| Tag |
Content |
| dbPAF ID |
dbPAF-0050756 |
| Uniprot Accession |
E9PZJ8; ASCC3_MOUSE; Q6PB36; Q8C1G1; Q8C707; Q8K292;
|
| Genbank Protein ID |
NP_932124.2;
|
| Genbank Nucleotide ID |
NM_198007.2;
|
| Protein Name |
Activating signal cointegrator 1 complex subunit 3 |
| Protein Synonyms/Alias |
|
| Gene Name |
Ascc3 |
| Gene Synonyms/Alias |
|
| Organism |
Mus musculus(Mouse) |
| NCBI Taxa ID |
10090 |
Functional Description
(View all) |
3'-5' DNA helicase involved in repair of alkylated DNA. Promotes DNA unwinding to generate single-stranded substrate needed for ALKHB3, enabling ALKHB3 to process alkylated N3-methylcytosine (3mC) within double-stranded regions. Enhances NF-kappa-B, SRF and AP1 transactivation (By similarity).Functional Description
3'-5' DNA helicase involved in repair of alkylated DNA. Promotes DNA unwinding to generate single-stranded substrate needed for ALKHB3, enabling ALKHB3 to process alkylated N3-methylcytosine (3mC) within double-stranded regions. Enhances NF-kappa-B, SRF and AP1 transactivation (By similarity). |
Phosphorylation Sites
|
dbPAF PTMs: 7 |
Sequence
(Fasta) | MALPRLTGAL RSFSNVTKQD NYNEEVADLK LKRSKLHEQV LDFGLTWKKI VKFLNEKLEK 60
NKMQNINEDL KDILQAAKQI VGTDNGREAI ESGAAFLFMT FHMTDSVGYM ETKAIRQTFG 120
PFPSSSATSA CNATNRIISH FSQDDLTAFV QMAENPCNDR VVFGKNLAFS FDMYDLDHFD 180
ELPINGESQK TISLDYKKFL NEQFQEPYTP ELKPVEKTNG SLLWCEVEKY LNATLKEMTE 240
AARVEDLCCT LYDMLASAKS GDELQDELFE LLGPEGLDLI EKLLQNRITI VDRFLNSSSD 300
HKFQVLQDSC KKILGENSKP NYGCQVTIQS EQEKQLMKQY RREEKRIARR EKKAGEDGEV 360
SGEGVLPFDP KELRIQREHA LLNARNAPIL GRQRDVEFEK IRYPHVYDSQ AQARETSAFI 420
AGAKMILPEG IQRENTKLYE EVRIPYGEPM PVGFEEKPVY IKDLDEVGQL AFKGMKRLNR 480
IQSIVFETAY NTNENMLICA PTGAGKTNIA MLTILHEIRQ HFHQGVIKKN EFKIVYVAPM 540
KALAAEMTNY FSKRLEPLGI VVKELTGDMQ LSKSEILRTQ MLVTTPEKWD VVTRKSVGDV 600
ALSQIVKLLI LDEVHLLHED RGPVLESIVA RTLRQVESTQ SMIRILGLSA TLPNYLDVAT 660
FLHVNPYIGL FYFDGRFRPV PLGQTFLGIK STNKMQQLNN MDEVCYESVL KQVKAGHQVM 720
VFVHARNATV RTAMSLIERA KNSGQISCFL PTEGPEYGHA LKQVQKSRNK QVRELFSDGF 780
SIHHAGMLRQ DRNLVENLFS NGHIKVLVCT ATLAWGVNLP AHAVVIKGTQ IYAAKRGSFV 840
DLGILDVMQI FGRAGRPQFD KFGEGIIITT HDKLSHYLSL LTQQNPIESQ FLESLADNLN 900
AEIALGTVTN VEEAVRWMSY TYLYVRMRAN PLAYGISHKA YQIDPTLRKH REQLLIEVGQ 960
KLDKAKMIRF EERTGYFSST DLGRTASHFY IKYNTIETFN ELFDAHKTEG DIFAIVSKAE 1020
EFDQIKVREE EIEELDALLN NFCELSAPGG VENSYGKINI LLQTYISRGE MDSFSLISDS 1080
AYVAQNAARI VRALFEIALR KRWPTMTYRL LNLSKVIDKR LWGWASPLRQ FSVLPPHILT 1140
RLEEKNLTVD KLKDMRKDEI GHILHHVNIG LKVKQCVHQI PSVTMEASIQ PITRTVLRVS 1200
LNIHPDFSWN DQVHGTVGEP WWIWVEDPTN DHIYHSEYFL ALKKQVINKE AQLLVFTIPI 1260
FEPLPSQYYI RAVSDRWLGA EAVCIINFQH LILPERHPPH TELLDLQPLP ITALGCKAYE 1320
ALYNFSHFNP VQTQIFHTLY HTDCNVLLGA PTGSGKTVAA ELAIFRVFNK YPTSKAVYIA 1380
PLKALVRERM DDWKIRIEEK LGKKVIELTG DVTPDMKSIA KADLIVTTPE KWDGVSRSWQ 1440
NRSYVQQVNI LIIDEIHLLG EERGPVLEVI VSRTNFISSH TEKPVRIVGL STALANARDL 1500
ADWLNIKQMG LFNFRPSVRP VPLEVHIQGF PGQHYCPRMA SMNKPAFQAI RSHSPAKPVL 1560
IFVSSRRQTR LTALELIAFL ATEEDPKQWL NMDEQEMDNI IGTVRDSNLK LTLAFGIGMH 1620
HAGLHERDRK TVEELFVNCK VQVLIATSTL AWGVNFPAHL VIIKGTEYYD GKTRRYVDFP 1680
ITDVLQMMGR AGRPQFDDQG KAVILVHDIK KDFYKKFLYE PFPVESSLLG VLSDHLNAEI 1740
AGGTITSKQD AMDYITWTYF FRRLIMNPSY YSLGDVSQDS INKFLSHLIG QSLVELELSH 1800
CIEVGEDNRT IEPLTCGRIA SYYYLKHKTV KMFKDRLKPE CSTEELLSIL SDAEEYTDLP 1860
VRHNEDHTNN ELAKCLPIEL NPHSFDSPHT KAHLLLQAHL SRAMLPCPDY DTDTKTVLDQ 1920
ALRVCQAMLD VAASQGWLVT VLNITHLIQM VIQGRWLKDS SLLTIPNIEQ HHLHLFRKWK 1980
PPVKSSHAKC RTSIECLPEL IHACEGKDHV FSSMVEKELQ PAKTKQAWNF LSRLPVINVG 2040
ISVKGSWDDL VEGHNELSIS TLTADKRDEN KWIKLHADQE YVLQVSLQRV HFGLPKGKHE 2100
NHAVTPRFPK LKDEGWFLIL GEVDKRELMA VKRVGFVRTH HDASISFFTP ETPGRYIFTL 2160
YLMSDCYLGL DQQYDIYLNV IKANISTKDS DVFTDLSV
2199Fasta Sequence
>E9PZJ8|Ascc3|Mus musculus(Mouse)
MALPRLTGALRSFSNVTKQDNYNEEVADLKLKRSKLHEQVLDFGLTWKKIVKFLNEKLEKNKMQNINEDLKDILQAAKQIVGTDNGREAIESGAAFLFMTFHMTDSVGYMETKAIRQTFGPFPSSSATSACNATNRIISHFSQDDLTAFVQMAENPCNDRVVFGKNLAFSFDMYDLDHFDELPINGESQKTISLDYKKFLNEQFQEPYTPELKPVEKTNGSLLWCEVEKYLNATLKEMTEAARVEDLCCTLYDMLASAKSGDELQDELFELLGPEGLDLIEKLLQNRITIVDRFLNSSSDHKFQVLQDSCKKILGENSKPNYGCQVTIQSEQEKQLMKQYRREEKRIARREKKAGEDGEVSGEGVLPFDPKELRIQREHALLNARNAPILGRQRDVEFEKIRYPHVYDSQAQARETSAFIAGAKMILPEGIQRENTKLYEEVRIPYGEPMPVGFEEKPVYIKDLDEVGQLAFKGMKRLNRIQSIVFETAYNTNENMLICAPTGAGKTNIAMLTILHEIRQHFHQGVIKKNEFKIVYVAPMKALAAEMTNYFSKRLEPLGIVVKELTGDMQLSKSEILRTQMLVTTPEKWDVVTRKSVGDVALSQIVKLLILDEVHLLHEDRGPVLESIVARTLRQVESTQSMIRILGLSATLPNYLDVATFLHVNPYIGLFYFDGRFRPVPLGQTFLGIKSTNKMQQLNNMDEVCYESVLKQVKAGHQVMVFVHARNATVRTAMSLIERAKNSGQISCFLPTEGPEYGHALKQVQKSRNKQVRELFSDGFSIHHAGMLRQDRNLVENLFSNGHIKVLVCTATLAWGVNLPAHAVVIKGTQIYAAKRGSFVDLGILDVMQIFGRAGRPQFDKFGEGIIITTHDKLSHYLSLLTQQNPIESQFLESLADNLNAEIALGTVTNVEEAVRWMSYTYLYVRMRANPLAYGISHKAYQIDPTLRKHREQLLIEVGQKLDKAKMIRFEERTGYFSSTDLGRTASHFYIKYNTIETFNELFDAHKTEGDIFAIVSKAEEFDQIKVREEEIEELDALLNNFCELSAPGGVENSYGKINILLQTYISRGEMDSFSLISDSAYVAQNAARIVRALFEIALRKRWPTMTYRLLNLSKVIDKRLWGWASPLRQFSVLPPHILTRLEEKNLTVDKLKDMRKDEIGHILHHVNIGLKVKQCVHQIPSVTMEASIQPITRTVLRVSLNIHPDFSWNDQVHGTVGEPWWIWVEDPTNDHIYHSEYFLALKKQVINKEAQLLVFTIPIFEPLPSQYYIRAVSDRWLGAEAVCIINFQHLILPERHPPHTELLDLQPLPITALGCKAYEALYNFSHFNPVQTQIFHTLYHTDCNVLLGAPTGSGKTVAAELAIFRVFNKYPTSKAVYIAPLKALVRERMDDWKIRIEEKLGKKVIELTGDVTPDMKSIAKADLIVTTPEKWDGVSRSWQNRSYVQQVNILIIDEIHLLGEERGPVLEVIVSRTNFISSHTEKPVRIVGLSTALANARDLADWLNIKQMGLFNFRPSVRPVPLEVHIQGFPGQHYCPRMASMNKPAFQAIRSHSPAKPVLIFVSSRRQTRLTALELIAFLATEEDPKQWLNMDEQEMDNIIGTVRDSNLKLTLAFGIGMHHAGLHERDRKTVEELFVNCKVQVLIATSTLAWGVNFPAHLVIIKGTEYYDGKTRRYVDFPITDVLQMMGRAGRPQFDDQGKAVILVHDIKKDFYKKFLYEPFPVESSLLGVLSDHLNAEIAGGTITSKQDAMDYITWTYFFRRLIMNPSYYSLGDVSQDSINKFLSHLIGQSLVELELSHCIEVGEDNRTIEPLTCGRIASYYYLKHKTVKMFKDRLKPECSTEELLSILSDAEEYTDLPVRHNEDHTNNELAKCLPIELNPHSFDSPHTKAHLLLQAHLSRAMLPCPDYDTDTKTVLDQALRVCQAMLDVAASQGWLVTVLNITHLIQMVIQGRWLKDSSLLTIPNIEQHHLHLFRKWKPPVKSSHAKCRTSIECLPELIHACEGKDHVFSSMVEKELQPAKTKQAWNFLSRLPVINVGISVKGSWDDLVEGHNELSISTLTADKRDENKWIKLHADQEYVLQVSLQRVHFGLPKGKHENHAVTPRFPKLKDEGWFLILGEVDKRELMAVKRVGFVRTHHDASISFFTPETPGRYIFTLYLMSDCYLGLDQQYDIYLNVIKANISTKDSDVFTDLSV
|
| Keyword |
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0227--DNA damage
KW-0234--DNA repair
KW-0347--Helicase
KW-0378--Hydrolase
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
|
| Interpro |
IPR003593--AAA+_ATPase
IPR000008--C2_dom
IPR011545--DEAD/DEAH_box_helicase_dom
IPR014001--Helicase_ATP-bd
IPR001650--Helicase_C
IPR014756--Ig_E-set
IPR027417--P-loop_NTPase
IPR004179--Sec63-dom
IPR011991--WHTH_DNA-bd_dom
|
| PROSITE |
PS51192--HELICASE_ATP_BIND_1
PS51194--HELICASE_CTER
|
| Pfam |
PF00270--DEAD
PF00271--Helicase_C
PF02889--Sec63
|
| Gene Ontology |
GO:0005737--C:cytoplasm
GO:0005794--C:Golgi apparatus
GO:0005622--C:intracellular
GO:0016020--C:membrane
GO:0005634--C:nucleus
GO:0005524--F:ATP binding
GO:0043140--F:ATP-dependent 3'-5' DNA helicase activity
GO:0044822--F:poly(A) RNA binding
GO:0008565--F:protein transporter activity
GO:0008283--P:cell proliferation
GO:0006307--P:DNA dealkylation involved in DNA repair
GO:0032508--P:DNA duplex unwinding
GO:0031204--P:posttranslational protein targeting to membrane, translocation
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
|
