dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0050728
Uniprot Accession E9PYK3; E9PYK3_MOUSE;
Genbank Protein ID NP_001139450.2;
Genbank Nucleotide ID NM_001145978.2;
Protein Name Poly [ADP-ribose] polymerase
Protein Synonyms/Alias
Gene Name Parp4
Gene Synonyms/Alias
Organism Mus musculus(Mouse)
NCBI Taxa ID 10090
Functional Description
(View all)
Phosphorylation Sites
 dbPAF PTMs: 13
PositionPeptidesSourceReferences ( PMIDs )
96VRNYDPLSPAPAAPPPhosphoSitePlus;curated22135298; 25338131
107AAPPAERSRSEVQSEcurated25338131
109PPAERSRSEVQSEYLcurated25338131
1214KQPEASISQTEIDSScurated25338131
1239HGVLQPVSVSSEVNEcurated25338131
1241VLQPVSVSSEVNEKPcurated25338131
1242LQPVSVSSEVNEKPScurated25338131
1266IKTIKKCSLDISEDFPHOSIDA;PhosphoSitePlus;curated21081558; 22135298; 21183079; 25338131
1282DRTAVAQSPATAQSLPhosphoSitePlus22135298
1452GGTLIPPSSSLFGGTPhosphoSitePlus22135298
1635GDTNIHDSEPPLLGFcurated25338131
1681SQGPNNISFSPKAPEcurated25338131
1683GPNNISFSPKAPEMGPHOSIDA;PhosphoSitePlus;SysPTM 2.0;curated21081558; 22135298; 17242355; 19366988; 18779572; 23684622;
Sequence
(Fasta)		MTLGIFANCI FCLKVKYLPR QQKKKLQTDI KENGGKFSFL LNPQCTHVIV DSADVLSRCH 60
LNSIQKNDVQ IANPAFIQDS VRQRRLLDVR NYDPLSPAPA APPAERSRSE VQSEYLPSDN 120
TPEKENTEVT EVSAENVEIP PFLQDFEVVK YNILEKVGGP ETVVVELQSS QDPESCPFVI 180
TAHFLLADQK TRRESTGKQT SEGAIEYYES YVEDLKRQGF LLQEHFTAEA TQLASEKLQA 240
LLLEEVISSG ALSQEVSDLL EVIWTEALGH LENTLLKPVN SMSLNDVSKA EGILLLVKTA 300
LKNGDSPGQL QKTMAEFYRL LPHRHPASEE VNLRLLAQKE DLCQLVRDMV NVCETNLSKP 360
NPPSLAKYRA LRCKIEHVDQ NTEEFSRVRK EVLQNNRSEQ PVDILQIFRV GRVNEATEFL 420
SKLGNVRLLF HGSPVRNILG ILSRGLLLPK VAEDRGVQRT DVGNLGSGIY FSDSLSTSIK 480
YAHAGETDGS RLLVVCDVAL GKCVNLFKKD FSLTEAPPGY DSVHGVSETT SVPTDFQDDE 540
FVVYKTNQVK MKYIVKFCTP GDQIKEFHPH ENTEVEEQRA EPSSVPEAGD FQLPDIKPFT 600
NIKAGLQDAS ANPVPLDSVH IKGRVIDFVA QVIVFQTYTN QSHVPIEAKY IFPLDDKAAV 660
CGFEAFINGK HIVGEIKEKE EARQEYREAV SQGHGAYLMD QDTPDVFTVS VGNLPPRAKV 720
LIKITYITEL SIQSPVAIFF IPGTVAPWQQ DKALNENLQD TVETIRIKEI GAEQSFSLAM 780
SIEMPYMIEF ISSDTHELRQ KSTDCKAVVS TVEGSSLDSG GFSLHIGLRD AYLPRMWVEK 840
HPEKESEACM LVFQPELADV LPDLRGKNEV IICLDCSSSM EGVTFTQAKQ VALYALSLLG 900
EEQKVNIMQF GTGYKELFSY PKCITDSKMA TEFIMSAAPS MGNTDFWKVL RYLSLLYPSE 960
GFRNILLISD GHLQSESLTL QLVKRNIQHT RVFTCAVGST ANRHILRTLS QCGAGVFEYF 1020
NSKSKHSWKK QIEAQMTRIR SPSCHSVSVK WQQLSRDAPE PLQAPAWVPS LFHNDRLLVY 1080
GFIPHCTQAT LQAFIQEKEF CTMVSTTELQ KTTGTMIHKL AARALIRDYE DGILHDDETN 1140
HEMKKNIMKS LIIELSKENS LITQFTSFVA VEKRDVNEIP FANVPNISEL VAKEDVDFLP 1200
YVSWQEKQPE ASISQTEIDS SRLKHNKLSD GHGVLQPVSV SSEVNEKPSL LLAAKKRKIK 1260
TIKKCSLDIS EDFEDRTAVA QSPATAQSLN FHLPLSVRPQ LKAVEQQLHG NRLEPKQRGG 1320
FRKLLMAKKC RNVPDSLVSS APAVTAEFSY LSACSSSSAF LSPLCDIPSS LPPHPLGGTH 1380
PPPPLPLPDG THLPSPLFGS THPPPPLFGG TLIPPPSSLF GGTHLPPPPP LPGGTHIPPP 1440
PPIPGGTLIP PSSSLFGGTH LPPPPLLSAG THIPPPPLLS AGTHLPPPPL LPAGTHIPPP 1500
PPITGSTHPP PPSSLFGGTH LPPPPPLPGG THIPPPPPIP GGTLIPSPSS LFGGTHLPPP 1560
PLLPAGTHIP PPPPITGSTH PPPPSSLFGG THLPPPPPAG TQFSLSPIGF IPPKLGPPKL 1620
SHSHKLVGDT NIHDSEPPLL GFKDLCSRDM GFSCGTAFSG SFASSKDFDP GKFSQGPNNI 1680
SFSPKAPEMG VLHQSPFCSP PKPPSAPPLV TNVLCSEAPQ SYFLNLQSAA VHQSPNNRVS 1740
EIIMESVESS LPSDYSSRDA SSYLALEGAE DSLLGGSSFE TDTDEAAAFI ANDLLTSIET 1800
SSDEECAFCD EDQESPVPWA SLFALQTENG FWKLTPELGL ILNLNVNALL TSLEEKGIRS 1860
LGTKGRERLL DLIATLLVLQ FLYTKLEQEG MVAKSLIKMD DAFISRNIPW AFENIKKARE 1920
WARKTEGQYP SICQRLELGK DWESATKQLL GIQPQANTSL HRILYYSQG
Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0328--Glycosyltransferase
KW-0520--NAD
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0808--Transferase
Interpro

IPR001357--BRCT_dom
IPR009408--Formin_homology_1
IPR031273--PARP4
IPR012317--Poly(ADP-ribose)pol_cat_dom
IPR004102--Poly(ADP-ribose)pol_reg_dom
IPR013694--VIT
IPR002035--VWF_A
PROSITE

PS50172--BRCT
PS51060--PARP_ALPHA_HD
PS51059--PARP_CATALYTIC
PS51468--VIT
PS50234--VWFA
Pfam

PF00533--BRCT
PF06346--Drf_FH1
PF00644--PARP
PF08487--VIT
Gene Ontology

GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0016020--C:membrane
GO:0005634--C:nucleus
GO:0005819--C:spindle
GO:0005876--C:spindle microtubule
GO:0019899--F:enzyme binding
GO:0003950--F:NAD+ ADP-ribosyltransferase activity
GO:0008219--P:cell death
GO:0006464--P:cellular protein modification process
GO:0006954--P:inflammatory response
GO:0006471--P:protein ADP-ribosylation