dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0050749
Uniprot Accession E9PZ36; E9PZ36_MOUSE;
Genbank Protein ID NP_694819.2;
Genbank Nucleotide ID NM_153179.3;
Protein Name Protein Pkhd1
Protein Synonyms/Alias
Gene Name Pkhd1
Gene Synonyms/Alias
Organism Mus musculus(Mouse)
NCBI Taxa ID 10090
Functional Description
(View all)
Phosphorylation Sites
dbPAF PTMs: 10
PositionPeptidesSourceReferences ( PMIDs )
1102ARAFTYVSSLNPVIVPhosphoSitePlus22135298
1110SLNPVIVSLSRNRSSPhosphoSitePlus22135298
1112NPVIVSLSRNRSSIAPhosphoSitePlus22135298
1375RMGFANMSVVPQKFEPhosphoSitePlus22135298
1877EVLIYNSSCNITMETPhosphoSitePlus22135298
2251TWGLKVDSNVFYKIVPhosphoSitePlus;SysPTM 2.022135298; 17203969; 19366988
2948AAEVGLLTRNIRIQPPhosphoSitePlus22135298
3220APQSANWTSTDRAPSPhosphoSitePlus22135298
3221PQSANWTSTDRAPSNPhosphoSitePlus22135298
3222QSANWTSTDRAPSNPPhosphoSitePlus22135298
Sequence
(Fasta)
MMLAWLVSLL SMEVLLLAKP YSSFQFEPAE GSLAGGTWIT VVFDGLDRSI LYPNNGSQLQ 60
IDLVSVAIPT LRIPCDVSPA FVDLPVVTCQ TRSLPSEADA GPYSLEMRSG EQVLGTPCPG 120
SLDSCTFKFS KDQTPVLYQV YPASGVPGEV VSVYGRVITT WLETFDPDVD YIESPLILEA 180
REDKWLTPCS LINRQTGSCF PIQEEHGLGN VQCRVEGDYI GSQNVSFSVF NKGRSMVHKE 240
AWLISAKQEL FLYQTYPEIL SVFPKVGSLG GRTDIIITGD FFDPSARVTI AGIPCDIRYV 300
SPRKIECTTR APGNEARLTA PQAGNRGLRF EVGDATKDVE LTEATPGYRW QIVPNASSPS 360
GFWSKEGRPF RARLSGFFVA PQTNNYTFWI QADSQASLCF SSSEEPRTKV EVASVGVGTA 420
DWFDSWEQIG NEGSWHQKTT KLELQGGAKY YLEAEQHGIA PSRGMRIGVQ IHNTWLNPDV 480
VNTYLLEKHQ IRARAQRLPE IQVLHVSGKG NFFLTWGNVS SQPVPANATA QQIQTTIEEL 540
LVVKCNLAPF SAHVLLRLGF EQGLEGSRSD GVRTSSTEPF CGRFSLGQLG HLILIPEAAD 600
KGYQLDRYPY LCLAYRGHMN KTLDMTVSFL FGFQTIMKNI TCDWSLTDPH PESWQFTCIN 660
LWDTCLCHSE DIQSSLANTP LLAHRIDIRP VVPEAGLLYV DEIILADTNV TVSQADSGRA 720
CPGGNVVESV SVVGVPPVYS ISSWLAGCGS ELPLITACSV STEGTGDGSE LIEVTAQRLQ 780
RTSPPLGGHF FLYLSDTVIP DVPVRMSARQ LHKLLQDSAD ESTSGYLNAG DFTVTEDLNS 840
CYEHVWTLSW TTQTGDLPNF IRVSDQNLTG VNPTVTARVV YDGGVFLGPI FGDMLATANQ 900
QTQVAVQVND IPAYCSGSCS FQYQQESTPS VDHVWYSLGS DVNLLVHFTG TGFPRDTQFL 960
QVTVNKTSCE VLFSNETNVA CELALLPVGV HQIFMLVIPS GLAVHASGED LLLHVEPRLD 1020
AVEPSTAAEI GGRWVTLRGS SLEGVSLVLF GTQSCVIDAI RSNSQQIQCK VPPRGKDGYT 1080
VNVTVISGDH STVLARAFTY VSSLNPVIVS LSRNRSSIAG GEILFLGMSL LVNYTDLDVQ 1140
IHVQDTSAQV LSQTAWGLEV VLPPLVPGIH VISAFINGVS IRSQGVDLYI QYLTEVFSVE 1200
PCSGSLLGGT LLSLLGTGLG RDPALIRVLV DNHPCDIVNL TEVNIWCETP PAVLPPRADV 1260
LTVLASVEIW AGNTSFFHGP SLVGKGFTFT YEAAATPVVT AMWGEFRNNS VRFYVEGSNI 1320
SDSVILLGSL KCELEVQFFG DSMNLSGCFF PLHSLEAGVY TLQVRHKRMG FANMSVVPQK 1380
FELSPQIIAI FPTHGSKCGG TVLTVKGMAF SSRKRSVHVD ISGPFACMIL SLEDHTVLCQ 1440
TRFVGDQFSE ASLALNITVL VNGLTSKCKG NCTLFIEEAA TPIVDALTIS ISGSLTMVLM 1500
RGRRLATTAD EPIAFVDDQL PCHTTFFNTS HVACQIRDLA PGFHYLSAVH TSAGYACLNS 1560
VSRNFFIVPQ VLDYFPKDFS IHGGSLLTIK GTALRGWKAT VVYVGRQACL TVNFSSDFIQ 1620
CIVPAGNGSA ALEIDVNGVL YHIGLVDYSS IFTPELLSVS RSQDILTFTV ARISGAANVD 1680
IFIGTSPCLG VAGNRTVLQC MVPLLPAGEY LVTGYDHSRG WASSTLILVL RATVTSVTKN 1740
YGCLGGRLLH VLGAGFSPGN ISAAVCGAPC QVLANATVSA FSCLVLPLHV SLAFLCDLRH 1800
AEDSCKVRSS TYLRCDLTVS MGTERLPGSW PYVYLCEESS LCLFEPDHWT ESVFPSFSGL 1860
FLSPKVERDE VLIYNSSCNI TMETEAEMEC EMPNQPITAK ITEIQKSWGQ NTQGNFSFQF 1920
CRRWSRPHSW FPQRVPHDGD SVTVETGHLL LLDANTSFLN SLHIKGGKLI FMDPGPIELR 1980
AHSILITDGG ELHIGSEEKP FQGKARIKIY GSVHSTPFFP YGVKFLAVRN GTLSLHGSVP 2040
EVTVTYLQAA AHAGDKVLTL GEAVDWKPGD EAVITSGMTV AGAEATEVVV VETVHNADLH 2100
LRNPLRYSYD FRENWVAGEN PILKPTVALL SRNIIIQGNF TLERVKLLNS CQEANTAKGN 2160
LKHCLYSKSE KMLGARDLGA RVIIQSFPEE PSFVKLKGVQ FRDLGQAFHK HLSSLALVGA 2220
MRGSYIQSCS VWNSFSRGLS MHRTWGLKVD SNVFYKIVGH ALLLGSYLDG RFSTSETVTG 2280
RKNGWWEQGS TIRNNVIISV SAAEGLSGSE MLAPAGIYTF SPTNVMEGNR VCAAGYGYVF 2340
HLVTSQTLQA PLLSFNWNTA HSCTRYGLLV YPKFQPPWNN DTGFTLFQNF MVWGSAGGAQ 2400
IFRSNNLHLK NFQVYACRDF GIDILESDAN TLITDSFLLG HFTHKGSLCM SAGIKTPQRW 2460
ELTISNTTFV NFDGNCVAIR TCSGCFQGQG GYTVKTRQLK FVNSSNLVAF PFPHAAVLED 2520
LDGSLSGKNG SHVLASMETL SDTCLTNASF SQIVPGSVCG EAVLFHRMSI ALANSLDVPK 2580
NLTITDISNK TITVNYVEDT LSNYYGWMAL LLDQETYSLQ FESPWMNRSL QYSATFDSFA 2640
PGNYLLIMHR DLPPYPDILL RCGSQVGHSL PFHPLPSQDR ACDWFFNRQL RQLTYLVSGE 2700
GQVKVFLQLK PGVPPSVSAS TSVPESASRW SLPETWQDVE KGWGGYNHTI PGPGDDVLIL 2760
PNKTVLVDTD LPVLRCLYVM GTLEFPVDRS NVLSVACLLI AGGELKVGTL ENPLEKDQRL 2820
LIFLRASEEV VCDYFEGIHV DPGTIGVYGK LRLHSAYPKK SWVHLGADIA PGNERIIVHN 2880
AVDWQPHDTI VLSSSSYEAH EAEVLTVKEV KGHHIRIYER LKHRHIGSTH TMEDGQQVHL 2940
AAEVGLLTRN IRIQPDSSCR GRLLVGSFRK SSGEDFSGVL QLLNVEIQNM GLPLYSSIEF 3000
TGVSAGSWVI SSTVHQSCSV GIHASSSHGV ILTDNVVFGT NGHGIDVEGQ NYSLTNNLVI 3060
LTMQSANSSP WVAGIKVNYA EDIILHGNVV AGSERLGFHV GGHGCSSEVL WSDNVVHSSL 3120
HGLHLYKKHE SNNCTGVSGF MAFKNFDYGA MVQTENSVDI QNITLVDNTV GLLAITYVSS 3180
ALLSSVSTVQ ITLRNSVIVA TSSSFDCIHD RKAPQSANWT STDRAPSNPR GGRIGILWPV 3240
SASEPNAWPQ EPWHKVRSRH SVPGIMKLQD VTFSSFVKSC YSNDLDVCIL PNEYSTGVMY 3300
PITAERTRML GIKDKNKFYF PVLQSSKDLV GTICPTLVCE YPRKYLFTDL DGRTLGLPPP 3360
VSVFPRTEEE WTGSFLNTGI FREEQKCTFR AMNQGFFCKQ TEHAVLILDN VDATWTIPKS 3420
HPLVSVTNGF VDTFSIVKDS DLCPPTSSLS TFYSILPTRQ MTKVCFPEQT PPFLRFLLLG 3480
NQRASKLILA VFYNEIQSPH VFLDKSFIPP TPLESAFSLL AEPSGANYFD IMNNLLYVVL 3540
QGEEPVEIHS SVSIHLALTV TFSVLEKGWE RAMLESLSDF FQIDPNQIRL TLEMPGNKET 3600
LEAIANSERK RKRNCPSVTC GGPSIRYGQR RPLMAEMTSL KITPATTLET FSKVIVIEVG 3660
DLPNIRNSEP IQSLPSNRLQ RLVNQVITAQ QTGALENVLG MTVGALLVTQ SKGVTGYRNA 3720
SSLITGNLIY TRPSELSILV QPSDGEVGIE LPVQPRLVFL DEKNERVESL GLPSEPWIIS 3780
VSLEGASESV LKGCTLAETR DGYVTFSRLA VLISGSNWHL FFTVISPPGT NFTARSRTFV 3840
VLPVASKERS TIILALSLCS VASWVALSCL VCCWFKKSKT RKIKPEDISE SQAKEQKKNT 3900
HNSSKPRGLQ AKTAKENTLM GEDMRMKVMQ GMQSQFPQHS MDGVSKRKVS RLAVTEERTT 3960
TPAPKIPRIT CVPGSLAQQL TLQEPGNWQE AQQQLLRYQL AGRNQLLLLR PDLRQERKQG 4020
QEPSQLDKGS DCTGLSQEKA TCIPTETFSL HTAPPETIQ
Keyword

KW-0181--Complete proteome
KW-0472--Membrane
KW-1185--Reference proteome
KW-0732--Signal
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR019316--G8_domain
IPR013783--Ig-like_fold
IPR014756--Ig_E-set
IPR002909--IPT
IPR006626--PbH1
IPR012334--Pectin_lyas_fold
IPR011050--Pectin_lyase_fold/virulence
IPR028839--PKHD1

PROSITE

PS51484--G8

Pfam

PF10162--G8
PF01833--TIG

Gene Ontology

GO:0016324--C:apical plasma membrane
GO:0005813--C:centrosome
GO:0036064--C:ciliary basal body
GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0016021--C:integral component of membrane
GO:0072686--C:mitotic spindle
GO:0048471--C:perinuclear region of cytoplasm
GO:0072372--C:primary cilium
GO:0006874--P:cellular calcium ion homeostasis
GO:0042384--P:cilium assembly
GO:0001822--P:kidney development
GO:0043066--P:negative regulation of apoptotic process
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:0051898--P:negative regulation of protein kinase B signaling
GO:0008284--P:positive regulation of cell proliferation
GO:0010824--P:regulation of centrosome duplication
GO:0070372--P:regulation of ERK1 and ERK2 cascade
GO:0032006--P:regulation of TOR signaling