dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0050640
Uniprot Accession E9PVD3; PCD16_MOUSE;
Genbank Protein ID NP_001156415.1;
Genbank Nucleotide ID NM_001162943.1;
Protein Name Protocadherin-16
Protein Synonyms/Alias Protein Dchs1;Protein dachsous homolog 1;
Gene Name Dchs1
Gene Synonyms/Alias
Organism Mus musculus(Mouse)
NCBI Taxa ID 10090
Functional Description
(View all)
Calcium-dependent cell-adhesion protein. Mediates functions in neuroprogenitor cell proliferation and differentiation.
Phosphorylation Sites
dbPAF PTMs: 7
PositionPeptidesSourceReferences ( PMIDs )
1284ERPHYVLTLSAHDQGPhosphoSitePlus22135298
2978TAPIASSSLQKLGREPhosphoSitePlus22135298
3048NEFPRVASVASSLAAPhosphoSitePlus;UniProt;curated22135298; 21183079
3051PRVASVASSLAARGPPhosphoSitePlus;curated22135298; 21183079
3052RVASVASSLAARGPDPhosphoSitePlus;curated22135298; 21183079
3237SPISHEGSLSSAAMScurated21183079
3252PSFSPSLSPLAARSPPhosphoSitePlus22135298
Sequence
(Fasta)
MQKELSVALS CPGMKSLRTL LPLLVLLGAT VPGSWGQAGS LDLQIDEEQP AGTLIGDISA 60
GLPPGTAPPP MYFISAQEGS GVGTDLAIDE HSGVVRTARV LDRERRDRYR FTAVTPDGAT 120
VEVTVRVADI NDHAPAFPQA RAALQIPEHT ALGTRYPLEP ARDADAGRLG TQGYALSGDG 180
AGETFRLETR PGPGGAPVPE LVIAGELDRE NRSHYMLQLE AYDGGSPPRR AQALLDVTLL 240
DINDHAPAFN QSRYHAVVSE SLAPGSPVLQ VFASDADAGA NGAVTYEINR RQSEGDGPFS 300
IDAHTGFLRL ERPLDFEQRR VHELVVQARD GGAHPELGSA FVTVHVRDAN DNQPSMTVIF 360
LSADGSPRVS EAAPPGQLVA RISVSDPDDG DFAHVNVSLE GGEGHFALST QDSVIYLVCV 420
ARRLDREERD VYNLRVTATD SGSPPLRAEA AFVLHVTDVN DNAPAFDRQL YRPEPLPEVA 480
LPGSFVVRVT ARDPDQGTNG QITYSLAPGT HTHWFSIDPT SGIITTAATL DYELEPQPQL 540
IVVATDGGLP PLVSSATVSV ALQDVNDNEP QFQRTFYNAS LPEGTQPGTC FLQVTATDAD 600
SGPFGLLSYS LGAGLGASGS PPFRIDAHSG DVCTTRTLDR DQGPSSFDFT VTAIDGGGLK 660
SMVYVKVFVA DENDNPPQFY PREYAASLSA QSTPGTAVLR VHAHDPDQGP HGRLSYHILA 720
GNSPPLFALD AHSGLLTVAW PLGRRANSVV QLEIGAQDGG GLQAEPIARV NISIVPGTPT 780
PPIFEQLQYV FSVPEDVAPG TSVGIIQAHN PPGRLGPVTL TLSGGDPRGL FSLDSPSGLL 840
KTLRPLDREL LGPVLELEVR AGSGTPPVFA VARIRVLLDD VNDNSPAFPA PEDTVLLPQN 900
TAPGTPIYTL RALDPDSGAN SRITFNLLAG GDGLFTVDPT TGHVRLMGPL GPPGGPAHEL 960
EVEARDGGSP PRTSHFRLRV VIQDLGIHGL APRFDSPTYR VDLPSGTTTG TQILQVQAQA 1020
PDGSPVTYHL AADGASSPFG LESQSGWLWV RTALDRESQE LYTLKVMAVS GSKAELGQQT 1080
GTATVRVIIL NQNDHSPRLS EEPTFLAVAE NQPPGTSVGR VFATDRDSGP NGRLTYSLQQ 1140
LSEDSKAFRI HPQTGEVTTL QTLDREQQSS FQLLVQVQDG GSPPRSATGT VHVAVLDLND 1200
NSPTFLQASG AAGGGLPIQV PDRVPPGTLV TTLQAKDPDE GENGTILYTL TGPGSELFSL 1260
HPHTGELHTA ASLVRAERPH YVLTLSAHDQ GSPPRSASLQ LLVQVLPSTR VVESPDLIEA 1320
DSAATVPVVL TVTAAEGLRP GSLLGSVAPQ EPASVGVLTY TLVGGADPEG TFALDSASGR 1380
LYLARPLDFE AGPAWRALTV RAEGPGGAGA RLLRVQVRVQ DENEHAPTFA RDPLALALPE 1440
NPDPGATLYT FRASDADGPG PNSEVRYRLL RQEPPVPALR LDARTGALSA PRGLDRETTP 1500
ALLLLVEATD RPANASRRRA ARVSARVFVT DENDNAPVFA SPSRVRLPED QPPGPAALHV 1560
VARDPDLGEA ARVSYRLAAG GDGHFRLHAT TGALSVVRPL DREQRAEHVL TVVALDHGSP 1620
PRSSTQLLTV SVVDVNDEAP AFPQQEYNVI LRENSPPGTS LLTLKATDPD LGANGQVTYG 1680
GVSGESFSLD PNTGVLTTLR ALDREEQEEI YLTVYARDRG LPPLLTHITV RVTVEDENDH 1740
TPTFGNTHLS LEVPEGQDPQ TLTTLRASDP DGGLNGQLQY RILDGDSSGA FALDLTSGEF 1800
GTMRPLDREV EPAFQLQIEA RDGGQPALSA TLLVTVTVLD ANDHAPVFPV PSYSVEVPED 1860
APVGTLLLQL QAHDPDDGDN GRVMYYLGAG TAGAFLLEPT SGELSTATAL DREHCASYAF 1920
SVTAVDGAAA GPLSTTVPIT ITVRDVNDHA PAFPTSPLRL RLPRPGPSLN KPTLALATLR 1980
AEDRDAGANA SILYRLAGTP PPGTTVDSYT GEIRVARSPV ALGPQDRVLF IVATDLGRPA 2040
RSATGVVVVG IQGEPERGPR FPRTSSEAVL RENAPPGTPV ISPKAVHSGG SNGPITYSIL 2100
SGNERGIFSI QPSTGAITVR SAEGLDFETS PRLRLVLQAE SGGAFAFSVL TLTLQDANDN 2160
APRFLRPHYV AFLPESRPLE GPLLQVEADD LDQGSGGQIS YSLAASQPAR GLFHVDPATG 2220
TITTTAILDR EIWAETRLVL MATDRGSPAL VGSATLTVMV IDTNDNRPTI PQPWELRVSE 2280
DALLGSEIAQ VTGNDVDSGP VLWYVLSPSG PQDPFSIGRY GGRVSLTGPL DFEQCDHYHL 2340
QLLAHDGPHE GHANLTVLVE DVNDNVPTFS QSLYQVMMLE HTPPGSAILS VSATDRDSGA 2400
NGHISYHLAS PAEGFRVDPN NGTLFTTVGA MALGHEGPGV VDVVLEARDH GAPGRTAQAT 2460
VHVQLKDQND HAPSFTLPHY RVAVSEDLPP GSTLLTLEAT DADGSRTHAT VDYSIISGNR 2520
GRVFQLEPRL AEVGDGVGPG PQALGCLVLL EPLDFESLTQ YNLTVAAADR GQPPRSSAVP 2580
VTVTVLDVND NPPVFTRASY RVTVPEDMPV GAELLHVEAS DADPGPHGLV HFTLSSGDPL 2640
GLFELDENSG ALRLSRPLDC ETQAQHQLVV QAADPAGTHF SLVPVTVEVQ DVNDHGPAFP 2700
LSLLSTSLAE NQPPGTLVTT LHAIDGDAGT FGRLRYSLLE AVPGPEGREA FSLNSSTGEL 2760
RARVPFDYEH TGSFRLLVGA ADAGNLSASV TVSVLITGED EYDPVFLAPS FHFQVPEGAQ 2820
RGHSLGHVQA TDEDGGADGL VLYSLATSSP YFGINQTTGA LYLRVDSRAP GSGTTTSGGG 2880
GRTRREAPRE LRLEVVARGP LPGSRSATVP VTVDITHTAL GLAPDLNLLL VGAVAASLGV 2940
VVVLALAALV LGLVRARSRK AEAAPGPMSQ TAPIASSSLQ KLGREPPSPP PSEHLYHQTL 3000
PSYGGPGAGG PYPRGGSLDP SHSSGRGSAE AAEDDEIRMI NEFPRVASVA SSLAARGPDS 3060
GIQQDADGLS DTSCEPPAPD TWYKGRKAGL LLPGAGATLY REEGPPATAT AFLGGCGLSP 3120
APAGDYGFPA DGKPCVAGAL TAIVAGEEEL RGSYNWDYLL SWCPQFQPLA SVFTEIARLK 3180
DEARPCPPAP RIDPPPLITA VAHPGAKSVP PKPASTAVAR AIFPPASHRS PISHEGSLSS 3240
AAMSPSFSPS LSPLAARSPV VSPFGVAQGP SASALSTESG LEPPDDTELR I 3292
Keyword

KW-0106--Calcium
KW-0130--Cell adhesion
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0325--Glycoprotein
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0732--Signal
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR002126--Cadherin
IPR015919--Cadherin-like
IPR020894--Cadherin_CS

PROSITE

PS00232--CADHERIN_1
PS50268--CADHERIN_2

Pfam

PF00028--Cadherin

Gene Ontology

GO:0045177--C:apical part of cell
GO:0016021--C:integral component of membrane
GO:0005622--C:intracellular
GO:0005886--C:plasma membrane
GO:0005509--F:calcium ion binding
GO:0001658--P:branching involved in ureteric bud morphogenesis
GO:0090102--P:cochlea development
GO:0048565--P:digestive tract development
GO:0001736--P:establishment of planar polarity
GO:0003007--P:heart morphogenesis
GO:0007157--P:heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
GO:0035329--P:hippo signaling
GO:0007156--P:homophilic cell adhesion via plasma membrane adhesion molecules
GO:0001822--P:kidney development
GO:0021915--P:neural tube development
GO:0022008--P:neurogenesis
GO:0043931--P:ossification involved in bone maturation
GO:0036342--P:post-anal tail morphogenesis