| Tag |
Content |
| dbPAF ID |
dbPAF-0050694 |
| Uniprot Accession |
E9PXD2; E9PXD2_MOUSE;
|
| Genbank Protein ID |
NP_001181869.1; XP_006509229.1;
|
| Genbank Nucleotide ID |
NM_001194940.2; XM_006509166.2;
|
| Protein Name |
Rho GTPase-activating protein 7 |
| Protein Synonyms/Alias |
|
| Gene Name |
Dlc1 |
| Gene Synonyms/Alias |
|
| Organism |
Mus musculus(Mouse) |
| NCBI Taxa ID |
10090 |
Functional Description
(View all) |
|
Phosphorylation Sites
|
dbPAF PTMs: 9 |
Sequence
(Fasta) | MSVAIRKRSW EEHVTQQTEQ PFISDEYDIA CHHGLASDSL EGRMEKDATL NVDHKEKCAS 60
LPDRCCGSET RDFPGRPMGH IAQEVDESDS QEGEERFLSL EASTETLVHI SDEDTDSDLN 120
LINDSQILTP QRHERDSQDS VKGAGSFMKT LSTMQSSQDS HNTWRMAGKA DMSPAEGSGE 180
RKDVEAINKS LGLCKNTSAD ETKDVPIGNT FQSLNTEDDV TPKTLLLDSS VLIEDVTPET 240
QLLDSAVITQ QCRKSDFPKD DQENNRHHVL EEDVLAAPYV DRGLPLLKAD CRSSLLQPPS 300
CPGGMSAEND LEKSGFSEYQ NKSTLGVSRE DGMQCLHLRG PVTTQETVDN QVRLRKRKET 360
REDRDRTRLD SMVLLIMKLD QLDQDIENAL STASSPSSTP TNLRRHVPDL ESGSESRTDS 420
MAVNQTQVNL SSESTDPSST PGSNSGTKPK AMAAPCVGEK EMAEIEAKEA CDWLRVTGFP 480
QYAQLYEDLL FPIDIALVKR EHDFLDRDAI EALCRRLNTL NKCAVMKLEI SPHRKRSEDS 540
DEDEPCAISG KWTFQRDSKR WSRLEEFDVF SPKQDPIPGS PDNSRLQSAT SHESMLTDLS 600
EHQEVASVRS LSSTSSSVPT HAAHSGDATT PRTNSVISVC SSGHFVGNDD SFSSLPSPKE 660
LSSFSFSMKG HHEKNTKSKT RSLLKRMESL KLKGSHHSKH KAPSKLGLII SAPILQEGMD 720
EAKLKQLNCV EISALNGNHI NVPMVRKRSV SNSTQTSSSS SQSETSSAVS TPSPVTRTRS 780
LSTCNKRVGM YLEGFDPFSQ STLNNVTEQN YKNRESYPED TVFYIPEDHK PGTFPKALSH 840
GSFCPSGNSS VNWRTGSFHG PGHLSLRREN SHDSPKELKR RNSSSSLSSR LSIYDNVPGS 900
ILYSSSGELA DLENEDIFPE LDDILYHVKG MQRIVNQWSE KFSDEGDSDS ALDSVSPCPS 960
SPKQIHLDVD HDRRTPSDLD STGNSLNEPE EPTDIPERRD SGVGASLTRC NRHRLRWHSF 1020
QSSHRPSLNS VSLQINCQSV AQMNLLQKYS LLKLTALLEK YTPSNKHGFS WAVPKFMKRI 1080
KVPDYKDRSV FGVPLTVNVQ RSGQPLPQSI QQAMRYLRNH CLDQVGLFRK SGVKSRIQAL 1140
RQMNESAEDN VNYEGQSAYD VADMLKQYFR DLPEPLMTNK LSETFLQIYQ YVPKDQRLQA 1200
IKAAIMLLPD ENREVLQTLL YFLSDVTAAV KENQMTPTNL AVCLAPSLFH LNTLKRENSS 1260
PRVMQRKQSL GKPDQKDLNE NLAATQGLAH MIAECKKLFQ VPEEMSRCRN SYTEQELKPL 1320
TLEALGHLNS DQPADYRHFL QDCVDGLFKE VKEKFKGWVS YPTSEQAELS YKKVSEGPPL 1380
RLWRSTIEVP AAPEEILKRL LKEQHLWDVD LLDSKVIEIL DSQTEIYQYV QNSMAPHPAR 1440
DYVVLRTWRT NLPRGACALL LTSVDHDRAP VAGVRVNVLL SRYLIEPCGS GKSKLTYMCR 1500
ADLRGHMPEW YSKSFGHLCA AEVVKIRDSF SNQNTESKDT RSR
1544Fasta Sequence
>E9PXD2|Dlc1|Mus musculus(Mouse)
MSVAIRKRSWEEHVTQQTEQPFISDEYDIACHHGLASDSLEGRMEKDATLNVDHKEKCASLPDRCCGSETRDFPGRPMGHIAQEVDESDSQEGEERFLSLEASTETLVHISDEDTDSDLNLINDSQILTPQRHERDSQDSVKGAGSFMKTLSTMQSSQDSHNTWRMAGKADMSPAEGSGERKDVEAINKSLGLCKNTSADETKDVPIGNTFQSLNTEDDVTPKTLLLDSSVLIEDVTPETQLLDSAVITQQCRKSDFPKDDQENNRHHVLEEDVLAAPYVDRGLPLLKADCRSSLLQPPSCPGGMSAENDLEKSGFSEYQNKSTLGVSREDGMQCLHLRGPVTTQETVDNQVRLRKRKETREDRDRTRLDSMVLLIMKLDQLDQDIENALSTASSPSSTPTNLRRHVPDLESGSESRTDSMAVNQTQVNLSSESTDPSSTPGSNSGTKPKAMAAPCVGEKEMAEIEAKEACDWLRVTGFPQYAQLYEDLLFPIDIALVKREHDFLDRDAIEALCRRLNTLNKCAVMKLEISPHRKRSEDSDEDEPCAISGKWTFQRDSKRWSRLEEFDVFSPKQDPIPGSPDNSRLQSATSHESMLTDLSEHQEVASVRSLSSTSSSVPTHAAHSGDATTPRTNSVISVCSSGHFVGNDDSFSSLPSPKELSSFSFSMKGHHEKNTKSKTRSLLKRMESLKLKGSHHSKHKAPSKLGLIISAPILQEGMDEAKLKQLNCVEISALNGNHINVPMVRKRSVSNSTQTSSSSSQSETSSAVSTPSPVTRTRSLSTCNKRVGMYLEGFDPFSQSTLNNVTEQNYKNRESYPEDTVFYIPEDHKPGTFPKALSHGSFCPSGNSSVNWRTGSFHGPGHLSLRRENSHDSPKELKRRNSSSSLSSRLSIYDNVPGSILYSSSGELADLENEDIFPELDDILYHVKGMQRIVNQWSEKFSDEGDSDSALDSVSPCPSSPKQIHLDVDHDRRTPSDLDSTGNSLNEPEEPTDIPERRDSGVGASLTRCNRHRLRWHSFQSSHRPSLNSVSLQINCQSVAQMNLLQKYSLLKLTALLEKYTPSNKHGFSWAVPKFMKRIKVPDYKDRSVFGVPLTVNVQRSGQPLPQSIQQAMRYLRNHCLDQVGLFRKSGVKSRIQALRQMNESAEDNVNYEGQSAYDVADMLKQYFRDLPEPLMTNKLSETFLQIYQYVPKDQRLQAIKAAIMLLPDENREVLQTLLYFLSDVTAAVKENQMTPTNLAVCLAPSLFHLNTLKRENSSPRVMQRKQSLGKPDQKDLNENLAATQGLAHMIAECKKLFQVPEEMSRCRNSYTEQELKPLTLEALGHLNSDQPADYRHFLQDCVDGLFKEVKEKFKGWVSYPTSEQAELSYKKVSEGPPLRLWRSTIEVPAAPEEILKRLLKEQHLWDVDLLDSKVIEILDSQTEIYQYVQNSMAPHPARDYVVLRTWRTNLPRGACALLLTSVDHDRAPVAGVRVNVLLSRYLIEPCGSGKSKLTYMCRADLRGHMPEWYSKSFGHLCAAEVVKIRDSFSNQNTESKDTRSR
|
| Keyword |
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome
|
| Interpro |
IPR028854--DLC1
IPR008936--Rho_GTPase_activation_prot
IPR000198--RhoGAP_dom
IPR001660--SAM
IPR013761--SAM/pointed
IPR023393--START-like_dom
IPR002913--START_lipid-bd_dom
|
| PROSITE |
PS50238--RHOGAP
PS50848--START
|
| Pfam |
PF00620--RhoGAP
PF07647--SAM_2
PF01852--START
|
| Gene Ontology |
GO:0005901--C:caveola
GO:0030864--C:cortical actin cytoskeleton
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005925--C:focal adhesion
GO:0005634--C:nucleus
GO:0032587--C:ruffle membrane
GO:0005096--F:GTPase activator activity
GO:0008289--F:lipid binding
GO:0042169--F:SH2 domain binding
GO:0030036--P:actin cytoskeleton organization
GO:0006919--P:activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006915--P:apoptotic process
GO:0048041--P:focal adhesion assembly
GO:0030900--P:forebrain development
GO:0003007--P:heart morphogenesis
GO:0021575--P:hindbrain morphogenesis
GO:0030336--P:negative regulation of cell migration
GO:0008285--P:negative regulation of cell proliferation
GO:0051895--P:negative regulation of focal adhesion assembly
GO:0035024--P:negative regulation of Rho protein signal transduction
GO:0051497--P:negative regulation of stress fiber assembly
GO:0001843--P:neural tube closure
GO:1900119--P:positive regulation of execution phase of apoptosis
GO:0043547--P:positive regulation of GTPase activity
GO:0035307--P:positive regulation of protein dephosphorylation
GO:0032956--P:regulation of actin cytoskeleton organization
GO:0008360--P:regulation of cell shape
GO:0007165--P:signal transduction
|
