dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0050757
Uniprot Accession E9PZM4; CHD2_MOUSE;
Genbank Protein ID NP_001074814.2;
Genbank Nucleotide ID NM_001081345.2;
Protein Name Chromodomain-helicase-DNA-binding protein 2
Protein Synonyms/Alias
Gene Name Chd2
Gene Synonyms/Alias
Organism Mus musculus(Mouse)
NCBI Taxa ID 10090
Functional Description
(View all)		 DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. Involved in myogenesis via interaction with MYOD1: binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression.
Phosphorylation Sites
 dbPAF PTMs: 35 (View all)
PositionPeptidesSourceReferences ( PMIDs )
20SSLHSNASSRSASEEPhosphoSitePlus22135298
21SLHSNASSRSASEEVPhosphoSitePlus22135298
33EEVSGSDSGSQSESEPhosphoSitePlus22135298
68ESQSESESESAGSKSPhosphoSitePlus22135298
70QSESESESAGSKSQPPhosphoSitePlus22135298
88EAKEKPASKKERIADPhosphoSitePlus22135298
129FNVKEEASSGSESGSPhosphoSitePlus;curated22135298; 23684622; 25338131
130NVKEEASSGSESGSPPhosphoSitePlus;curated22135298; 23684622; 25338131
132KEEASSGSESGSPKRPhosphoSitePlus;curated22135298; 23684622; 25338131
134EASSGSESGSPKRRGcurated23684622
136SSGSESGSPKRRGQRcurated25338131
156EKWKQDPSEDEQEQGcurated25338131
165DEQEQGTSAESEAEQcurated25338131
168EQGTSAESEAEQKKGcurated25338131
207GKRKKQESSDDDDDDPHOSIDA;PhosphoSitePlus;UniProt;curated21081558; 22135298; 21183079; 23684622; 20469934; 25338131
208KRKKQESSDDDDDDDPHOSIDA;PhosphoSitePlus;curated21081558; 22135298; 23684622; 21183079; 20469934; 25338131
240KEDDDFETDSDDLIEPhosphoSitePlus;UniProt;curated22135298; 21183079; 25338131
242DDDFETDSDDLIEMTPhosphoSitePlus;UniProt;curated22135298; 21183079; 25338131
774LIKAPEDSERESGQEcurated25338131
960NNSGRSNSNPFNKEEcurated25338131
Sequence
(Fasta)		MMRNKDKSQE EDSSLHSNAS SRSASEEVSG SDSGSQSESE QGSEPGSGHG SESNSSSESS 60
ESQSESESES AGSKSQPVLP EAKEKPASKK ERIADVKKMW EEYPDVYGVR RSNRSRQEPS 120
RFNVKEEASS GSESGSPKRR GQRQLKKQEK WKQDPSEDEQ EQGTSAESEA EQKKGKARRP 180
VPRRTVPKPQ VKKQPKIQRG KRKKQESSDD DDDDDEAPKR QTRRRAAKNV SYKEDDDFET 240
DSDDLIEMTG EGGDEQQDNS ETIEKVLDSR LGKKGATGAS TTVYAVEANG DPSDDFDTER 300
EEGEVQYLIK WKGWSYIHST WESEDSLQQQ KVKGLKKLEN FKKKEDEVKQ WLGKVSPEDV 360
EYFSCQQELA SELNKQYQIV ERVIAVKTSK STLGQTDFPA HSRKPAPSNE PEYLCKWMGL 420
PYSECSWEDE ALIGKKFQNC IDSFHSRNNS KTIPTRECKA LKQRPRFVAL KKQPAYLGGE 480
SLELRDYQLE GLNWLAHSWC KSNSVILADE MGLGKTIQTI SFLSYLFHQH QLYGPFLIVV 540
PLSTLTSWQR EFEIWAPEIN VVVYIGDLMS RNTIREYEWI HSQTKRLKFN ALITTYEILL 600
KDKTVLGSIN WAFLGVDEAH RLKNDDSLLY KTLIDFKSNH RLLITGTPLQ NSLKELWSLL 660
HFIMPEKFEF WEDFEEDHGK GRENGYQSLH KVLEPFLLRR VKKDVEKSLP AKVEQILRVE 720
MSALQKQYYK WILTRNYKAL AKGTRGSTSG FLNIVMELKK CCNHCYLIKA PEDSERESGQ 780
EVLQSLIRSS GKLILLDKLL TRLRERGNRV LIFSQMVRML DILAEYLTIK HYPFQRLDGS 840
IKGEIRKQAL DHFNADGSED FCFLLSTRAG GLGINLASAD TVVIFDSDWN PQNDLQAQAR 900
AHRIGQKKQV NIYRLVTKGT VEEEIIERAK KKMVLDHLVI QRMDTTGRTV LENNSGRSNS 960
NPFNKEELTA ILKFGAEDLF KEIEGEESEP QEMDIDEILR LAETRENEVS TSATDELLSQ 1020
FKVANFATME DEEELEERPH KDWDEIIPEE QRKKVEEEER QKELEEIYML PRIRSSTKKA 1080
QTNDSDSDTE SKRQAQRSSA SESETDDSDD DKKPKRRGRP RSVRKDLVEG FTDAEIRRFI 1140
KAYKKFGLPL ERLECIARDA ELVDKSVADL KRLGELIHNS CVSAMQEYEE QLKESTSEGK 1200
GPGKRRGPTI KISGVQVNVK SIIQHEEEFE MLHKSIPVDP EEKKKYCLTC RVKAAHFDVE 1260
WGVEDDSRLL LGIYEHGYGN WELIKTDPEL KLTDKILPVE TDKKPQGKQL QTRVDYLLKL 1320
LRKGLEKKGT VASGEEAKLK KRKPRVKKEN KAPRLKDEHG LEPASPRHSD NPSEEGEVKD 1380
DGLEKSPTKK KQKKKENKEN KEKPVSSRKD REGDKERKKS KDKKEKVKGG DGKSSSKSKR 1440
SQGPVHITAG SEPVPIGEDE DDDLDQETFS ICKERMRPVK KALKQLDKPD KGLSVQEQLE 1500
HTRNCLLKIG DRIAECLKAY SDQEHIKLWR RNLWIFVSKF TEFDARKLHK LYKMAHKKRS 1560
QEEEEQKKKD DSLGGKKPFR PEASGSSRDS LISQSHTSHN LHPQKPHLPA SHGPQMHGHP 1620
RDNYSHPNKR HFSNADRGDW QRERKFNYGG GNSAPWGGDR HHQYEQHWYK DHHYGDRRHM 1680
DAHRSGSYRP NNMSRKRPYE QYNSDRDHRG HRDYYDRHHH DSKRRRSDDF RPQNYHQQDF 1740
RRMSDHRPTM GYHGQGPSDH YRSFHTDKLG EYKQPMPSLH TALSDPRSPP SQKSPHDSKS 1800
PLDHRSPLER SLEQKNNPDY NWNVRKT 1828
Keyword

KW-0067--ATP-binding
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0347--Helicase
KW-0378--Hydrolase
KW-0517--Myogenesis
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
Interpro

IPR030485--CHD2
IPR000953--Chromo/shadow_dom
IPR023780--Chromo_domain
IPR016197--Chromodomain-like
IPR023779--Chromodomain_CS
IPR025260--DUF4208
IPR014001--Helicase_ATP-bd
IPR001650--Helicase_C
IPR027417--P-loop_NTPase
IPR000330--SNF2_N
PROSITE

PS00598--CHROMO_1
PS50013--CHROMO_2
PS51192--HELICASE_ATP_BIND_1
PS51194--HELICASE_CTER
Pfam

PF00385--Chromo
PF13907--DUF4208
PF00271--Helicase_C
PF00176--SNF2_N
Gene Ontology

GO:0070062--C:extracellular exosome
GO:0043231--C:intracellular membrane-bounded organelle
GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0005524--F:ATP binding
GO:0001046--F:core promoter sequence-specific DNA binding
GO:0004386--F:helicase activity
GO:0042393--F:histone binding
GO:0044822--F:poly(A) RNA binding
GO:0006974--P:cellular response to DNA damage stimulus
GO:0016568--P:chromatin modification
GO:0060218--P:hematopoietic stem cell differentiation
GO:0007517--P:muscle organ development
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated