dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0050624
Uniprot Accession E9PV24; FIBA_MOUSE; Q99K47;
Genbank Protein ID NP_001104518.1; NP_034326.1;
Genbank Nucleotide ID NM_001111048.2; NM_010196.4;
Protein Name Fibrinogen alpha chain
Protein Synonyms/Alias
Gene Name Fga
Gene Synonyms/Alias
Organism Mus musculus(Mouse)
NCBI Taxa ID 10090
Functional Description
(View all)		 Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots (PubMed:7649481). In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization (PubMed:11389004). Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood (PubMed:7649481). However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo (PubMed:10930441). Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway (PubMed:19332769). Maternal fibrinogen is essential for successful pregnancy (PubMed:7649481). Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage (PubMed:12629066). May also facilitate the immune response via both innate and T-cell mediated pathways (PubMed:23487423).
Phosphorylation Sites
 dbPAF PTMs: 8
PositionPeptidesSourceReferences ( PMIDs )
46RVVERHQSQCKDSDWPhosphoSitePlus;SysPTM 2.0;UniProt;curated22135298; 17242355; 19366988; 21183079; 22817900
92RINKLKNSLFDFQRNPhosphoSitePlus;curated22135298; 22817900; 21183079
279RGDSPGDSRGDSRGDPHOSIDA;PhosphoSitePlus21081558; 22135298
283PGDSRGDSRGDFATRPhosphoSitePlus;curated22135298; 22817900; 21183079
330RNPGTTGSDGTGDWGcurated21743459
447DATELDISHSFSGSLPhosphoSitePlus;UniProt;curated22135298; 21183079; 22817900
494HSDSDILTNIEDPSScurated23567750
531KMADEAGSEAHREGEPhosphoSitePlus;curated22135298; 22817900; 21183079
Sequence
(Fasta)		MLSLRVTCLI LSVASTVWTT DTEDKGEFLS EGGGVRGPRV VERHQSQCKD SDWPFCSDDD 60
WNHKCPSGCR MKGLIDEANQ DFTNRINKLK NSLFDFQRNN KDSNSLTRNI MEYLRGDFAN 120
ANNFDNTYGQ VSEDLRRRIE ILRRKVIEKA QQIQALQSNV RAQLIDMKRL EVDIDIKIRS 180
CKGSCSRAVN REINLQDYEG HQKQLQQVIA KELLPTKDRQ YLPALKMSPV PDLVPGSFKS 240
QLQEAPPEWK ALTEMRQMRM ELERPGKDGG SRGDSPGDSR GDSRGDFATR GPGSKAENPT 300
NPGPGGSGYW RPGNSGSGSD GNRNPGTTGS DGTGDWGTGS PRPGSDSGNF RPANPNWGVF 360
SEFGDSSSPA TRKEYHTGKA VTSKGDKELL IGKEKVTSSG TSTTHRSCSK TITKTVTGPD 420
GRREVVKEVI TSDDGSDCGD ATELDISHSF SGSLDELSER HPDLSGFFDN HFGLISPNFK 480
EFGSKTHSDS DILTNIEDPS SHVPEFSSSS KTSTVKKQVT KTYKMADEAG SEAHREGETR 540
NTKRGRARAR PTRDCDDVLQ TQTSGAQNGI FSIKPPGSSK VFSVYCDQET SLGGWLLIQQ 600
RMDGSLNFNR TWQDYKRGFG SLNDKGEGEF WLGNDYLHLL TLRGSVLRVE LEDWAGKEAY 660
AEYHFRVGSE AEGYALQVSS YRGTAGDALV QGSVEEGTEY TSHSNMQFST FDRDADQWEE 720
NCAEVYGGGW WYNSCQAANL NGIYYPGGTY DPRNNSPYEI ENGVVWVPFR GADYSLRAVR 780
MKIRPLVGQ
Keyword

KW-1064--Adaptive immunity
KW-0025--Alternative splicing
KW-0094--Blood coagulation
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1015--Disulfide bond
KW-0325--Glycoprotein
KW-0356--Hemostasis
KW-0379--Hydroxylation
KW-0391--Immunity
KW-0399--Innate immunity
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0964--Secreted
KW-0732--Signal
Interpro

IPR014716--Fibrinogen_a/b/g_C_1
IPR014715--Fibrinogen_a/b/g_C_2
IPR002181--Fibrinogen_a/b/g_C_dom
IPR012290--Fibrinogen_a/b/g_coil_dom
IPR021996--Fibrinogen_aC
IPR020837--Fibrinogen_CS
PROSITE

PS00514--FIBRINOGEN_C_1
PS51406--FIBRINOGEN_C_2
Pfam

PF08702--Fib_alpha
PF12160--Fibrinogen_aC
PF00147--Fibrinogen_C
Gene Ontology

GO:0072562--C:blood microparticle
GO:0005938--C:cell cortex
GO:0009986--C:cell surface
GO:0009897--C:external side of plasma membrane
GO:0070062--C:extracellular exosome
GO:0005615--C:extracellular space
GO:1903561--C:extracellular vesicle
GO:0005577--C:fibrinogen complex
GO:0031091--C:platelet alpha granule
GO:0005791--C:rough endoplasmic reticulum
GO:0005198--F:structural molecule activity
GO:0006953--P:acute-phase response
GO:0002250--P:adaptive immune response
GO:0007596--P:blood coagulation
GO:0072377--P:blood coagulation, common pathway
GO:0072378--P:blood coagulation, fibrin clot formation
GO:0007160--P:cell-matrix adhesion
GO:0043623--P:cellular protein complex assembly
GO:1990643--P:cellular response to granulocyte colony-stimulating factor
GO:0071354--P:cellular response to interleukin-6
GO:0071407--P:cellular response to organic cyclic compound
GO:0042730--P:fibrinolysis
GO:0043152--P:induction of bacterial agglutination
GO:0045087--P:innate immune response
GO:0097421--P:liver regeneration
GO:2000352--P:negative regulation of endothelial cell apoptotic process
GO:1902042--P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:0031639--P:plasminogen activation
GO:0070527--P:platelet aggregation
GO:0070374--P:positive regulation of ERK1 and ERK2 cascade
GO:0045921--P:positive regulation of exocytosis
GO:0034116--P:positive regulation of heterotypic cell-cell adhesion
GO:0090277--P:positive regulation of peptide hormone secretion
GO:0050714--P:positive regulation of protein secretion
GO:0045907--P:positive regulation of vasoconstriction
GO:0006461--P:protein complex assembly
GO:0051258--P:protein polymerization
GO:0051592--P:response to calcium ion
GO:0046898--P:response to cycloheximide
GO:0032355--P:response to estradiol
GO:0033595--P:response to genistein
GO:0043278--P:response to morphine
GO:0007165--P:signal transduction