dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0048293
Uniprot Accession D3Z7U4; D3Z7U4_MOUSE;
Genbank Protein ID
Genbank Nucleotide ID
Protein Name Methyl-CpG-binding protein 2
Protein Synonyms/Alias
Gene Name Mecp2
Gene Synonyms/Alias
Organism Mus musculus(Mouse)
NCBI Taxa ID 10090
Functional Description
(View all)
Phosphorylation Sites
dbPAF PTMs: 2
PositionPeptidesSourceReferences ( PMIDs )
15AAAAAAPSGGGGGGEPhosphoSitePlus22135298
30EERLEEKSEDQDLQGcurated20469934
Sequence
(Fasta)
MAAAAATAAA AAAPSGGGGG GEEERLEEKS EDQDLQGLRD KPLKFKKAKK DKKEDKEGKH 60
EPLQPSAHHS AEPAEAGKAE TSESSGSAPA VPEASASPKQ RRSIIRDRGP MYDDPTLPEG 120
WTRKLKQRKS GRSAGKYDVY LINPQGKAFR SKVELIAYFE KLQELAGVGD APKGAALGDQ 180
RQQHQKVFR
Keyword

KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome

Interpro

IPR016177--DNA-bd_dom
IPR001739--Methyl_CpG_DNA-bd

PROSITE

PS50982--MBD

Pfam

PF01429--MBD

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005615--C:extracellular space
GO:0000792--C:heterochromatin
GO:0005739--C:mitochondrion
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0003682--F:chromatin binding
GO:0003677--F:DNA binding
GO:0010385--F:double-stranded methylated DNA binding
GO:0008327--F:methyl-CpG binding
GO:0003729--F:mRNA binding
GO:0044822--F:poly(A) RNA binding
GO:0019904--F:protein domain specific binding
GO:0047485--F:protein N-terminus binding
GO:0035197--F:siRNA binding
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0008134--F:transcription factor binding
GO:0008344--P:adult locomotory behavior
GO:0001662--P:behavioral fear response
GO:0007420--P:brain development
GO:0032048--P:cardiolipin metabolic process
GO:0050432--P:catecholamine secretion
GO:0006576--P:cellular biogenic amine metabolic process
GO:0021549--P:cerebellum development
GO:0006342--P:chromatin silencing
GO:0016358--P:dendrite development
GO:0060079--P:excitatory postsynaptic potential
GO:0008211--P:glucocorticoid metabolic process
GO:0006541--P:glutamine metabolic process
GO:0016573--P:histone acetylation
GO:0016571--P:histone methylation
GO:0006020--P:inositol metabolic process
GO:0007612--P:learning
GO:0007616--P:long-term memory
GO:0060291--P:long-term synaptic potentiation
GO:0007613--P:memory
GO:0006122--P:mitochondrial electron transport, ubiquinol to cytochrome c
GO:0033555--P:multicellular organismal response to stress
GO:0035067--P:negative regulation of histone acetylation
GO:0031061--P:negative regulation of histone methylation
GO:0043524--P:negative regulation of neuron apoptotic process
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0001976--P:neurological system process involved in regulation of systemic arterial blood pressure
GO:0050905--P:neuromuscular process
GO:0050884--P:neuromuscular process controlling posture
GO:0030182--P:neuron differentiation
GO:0042551--P:neuron maturation
GO:0031175--P:neuron projection development
GO:0009405--P:pathogenesis
GO:0046470--P:phosphatidylcholine metabolic process
GO:0008284--P:positive regulation of cell proliferation
GO:0051965--P:positive regulation of synapse assembly
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0009791--P:post-embryonic development
GO:0019230--P:proprioception
GO:0008104--P:protein localization
GO:0010468--P:regulation of gene expression
GO:0006349--P:regulation of gene expression by genetic imprinting
GO:0040029--P:regulation of gene expression, epigenetic
GO:0002087--P:regulation of respiratory gaseous exchange by neurological system process
GO:0048167--P:regulation of synaptic plasticity
GO:0006355--P:regulation of transcription, DNA-templated
GO:0007585--P:respiratory gaseous exchange
GO:0001666--P:response to hypoxia
GO:0019233--P:sensory perception of pain
GO:0035176--P:social behavior
GO:0001964--P:startle response
GO:0007416--P:synapse assembly
GO:0007268--P:synaptic transmission
GO:0021591--P:ventricular system development
GO:0008542--P:visual learning