dbPAF Protein Information
| Tag | Content |
|---|---|
| dbPAF ID | dbPAF-0044142 |
| Uniprot Accession | Q9Y821; MED4_SCHPO; |
| Genbank Protein ID | NP_596462.1; |
| Genbank Nucleotide ID | NM_001022381.2; |
| Protein Name | Mediator of RNA polymerase II transcription subunit 4 |
| Protein Synonyms/Alias | Mediator complex subunit 4;RNA polymerase II mediator complex protein pmc4; |
| Gene Name | med4 |
| Gene Synonyms/Alias | pmc4;SPBC1105.06; |
| Organism | Schizosaccharomyces pombe (strain 972 / ATCC 24843)(Fission yeast) |
| NCBI Taxa ID | 284812 |
| Functional Description (View all) |
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. |
| Phosphorylation Sites |
dbPAF PTMs: 3 |
| Sequence (Fasta) | MEYQRAIDSI EECLNKQLRL SSEKVDQYVL IENWTSLVGH LKTLHSLISN YTNGRELQNE 60 ISSLLKQDKE LDLQIQDCMR EMTSIYDTHL PKTVSGRKRQ KVNAETLLDY GRKLSKFSSA 120 PPGYNPETGQ DAKAPVHYPW PSEDQMRKTL LFQFSTSMVP NLSATASQLF SEQPPKTNEP 180 TETETEIDAN KAVEEKTKMN YPASPTFTTQ EENKEVESPA NKDVFAGFDL FDPEMEEDF 240 |
| Keyword | KW-0010--Activator |
| Interpro | IPR019258--Mediator_Med4 |
| PROSITE | |
| Pfam | PF10018--Med4 |
| Gene Ontology | GO:0005829--C:cytosol |