dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0050605
Uniprot Accession E9PUF7; E9PUF7_MOUSE;
Genbank Protein ID NP_001123623.1;
Genbank Nucleotide ID NM_001130151.1;
Protein Name Rho guanine nucleotide exchange factor 1
Protein Synonyms/Alias
Gene Name Arhgef1
Gene Synonyms/Alias
Organism Mus musculus(Mouse)
NCBI Taxa ID 10090
Functional Description
(View all)
Phosphorylation Sites
 dbPAF PTMs: 12
PositionPeptidesSourceReferences ( PMIDs )
381LSGRLGRSESLRVSDPhosphoSitePlus;SysPTM 2.0;curated22135298; 17242355; 19366988; 22817900; 21183079; 23984901
383GRLGRSESLRVSDRRPhospho.ELM 9.0;PHOSIDA;PhosphoSitePlus;curated19144319; 21081558; 22135298; 22817900; 21183079
387RSESLRVSDRRRPSRPhospho.ELM 9.0;PHOSIDA;PhosphoSitePlus;SysPTM 2.0;curated19144319; 21081558; 22135298; 17242355; 19366988; 22817900;
393VSDRRRPSRGSLGAKPHOSIDA;PhosphoSitePlus;curated21081558; 22135298; 25266776
396RRRPSRGSLGAKGRGPHOSIDA;PhosphoSitePlus;curated21081558; 22135298; 25266776
407KGRGGGRSRSDVDMDPHOSIDA;PhosphoSitePlus;curated21081558; 22135298; 25266776
409RGGGRSRSDVDMDPGPhospho.ELM 9.0;PHOSIDA;PhosphoSitePlus;curated19144319; 21081558; 22135298; 25266776; 22817900; 21183079
417DVDMDPGSATAVLGPPHOSIDA;PhosphoSitePlus;curated21081558; 22135298; 25266776; 22817900; 21183079
419DMDPGSATAVLGPTRcurated25266776
425ATAVLGPTRRATPEPPHOSIDA;curated21081558; 25266776
429LGPTRRATPEPGDDGPhospho.ELM 9.0;PHOSIDA;PhosphoSitePlus;curated19144319; 21081558; 22135298; 25266776; 23684622; 22817900;
441DDGEPGRSGLELEPEcurated25266776
Sequence
(Fasta)		MGEVAGGAAP GPPRSGLVSI IIGAEDEDFE NELEANSEDQ NSQFQSLEQV KRRPAHLMAL 60
LQHVALQFEP GPLLCCLHAD MLSSLGPKEA KKAFLDFYHS FLEKTAVLRV PVPPSVAFEL 120
DRTRPDLISE DVQRRFIQEV VQSQQAAVSR QLEDFRSKRL MGMTPWEQEL SLLEPWIGKD 180
RGNYEARERH VAERLLSHLE ETQHTISTDE EKSAAVVTAI SLYMRHLGVR TKSGDKKSGR 240
NFFRKKVMGN RRSDEPPKTK KGLSSILDPA RWNRGEPSAP DCRHLKVEAD AEKPGPADRK 300
GGLGMSSRDR TVGTPGQDNP GVSLHPLSTD SVDSREPGVD TPQEPGDTPP QGPTSLEPLA 360
PPESTEDNGE TERLSGRLGR SESLRVSDRR RPSRGSLGAK GRGGGRSRSD VDMDPGSATA 420
VLGPTRRATP EPGDDGEPGR SGLELEPEEP PGWRELVPPD TLLSLPKSQV KRQEVISELL 480
VTEAAHVRML RVLHDLFYQP MADGGFFPLD ELQNIFPSLD ELIEVHSLFL DRLMKRRQES 540
GYLIEEIGDV LLARFDGAEG SWFQKISSRF CSRQSFALEQ LKAKQRKEPR FCAFVQEAES 600
RPRCRRLQLK DMIPTEMQRL TKYPLLLQSI GQNTEESTER GKVELAAECC REILHHVNQA 660
VRDMEDLLRL KDYQRRLDLT HLRQSSDPML SEFKNLDITK KKLVHEGPLT WRVTKDKAIE 720
VHVLLLDDLL LLLQRQDERL LLKSHSRTLT PTPDGKTMLR PVLRLTSAMT REVATDHKAF 780
YVIFTWDQEA QIYELVAQTS SERKNWCNLI TETAGSLKVP APASRLKPRP SPSSIREPLL 840
SSSENGTGGA EMAPADARTE RLLNDLLPFC RPGPEGQLAA TALQKVLSLK QILLSTEEDS 900
GAGPPRDGDG VPGGRAPGPV HTQEIEENLL SLEVAIRQLE ELEEEFCRLR PLLSQLGGTL 960
SPNLAAPERS AQTGLS 977
Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome
Interpro

IPR000219--DH-domain
IPR011993--PH/PTB_dom
IPR001849--PH_domain
IPR016137--RGS
IPR015212--RGS-like_dom
PROSITE

PS50010--DH_2
PS50003--PH_DOMAIN
Pfam

PF16652--PH_13
PF09128--RGS-like
PF00621--RhoGEF
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005886--C:plasma membrane
GO:0044822--F:poly(A) RNA binding
GO:0005089--F:Rho guanyl-nucleotide exchange factor activity
GO:0035023--P:regulation of Rho protein signal transduction