dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0050724
Uniprot Accession E9PYH6; E9PYH6_MOUSE;
Genbank Protein ID NP_821172.2;
Genbank Nucleotide ID NM_178029.3;
Protein Name Protein Setd1a
Protein Synonyms/Alias
Gene Name Setd1a
Gene Synonyms/Alias
Organism Mus musculus(Mouse)
NCBI Taxa ID 10090
Functional Description
(View all)
Phosphorylation Sites
 dbPAF PTMs: 38 (View all)
PositionPeptidesSourceReferences ( PMIDs )
220TTEARRRSSSDTAAYcurated23684622; 25338131
221TEARRRSSSDTAAYPcurated23684622
222EARRRSSSDTAAYPAcurated25338131
224RRRSSSDTAAYPAGTcurated23684622; 21183079
236AGTTVGGTPGNGTPCcurated23684622
463GGGGGAPSPEREEARPhosphoSitePlus22135298
471PEREEARTPPRPASPPhosphoSitePlus;curated22135298; 21743459; 25338131
477RTPPRPASPARSGSPPhosphoSitePlus;curated22135298; 21743459; 25338131
481RPASPARSGSPAPETPHOSIDA;PhosphoSitePlus;SysPTM 2.0;curated21081558; 22135298; 18846507; 19366988; 21743459; 22817900;
483ASPARSGSPAPETTNPHOSIDA;PhosphoSitePlus;SysPTM 2.0;curated21081558; 22135298; 18846507; 19366988; 21743459; 22817900;
517KEQRSKFSFLASDTEPhosphoSitePlus;curated22135298; 22817900; 21183079
521SKFSFLASDTEEEEEPhosphoSitePlus;curated22135298; 22817900; 21183079; 25338131
523FSFLASDTEEEEENSPhosphoSitePlus;curated22135298; 22817900; 21183079; 25338131
545DAGAEVPSGAGHGPCcurated23684622; 25338131
553GAGHGPCTPPPAPANPhosphoSitePlus;curated22135298; 23684622; 22817900; 21183079; 25338131
567NFEDVAPTGSGEPGAPhosphoSitePlus;curated22135298; 23684622; 22817900; 21183079
578EPGAARESPKANGQNPhosphoSitePlus;curated22135298; 23684622; 22817900; 21183079; 25338131
907RGALRLPSFKVKRKEPhosphoSitePlus22135298
930EEKRPRPSTPAEEDEPhosphoSitePlus;SysPTM 2.0;curated22135298; 17203969; 19366988; 22817900; 21183079; 25338131
931EKRPRPSTPAEEDEDPhosphoSitePlus;SysPTM 2.0;curated22135298; 17203969; 19366988; 23684622; 21743459; 20469934
Sequence
(Fasta)		MDQEGGGDGQ KAPSFQWRNY KLIVDPALDP ALRRPSQKVY RYDGVHFSVS DSKYTPVEDL 60
QDPRCHVRSK ARDFSLPVPK FKLDEFYIGQ IPLKEVTFAR LNDNVRETFL KDMCRKYGEV 120
EEVEILLHPR TRKHLGLARV LFTSTRGAKE TVKNLHLTSV MGNIIHAQLD IKGQQRMKYY 180
ELIVNGSYTP QTVPTGGKAL SEKFQGSGAA AETTEARRRS SSDTAAYPAG TTVGGTPGNG 240
TPCSQDTNFS SSRQDTPSSF GQFTPQSSQG TPYTSRGSTP YSQDSAYSSS TTSTSFKPRR 300
SENSYQDSFS RRHFSTSSAP ATTATATSAT AAATAASSSS SSSSSSSSSS SSSSSASQFR 360
GSDSSYPAYY ESWNRYQRHT SYPPRRATRE DPSGASFAEN TAERFPPSYT SYLAPEPNRS 420
TDQDYRPPAS EAPPPEPPEP GGGGGGSGGG GGGGGGGGGG APSPEREEAR TPPRPASPAR 480
SGSPAPETTN ESVPFAQHSS LDSRIEMLLK EQRSKFSFLA SDTEEEEENS SAGPGARDAG 540
AEVPSGAGHG PCTPPPAPAN FEDVAPTGSG EPGAARESPK ANGQNQASPC SSGEDMEISD 600
DDRGGSPPPA PTPPQQPPPP PPPPPPPPPP YLASLPLGYP PHQPAYLLPP RPDGPPPPEY 660
PPPPPPPPPH IYDFVNSLEL MDRLGAQWGG MPMSFQMQTQ MLTRLHQLRQ GKGLTAASAG 720
PPGGAFGEAF LPFPPPQEAA YGLPYALYTQ GQEGRGSYSR EAYHLPLPMA AEPLPSSSVS 780
GEEARLPHRE EAEIAESKVL PSAGTVGRVL ATLVQEMKSI MQRDLNRKMV ENVAFGAFDQ 840
WWESKEEKAK PFQNAAKQQA KEEDKEKMKL KEPGMLSLVD WAKSGGITGI EAFAFGSGLR 900
GALRLPSFKV KRKEPSEISE ASEEKRPRPS TPAEEDEDDP EREKEAGEPG RPGTKPPKRD 960
EERGKTQGKH RKSFTLDSEG EEASQESSSE KDEDDDDEDE EDEEQEEAVD ATKKEAEASD 1020
GEDEDSDSSS QCSLYADSDG ENGSTSDSES GSSSSSSSSS SSSSSSSSSE SSSEEEEQSA 1080
VIPSASPPRE VPEPLPAPDE KPETDGLVDS PVMPLSEKET LPTQPAGPAE EPPPSVPQPP 1140
AEPPAGPPDA APRLDERPSS PIPLLPPPKK RRKTVSFSAA EEAPVPEPST AAPLQAKSSG 1200
PVSRKVPRVV ERTIRNLPLD HASLVKSWPE EVARGGRNRA GGRVRSTEEE EATESGTEVD 1260
LAVLADLALT PARRGLATLP TGDDSEATET SDEAERPSPL LSHILLEHNY ALAIKPPPTT 1320
PAPRPLEPAP ALAALFSSPA DEVLEAPEVV VAEAEEPKQQ LQQQHPEQEG EEEEEDEEEE 1380
SESSESSSSS SSDEEGAIRR RSLRSHTRRR RPPLPPPPPP PPSFEPRSEF EQMTILYDIW 1440
NSGLDLEDMS YLRLTYERLL QQTSGADWLN DTHWVQHTIT NLSTPKRKRR PQDGPREHQT 1500
GSARSEGYYP ISKKEKDKYL DVCPVSARQL EGGDTQGTNR VLSERRSEQR RLLSAIGTSA 1560
IMDSDLLKLN QLKFRKKKLR FGRSRIHEWG LFAMEPIAAD EMVIEYVGQN IRQMVADMRE 1620
KRYVQEGIGS SYLFRVDHDT IIDATKCGNL ARFINHCCTP NCYAKVITIE SQKKIVIYSK 1680
QPIGVDEEIT YDYKFPLEDN KIPCLCGTES CRGSLN 1717
Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0489--Methyltransferase
KW-0539--Nucleus
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0949--S-adenosyl-L-methionine
KW-0808--Transferase
Interpro

IPR024657--COMPASS_Set1_N-SET
IPR012677--Nucleotide-bd_a/b_plait
IPR003616--Post-SET_dom
IPR000504--RRM_dom
IPR001214--SET_dom
PROSITE

PS50868--POST_SET
PS50102--RRM
PS50280--SET
Pfam

PF11764--N-SET
PF00076--RRM_1
PF00856--SET
Gene Ontology

GO:0035097--C:histone methyltransferase complex
GO:0005719--C:nuclear euchromatin
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0048188--C:Set1C/COMPASS complex
GO:0008013--F:beta-catenin binding
GO:1990188--F:euchromatin binding
GO:0042800--F:histone methyltransferase activity (H3-K4 specific)
GO:0003676--F:nucleic acid binding
GO:0000166--F:nucleotide binding
GO:0048096--P:chromatin-mediated maintenance of transcription
GO:0051568--P:histone H3-K4 methylation
GO:2000179--P:positive regulation of neural precursor cell proliferation
GO:2000648--P:positive regulation of stem cell proliferation
GO:0019827--P:stem cell population maintenance