKFKKE PALTAAGRLL GFEANGANGS KAVARTARKR KPSPEPEGEV GPPKINGETQ 360
PWLSTSTEGL KIPITPTSSF VSPPPPTASP HSNRTTPPEA AQNGQSPMAA LILVADNAGG 420
SHASKDATQV HSTTRRNSSS PPSPSSMNQR RLGPREVGGQ ATGSTGGLEP VHPASLPDSS 480
LAASAPLCCT LCHERLEDTH FVQCPSVPSH KFCFPCSRQS IKQQGASGEV YCPSGEKCPL 540
VGSNVPWAFM QGEIATILAG DVKVKKERDS 571
Keyword

KW-0007--Acetylation
KW-0010--Activator
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR022750--Interferon_reg_fac2-bd1_2_Znf
PROSITE
Pfam

PF11261--IRF-2BP1_2
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0046872--F:metal ion binding
GO:0003714--F:transcription corepressor activity
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0006351--P:transcription, DNA-templated