dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0050729
Uniprot Accession E9PYK8; E9PYK8_MOUSE;
Genbank Protein ID
Genbank Nucleotide ID
Protein Name Rho guanine nucleotide exchange factor 4
Protein Synonyms/Alias
Gene Name Arhgef4
Gene Synonyms/Alias
Organism Mus musculus(Mouse)
NCBI Taxa ID 10090
Functional Description
(View all)
Phosphorylation Sites
dbPAF PTMs: 2
PositionPeptidesSourceReferences ( PMIDs )
307KTLVRAHSIASFPLGPhosphoSitePlus;curated22135298; 21183079
1277TTITSPESPHLPRRSPhosphoSitePlus22135298
Sequence
(Fasta)
MLGVVHFLRS FFKTPEPGVP PPGEEECEDN QLHPGPADSE EQETNPEDLE TLSHKSESRS 60
GSDTKTDPFE SASEAESLPG DLTGGVGLSE REAGWGCPED STVRLPQGRH LVCDEGLHTE 120
EEPDLPSGLK AGSQLSKLHM LTAGRRDEAC PCSRVASFVQ ESVPASVCFS KHASSNSSPH 180
LQQARSRGYL DAPVVCPCFR RHCELGQSWP QIHIRTAAAK IPPTGSQHND FPLWIRTKKG 240
PAPRSTVGTD LFWVHPFLDI ACQPRLGTPY LLDTKCHQST PENLGANAKP PQGYLCWQVK 300
TLVRAHSIAS FPLGCPKEPL KQKGTNWPYL REGTEIEPDH PILHKTQSPG PTQLSRLLPT 360
SQSRAPPLQG ECKLSDCSFK RASPDTPCVG LPLENQVEQA SRSCPAPSHL TSELLKLNSQ 420
EEVPRPAECK PGHSPESRLE EPKGVHPDDV ISKQQCLLNI SGEAGSQTEN YPSMSALQEE 480
RKPPDRASLF PQHCCHGEVP VCNRMLAGSW EEESDSACAP RTALKSSVIG SLEAAEEGVV 540
LDLQRNGKAL QSLLDFPTLE VSHRNPGSEC AQGPGDDPEP SPSGQRQAPG AHGASRHSCK 600
FIMIAVKQEG RQTSTRKAHC LIEPQCGHLP EKGTSATAYE SSRASEMPVF GNECELLGCP 660
GAEVDGGALQ LLAQGIEHVR VPVSRTSSDD TLSSEETLEG ELLGERLDLG SECVHTEQNQ 720
ELPSSDRKRG RCGTGDAENA EICACAGEVE GPLSRVLASS TTTLEFQEPC GGFQQSVLES 780
EQHPACLQMT PLRTDMPWSR EMPGGDIPYS QALTSEDLNP VCPSPEERVP HSPCQGEPPL 840
HHVHQSVSLE TKSGVIQVGT SGDLSGEGPS PESYNIKRLK TTESKIKARL ALAHKTFTNF 900
FEAKVMEKTN TGSVKGEKEK RRRARGSWRA FLRSKDAEGS KRPALVSGVP EPGFPQLLCS 960
SPPATRGHCE KWTIDTDSHV FGEHWTPLNS PATLSSSHLA SPEHRRRSEP TIRRTAAQES 1020
STHLSSGVFP KSSWLTSATS PGAAQIDISF ALPCSSACHL TYENQGMPCR PTSPKPRSPM 1080
AGAQRMDLCL RGRTSAVSMV SLRSDKDANR SSEVPERPKA SKARASLLLS LQTLNQNDQK 1140
EDKSQCQCYH GLGTVPFLRD HPGNESYIAQ ESPPDKKRNC SHDQKTYTEP PHRPVSATEV 1200
TRTLPSMSAE QVPREVPLQF RRAPQHSHFS FDDIWLEKAQ RRKLKKQMLL RRQMCAELVP 1260
EDPVQCWRKT TITSPESPHL PRRSHLLSQS APMGLDHTGW PEPTSDTGMP DGTLDTVCAE 1320
ETGSEEDLYE ELHNSGHHYS HPRGGGEQLA INELISDGSV VCAEALWDHV TMDDQELGFK 1380
AGDVIEVMDA TNREWWWGRV ADGEGWFPAS FVRLRVNQDE PADDYEAPRA GAREADDSGP 1440
EAQSCKDQMR TNVINEILST ERDYIKHLRD ICEGYVRQCR KREDMFSEEQ LRTIFGNIED 1500
IYRCQKAFVK ALEQKFNTER PHLSELGACF LEHQADFQIY SEYCNNHPNA CVELSRLTKL 1560
SKYVYFFEAC RLLQRMIDIS LDGFLLTPVQ KICKYPLQLA ELLKYTHPQH RDFKNVEAAL 1620
HAMKNVAQLI NERKRRLENI DKIAQWQSSI EDWEGEDLLV RSSELIHSGE LTRVTQPQAR 1680
SQQRMFFLFD RQLIYCKKDL LRRDVLYYKG RLDMDDLEVV DVEDGKDRDL HVSVKNAFRL 1740
YCGTTGDSHL LCARKPEQKQ RWLKAFARER EQVRLDQETG FSITELQRKQ AMLNASKQQA 1800
TGKPKAVGRP GYLTRHKHPS LPASRPQQQV LVLAEPRRKP SNFWHSISRL APFRK 1856
Keyword

KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0728--SH3 domain

Interpro

IPR000219--DH-domain
IPR001331--GDS_CDC24_CS
IPR011993--PH/PTB_dom
IPR001849--PH_domain
IPR001452--SH3_domain

PROSITE

PS00741--DH_1
PS50010--DH_2
PS50003--PH_DOMAIN
PS50002--SH3

Pfam

PF00169--PH
PF00621--RhoGEF
PF00018--SH3_1

Gene Ontology

GO:0005622--C:intracellular
GO:0005085--F:guanyl-nucleotide exchange factor activity
GO:0019904--F:protein domain specific binding
GO:0030676--F:Rac guanyl-nucleotide exchange factor activity
GO:0046847--P:filopodium assembly
GO:0035556--P:intracellular signal transduction
GO:0030032--P:lamellipodium assembly
GO:0043547--P:positive regulation of GTPase activity
GO:0035023--P:regulation of Rho protein signal transduction