dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0050759
Uniprot Accession E9PZP8; E9PZP8_MOUSE;
Genbank Protein ID NP_663592.3;
Genbank Nucleotide ID NM_145617.3;
Protein Name Protein Herc1
Protein Synonyms/Alias
Gene Name Herc1
Gene Synonyms/Alias
Organism Mus musculus(Mouse)
NCBI Taxa ID 10090
Functional Description
(View all)
Phosphorylation Sites
 dbPAF PTMs: 44 (View all)
PositionPeptidesSourceReferences ( PMIDs )
133KVKQQQHSPESSSGSPhosphoSitePlus;curated22135298; 25338131
223PMGLDCLSQVTTFLKPhosphoSitePlus22135298
1069MLCQIVNSLLLLPVSPhosphoSitePlus22135298
1318KNLELIQTRSSSRDRPHOSIDA;PhosphoSitePlus;curated21081558; 22135298; 22817900; 21183079
1320LELIQTRSSSRDRWIcurated23684622
1321ELIQTRSSSRDRWITcurated23684622
1322LIQTRSSSRDRWITDcurated23684622
1333WITDNQDSADVDPQEPHOSIDA;PhosphoSitePlus;curated21081558; 22135298; 25338131
1342DVDPQEHSFTRTIDEcurated21183079
1406RDRDRMNSGAGSGVRPhosphoSitePlus;curated22135298; 23684622; 25338131
1428SQQERRVSTDLPEGQPHOSIDA;PhosphoSitePlus;curated21081558; 22135298; 22817900; 21183079; 25338131
1429QQERRVSTDLPEGQDPHOSIDA;PhosphoSitePlus21081558; 22135298
1491GLMTRSESLTAESRLPHOSIDA;PhosphoSitePlus;curated21081558; 22135298; 21743459; 22817900; 21183079; 25521595
1502ESRLVHASPSYRLIKPhosphoSitePlus;curated22135298; 22817900; 21183079; 25338131
1504RLVHASPSYRLIKSRPhosphoSitePlus;curated22135298; 22817900; 21183079
1510PSYRLIKSRSESDLSPhosphoSitePlus;curated22135298; 23567750; 24723360
1512YRLIKSRSESDLSQPPhosphoSitePlus;curated22135298; 22817900; 21183079; 25338131
1514LIKSRSESDLSQPEScurated25338131
1517SRSESDLSQPESDEEPhosphoSitePlus;curated22135298; 22817900; 21183079; 25521595; 25338131
1521SDLSQPESDEEGYALPhosphoSitePlus;curated22135298; 22817900; 21183079; 24723360; 25338131
Sequence
(Fasta)		MATMVPPVKL KWLEHLNSSW ITEDSESIAT REGVTVLYSK LISNKEVVPL PQQVLCLKGP 60
QLPDFERESL SSDEQDHYLD ALLSSQLALA KMVCSDSPFA GALRKRLLVL QRVFYALSNK 120
YHDKGKVKQQ QHSPESSSGS ADVHSVSERP RSSTDALIEM GVRTGLSLLF ALLRQSWMMP 180
VSGPGLSLCN DVIHTAIEVV SSLPPLSLAN ESKIPPMGLD CLSQVTTFLK GVTIPNSGAD 240
TLGRRLASEL LLGLAAQRGS LRYLLEWIEM ALGASAVVYT MEKNKLLSSQ EGMISFDCFM 300
AILMQMRRSL GSSADRSQWR EPTRTSEGLC SLYEAALCLF EEVCRMASDY SRTCASPDSI 360
QTGDAPIVSE TCEVYVWGSN SSHQLVEGTQ EKILQPKLAP SFSDAQTIEA GQYCTFVIST 420
DGSVRACGKG SYGRLGLGDS NNQSTLKKLT FEPHRSIKKV SSSKGSDGHT LAFTTEGEVF 480
SWGDGDYGKL GHGNSSTQKY PKLIQGPLQG KVVVCVSAGY RHSAAVTEDG ELYTWGEGDF 540
GRLGHGDSNS RNIPTLVKDI SNVGEVSCGS SHTIALSKDG RTVWSFGGGD NGKLGHGDTN 600
RVYKPKVIEA LQGMFIRKVC AGSQSSLALT STGQVYAWGC GACLGCGSSE ATALRPKLIE 660
ELAATRIVDI SIGDSHCLSL SHDNEVYAWG NNSMGQCGQG NSTGPITKPK KVSGLDGIAI 720
QQISAGTSHS LAWTALPRDR QVVAWHRPYC VDLEESTFSH LRSFLERYCD KINSEIPPLP 780
FPSSREHHNF LKLCLKLLSN HLALALAGGV ATSILGRQAG PLRNLLFRLM DSTVPDEIQE 840
VVIETLSVGA TMLLPPLRER MELLHSLLPQ GPDRWESLSK GQRMQLDIIL TSLQDHTHVA 900
SLLGYSSPSD AADLSTVCMG YGNLSDQPYG SQICHPDTHL AEILMKTLLR NLGFYTDQAF 960
GELEKNSDKY LLGTSSSENS QPAHLHELLC SLQKQLLAFC HINNVTENSS SVALLHKHLQ 1020
LLLPHATDIY SRSANLLKES PWNGSVGEKL RDVIYVSAAG SMLCQIVNSL LLLPVSVARP 1080
LLSYLLDLLP PLDCLNRLLP AAALLEDQEL QWPLHGGPEV IDPAGVPLPQ PAQSWVWLVD 1140
LERTIALLIG RCLGGMLQGS PVSPEEQDTA YWMKTPLFSD GVEMDTPQLD KCMSCLLEVA 1200
LSGNEEQKPF DYKLRPEVAV YVDLALGCSK EPARSLWISM QDYAVSKDWD SATLSNESLL 1260
DTVSRFVLAA LLKHTNLLSQ ACGESRYQPG KSLSEVYRCV YKVRSRLLAC KNLELIQTRS 1320
SSRDRWITDN QDSADVDPQE HSFTRTIDEE AEMEELAERD REDGHPEPED EEEEREHEVM 1380
TAGKIFQCFL SAREVARSRD RDRMNSGAGS GVRADDPPPQ SQQERRVSTD LPEGQDVYTA 1440
ACNSVIHRCA LLILGVSPVI DELQKRREEG QLQQPSVSAS EGTGLMTRSE SLTAESRLVH 1500
ASPSYRLIKS RSESDLSQPE SDEEGYALSG RRNVDFDLAS SHRKRGPMHS QLESLSDSWT 1560
RLKHTRDWFY NSSYSFESDF DLTKSLGVHT LIENVVSFVS GDVGNAPGFK EPEESMSTSP 1620
QASIIAMEQQ QLRAELRLEA LHQILTLLSG MEEKGNVLLT GSRSSSGFQS STLLTSVRLQ 1680
FLAGCFGLGT VGHTGTKGES GRLHHYQDGI RAAKRNIQVE IQVAVHKIYQ QLSATLERAL 1740
QANKHHIEAQ QRLLLVTVFA LSVHYQPVDV SLAISTGLLN VLSQLCGTDT MLGQPLQLLP 1800
KTGVSQLSTA LKVASTRLLQ ILAITTGTYA DKLSPKVVQS LLDLLCSQLK NLLSQTGVLF 1860
MASFGEGEEG EEEEKKVDSS GEAEKRDFRA ALRKQHAAEL HLGDFLVFLR RVVSSKAIQS 1920
KMASPKWTEV LLNIASQKCS SGIPLVGNLR TRLLALHVLE AVLPACESGV EDDQMAQVVE 1980
RLFSLLSDCM WETPIAQAKH AIQIKEKEQE IKLQKQGELE EEDENLPIQE VSFDPEKAQC 2040
CIVENGQILT HGSGGKGYGL ASTGVTSGCY QWKFYIVKEN RGNEGTCVGV SRWPVHDFNH 2100
RTTSDMWLYR AYSGNLYHNG EQTLTLSSFT QGDFITCVLD MEARTISFGK NGEEPKLAFE 2160
DVDAAELYPC VMFYSSNPGE KVKICDMQMR GTPRDLLPGD PICSPVAAVL AEATIQLIRI 2220
LHRTDRWTYC INKKMMERLH KIKICIKESG QKLKKSRSVQ SREENEMREE KENKEEEKGK 2280
HNRHGLADLS EPQLRTLCIE VWPVLAVIGG VDAGLRVGGR CVHKQTGRHA TLLGVVKEGS 2340
TSAKVQWDEA EITISFPTFW SPSDTPLYNL EPCEPLLFDV ARFRGLTASV LLDLTYLTGI 2400
HEDVGKQSIK RHEKKHRHES EEKGDIEQKP ESESILDVRT GLMSDDVKSQ GTTSSKSENE 2460
IASFSLEPTL PGVESQHQIT EGKRKNHEHI SKTHDIAQSE IRAVQLSYLY LGAMKSLSAL 2520
LGCSKYAELL LIPKVLAENG HNSDCASSPV VHEDVEMRAA LQFLMRHMVK RAVMRSPIKR 2580
ALGLADLERA QAMIYKLVVH GLLEDQFGGK IKQEIDQQAE ESDQAQQAQT PVTTSPSASS 2640
TTSFMSSSLE DTTTATTPVT DTETVPASES PGVMPLSLLR QMFSSYPTTT VLPTRRAQTP 2700
PISSLPASPS DEVGRRQSLT SPDSQSTRPA NRTALSDPSS RLSTSPPPPA IAVPLLEMGF 2760
SLRQIAKAME ATGARGEADA QSITVLAMWM IEHPGHEDEE EPQPSSTADS RHGATVLGSG 2820
GKSNDPCYLQ SPGDIPSADA AEMEEGFSES PDNLDHTENA ASGSGPPTRG RSTVTRRHKF 2880
DLAARTLLAR AAGLYRSVQA HRNQSRREGI SLQQDPGALY DFNLDEELEI DLDDEAMEAM 2940
FGQDLTSDND ILGMWIPEVL DWPTWHVCES EDREEVVVCE LCECNVVSFN QHMKRNHPGC 3000
GRSANRQGYR SNGSYVDGWF GGECGSGNPY YLLCGSCREK YLALKTKTKT TNSERYKGQA 3060
PDLIGKQDSV YEEDWDMLDV DEDEKLTGEE EFELLAGPLG LNDRRIVPEP VQFPDSDPLG 3120
ASVAMVTATN SMEETLMQIG CHGSVEKSSS GRVTLGEQAA ALANPHDRVV ALRRVTAAAQ 3180
VLLARTMVMR ALSLLSVSGS SCSLAAGLES LGLTDIRTLV RLMCLAAAGR AGLSTSPSAI 3240
ASTSERSRGG HSKASKPISC LAYLSTAVGC LASNTPSAAK LLVQLCTQNL ISAATGVNLT 3300
TVDDPIQRKF LPSFLRGIAE ENKLVTSPNF VVTQALVALL ADKGAKLRPN YDKTEIEKKG 3360
PLELANALAA CCLSSRLSSQ HRQWAAQQLV RTLAAHDRDN QTAPQTLADM GGDLRKCSFI 3420
KLEAHQNRVM TCVWCNKKGL LATSGNDGTI RVWNVTKKQY SLQQTCVFNR LEGDAEESLG 3480
SPSDPSFSPV SWSISGKYLA GALEKMVNIW QVNGGKGLVD IQPHWVSALA WPEEGPATTW 3540
SGESPELLLV GRMDGSLGLI EVVDVSTMHR RELEHCYRKD VSVTCIAWFS EDRPFAVGYF 3600
DGKLLMGTKE PLEKGGIVLI DAHKETLVSM KWDPTGHILM TCAKEENVKL WGPVSGCWRC 3660
LHSLCHPSTV NGIAWCSLPG KGSKMQLLMA TGCQNGLVCV WRIPQDTTQT SMTSSEGWWD 3720
QESNCQDGYR KSAGAKCVYQ LRGHITPVRT VAFSSDGLAL VSGGLGGLMN IWSLRDGSVL 3780
QTVVIGSGAI QTTVWIPEVG VAACSNRSKD VLVVNCTAEW ASANHILATC RTALKQQGVL 3840
GLNMAPCMRA FLERLPMMLQ EQYAYEKPHV VCGDQLVHSP YMQCLASLAV GLHLDQLLCN 3900
PPVPPHHQNC LPDPTSWNPN EWAWLECFST TIKAAEALTN GAQFPESFTV PDLEPVPEDE 3960
LVLLMDNSKW INGMDEQIMS WATSRPEDWH LGGKCDVYLW GAGRHGQLAE AGRNVMVPAT 4020
APSFSQAQQV ICGQNCTFVI QANGTVLACG EGSYGRLGQG NSDDLHVLTV ISALQGFVVT 4080
QLVTSCGSDG HSMALTESGE VFSWGDGDYG KLGHGNSDRQ RRPRQIEALQ GEEVVQMSCG 4140
FKHSAVVTSD GKLFTFGNGD YGRLGLGNTS NKKLPERVTA LEGYQIGQVA CGLNHTLAVS 4200
ADGSMVWAFG DGDYGKLGLG NSTAKSSPQK VDVLCGIGIK KVACGTQFSV ALTKDGHVYT 4260
FGQDRLIGLP EGRARNHNRP QQIPVLAGVV IEDVAVGAEH TLALASTGDV YAWGSNSEGQ 4320
LGLGHTNHVR EPTLVTVLQG KNIRQISAGR CHSAAWTAPP VPPRAPGVSV PLQLGLPDAV 4380
PPQYGALREV SIHTVRARLR LLYHFSDLMY SSWRLLNLSP NNQNSTSHYN AGTWGIVQGQ 4440
LRPLLAPRVY TLPMVRSIGK TMVQGKNYGP QITVKRISTR GRKCKPIFVQ IARQVVKLNA 4500
SDLRLPSRAW KVKLVGEGAD DAGGVFDDTI TEMCQELETG IVDLLIPSPN ATAEVGYNRD 4560
RFLFNPSACL DEHLMQFKFL GILMGVAIRT KKPLDLHLAP LVWKQLCCVP LTLEDLEEVD 4620
LLYVQTLNSI LHIEDSGITE ESFHEMIPLD SFVGQSADGK MVPIIPGGNS IPLTFSNRKE 4680
YVERAIEYRL HEMDRQVAAV REGMSWIVPV PLLSLLTAKQ LEQMVCGMPE ICVDVLKKVV 4740
RYREVDEQHQ LVQWLWRTLE EFSNEERVLF MRFVSGRSRL PANTADISQR FQIMKVDRPY 4800
DSLPTSQTCF FQLRLPPYSS QLVMAERLRY AINNCRSIDM DNYMLSRNVD NAEGSDTDY 4860
Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0436--Ligase
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat
Interpro

IPR001870--B30
2/SPRY--
IPR013320--ConA-like_dom
IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens
IPR003877--SPRY_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS50188--B302_SPRY
PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF00632--HECT
PF00415--RCC1
PF00622--SPRY
PF00400--WD40
Gene Ontology

GO:0016874--F:ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0021702--P:cerebellar Purkinje cell differentiation
GO:0010507--P:negative regulation of autophagy
GO:0050885--P:neuromuscular process controlling balance
GO:0031175--P:neuron projection development