dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0050639
Uniprot Accession E9PVD1; CCD62_MOUSE; F6WEA5;
Genbank Protein ID NP_001128239.1; XP_006530318.1;
Genbank Nucleotide ID NM_001134767.1; XM_006530255.2;
Protein Name Coiled-coil domain-containing protein 62
Protein Synonyms/Alias
Gene Name Ccdc62
Gene Synonyms/Alias
Organism Mus musculus(Mouse)
NCBI Taxa ID 10090
Functional Description
(View all)
Nuclear receptor coactivator that can enhance preferentially estrogen receptors ESR1 and ESR2 transactivation. Modulates also progesterone/PGR, glucocorticoid/NR3C1 and androgen/AR receptors transactivation, although at lower level; little effect on vitamin D receptor/VDR (By similarity).
Phosphorylation Sites
dbPAF PTMs: 1
PositionPeptidesSourceReferences ( PMIDs )
460SLGGKIQTEPENKVTPhosphoPep 2.019060867
Sequence
(Fasta)
MRSSEGAPSW AVALPPPLRP CAYGVSEVTR CWHQLSLGAG ESSMNPSATL YRRQNIGSEV 60
ETSTIEKQRK ELQLLIGELK DRDKELNDMV AVHQRQLLSW EEDRQKVLTL EERCSKLEGE 120
LHKRTDIIKS LMKKVKTLES NQAECQTALQ KTQQQLQEMA QKATHSTLLS EDLEARNENL 180
SSTLVDLSAQ VGQLQAREQA LTTMIKLKDK DIIEAVNHIS DCSGKFKLLE HALRDAKMAE 240
TCVVREKQDY KQKLKALRIE VNKLKEDLNE KTTENNEQRE EIIRLKQEKS CLHDELIFTV 300
EREKRKDELL DIAKSKQDRT NSELQNLRQI YVKQQSDLQF LNFNIESSQE LIQIHGLKME 360
EPKALECSKD MCLSDLDNNY PKIDIKRERN QKSLVKDQTF EVMLAQHNGS DKSSCDACRE 420
KKLQVNTALG EKSVIALSSL FTKDLLDKQK SWSLGGKIQT EPENKVTLCK VHAKSPKCDG 480
VGLPTEEKQL SETSVSLSDE KQWHDINVYL GLSSCSKQPD RLDGDGHDRT GTSEVSCCTP 540
NVVCIGDNDL SESKCCHPSN IIIEAPGHMT DTEWMNIFKP SRAQRIVRHK TMCTCSRSVS 600
AMKYNSSASE LIGMQPSQCV GSLKSAEREE ESAALPDRRT SANEKDDFSP TSKLQRLLAE 660
SRQMVTDLEL STLLPISCEN LNRSKLEVSE EPDEKTTLVS H 702
Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat

Interpro
PROSITE
Pfam
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0030331--F:estrogen receptor binding
GO:0030374--F:ligand-dependent nuclear receptor transcription coactivator activity
GO:0071392--P:cellular response to estradiol stimulus
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter