| Tag |
Content |
| dbPAF ID |
dbPAF-0048290 |
| Uniprot Accession |
D3Z7P3; GLSK_MOUSE; E9PUF0; Q69ZX9;
|
| Genbank Protein ID |
NP_001074550.1; NP_001106854.1;
|
| Genbank Nucleotide ID |
NM_001081081.2; NM_001113383.1;
|
| Protein Name |
Glutaminase kidney isoform, mitochondrial |
| Protein Synonyms/Alias |
|
| Gene Name |
Gls |
| Gene Synonyms/Alias |
Gls1;Kiaa0838; |
| Organism |
Mus musculus(Mouse) |
| NCBI Taxa ID |
10090 |
Functional Description
(View all) |
Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate in the brain.Functional Description
Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate in the brain. |
Phosphorylation Sites
|
dbPAF PTMs: 5 |
Sequence
(Fasta) | MMRLRGSAML RELLLRPPAA VGAVLRRAQP LGTLCRRPRG GSRPTAGLVA AARLHPWWGG 60
GGRAKGPGAG GLSSSPSEIL QELGKGGTPP QQQQQQQQQP GASPPAAPGP KDSPGETDAF 120
GNSEGKEMVA AGDNKIKQGL LPSLEDLLFY TIAEGQEKIP VHKFITALKS TGLRTSDPRL 180
KECMDMLRLT LQTTSDGVML DKDLFKKCVQ SNIVLLTQAF RRKFVIPDFM SFTSHIDELY 240
ESAKKQSGGK VADYIPQLAK FSPDLWGVSV CTVDGQRHSI GDTKVPFCLQ SCVKPLKYAI 300
AVNDLGTEYV HRYVGKEPSG LRFNKLFLNE DDKPHNPMVN AGAIVVTSLI KQGVNNAEKF 360
DYVMQFLNKM AGNEYVGFSN ATFQSERESG DRNFAIGYYL KEKKCFPEGT DMVGILDFYF 420
QLCSIEVTCE SASVMAATLA NGGFCPITGE RVLSPEAVRN TLSLMHSCGM YDFSGQFAFH 480
VGLPAKSGVA GGILLVVPNV MGMMCWSPPL DKMGNSVKGI HFCHDLVSLC NFHNYDNLRH 540
FAKKLDPRRE GGDQRVKSVI NLLFAAYTGD VSALRRFALS AMDMEQRDYD SRTALHVAAA 600
EGHVEVVKFL LEACKVNPFP KDRWNNTPMD EALHFGHHDV FKILQEYQVQ YTPQGDSDDG 660
KGNQTVHKNL DGLL
675Fasta Sequence
>D3Z7P3|Gls|Mus musculus(Mouse)
MMRLRGSAMLRELLLRPPAAVGAVLRRAQPLGTLCRRPRGGSRPTAGLVAAARLHPWWGGGGRAKGPGAGGLSSSPSEILQELGKGGTPPQQQQQQQQQPGASPPAAPGPKDSPGETDAFGNSEGKEMVAAGDNKIKQGLLPSLEDLLFYTIAEGQEKIPVHKFITALKSTGLRTSDPRLKECMDMLRLTLQTTSDGVMLDKDLFKKCVQSNIVLLTQAFRRKFVIPDFMSFTSHIDELYESAKKQSGGKVADYIPQLAKFSPDLWGVSVCTVDGQRHSIGDTKVPFCLQSCVKPLKYAIAVNDLGTEYVHRYVGKEPSGLRFNKLFLNEDDKPHNPMVNAGAIVVTSLIKQGVNNAEKFDYVMQFLNKMAGNEYVGFSNATFQSERESGDRNFAIGYYLKEKKCFPEGTDMVGILDFYFQLCSIEVTCESASVMAATLANGGFCPITGERVLSPEAVRNTLSLMHSCGMYDFSGQFAFHVGLPAKSGVAGGILLVVPNVMGMMCWSPPLDKMGNSVKGIHFCHDLVSLCNFHNYDNLRHFAKKLDPRREGGDQRVKSVINLLFAAYTGDVSALRRFALSAMDMEQRDYDSRTALHVAAAEGHVEVVKFLLEACKVNPFPKDRWNNTPMDEALHFGHHDVFKILQEYQVQYTPQGDSDDGKGNQTVHKNLDGLL
|
| Keyword |
KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0040--ANK repeat
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0378--Hydrolase
KW-0496--Mitochondrion
KW-1185--Reference proteome
KW-0677--Repeat
KW-0809--Transit peptide
|
| Interpro |
IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR012338--Beta-lactam/transpept-like
IPR015868--Glutaminase
|
| PROSITE |
PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
|
| Pfam |
PF12796--Ank_2
PF04960--Glutaminase
|
| Gene Ontology |
GO:0005829--C:cytosol
GO:0005759--C:mitochondrial matrix
GO:0005739--C:mitochondrion
GO:0004359--F:glutaminase activity
GO:0006537--P:glutamate biosynthetic process
GO:0006543--P:glutamine catabolic process
GO:0051289--P:protein homotetramerization
GO:0002087--P:regulation of respiratory gaseous exchange by neurological system process
GO:0001967--P:suckling behavior
GO:0007268--P:synaptic transmission
|
