dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0050608
Uniprot Accession E9PUM4; E9PUM4_MOUSE;
Genbank Protein ID NP_001074711.2;
Genbank Nucleotide ID NM_001081242.2;
Protein Name Talin-2
Protein Synonyms/Alias
Gene Name Tln2
Gene Synonyms/Alias
Organism Mus musculus(Mouse)
NCBI Taxa ID 10090
Functional Description
(View all)
Phosphorylation Sites
dbPAF PTMs: 2
PositionPeptidesSourceReferences ( PMIDs )
428TMLEESVSPKKSTILcurated22817900; 21183079
1843MSKLDEGTPPEPKGTPHOSIDA;PhosphoSitePlus;SysPTM 2.0;curated21081558; 22135298; 17242355; 19366988; 18056256; 22817900;
Sequence
(Fasta)
MVALSLKICV RHCNVVKTMQ FEPSTAVYDA CRVIRERVPE AQTGQASDYG LFLSDEDPRK 60
GIWLEAGRTL DYYMLRNGDI LEYKKKQRPQ KIRMLDGSVK TVMVDDSKTV GELLVTICSR 120
IGITNYEEYS LIQETIEEKK EEGTGTLKKD RTLLRDERKM EKLKAKLHTD DDLNWLDHSR 180
TFREQGVDEN ETLLLRRKFF YSDQNVDSRD PVQLNLLYVQ ARDDILNGSH PVSFEKACEF 240
GGFQAQIQFG PHVEHKHKPG FLDLKEFLPK EYIKQRGAEK RIFQEHKNCG EMSEIEAKVK 300
YVKLARSLRT YGVSFFLVKE KMKGKNKLVP RLLGITKDSV MRVDEKTKEV LQEWPLTTVK 360
RWAASPKSFT LDFGEYQESY YSVQTTEGEQ ISQLIAGYID IILKKKQSKD RFGLEGDEES 420
TMLEESVSPK KSTILQQQFN RTGKAEHGSV ALPAVMRSGS SGPETFNVGS MPSPQQQVMV 480
GQMHRGHMPP LTSAQQALMG TINTSMHAVQ QAQDDLSELD SLPPLGQDMA SRVWVQNKVD 540
ESKHEIHSQV DAITAGTASV VNLTAGDPAD TDYTAVGCAI TTISSNLTEM SKGVKLLAAL 600
MDDDVGSGED LLRAARTLAG AVSDLLKAVQ PTSGEPRQTV LTAAGSIGQA SGDLLRQIGE 660
NETDERFQDV LMSLAKAVAN AAAMLVLKAK NVAQVAEDTV LQNRVIAAAT QCALSTSQLV 720
ACAKVVSPTI SSPVCQEQLI EAGKLVDRSV ENCVRACQAA TSDSELLKQV SAAASVVSQA 780
LHDLLQHVRQ FASRGEPIGR YDQATDTIMC VTESIFSSMG DAGEMVRQAR VLAQATSDLV 840
NAMRSDAEAE IDMENSKKLL AAAKLLADST ARMVEAAKGA AANPENEDQQ QRLREAAEGL 900
RVATNAAAQN AIKKKIVNRL EVAAKQAAAA ATQTIAASQN AAISNKNPSA QQQLVQSCKA 960
VADHIPQLVQ GVRGSQAQAE DLSAQLALII SSQNFLQPGS KMVSSAKAAV PTVSDQAAAM 1020
QLSQCAKNLA TSLAELRTAS QKAHEACGPM EIDSALNTVQ TLKNELQDAK MAAAESQLKP 1080
LPGETLEKCA QDLGSTSKGV GSSMAQLLTC AAQGNEHYTG VAARETAQAL KTLAQAARGV 1140
AASTNDPEAA HAMLDSARDV MEGSAMLIQE AKQALIAPGD TESQQRLAQV AKAVSHSLNN 1200
CVNCLPGQKD VDVALKSIGE ASKKLLVDSL PPSTKPFQEA QSELNQAAAD LNQSAGEVVH 1260
ATRGQSGELA AASGKFSDDF DEFLDAGIEM AGQAQTKEDQ MQVIGNLKNI SMASSKLLLA 1320
AKSLSVDPGA PNAKNLLAAA ARAVTESINQ LIMLCTQQAP GQKECDNALR ELETVKGMLE 1380
NPNEPVSDLS YFDCIESVME NSKVLGESMA GISQNAKTGD LPAFGECVGI ASKALCGLTE 1440
AAAQAAYLVG ISDPNSQAGH QGLVDPIQFA RANQAIQMAC QNLVDPGSSP SQVLSAATIV 1500
AKHTSALCNA CRIASSKTAN PVAKRHFVQS AKEVANSTAN LVKTIKALDG DFSEDNRNKC 1560
RIATTPLIEA VENLTAFASN PEFASIPAQI SSEGSQAQEP ILVSAKTMLE SSSYLIRTAR 1620
SLAINPKDPP TWSVLAGHSH TVSDSIKSLI TSIRDKAPGQ RECDYSIDGI NRCIRDIEQA 1680
SLAAVSQSLA TRDDISVEAL QEQLTSVVQE IGHLIDPIAT AARGEAAQLG HKVTQLASYF 1740
EPLILAAVGV ASKMLDHQQQ MTVLDQTKTL AESALQMLYA AKEGGGNPKA QHTHDAITEA 1800
AQLMKEAVDD IMVTLNEAAS EVGLVGGMVD AIAEAMSKLD EGTPPEPKGT FVDYQTTVVK 1860
YSKAIAVTAQ EMMTKSVTNP EELGGLASQM TTDYGHLALQ GQMAAATAEP EEIGFQIRTR 1920
VQDLGHGCIF LVQKAGALQV CPTDSYTKRE LIECARSVTE KVSLVLSALQ AGNKGTQACI 1980
TAATAVSGII ADLDTTIMFA TAGTLNAENG ETFADHRENI LKTAKALVED TKLLVSGAAS 2040
TPDKLAQAAQ SSAATITQLA EVVKLGAASL GSNDPETQVV LINAIKDVAK ALSDLIGATK 2100
GAASKPADDP SMYQLKGAAK VMVTNVTSLL KTVKAVEDEA TRGTRALEAT IEYIKQELTV 2160
FQSKDIPEKT SSPEESIRMT KGITMATAKA VAAGNSCRQE DVIATANLSR KAVSDMLIAC 2220
KQASFYPDVS EEVRTRALRY GTECTLGYLD LLEHVLVILQ KPTPELKHQL AAFSKRVAGA 2280
VTELIQAAEA MKGTEWVDPE DPTVIAETEL LGAAASIEAA AKKLEQLKPR AKPKQADETL 2340
DFEEQILEAA KSIAAATSAL VKSASAAQRE LVAQGKVGSI PANAADDGQW SQGLISAARM 2400
VAAATSSLCE AANASVQGHA SEEKLISSAK QVAASTAQLL VACKVKADQD SEAMKRLQAA 2460
GNAVKRASDN LVRAAQKAAF GKADDDDVVV KTKFVGGIAQ IIAAQEEMLK KERELEEARK 2520
KLAQIRQQQY KFLPTELRED EG 2543
Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome

Interpro

IPR019749--Band_41_domain
IPR014352--FERM/acyl-CoA-bd_prot_3-hlx
IPR019748--FERM_central
IPR019747--FERM_CS
IPR000299--FERM_domain
IPR032425--FERM_f0
IPR018979--FERM_N
IPR002558--ILWEQ_dom
IPR011993--PH/PTB_dom
IPR015711--Talin-2
IPR015224--Talin_cent
IPR029071--Ubiquitin-rel_dom
IPR015009--Vinculin-bd_dom
IPR006077--Vinculin/catenin

PROSITE

PS00661--FERM_2
PS50057--FERM_3
PS50945--I_LWEQ

Pfam

PF16511--FERM_f0
PF00373--FERM_M
PF09379--FERM_N
PF01608--I_LWEQ
PF09141--Talin_middle
PF08913--VBS

Gene Ontology

GO:0005856--C:cytoskeleton
GO:0005916--C:fascia adherens
GO:0005925--C:focal adhesion
GO:0001726--C:ruffle
GO:0045202--C:synapse
GO:0005200--F:structural constituent of cytoskeleton
GO:0007155--P:cell adhesion
GO:0007016--P:cytoskeletal anchoring at plasma membrane